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Aliases for VPREB1 Gene

Aliases for VPREB1 Gene

  • V-Set Pre-B Cell Surrogate Light Chain 1 2 3 5
  • CD179 Antigen-Like Family Member A 3 4
  • Immunoglobulin Iota Chain 3 4
  • Pre-B Lymphocyte 1 2 3
  • V(Pre)B Protein 3 4
  • VPREB 3 4
  • CD179a Antigen 4
  • Protein VPreB1 4
  • VpreB Protein 4
  • CD179a 3
  • IGVPB 3
  • IGI 3

External Ids for VPREB1 Gene

Previous GeneCards Identifiers for VPREB1 Gene

  • GC22P019297
  • GC22P020923
  • GC22P022600
  • GC22P005557

Summaries for VPREB1 Gene

Entrez Gene Summary for VPREB1 Gene

  • The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for VPREB1 Gene

VPREB1 (V-Set Pre-B Cell Surrogate Light Chain 1) is a Protein Coding gene. Diseases associated with VPREB1 include Conidiobolomycosis and Mu Chain Disease. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is IGLV5-37.

UniProtKB/Swiss-Prot for VPREB1 Gene

  • Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.

Gene Wiki entry for VPREB1 Gene

Additional gene information for VPREB1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPREB1 Gene

Genomics for VPREB1 Gene

GeneHancer (GH) Regulatory Elements for VPREB1 Gene

Promoters and enhancers for VPREB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VPREB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VPREB1 gene promoter:
  • FAC1
  • HEN1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • MIF-1
  • RORalpha1
  • STAT1
  • Zic3

Genomic Locations for VPREB1 Gene

Genomic Locations for VPREB1 Gene
chr22:22,244,675-22,245,515
(GRCh38/hg38)
Size:
841 bases
Orientation:
Plus strand
chr22:22,599,087-22,599,927
(GRCh37/hg19)
Size:
841 bases
Orientation:
Plus strand

Genomic View for VPREB1 Gene

Genes around VPREB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VPREB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VPREB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPREB1 Gene

Proteins for VPREB1 Gene

  • Protein details for VPREB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12018-VPREB_HUMAN
    Recommended name:
    Immunoglobulin iota chain
    Protein Accession:
    P12018
    Secondary Accessions:
    • B5MCG2

    Protein attributes for VPREB1 Gene

    Size:
    145 amino acids
    Molecular mass:
    16605 Da
    Quaternary structure:
    • Associates non-covalently with IGLL1.

    Three dimensional structures from OCA and Proteopedia for VPREB1 Gene

neXtProt entry for VPREB1 Gene

Post-translational modifications for VPREB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VPREB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VPREB1 Gene

Domains & Families for VPREB1 Gene

Gene Families for VPREB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted secreted proteins

Protein Domains for VPREB1 Gene

Suggested Antigen Peptide Sequences for VPREB1 Gene

GenScript: Design optimal peptide antigens:
  • V(pre)B protein (VPREB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P12018

UniProtKB/Swiss-Prot:

VPREB_HUMAN :
  • Belongs to the immunoglobulin superfamily.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with VPREB1: view

Function for VPREB1 Gene

Molecular function for VPREB1 Gene

UniProtKB/Swiss-Prot Function:
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.
GENATLAS Biochemistry:
immunoglobulin-like V gene,expressed in pre-B cells

Phenotypes From GWAS Catalog for VPREB1 Gene

genes like me logo Genes that share phenotypes with VPREB1: view

Animal Models for VPREB1 Gene

MGI Knock Outs for VPREB1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VPREB1

Clone Products

  • Applied Biological Materials (abm): Clones for VPREB1 - Now 50% OFF >
  • * VPREB1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * VPREB1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VPREB1 Gene

Localization for VPREB1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VPREB1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for VPREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with VPREB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for VPREB1 Gene

Pathways & Interactions for VPREB1 Gene

genes like me logo Genes that share pathways with VPREB1: view

Pathways by source for VPREB1 Gene

2 Reactome pathways for VPREB1 Gene

Interacting Proteins for VPREB1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000385361%0d9606.ENSP00000329312%0d9606.ENSP00000215909%0d9606.ENSP00000248948%0d9606.ENSP00000358525%0d9606.ENSP00000397297%0d
Selected Interacting proteins: ENSP00000385361 P12018-VPREB_HUMAN for VPREB1 Gene via STRING IID

Symbol External ID(s) Details
HLA-B
HLA-A
ABL1
HLA-C
IGLL1

Gene Ontology (GO) - Biological Process for VPREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002377 immunoglobulin production IBA 21873635
GO:0006955 immune response IBA 21873635
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with VPREB1: view

No data available for SIGNOR curated interactions for VPREB1 Gene

Drugs & Compounds for VPREB1 Gene

(1) Drugs for VPREB1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with VPREB1: view

Transcripts for VPREB1 Gene

mRNA/cDNA for VPREB1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for VPREB1 Gene

Pre-B lymphocyte 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VPREB1

Clone Products

  • Applied Biological Materials (abm): Clones for VPREB1 - Now 50% OFF >
  • * VPREB1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * VPREB1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for VPREB1 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -
SP2:

Relevant External Links for VPREB1 Gene

GeneLoc Exon Structure for
VPREB1
ECgene alternative splicing isoforms for
VPREB1

Expression for VPREB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VPREB1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VPREB1 Gene



NURSA nuclear receptor signaling pathways regulating expression of VPREB1 Gene:

VPREB1

SOURCE GeneReport for Unigene cluster for VPREB1 Gene:

Hs.247979

mRNA Expression by UniProt/SwissProt for VPREB1 Gene:

P12018-VPREB_HUMAN
Tissue specificity: Only expressed by pre-B-cells.

Evidence on tissue expression from TISSUES for VPREB1 Gene

  • Bone marrow(2.5)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with VPREB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VPREB1 Gene

Orthologs for VPREB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VPREB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPREB1 35 34
  • 98.62 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Vpreb2 17 35 34
  • 83.75 (n)
Vpreb1 35
  • 73 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Vpreb2 34
  • 81.82 (n)
dog
(Canis familiaris)
Mammalia VPREB1 35 34
  • 80.44 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 28 (a)
OneToMany
Species where no ortholog for VPREB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VPREB1 Gene

ENSEMBL:
Gene Tree for VPREB1 (if available)
TreeFam:
Gene Tree for VPREB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for VPREB1: view image

Paralogs for VPREB1 Gene

genes like me logo Genes that share paralogs with VPREB1: view

Variants for VPREB1 Gene

Sequence variations from dbSNP and Humsavar for VPREB1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000474553 -- 22,243,662(+) A/C/T upstream_transcript_variant
rs1002247176 -- 22,245,781(+) A/G downstream_transcript_variant
rs1003785685 -- 22,243,831(+) C/T upstream_transcript_variant
rs1004929482 -- 22,244,760(+) T/A/G upstream_transcript_variant
rs1005032993 -- 22,244,563(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for VPREB1 Gene

Variant ID Type Subtype PubMed ID
dgv22e196 CNV deletion 17116639
dgv37n64 CNV loss 17921354
dgv4504n100 CNV gain 25217958
dgv548n27 CNV loss 19166990
dgv728n67 CNV loss 20364138
dgv7998n54 CNV loss 21841781
esv2422480 CNV deletion 17116639
esv2544553 CNV deletion 19546169
esv2670821 CNV deletion 23128226
esv3647335 CNV loss 21293372
esv3647345 CNV loss 21293372
esv3647351 CNV loss 21293372
esv3647352 CNV gain 21293372
esv3893447 CNV gain 25118596
nsv1058897 CNV loss 25217958
nsv1062771 CNV loss 25217958
nsv433331 CNV loss 18776910
nsv459421 CNV gain 19166990
nsv459450 CNV loss 19166990
nsv459451 CNV loss 19166990
nsv469749 CNV loss 16826518
nsv526328 CNV gain 19592680
nsv588348 CNV gain 21841781
nsv588391 CNV loss 21841781
nsv588393 CNV loss 21841781
nsv7350 OTHER inversion 18451855
nsv817937 CNV loss 17921354
nsv817943 CNV loss 17921354
nsv820089 CNV gain 19587683
nsv834147 CNV loss 17160897

Variation tolerance for VPREB1 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VPREB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VPREB1
Human Gene Mutation Database (HGMD)
VPREB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPREB1 Gene

Disorders for VPREB1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for VPREB1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
conidiobolomycosis
  • infection by conidiobolus
mu chain disease
  • mu-chain disease
common variable immunodeficiency
  • acquired agammaglobulinemia
prediabetes syndrome
  • prediabetes
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for VPREB1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with VPREB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VPREB1 Gene

Publications for VPREB1 Gene

  1. The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain. (PMID: 7935499) Guelpa-Fonlupt V … Schiff C (Molecular immunology 1994) 3 4 23 58
  2. Engineering and characterization of a single chain surrogate light chain variable domain. (PMID: 18287279) Morstadt L … Baleja JD (Protein science : a publication of the Protein Society 2008) 4 23 58
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  4. Secretion of soluble pre-B cell receptors by pre-B cells. (PMID: 9058786) Bornemann KD … Corley RB (Journal of immunology (Baltimore, Md. : 1950) 1997) 3 23 58
  5. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K … Shimizu N (Genome research 1997) 3 4 58

Products for VPREB1 Gene

Sources for VPREB1 Gene

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