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Aliases for VPREB3 Gene

Aliases for VPREB3 Gene

  • V-Set Pre-B Cell Surrogate Light Chain 3 2 3 5
  • Pre-B Lymphocyte Protein 3 3 4
  • Pre-B Lymphocyte 3 2 3
  • N27C7-2 3 4
  • Pre-B Lymphocyte Gene 3 3
  • Protein VPreB3 4
  • 8HS20 3

External Ids for VPREB3 Gene

Previous GeneCards Identifiers for VPREB3 Gene

  • GC22M020791
  • GC22M022419
  • GC22M024094
  • GC22M007083

Summaries for VPREB3 Gene

Entrez Gene Summary for VPREB3 Gene

  • The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]

GeneCards Summary for VPREB3 Gene

VPREB3 (V-Set Pre-B Cell Surrogate Light Chain 3) is a Protein Coding gene. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is IGLV5-37.

UniProtKB/Swiss-Prot for VPREB3 Gene

  • Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.

Gene Wiki entry for VPREB3 Gene

Additional gene information for VPREB3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPREB3 Gene

Genomics for VPREB3 Gene

GeneHancer (GH) Regulatory Elements for VPREB3 Gene

Promoters and enhancers for VPREB3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J023766 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 617.1 -13.2 -13158 3.2 HDGF SP1 ELF3 ZFX CTCF MNT ZNF148 NKRF POLR2A ZNF121 VPREB3 CHCHD10 MMP11 SMARCB1 ENSG00000234353 POM121L9P SNRPD3 CABIN1 MIF-AS1 ENSG00000272578
GH22J023754 Promoter 0.6 EPDnew 600.7 0.0 -1 0.1 RUNX3 VPREB3 C22orf15
GH22J023772 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 11.4 -20.1 -20107 4.4 HDGF ZFX ELF3 MNT ZNF148 NKRF CEBPG RERE ZNF687 NFIB MMP11 VPREB3 ZNF70 SMARCB1 GUSBP11 RGL4 CHCHD10 ENSG00000273295
GH22J023762 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 14.9 -9.0 -9026 1.7 RFX1 POLR2A GABPA MNT NR2F1 SUPT5H ZBTB33 C22orf15 VPREB3 SMARCB1 MMP11
GH22J023715 Promoter/Enhancer 1.6 Ensembl ENCODE 12.7 +37.6 37595 2.2 HDGF SP1 ELF3 ZFX MNT SIX5 CBFA2T2 NKRF POLR2A CEBPG ENSG00000272578 GUSBP11 ZNF70 ENSG00000234353 SPECC1L VPREB3 C22orf15 RGL4 MMP11 CHCHD10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VPREB3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VPREB3 gene promoter:
  • AML1a
  • ARP-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • Meis-1
  • Meis-1a
  • Meis-1b
  • p300
  • Pax-4a

Genomic Locations for VPREB3 Gene

Genomic Locations for VPREB3 Gene
1,701 bases
Minus strand
1,726 bases
Minus strand

Genomic View for VPREB3 Gene

Genes around VPREB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VPREB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VPREB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPREB3 Gene

Proteins for VPREB3 Gene

  • Protein details for VPREB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pre-B lymphocyte protein 3
    Protein Accession:
    Secondary Accessions:
    • B2R587

    Protein attributes for VPREB3 Gene

    123 amino acids
    Molecular mass:
    13710 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VPREB3 Gene

Post-translational modifications for VPREB3 Gene

No Post-translational modifications

Other Protein References for VPREB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VPREB3 Gene

Domains & Families for VPREB3 Gene

Gene Families for VPREB3 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for VPREB3 Gene

Suggested Antigen Peptide Sequences for VPREB3 Gene

GenScript: Design optimal peptide antigens:
  • Protein VPreB3 (VPRE3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily.
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with VPREB3: view

Function for VPREB3 Gene

Molecular function for VPREB3 Gene

UniProtKB/Swiss-Prot Function:
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.

Phenotypes From GWAS Catalog for VPREB3 Gene

genes like me logo Genes that share phenotypes with VPREB3: view

Animal Model Products

CRISPR Products

miRNA for VPREB3 Gene

miRTarBase miRNAs that target VPREB3

Clone Products

  • Applied Biological Materials (abm): Clones for VPREB3 - Now 50% OFF >
  • * VPREB3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * VPREB3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VPREB3 Gene

Localization for VPREB3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VPREB3 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
mitochondrion 0
cytosol 0

Gene Ontology (GO) - Cellular Components for VPREB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005783 endoplasmic reticulum NAS 10702669
genes like me logo Genes that share ontologies with VPREB3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for VPREB3 Gene

Pathways & Interactions for VPREB3 Gene

genes like me logo Genes that share pathways with VPREB3: view

Pathways by source for VPREB3 Gene

2 Reactome pathways for VPREB3 Gene

Gene Ontology (GO) - Biological Process for VPREB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002377 immunoglobulin production IBA 21873635
GO:0006955 immune response IBA 21873635
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with VPREB3: view

No data available for SIGNOR curated interactions for VPREB3 Gene

Drugs & Compounds for VPREB3 Gene

No Compound Related Data Available

Transcripts for VPREB3 Gene

mRNA/cDNA for VPREB3 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for VPREB3 Gene

Pre-B lymphocyte 3:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for VPREB3 - Now 50% OFF >
  • * VPREB3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * VPREB3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for VPREB3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP2: -

Relevant External Links for VPREB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VPREB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VPREB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VPREB3 Gene

This gene is overexpressed in Spleen (x15.6), Small Intestine - Terminal Ileum (x13.4), and Whole Blood (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of VPREB3 Gene:


SOURCE GeneReport for Unigene cluster for VPREB3 Gene:


mRNA Expression by UniProt/SwissProt for VPREB3 Gene:

Tissue specificity: Expressed in B-cell precursors. Expressed in fetal liver, bone marrow, spleen and lymph node.

Evidence on tissue expression from TISSUES for VPREB3 Gene

  • Spleen(4.4)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with VPREB3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VPREB3 Gene

Orthologs for VPREB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VPREB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VPREB3 35 34
  • 99.46 (n)
(Canis familiaris)
Mammalia VPREB3 35 34
  • 82.63 (n)
(Bos Taurus)
Mammalia VPREB3 35 34
  • 77.97 (n)
(Rattus norvegicus)
Mammalia Vpreb3 34
  • 73.81 (n)
(Mus musculus)
Mammalia Vpreb3 17 35 34
  • 71.86 (n)
(Gallus gallus)
Aves VPREB3 35 34
  • 63.61 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 30 (a)
-- 35
  • 25 (a)
Species where no ortholog for VPREB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VPREB3 Gene

Gene Tree for VPREB3 (if available)
Gene Tree for VPREB3 (if available)
Evolutionary constrained regions (ECRs) for VPREB3: view image

Paralogs for VPREB3 Gene

genes like me logo Genes that share paralogs with VPREB3: view

Variants for VPREB3 Gene

Sequence variations from dbSNP and Humsavar for VPREB3 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000406583 -- 23,752,297(-) C/T downstream_transcript_variant
rs1000631368 -- 23,756,214(-) T/A/C upstream_transcript_variant
rs1000874050 -- 23,756,201(-) G/A/T upstream_transcript_variant
rs1001342369 -- 23,755,517(-) C/G upstream_transcript_variant
rs1002293904 -- 23,754,230(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for VPREB3 Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv2724041 CNV deletion 23290073
esv3575443 CNV gain 25503493
esv3893457 CNV gain 25118596
esv3893461 CNV gain 25118596
nsv1062411 CNV gain 25217958
nsv1066891 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv526567 CNV gain 19592680
nsv7350 OTHER inversion 18451855

Variation tolerance for VPREB3 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VPREB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPREB3 Gene

Disorders for VPREB3 Gene

Additional Disease Information for VPREB3

No disorders were found for VPREB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VPREB3 Gene

Publications for VPREB3 Gene

  1. VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse. (PMID: 10702669) Rosnet O … Schiff C (Cytogenetics and cell genetics 1999) 2 3 4 23 58
  2. Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells. (PMID: 14670953) Rosnet O … Schiff C (The Journal of biological chemistry 2004) 2 3 58
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for VPREB3 Gene

Sources for VPREB3 Gene

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