Aliases for VMP1 Gene
External Ids for VMP1 Gene
Previous HGNC Symbols for VMP1 Gene
Previous GeneCards Identifiers for VMP1 Gene
This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]
GeneCards Summary for VMP1 Gene
VMP1 (Vacuole Membrane Protein 1) is a Protein Coding gene. Diseases associated with VMP1 include Pancreatitis and Acute Pancreatitis. Among its related pathways are Nanoparticle triggered autophagic cell death and Autophagy - animal. An important paralog of this gene is PGRMC2.
UniProtKB/Swiss-Prot Summary for VMP1 Gene
Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions (PubMed:17724469). Required for autophagosome formation (PubMed:30093494, PubMed:30933966).