Aliases for VN1R5 Gene

Aliases for VN1R5 Gene

  • Vomeronasal 1 Receptor 5 (Gene/Pseudogene) 2 3 5
  • G-Protein Coupled Receptor GPCR26 3 4
  • Vomeronasal Type-1 Receptor 5 3 4
  • V1r-Like Receptor 5 3 4
  • HGPCR26 3 4
  • V1RL5 3 4
  • Vomeronasal 1 Receptor 5 2
  • Pheromone Receptor 3
  • V1R-Like 5 3

External Ids for VN1R5 Gene

Previous GeneCards Identifiers for VN1R5 Gene

  • GC01U900013
  • GC01P243516
  • GC01P244366
  • GC01P243746
  • GC01P245485
  • GC01P247419
  • GC01P217813

Summaries for VN1R5 Gene

GeneCards Summary for VN1R5 Gene

VN1R5 (Vomeronasal 1 Receptor 5 (Gene/Pseudogene)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include pheromone receptor activity. An important paralog of this gene is VN1R2.

UniProtKB/Swiss-Prot Summary for VN1R5 Gene

Gene Wiki entry for VN1R5 Gene

Additional gene information for VN1R5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VN1R5 Gene

Genomics for VN1R5 Gene

GeneHancer (GH) Regulatory Elements for VN1R5 Gene

Promoters and enhancers for VN1R5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J247256 Enhancer 0.2 Ensembl 500.7 +0.6 629 0.4 VN1R5 LOC105373273
GH01J247272 Enhancer 0.3 Ensembl 0.4 +17.3 17329 0.6 USF1 TCF7L2 LOC105373273 OR2G3 ZNF496 ENSG00000259865 VN1R5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VN1R5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VN1R5

Top Transcription factor binding sites by QIAGEN in the VN1R5 gene promoter:
  • Evi-1
  • GATA-1

Genomic Locations for VN1R5 Gene

Genomic Locations for VN1R5 Gene
chr1:247,255,972-247,257,210
(GRCh38/hg38)
Size:
1,239 bases
Orientation:
Plus strand
chr1:247,419,374-247,420,447
(GRCh37/hg19)
Size:
1,074 bases
Orientation:
Plus strand

Genomic View for VN1R5 Gene

Genes around VN1R5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VN1R5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VN1R5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VN1R5 Gene

Proteins for VN1R5 Gene

  • Protein details for VN1R5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5H4-VN1R5_HUMAN
    Recommended name:
    Vomeronasal type-1 receptor 5
    Protein Accession:
    Q7Z5H4
    Secondary Accessions:
    • A0AVG1
    • Q8NEU5
    • Q8TDU3

    Protein attributes for VN1R5 Gene

    Size:
    357 amino acids
    Molecular mass:
    40779 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.

neXtProt entry for VN1R5 Gene

Post-translational modifications for VN1R5 Gene

  • Glycosylation at Asn297
  • Modification sites at PhosphoSitePlus

Other Protein References for VN1R5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VN1R5 Gene

Domains & Families for VN1R5 Gene

Gene Families for VN1R5 Gene

Protein Domains for VN1R5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VN1R5 Gene

GenScript: Design optimal peptide antigens:
  • V1r-like receptor 5 (VN1R5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z5H4

UniProtKB/Swiss-Prot:

VN1R5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with VN1R5: view

Function for VN1R5 Gene

Molecular function for VN1R5 Gene

UniProtKB/Swiss-Prot Function:
Putative pheromone receptor.

Phenotypes From GWAS Catalog for VN1R5 Gene

Gene Ontology (GO) - Molecular Function for VN1R5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016503 pheromone receptor activity IEA --
genes like me logo Genes that share ontologies with VN1R5: view
genes like me logo Genes that share phenotypes with VN1R5: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VN1R5 Gene

Localization for VN1R5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VN1R5 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for VN1R5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VN1R5: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for VN1R5 Gene

Pathways & Interactions for VN1R5 Gene

PathCards logo

SuperPathways for VN1R5 Gene

No Data Available

Interacting Proteins for VN1R5 Gene

;

Gene Ontology (GO) - Biological Process for VN1R5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0019236 response to pheromone IEA --
genes like me logo Genes that share ontologies with VN1R5: view

No data available for Pathways by source and SIGNOR curated interactions for VN1R5 Gene

Drugs & Compounds for VN1R5 Gene

No Compound Related Data Available

Transcripts for VN1R5 Gene

mRNA/cDNA for VN1R5 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VN1R5 Gene

No ASD Table

Relevant External Links for VN1R5 Gene

GeneLoc Exon Structure for
VN1R5

Expression for VN1R5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VN1R5 Gene

mRNA differential expression in normal tissues according to GTEx for VN1R5 Gene

This gene is overexpressed in Testis (x6.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VN1R5

SOURCE GeneReport for Unigene cluster for VN1R5 Gene:

Hs.553686
genes like me logo Genes that share expression patterns with VN1R5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for VN1R5 Gene

Orthologs for VN1R5 Gene

Evolution for VN1R5 Gene

ENSEMBL:
Gene Tree for VN1R5 (if available)
TreeFam:
Gene Tree for VN1R5 (if available)

No data available for Orthologs for VN1R5 Gene

Paralogs for VN1R5 Gene

Paralogs for VN1R5 Gene

(1) SIMAP similar genes for VN1R5 Gene using alignment to 1 proteins:

  • VN1R5_HUMAN
genes like me logo Genes that share paralogs with VN1R5: view

Variants for VN1R5 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for VN1R5 Gene

VN1R5_HUMAN-Q7Z5H4
There is an allele VN1R5*2 with a truncating mutation in position 46. It was found with a frequency of about 32%.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VN1R5 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs41308154 - p.Arg350Cys

Structural Variations from Database of Genomic Variants (DGV) for VN1R5 Gene

Variant ID Type Subtype PubMed ID
esv33129 CNV gain+loss 17666407
nsv5299 CNV insertion 18451855
nsv549587 CNV loss 21841781
nsv833126 CNV loss 17160897

Additional Variant Information for VN1R5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VN1R5

SNP Genotyping and Copy Number Assay Products

No data available for Additional dbSNP identifiers (rs#s) and Variation tolerance for VN1R5 Gene

Disorders for VN1R5 Gene

Additional Disease Information for VN1R5

No disorders were found for VN1R5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VN1R5 Gene

Publications for VN1R5 Gene

  1. Novel human vomeronasal receptor-like genes reveal species-specific families. (PMID: 12123587) Rodriguez I … Mombaerts P (Current biology : CB 2002) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. (PMID: 12826614) Zhang J … Webb DM (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 54
  4. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 54
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 54

Products for VN1R5 Gene

Sources for VN1R5 Gene