Aliases for VPS26B Gene
External Ids for VPS26B Gene
Previous GeneCards Identifiers for VPS26B Gene
GeneCards Summary for VPS26B Gene
VPS26B (VPS26, Retromer Complex Component B) is a Protein Coding gene. Diseases associated with VPS26B include Jacobsen Syndrome and Alkuraya-Kucinskas Syndrome. Among its related pathways are Endocytosis. Gene Ontology (GO) annotations related to this gene include protein transporter activity. An important paralog of this gene is VPS26A.
UniProtKB/Swiss-Prot Summary for VPS26B Gene
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity).