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VPS26B (VPS26, Retromer Complex Component B) is a Protein Coding gene. Diseases associated with VPS26B include Jacobsen Syndrome and Alkuraya-Kucinskas Syndrome. Among its related pathways are Endocytosis. Gene Ontology (GO) annotations related to this gene include protein transporter activity. An important paralog of this gene is VPS26A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 26496610 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005768 | endosome | IEA,IBA | 21873635 |
GO:0005769 | early endosome | ISS | -- |
GO:0005770 | late endosome | ISS | -- |
GO:0005829 | cytosol | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Endocytosis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006886 | intracellular protein transport | IEA,IBA | 21873635 |
GO:0015031 | protein transport | IEA | -- |
GO:0016241 | regulation of macroautophagy | TAS | 26172538 |
GO:0042147 | retrograde transport, endosome to Golgi | NAS | 26220253 |
GO:0071346 | cellular response to interferon-gamma | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | VPS26B 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | VPS26B 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | VPS26B 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Vps26b 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Vps26b 30 |
|
||
Cow (Bos Taurus) |
Mammalia | VPS26B 30 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | VPS26B 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | VPS26B 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | vps26b 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | vps26bl 31 |
|
OneToMany | |
vps26b 31 |
|
OneToMany | |||
Dr.4181 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Vps26 30 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | vps-26 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PEP8 31 |
|
OneToMany | |
Barley (Hordeum vulgare) |
Liliopsida | Hv.2754 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2536 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2076 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2745323 | CNV | deletion | 23290073 |
esv3892114 | CNV | gain | 25118596 |
nsv521581 | CNV | gain | 19592680 |
nsv826147 | CNV | gain | 20364138 |
nsv832299 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
jacobsen syndrome |
|
|
alkuraya-kucinskas syndrome |
|
|
parkinson disease, late-onset |
|
|