Aliases for VPREB3 Gene
External Ids for VPREB3 Gene
Previous GeneCards Identifiers for VPREB3 Gene
The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]
GeneCards Summary for VPREB3 Gene
VPREB3 (V-Set Pre-B Cell Surrogate Light Chain 3) is a Protein Coding gene. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is IGLV2-11.
UniProtKB/Swiss-Prot Summary for VPREB3 Gene
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.