Aliases for VOPP1 Gene

Aliases for VOPP1 Gene

  • VOPP1 WW Domain Binding Protein 2 3 5
  • Vesicular, Overexpressed In Cancer, Prosurvival Protein 1 2 3 4
  • EGFR-Coamplified And Overexpressed Protein 2 3 4
  • Glioblastoma-Amplified Secreted Protein 2 3 4
  • Putative NF-Kappa-B-Activating Protein 055N 3 4
  • VOPP1, WBP1/VOPP1 Family Member 2 3
  • ECOP 3 4
  • GASP 3 4
  • Hypothetical Protein DKFZp564K0822 3
  • WBP1L2 3
  • ECop 4

External Ids for VOPP1 Gene

Previous GeneCards Identifiers for VOPP1 Gene

  • GC07M055503
  • GC07M055374

Summaries for VOPP1 Gene

GeneCards Summary for VOPP1 Gene

VOPP1 (VOPP1 WW Domain Binding Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity.

UniProtKB/Swiss-Prot Summary for VOPP1 Gene

  • Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.

Gene Wiki entry for VOPP1 Gene

Additional gene information for VOPP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VOPP1 Gene

Genomics for VOPP1 Gene

GeneHancer (GH) Regulatory Elements for VOPP1 Gene

Promoters and enhancers for VOPP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J055567 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 513.5 +2.0 1976 8 HNRNPK SIN3A NRF1 USF1 PHF8 JUND FOS CTCF ZNF639 ZIC2 VOPP1 ENSG00000223475 lnc-VOPP1-3 piR-38095 SEC61G
GH07J055545 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 527.5 +20.5 20477 15.6 EP300 SP1 JUND FOS CTCF ZIC2 RFX1 RELA RAD21 POLR2A VOPP1 ENSG00000223475 LOC100129276 piR-56020 lnc-VOPP1-3 piR-56580-041
GH07J055531 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.4 +38.2 38177 7.3 RXRA ZNF217 SIN3A SP1 JUND FOS EP300 RELA MEF2C REST VOPP1 piR-56580-041 piR-56020 lnc-VOPP1-3
GH07J055502 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 14.6 +67.5 67455 12.6 FOS REST RELA ATF2 POLR2A CREB1 GATA3 SPI1 FOSL1 JUND VOPP1 LOC100129276 piR-56580-041 lnc-SEPT14-4 lnc-VOPP1-3
GH07J055497 Enhancer 0.7 Ensembl ENCODE dbSUPER 14.9 +74.9 74854 1.8 ZIC2 POLR2A ESR1 VOPP1 piR-56580-041 lnc-SEPT14-4 lnc-VOPP1-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VOPP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VOPP1

Genomic Locations for VOPP1 Gene

Genomic Locations for VOPP1 Gene
chr7:55,434,406-55,573,355
(GRCh38/hg38)
Size:
138,950 bases
Orientation:
Minus strand
chr7:55,503,749-55,640,681
(GRCh37/hg19)
Size:
136,933 bases
Orientation:
Minus strand

Genomic View for VOPP1 Gene

Genes around VOPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VOPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VOPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VOPP1 Gene

Proteins for VOPP1 Gene

  • Protein details for VOPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AW1-VOPP1_HUMAN
    Recommended name:
    Vesicular, overexpressed in cancer, prosurvival protein 1
    Protein Accession:
    Q96AW1
    Secondary Accessions:
    • B0AZU1
    • B2RAT4
    • B3KS72
    • C9JWR3
    • Q6FIE3
    • Q8NBN8
    • Q96RE5
    • Q9H0W4

    Protein attributes for VOPP1 Gene

    Size:
    172 amino acids
    Molecular mass:
    19224 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK82888.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for VOPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VOPP1 Gene

Post-translational modifications for VOPP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VOPP1 Gene

Domains & Families for VOPP1 Gene

Gene Families for VOPP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for VOPP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VOPP1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ79531, highly similar to Homo sapiens EGFR-coamplified and overexpressed protein (ECOP) (B0AZU1_HUMAN)
  • cDNA FLJ35673 fis, clone SPLEN2018285, highly similar to Homo sapiens EGFR-coamplified and overexpressed protein (ECOP), mRNA (B3KS72_HUMAN)
  • Putative NF-kappa-B-activating protein 055N (VOPP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96AW1

UniProtKB/Swiss-Prot:

VOPP1_HUMAN :
  • Belongs to the VOPP1/ECOP family.
Family:
  • Belongs to the VOPP1/ECOP family.
genes like me logo Genes that share domains with VOPP1: view

Function for VOPP1 Gene

Molecular function for VOPP1 Gene

UniProtKB/Swiss-Prot Function:
Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.

Phenotypes From GWAS Catalog for VOPP1 Gene

genes like me logo Genes that share phenotypes with VOPP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for VOPP1

CRISPR Products

Clone Products

  • Addgene plasmids for VOPP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VOPP1 Gene

Localization for VOPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VOPP1 Gene

Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=When overexpressed, localizes in the nucleus and perinuclear regions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VOPP1 gene
Compartment Confidence
endosome 4
plasma membrane 3
extracellular 3
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for VOPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA,IDA 20571887
GO:0031301 integral component of organelle membrane IDA 20571887
genes like me logo Genes that share ontologies with VOPP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VOPP1 Gene

Pathways & Interactions for VOPP1 Gene

PathCards logo

SuperPathways for VOPP1 Gene

No Data Available

Interacting Proteins for VOPP1 Gene

;

Gene Ontology (GO) - Biological Process for VOPP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VOPP1 Gene

Drugs & Compounds for VOPP1 Gene

No Compound Related Data Available

Transcripts for VOPP1 Gene

mRNA/cDNA for VOPP1 Gene

13 REFSEQ mRNAs :
28 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for VOPP1

Alternative Splicing Database (ASD) splice patterns (SP) for VOPP1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a ·
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - -
SP13: - - - -
SP14: - - -

ExUns: 17b · 17c · 17d · 17e · 17f · 17g · 17h · 17i
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for VOPP1 Gene

GeneLoc Exon Structure for
VOPP1

Expression for VOPP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VOPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VOPP1 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VOPP1 Gene



Protein tissue co-expression partners for VOPP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VOPP1

SOURCE GeneReport for Unigene cluster for VOPP1 Gene:

Hs.488307

mRNA Expression by UniProt/SwissProt for VOPP1 Gene:

Q96AW1-VOPP1_HUMAN
Tissue specificity: Widely expressed with highest levels in thymus and ovary.

Evidence on tissue expression from TISSUES for VOPP1 Gene

  • Nervous system(4.8)
  • Lung(4.4)
  • Spleen(4.4)
  • Blood(4.3)
  • Eye(2)
genes like me logo Genes that share expression patterns with VOPP1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for VOPP1 Gene

Orthologs for VOPP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VOPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VOPP1 31 30
  • 99.81 (n)
OneToOne
cow
(Bos Taurus)
Mammalia VOPP1 31 30
  • 87.15 (n)
OneToOne
dog
(Canis familiaris)
Mammalia VOPP1 31 30
  • 84.92 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Vopp1 17 31 30
  • 84.11 (n)
rat
(Rattus norvegicus)
Mammalia Vopp1 30
  • 83.91 (n)
oppossum
(Monodelphis domestica)
Mammalia VOPP1 31
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VOPP1 31
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves VOPP1 31 30
  • 74.55 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vopp1 30
  • 71.81 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19741 30
zebrafish
(Danio rerio)
Actinopterygii vopp1 31 30
  • 65.38 (n)
OneToMany
VOPP1 (1 of 2) 31
  • 43 (a)
OneToMany
Species where no ortholog for VOPP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VOPP1 Gene

ENSEMBL:
Gene Tree for VOPP1 (if available)
TreeFam:
Gene Tree for VOPP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for VOPP1: view image

Paralogs for VOPP1 Gene

No data available for Paralogs for VOPP1 Gene

Variants for VOPP1 Gene

Additional dbSNP identifiers (rs#s) for VOPP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for VOPP1 Gene

Variant ID Type Subtype PubMed ID
dgv6360n100 CNV loss 25217958
dgv6361n100 CNV loss 25217958
esv2734425 CNV deletion 23290073
esv28230 CNV gain+loss 19812545
esv3571865 CNV loss 25503493
esv3613244 CNV gain 21293372
esv997261 CNV deletion 20482838
nsv1017797 CNV gain 25217958
nsv1019204 CNV gain 25217958
nsv1020959 CNV gain 25217958
nsv469822 CNV gain 16826518
nsv472715 CNV novel sequence insertion 20440878
nsv981471 CNV duplication 23825009

Variation tolerance for VOPP1 Gene

Residual Variation Intolerance Score: 70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VOPP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VOPP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VOPP1 Gene

Disorders for VOPP1 Gene

Additional Disease Information for VOPP1

No disorders were found for VOPP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VOPP1 Gene

Publications for VOPP1 Gene

  1. ECop (EGFR-coamplified and overexpressed protein), a novel protein, regulates NF-kappaB transcriptional activity and associated apoptotic response in an IkappaBalpha-dependent manner. (PMID: 15735698) Park S … James CD (Oncogene 2005) 2 3 4 23 54
  2. Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. (PMID: 22120523) Pei J … Grishin NV (Cellular signalling 2012) 2 3 54
  3. Intracellular localization of GASP/ECOP/VOPP1. (PMID: 20571887) Baras A … Moskaluk CA (Journal of molecular histology 2010) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 54

Products for VOPP1 Gene

Sources for VOPP1 Gene