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Aliases for VN1R2 Gene

Aliases for VN1R2 Gene

  • Vomeronasal 1 Receptor 2 2 3 5
  • G-Protein Coupled Receptor GPCR25 3 4
  • V1r-Like Receptor 2 3 4
  • HGPCR25 3 4
  • V1RL2 3 4
  • Vomeronasal Type-1 Receptor 2 3
  • Pheromone Receptor 3
  • V1R-Like 2 3

External Ids for VN1R2 Gene

Previous GeneCards Identifiers for VN1R2 Gene

  • GC19M054122
  • GC19P058437
  • GC19P058454
  • GC19P058455
  • GC19P058457
  • GC19P053760
  • GC19P050082

Summaries for VN1R2 Gene

GeneCards Summary for VN1R2 Gene

VN1R2 (Vomeronasal 1 Receptor 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and pheromone receptor activity. An important paralog of this gene is VN1R4.

UniProtKB/Swiss-Prot for VN1R2 Gene

  • Putative pheromone receptor.

Gene Wiki entry for VN1R2 Gene

Additional gene information for VN1R2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VN1R2 Gene

Genomics for VN1R2 Gene

GeneHancer (GH) Regulatory Elements for VN1R2 Gene

Promoters and enhancers for VN1R2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I052941 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 10 -313.8 -313799 6.1 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 POLR2B E2F8 ZNF321P ZNF816 ZNF160 VN1R2 ZNF677 ZNF665 ZNF761 ZNF347 ZNF415 ZNF83
GH19I053364 Promoter/Enhancer 1.4 Ensembl ENCODE 10.3 +107.6 107553 1.9 HDAC1 ELF3 SMAD1 RB1 ARID4B SIN3A GLI4 ZBTB40 RAD21 ZNF335 ZNF525 VN1R2 ZNF677 PIR40972
GH19I053037 Promoter/Enhancer 1 Ensembl ENCODE 10.8 -220.6 -220591 1 POLR2A GABPB1 NR2C1 ZBTB33 ZBTB40 NR2C2 EZH2 ZNF702P ZNF347 ZNF160 ZNF677 VN1R2 BIRC8 ERVV-1
GH19I053308 Enhancer 0.6 ENCODE 11.4 +50.3 50291 0.2 CTCF ZNF654 USF1 BACH1 RAD21 ETS1 SP1 ZNF143 EZH2 FAM90A28P FAM90A27P VN1R2 ZNF677 ZNF347 BIRC8
GH19I053224 Promoter 0.5 Ensembl 11.8 -33.5 -33491 0.4 NDUFV2P1 GC19P053223 ZNF677 VN1R2 FAM90A27P ZNF160
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VN1R2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VN1R2 gene promoter:

Genomic Locations for VN1R2 Gene

Genomic Locations for VN1R2 Gene
3,546 bases
Plus strand

Genomic View for VN1R2 Gene

Genes around VN1R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VN1R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VN1R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VN1R2 Gene

Proteins for VN1R2 Gene

  • Protein details for VN1R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vomeronasal type-1 receptor 2
    Protein Accession:
    Secondary Accessions:
    • A1L411
    • Q8TDU4

    Protein attributes for VN1R2 Gene

    395 amino acids
    Molecular mass:
    44476 Da
    Quaternary structure:
    No Data Available
    • The chimpanzee, gorilla and orangutan orthologous proteins do not exist, their genes are pseudogenes.

neXtProt entry for VN1R2 Gene

Post-translational modifications for VN1R2 Gene

  • Glycosylation at posLast=239239 and posLast=343343

Other Protein References for VN1R2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VN1R2 Gene

Domains & Families for VN1R2 Gene

Gene Families for VN1R2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for VN1R2 Gene

Suggested Antigen Peptide Sequences for VN1R2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with VN1R2: view

Function for VN1R2 Gene

Molecular function for VN1R2 Gene

UniProtKB/Swiss-Prot Function:
Putative pheromone receptor.

Gene Ontology (GO) - Molecular Function for VN1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0016503 pheromone receptor activity IEA --
genes like me logo Genes that share ontologies with VN1R2: view
genes like me logo Genes that share phenotypes with VN1R2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VN1R2 Gene

Localization for VN1R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VN1R2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VN1R2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for VN1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VN1R2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VN1R2 Gene

Pathways & Interactions for VN1R2 Gene

SuperPathways for VN1R2 Gene

No Data Available

Interacting Proteins for VN1R2 Gene

Gene Ontology (GO) - Biological Process for VN1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007606 sensory perception of chemical stimulus IBA --
GO:0019236 response to pheromone IEA --
genes like me logo Genes that share ontologies with VN1R2: view

No data available for Pathways by source and SIGNOR curated interactions for VN1R2 Gene

Drugs & Compounds for VN1R2 Gene

No Compound Related Data Available

Transcripts for VN1R2 Gene

mRNA/cDNA for VN1R2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VN1R2 Gene

No ASD Table

Relevant External Links for VN1R2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VN1R2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VN1R2 Gene

mRNA differential expression in normal tissues according to GTEx for VN1R2 Gene

This gene is overexpressed in Testis (x19.9).

Protein differential expression in normal tissues from HIPED for VN1R2 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VN1R2 Gene

Protein tissue co-expression partners for VN1R2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VN1R2 Gene:


SOURCE GeneReport for Unigene cluster for VN1R2 Gene:

genes like me logo Genes that share expression patterns with VN1R2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for VN1R2 Gene

Orthologs for VN1R2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for VN1R2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VN1R2 33 34
  • 98.72 (n)
(Canis familiaris)
Mammalia LOC100856009 33
  • 77.55 (n)
(Mus musculus)
Mammalia Vmn1r224 33 16
  • 63.13 (n)
Vmn1r237 34
  • 44 (a)
(Bos Taurus)
Mammalia -- 34
  • 49 (a)
Species where no ortholog for VN1R2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VN1R2 Gene

Gene Tree for VN1R2 (if available)
Gene Tree for VN1R2 (if available)

Paralogs for VN1R2 Gene

Variants for VN1R2 Gene

Sequence variations from dbSNP and Humsavar for VN1R2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1001102139 -- 53,258,397(+) A/G coding_sequence_variant, missense_variant
rs1001471363 -- 53,258,190(+) C/A upstream_transcript_variant
rs1001969843 -- 53,259,820(+) A/G downstream_transcript_variant
rs1003568617 -- 53,256,702(+) T/A/C upstream_transcript_variant
rs1003597805 -- 53,257,078(+) TGTATGTATGT/TGTATGT/TGTATGTATGTATGT upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for VN1R2 Gene

Variant ID Type Subtype PubMed ID
nsv1141887 OTHER inversion 24896259
nsv1078889 OTHER inversion 25765185
nsv1055236 CNV gain 25217958
esv3644741 CNV gain 21293372
esv2718812 CNV deletion 23290073
esv2718787 CNV deletion 23290073
dgv3645n100 CNV gain 25217958

Variation tolerance for VN1R2 Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.61; 72.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VN1R2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VN1R2 Gene

Disorders for VN1R2 Gene

Additional Disease Information for VN1R2

No disorders were found for VN1R2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VN1R2 Gene

Publications for VN1R2 Gene

  1. Novel human vomeronasal receptor-like genes reveal species-specific families. (PMID: 12123587) Rodriguez I … Mombaerts P (Current biology : CB 2002) 2 3 4 58
  2. Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. (PMID: 12826614) Zhang J … Webb DM (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58
  3. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 58
  4. Extreme variability among mammalian V1R gene families. (PMID: 19952141) Young JM … Trask BJ (Genome research 2010) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for VN1R2 Gene

Sources for VN1R2 Gene

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