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This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Jul 2013]
VPS25 (Vacuolar Protein Sorting 25 Homolog) is a Protein Coding gene. Diseases associated with VPS25 include Frontotemporal Dementia, Chromosome 3-Linked and Rigid Spine Muscular Dystrophy 1. Among its related pathways are Budding and maturation of HIV virion and Delta508-CFTR traffic / Sorting endosome formation in CF. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein N-terminus binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005198 | structural molecule activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 14505570 |
GO:0042803 | protein homodimerization activity | IBA,IPI | 14519844 |
GO:0047485 | protein N-terminus binding | IPI | 16973552 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000814 | ESCRT II complex | IEA,TAS | 20588296 |
GO:0005634 | nucleus | IEA,IDA | 16371348 |
GO:0005654 | nucleoplasm | IEA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 16973552 |
GO:0005768 | endosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Vesicle-mediated transport | ||
2 | Endocytosis | ||
3 | Budding and maturation of HIV virion | ||
4 | Delta508-CFTR traffic / Sorting endosome formation in CF |
Delta508-CFTR traffic / Sorting endosome formation in CF
-
|
|
5 | Delta508-CFTR traffic / ER-to-Golgi in CF |
wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
.33
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity | IMP | 16973552 |
GO:0015031 | protein transport | IEA | -- |
GO:0016197 | endosomal transport | TAS | -- |
GO:0016236 | macroautophagy | TAS | 20588296 |
GO:0036258 | multivesicular body assembly | TAS | 20588296 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | VPS25 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | VPS25 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | VPS25 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | VPS25 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Vps25 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Vps25 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | VPS25 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | VPS25 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | VPS25 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | vps25 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.7309 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | vps25 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3769 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Vps25 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011497 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | vps-25 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS25 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | VPS25 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0658500 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU03898 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | vps25 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
791412 | Benign: not provided | 42,774,672(+) | A/G | MISSENSE_VARIANT | |
rs34494804 | - | p.Ile76Val |
Disorder | Aliases | PubMed IDs |
---|---|---|
frontotemporal dementia, chromosome 3-linked |
|
|
rigid spine muscular dystrophy 1 |
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|
cone-rod dystrophy 2 |
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