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Aliases for VN1R1 Gene

Aliases for VN1R1 Gene

  • Vomeronasal 1 Receptor 1 2 3 5
  • Vomeronasal Olfactory Receptor, (Chromosome 19) Subtype I, Member 1 2 3
  • Vomeronasal Olfactory Receptor Chromosome 19 Subtype I Member 1 3 4
  • G-Protein Coupled Receptor GPCR24 3 4
  • V3r-Related Gene Protein 3 4
  • V1r-Like Receptor 1 3 4
  • VNR19I1 3 4
  • HGPCR24 3 4
  • V1RL1 3 4
  • Vomeronasal Type-1 Receptor 1 3
  • V1R-Like 1 3
  • ZVNH1 3
  • ZVNR1 3

External Ids for VN1R1 Gene

Previous HGNC Symbols for VN1R1 Gene

  • VNR19I1

Previous GeneCards Identifiers for VN1R1 Gene

  • GC19M058408
  • GC19M062642
  • GC19M062658
  • GC19M057966
  • GC19M054279

Summaries for VN1R1 Gene

Entrez Gene Summary for VN1R1 Gene

  • Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for VN1R1 Gene

VN1R1 (Vomeronasal 1 Receptor 1) is a Protein Coding gene. Among its related pathways are GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and pheromone receptor activity. An important paralog of this gene is VN1R4.

UniProtKB/Swiss-Prot for VN1R1 Gene

  • Putative pheromone receptor.

Gene Wiki entry for VN1R1 Gene

Additional gene information for VN1R1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VN1R1 Gene

Genomics for VN1R1 Gene

GeneHancer (GH) Regulatory Elements for VN1R1 Gene

Promoters and enhancers for VN1R1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I057456 Promoter 0.5 EPDnew 550.8 +0.4 421 0.1 VN1R1 ENSG00000276449 ENSG00000268163 GC19M057458 GC19M057341
GH19I057476 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 42.1 -20.3 -20336 1.5 PKNOX1 ATF1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 ZNF772 ENSG00000268163 ENSG00000268266 ZNF773 ZNF417 VN1R1 ZNF446 ZNF606 ZNF134 ZNF17
GH19I057487 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 29.3 -30.9 -30902 1.9 HDGF PKNOX1 ATF1 ARID4B SIN3A YBX1 ZNF48 YY1 ETS1 ELK1 ZNF419 ENSG00000268107 GC19P057489 VN1R1 ZNF264 ZNF773 ZNF543 ZNF805 ZNF550 ZNF544
GH19I057526 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 21.2 -70.4 -70425 1.7 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 ETS1 ZNF302 ELK1 ZNF549 GC19M057527 GC19P057528 ZNF548 ZNF417 ZNF134 ZNF773 ZNF256 VN1R1 LOC105372483
GH19I057558 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 19.4 -102.5 -102513 2.5 PKNOX1 ATF1 ARID4B SIN3A GLI4 ZNF48 YY1 ETS1 POLR2B ELK1 ZNF550 ZNF549 ZNF134 VN1R1 ZNF264 ZNF805 TRIM28 ZNF548 ZNF543 ZNF530
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VN1R1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VN1R1 gene promoter:

Genomic Locations for VN1R1 Gene

Genomic Locations for VN1R1 Gene
2,353 bases
Minus strand

Genomic View for VN1R1 Gene

Genes around VN1R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VN1R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VN1R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VN1R1 Gene

Proteins for VN1R1 Gene

  • Protein details for VN1R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vomeronasal type-1 receptor 1
    Protein Accession:
    Secondary Accessions:
    • B3KSV5
    • Q7Z5H8
    • Q7Z5H9

    Protein attributes for VN1R1 Gene

    353 amino acids
    Molecular mass:
    40021 Da
    Quaternary structure:
    No Data Available
    • The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.

neXtProt entry for VN1R1 Gene

Post-translational modifications for VN1R1 Gene

  • Glycosylation at isoforms=117 and isoforms=198
  • Modification sites at PhosphoSitePlus

Other Protein References for VN1R1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VN1R1 Gene

Domains & Families for VN1R1 Gene

Gene Families for VN1R1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for VN1R1 Gene

Suggested Antigen Peptide Sequences for VN1R1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with VN1R1: view

Function for VN1R1 Gene

Molecular function for VN1R1 Gene

UniProtKB/Swiss-Prot Function:
Putative pheromone receptor.

Phenotypes From GWAS Catalog for VN1R1 Gene

Gene Ontology (GO) - Molecular Function for VN1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0016503 pheromone receptor activity IEA --
genes like me logo Genes that share ontologies with VN1R1: view
genes like me logo Genes that share phenotypes with VN1R1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VN1R1 Gene

Localization for VN1R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VN1R1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VN1R1 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VN1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VN1R1: view

Pathways & Interactions for VN1R1 Gene

SuperPathways for VN1R1 Gene

SuperPathway Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with VN1R1: view

Pathways by source for VN1R1 Gene

1 BioSystems pathway for VN1R1 Gene

Interacting Proteins for VN1R1 Gene

Gene Ontology (GO) - Biological Process for VN1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007606 sensory perception of chemical stimulus IBA --
GO:0008150 biological_process ND --
GO:0019236 response to pheromone IEA --
genes like me logo Genes that share ontologies with VN1R1: view

No data available for SIGNOR curated interactions for VN1R1 Gene

Drugs & Compounds for VN1R1 Gene

No Compound Related Data Available

Transcripts for VN1R1 Gene

mRNA/cDNA for VN1R1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(74) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VN1R1 Gene

Vomeronasal 1 receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for VN1R1 Gene

No ASD Table

Relevant External Links for VN1R1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VN1R1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VN1R1 Gene

Protein differential expression in normal tissues from HIPED for VN1R1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VN1R1 Gene

Protein tissue co-expression partners for VN1R1 Gene

NURSA nuclear receptor signaling pathways regulating expression of VN1R1 Gene:


SOURCE GeneReport for Unigene cluster for VN1R1 Gene:


mRNA Expression by UniProt/SwissProt for VN1R1 Gene:

Tissue specificity: Expressed in the olfactory mucosa, very low expression in brain, lung and kidney.

Evidence on tissue expression from TISSUES for VN1R1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with VN1R1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for VN1R1 Gene

Orthologs for VN1R1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for VN1R1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VN1R1 33 34
  • 74.97 (n)
(Rattus norvegicus)
Mammalia Vom1r52 33
  • 62.58 (n)
(Pan troglodytes)
Mammalia VN1R3 34
  • 47 (a)
(Monodelphis domestica)
Mammalia monDomV1R1235 34
  • 45 (a)
monDomV1R1234 34
  • 42 (a)
monDomV1R1224 34
  • 41 (a)
monDomV1R1225 34
  • 40 (a)
monDomV1R1223 34
  • 39 (a)
monDomV1R1228 34
  • 39 (a)
monDomV1R1271 34
  • 39 (a)
monDomV1R1272 34
  • 39 (a)
monDomV1R1281 34
  • 39 (a)
monDomV1R1282 34
  • 39 (a)
monDomV1R1283 34
  • 39 (a)
-- 34
  • 38 (a)
monDomV1R1233 34
  • 38 (a)
monDomV1R1238 34
  • 38 (a)
monDomV1R1230 34
  • 37 (a)
monDomV1R1232 34
  • 37 (a)
monDomV1R1236 34
  • 37 (a)
monDomV1R1239 34
  • 37 (a)
monDomV1R1243 34
  • 37 (a)
monDomV1R1270 34
  • 37 (a)
monDomV1R1294 34
  • 37 (a)
monDomV1R1231 34
  • 36 (a)
monDomV1R1246 34
  • 36 (a)
monDomV1R1267 34
  • 36 (a)
monDomV1R1290 34
  • 36 (a)
monDomV1R1292 34
  • 36 (a)
-- 34
  • 35 (a)
monDomV1R1221 34
  • 35 (a)
monDomV1R1244 34
  • 35 (a)
monDomV1R1245 34
  • 35 (a)
monDomV1R1259 34
  • 35 (a)
monDomV1R1261 34
  • 35 (a)
monDomV1R1266 34
  • 35 (a)
monDomV1R1280 34
  • 35 (a)
monDomV1R1242 34
  • 34 (a)
monDomV1R1254 34
  • 34 (a)
monDomV1R1257 34
  • 34 (a)
monDomV1R1258 34
  • 34 (a)
monDomV1R1260 34
  • 34 (a)
monDomV1R1268 34
  • 34 (a)
monDomV1R1256 34
  • 33 (a)
monDomV1R1263 34
  • 32 (a)
(Mus musculus)
Mammalia Vmn1r83 34
  • 36 (a)
Species where no ortholog for VN1R1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VN1R1 Gene

Gene Tree for VN1R1 (if available)
Gene Tree for VN1R1 (if available)

Paralogs for VN1R1 Gene

Variants for VN1R1 Gene

Sequence variations from dbSNP and Humsavar for VN1R1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000281910 -- 57,456,904(-) T/A upstream_transcript_variant
rs1001955317 -- 57,455,265(-) A/T 3_prime_UTR_variant
rs1004516781 -- 57,457,267(-) G/T upstream_transcript_variant
rs1004652457 -- 57,457,521(-) C/T upstream_transcript_variant
rs1005319935 -- 57,454,688(-) C/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for VN1R1 Gene

Variant ID Type Subtype PubMed ID
esv3583608 CNV loss 25503493

Variation tolerance for VN1R1 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.48; 71.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VN1R1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VN1R1 Gene

Disorders for VN1R1 Gene

Additional Disease Information for VN1R1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for VN1R1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VN1R1 Gene

Publications for VN1R1 Gene

  1. A putative pheromone receptor gene expressed in human olfactory mucosa. (PMID: 10973240) Rodriguez I … Mombaerts P (Nature genetics 2000) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. (PMID: 12826614) Zhang J … Webb DM (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58

Products for VN1R1 Gene

Sources for VN1R1 Gene

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