Aliases for VPS25 Gene
External Ids for VPS25 Gene
Previous GeneCards Identifiers for VPS25 Gene
This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Jul 2013]
GeneCards Summary for VPS25 Gene
VPS25 (Vacuolar Protein Sorting 25 Homolog) is a Protein Coding gene. Diseases associated with VPS25 include Frontotemporal Dementia, Chromosome 3-Linked and Rigid Spine Muscular Dystrophy 1. Among its related pathways are Budding and maturation of HIV virion and Delta508-CFTR traffic / Sorting endosome formation in CF. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein N-terminus binding.
UniProtKB/Swiss-Prot Summary for VPS25 Gene
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.