Aliases for VMP1 Gene
Aliases for VMP1 Gene
External Ids for VMP1 Gene
- HGNC: 29559
- Entrez Gene: 81671
- Ensembl: ENSG00000062716
- OMIM: 611753
- UniProtKB: Q96GC9
Previous HGNC Symbols for VMP1 Gene
- TMEM49
Previous GeneCards Identifiers for VMP1 Gene
- GC17P057536
- GC17P060234
- GC17P058126
- GC17P058259
- GC17P055139
- GC17P057785
Summaries for VMP1 Gene
-
This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]
GeneCards Summary for VMP1 Gene
VMP1 (Vacuole Membrane Protein 1) is a Protein Coding gene. Diseases associated with VMP1 include Pancreatitis and Acute Pancreatitis. Among its related pathways are Autophagy - animal and Autophagy Pathway.
UniProtKB/Swiss-Prot for VMP1 Gene
-
Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions.
Additional gene information for VMP1 Gene
- Monarch Initiative
- Search for VMP1 at DataMed
- Search for VMP1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VMP1 Gene
Genomics for VMP1 Gene
GeneHancer (GH) Regulatory Elements for VMP1 Gene
Promoters and enhancers for VMP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around VMP1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for VMP1 Gene
Genomic Locations for VMP1 Gene
- chr17:59,707,192-59,842,255
- (GRCh38/hg38)
- Size:
- 135,064 bases
- Orientation:
- Plus strand
- chr17:57,784,553-57,919,616
- (GRCh37/hg19)
Genomic View for VMP1 Gene
Genes around VMP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q23.1 by Ensembl
- 17q23.1 by Entrez Gene
- 17q23.1 by HGNC
VMP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VMP1 Gene
Proteins for VMP1 Gene
-
Protein details for VMP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96GC9-VMP1_HUMAN
- Recommended name:
- Vacuole membrane protein 1
- Protein Accession:
- Q96GC9
- B4DVV9
- Q9H0P4
- Q9P089
Protein attributes for VMP1 Gene
- Size:
- 406 amino acids
- Molecular mass:
- 46238 Da
- Quaternary structure:
-
- Interacts with BECN1. Interacts with TJP1. Interacts with TP53INP2.
Protein Expression for VMP1 Gene
Post-translational modifications for VMP1 Gene
Other Protein References for VMP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for VMP1
- Novus Biologicals Antibodies for VMP1
-
Abcam antibodies for VMP1
- Invitrogen Antibodies for VMP1
- GeneTex VMP1 antibody for VMP1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for VMP1
- Origene Custom Protein Services for VMP1
- antibodies-online: Search results for 3 available VMP1 Proteins ranked by validation data
- Compare Top VMP1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for VMP1
-
Abcam proteins for VMP1
Assay Products
- antibodies-online: Search results for 4 available VMP1 Elisa Kits ranked by validation data
- Compare Top VMP1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for VMP1 Gene
Domains & Families for VMP1 Gene
Gene Families for VMP1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for VMP1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for VMP1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ52586, highly similar to Homo sapiens transmembrane protein 49 (TMEM49), mRNA (B4DED7_HUMAN)
- cDNA FLJ50508, highly similar to Homo sapiens transmembrane protein 49 (TMEM49), mRNA (B4DGZ7_HUMAN)
- cDNA FLJ50706, highly similar to Homo sapiens transmembrane protein 49 (TMEM49), mRNA (B4DVV9_HUMAN)
- Transmembrane protein 49, isoform CRA_b (D3DU01_HUMAN)
- Transmembrane protein 49 (VMP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96GC9- Family:
-
- Belongs to the VMP1 family.
Function for VMP1 Gene
Molecular function for VMP1 Gene
- UniProtKB/Swiss-Prot Function:
- Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions.
Phenotypes From GWAS Catalog for VMP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17724469 |
Phenotypes for VMP1 Gene
- GenomeRNAi human phenotypes for VMP1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for VMP1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for VMP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VMP1 gene
- Search ViGene Biosciences for VMP1
CRISPR Products
-
OriGene CRISPR knockouts for VMP1
- genomics-online: gRNA clones - Search results for 104 available VMP1 gene related products
- Overview of 104 available VMP1 gene related products
- Applied Biological Materials CRISPR for VMP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VMP1
- GenScript: Design CRISPR guide RNA sequences for VMP1
miRNA for VMP1 Gene
- miRTarBase miRNAs that target VMP1
-
- hsa-mir-210-3p (MIRT006663)
- hsa-mir-1-3p (MIRT023611)
- hsa-mir-16-5p (MIRT031480)
- hsa-mir-296-3p (MIRT038376)
- hsa-mir-25-3p (MIRT050331)
- bta-mir-31 (MIRT053895)
- hsa-mir-4776-3p (MIRT464155)
- hsa-mir-744-3p (MIRT464156)
- hsa-mir-4659b-5p (MIRT464157)
- hsa-mir-4659a-5p (MIRT464158)
- hsa-mir-5590-5p (MIRT464159)
- hsa-mir-7159-5p (MIRT464160)
- hsa-mir-4423-5p (MIRT464161)
- hsa-mir-6501-5p (MIRT464162)
- hsa-mir-4694-5p (MIRT464163)
- hsa-mir-5186 (MIRT464164)
- hsa-mir-7978 (MIRT464165)
- hsa-mir-181a-3p (MIRT464166)
- hsa-mir-5685 (MIRT464167)
- hsa-mir-4690-3p (MIRT464168)
- hsa-mir-1324 (MIRT464169)
- hsa-mir-4709-5p (MIRT464170)
- hsa-mir-4272 (MIRT464171)
- hsa-mir-6856-3p (MIRT464172)
- hsa-mir-513b-3p (MIRT464173)
- hsa-mir-505-3p (MIRT464174)
- hsa-mir-421 (MIRT464175)
- hsa-mir-3161 (MIRT464176)
- hsa-mir-622 (MIRT464177)
- hsa-mir-4761-5p (MIRT464178)
- hsa-mir-624-3p (MIRT464179)
- hsa-mir-132-3p (MIRT464180)
- hsa-mir-212-3p (MIRT464181)
- hsa-mir-4482-3p (MIRT651704)
- hsa-mir-7159-3p (MIRT651705)
- hsa-mir-138-2-3p (MIRT651706)
- hsa-mir-4282 (MIRT651707)
- hsa-mir-4698 (MIRT683173)
- hsa-mir-6809-3p (MIRT715340)
- hsa-mir-6833-3p (MIRT715341)
- hsa-mir-4768-5p (MIRT715342)
- hsa-mir-6873-3p (MIRT715343)
- hsa-mir-555 (MIRT715344)
- hsa-mir-6817-3p (MIRT715345)
- hsa-mir-7110-3p (MIRT715346)
- hsa-mir-6845-3p (MIRT715347)
- hsa-mir-3925-3p (MIRT715348)
- hsa-mir-766-3p (MIRT715349)
- hsa-mir-5680 (MIRT715350)
- hsa-mir-4506 (MIRT715351)
- hsa-mir-150-3p (MIRT737829)
miRNA Products
- Search ViGene Biosciences for VMP1
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for VMP1
- Browse OriGene Inhibitory RNA Products For VMP1
- genomics-online: shRNA clones - Search results for 104 available VMP1 gene related products
- Overview of 104 available VMP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for VMP1 gene
Clone Products
- Sino Biological Human cDNA Clone for VMP1
- VectorBuilder custom plasmid, inducible vectors for VMP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VMP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for VMP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for VMP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for VMP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VMP1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VMP1 Gene
Localization for VMP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for VMP1 Gene
- Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Endoplasmic reticulum.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| extracellular | 1 |
- Endoplasmic reticulum (3)
- Nucleoli (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000407 | phagophore assembly site | IBA | -- |
| GO:0000421 | autophagosome membrane | ISS,IEA | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005773 | vacuole | IEA | -- |
| GO:0005774 | vacuolar membrane | IEA | -- |
Pathways & Interactions for VMP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Autophagy Pathway | ||
| 2 | Autophagy - animal | ||
| 3 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||
Pathways by source for VMP1 Gene
2 BioSystems pathways for VMP1 Gene
1 KEGG pathway for VMP1 Gene
1 R&D Systems pathway for VMP1 Gene
Interacting Proteins for VMP1 Gene
Selected Interacting proteins:
Q96GC9-VMP1_HUMAN
ENSP00000262291
for VMP1 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006887 | exocytosis | IBA | -- |
| GO:0006914 | autophagy | IEA | -- |
| GO:0007029 | endoplasmic reticulum organization | IBA | -- |
| GO:0007030 | Golgi organization | IBA | -- |
| GO:0007155 | cell adhesion | IEA | -- |
No data available for SIGNOR curated interactions for VMP1 Gene
Transcripts for VMP1 Gene
mRNA/cDNA for VMP1 Gene
- (10) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (653) Selected AceView cDNA sequences:
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for VMP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for VMP1
- genomics-online: gRNA clones - Search results for 104 available VMP1 gene related products
- Overview of 104 available VMP1 gene related products
- Applied Biological Materials CRISPR for VMP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VMP1
- GenScript: Design CRISPR guide RNA sequences for VMP1
miRNA Products
- Search ViGene Biosciences for VMP1
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for VMP1
- Browse OriGene Inhibitory RNA Products For VMP1
- genomics-online: shRNA clones - Search results for 104 available VMP1 gene related products
- Overview of 104 available VMP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for VMP1 gene
Clone Products
- Sino Biological Human cDNA Clone for VMP1
- VectorBuilder custom plasmid, inducible vectors for VMP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VMP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for VMP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||
| SP7: |
Expression for VMP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Intestine (Gastrointestinal Tract)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for VMP1 Gene
This gene is overexpressed in Whole Blood (x9.7).
This gene is overexpressed in Breast (12.5), Ovary (11.2), and Testis (10.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VMP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of VMP1 Gene:
VMP1SOURCE GeneReport for Unigene cluster for VMP1 Gene:
Hs.444569Evidence on tissue expression from TISSUES for VMP1 Gene
- Blood(4.8)
- Nervous system(4.7)
- Kidney(4.6)
- Spleen(4.4)
- Liver(4)
- Intestine(3.5)
- Lung(2.9)
- Heart(2.5)
- Pancreas(2.5)
- Muscle(2.4)
- Lymph node(2.3)
- Stomach(2.3)
- Gall bladder(2.1)
Primer Products
-
OriGene qPCR primer pairs for VMP1
-
OriGene qPCR primer pairs and template standards for VMP1
- genomics-online: primer clones - Search results for 104 available VMP1 gene related products
- Overview of 104 available VMP1 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VMP1 Gene
Orthologs for VMP1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | VMP1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | VMP1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | VMP1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Vmp1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Vmp1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | VMP1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | VMP1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | vmp1 33 |
|
||
| Str.11181 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.13697 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | vmp1 33 34 |
|
||
| Dr.982 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010304 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Tango5 33 34 |
|
||
| CG32087 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | epg-3 33 34 |
|
||
| Y37D8A.22 35 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G05360 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0778700 33 |
|
||
| Os.14351 33 |
|
||||
| corn (Zea mays) |
Liliopsida | Zm.17241 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6481 34 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.10369 33 |
|
- Species where no ortholog for VMP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for VMP1 Gene
(1) SIMAP similar genes for VMP1 Gene using alignment to 15 proteins:
Pseudogenes.org Pseudogenes for VMP1 Gene
No data available for Paralogs for VMP1 Gene
Variants for VMP1 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs869025245 | uncertain-significance, Monoclonal B-Cell Lymphocytosis | 59,738,863(+) | TCT/T | coding_sequence_variant, frameshift | |
| rs548846183 | likely-benign, not specified | 59,707,407(+) | C/T | upstream_transcript_variant | |
| rs563049020 | likely-benign, not specified | 59,707,387(+) | C/T | upstream_transcript_variant | |
| rs1000046922 | -- | 59,761,639(+) | T/C | intron_variant | |
| rs1000082737 | -- | 59,765,758(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1491n106 | CNV | deletion | 24896259 |
| dgv959e212 | CNV | loss | 25503493 |
| esv2483856 | CNV | deletion | 19546169 |
| esv2662935 | CNV | deletion | 23128226 |
| esv2716083 | CNV | deletion | 23290073 |
| esv3554612 | CNV | deletion | 23714750 |
| esv3640910 | CNV | loss | 21293372 |
| esv3640911 | CNV | loss | 21293372 |
| esv3640912 | CNV | loss | 21293372 |
| esv998658 | CNV | gain | 20482838 |
| nsv1109095 | CNV | deletion | 24896259 |
| nsv512497 | CNV | loss | 21212237 |
| nsv821151 | CNV | deletion | 20802225 |
| nsv828072 | CNV | gain+loss | 20364138 |
| nsv833501 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
20.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.74;
15.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VMP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- VMP1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VMP1 Gene
Disorders for VMP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pancreatitis |
|
|
| acute pancreatitis |
|
|
Search VMP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for VMP1
No data available for UniProtKB/Swiss-Prot and Genatlas for VMP1 Gene
Publications for VMP1 Gene
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
- The TP53INP2 protein is required for autophagy in mammalian cells. (PMID: 19056683) Nowak J … Iovanna JL (Molecular biology of the cell 2009) 3 4 58
- Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells. (PMID: 17724469) Sauermann M … Arlt D (Oncogene 2008) 3 4 58
- Cloning and expression of the rat vacuole membrane protein 1 (VMP1), a new gene activated in pancreas with acute pancreatitis, which promotes vacuole formation. (PMID: 11785947) Dusetti NJ … Iovanna JL (Biochemical and biophysical research communications 2002) 2 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for VMP1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for VMP1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for VMP1
- Origene Custom Protein Services for VMP1
- Origene shrna and RNAi products in human, mouse, rat for VMP1
- Browse OriGene Inhibitory RNA Products For VMP1
- OriGene qPCR primer pairs and template standards for VMP1
- OriGene qPCR primer pairs for VMP1
- OriGene CRISPR knockouts for VMP1
- OriGene ORF clones in human for VMP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For VMP1
- GenScript: Next-day shipping of latest version cDNA ORF clones for VMP1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for VMP1
- GenScript Custom Assay Services for VMP1
- GenScript Custom overexpressing Cell Line Services for VMP1
- GenScript: Design CRISPR guide RNA sequences for VMP1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for VMP1
- Sino Biological Human cDNA Clone for VMP1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for VMP1
- Novus Biologicals lysates and proteins for VMP1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for VMP1
- Abcam proteins for VMP1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for VMP1
- VectorBuilder custom plasmid, inducible vectors for VMP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VMP1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 51 available VMP1 Antibodies ranked by validation data
- Compare Top VMP1 Antibodies
- antibodies-online: Search results for 4 available VMP1 Elisa Kits ranked by validation data
- Compare Top VMP1 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 3 available VMP1 Proteins ranked by validation data
- Compare Top VMP1 Proteins
- Quality Products:
- GeneTex VMP1 antibody for VMP1
- Search GeneTex for Proteins for VMP1
- ViGene Biosciences adenoviral particle packaged cDNA for VMP1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for VMP1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for VMP1 gene
- Search ViGene Biosciences for VMP1
- genomics-online: cdna clones - Search results for 104 available VMP1 gene related products
- Overview of 104 available VMP1 gene related products
- orf clones - Search results for 104 available VMP1 gene related products
- Overview of 104 available VMP1 gene related products
- genomics-online: gRNA clones - Search results for 104 available VMP1 gene related products
- Overview of 104 available VMP1 gene related products
- genomics-online: primer clones - Search results for 104 available VMP1 gene related products
- Overview of 104 available VMP1 gene related products
- genomics-online: shRNA clones - Search results for 104 available VMP1 gene related products
- Overview of 104 available VMP1 gene related products
Sources for VMP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems