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This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleter... See more...
Aliases for VMP1 Gene
Aliases for VMP1 Gene
External Ids for VMP1 Gene
- HGNC: 29559
- Entrez Gene: 81671
- Ensembl: ENSG00000062716
- OMIM: 611753
- UniProtKB: Q96GC9
Previous HGNC Symbols for VMP1 Gene
- TMEM49
Previous GeneCards Identifiers for VMP1 Gene
- GC17P057536
- GC17P060234
- GC17P058126
- GC17P058259
- GC17P055139
- GC17P057785
Summaries for VMP1 Gene
-
This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]
GeneCards Summary for VMP1 Gene
VMP1 (Vacuole Membrane Protein 1) is a Protein Coding gene. Diseases associated with VMP1 include Pancreatitis and Acute Pancreatitis. Among its related pathways are Nanoparticle triggered autophagic cell death and Autophagy - animal. An important paralog of this gene is PGRMC2.
UniProtKB/Swiss-Prot Summary for VMP1 Gene
-
Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions (PubMed:17724469). Required for autophagosome formation (PubMed:30093494, PubMed:30933966).
Additional gene information for VMP1 Gene
- HGNC(29559)
- Entrez Gene(81671)
- Ensembl(ENSG00000062716)
- OMIM(611753)
- UniProtKB(Q96GC9)
- Open Targets Platform(ENSG00000062716)
- Monarch Initiative
- Search for VMP1 at DataMed
- Search for VMP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VMP1 Gene
Genomics for VMP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for VMP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around VMP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VMP1
Genomic Locations for VMP1 Gene
Genomic Locations for VMP1 Gene
- chr17:59,707,192-59,842,255
- (GRCh38/hg38)
- Size:
- 135,064 bases
- Orientation:
- Plus strand
- chr17:57,784,553-57,919,616
- (GRCh37/hg19)
- Size:
- 135,064 bases
- Orientation:
- Plus strand
Genomic View for VMP1 Gene
Genes around VMP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q23.1 by HGNC
- 17q23.1 by Entrez Gene
- 17q23.1 by Ensembl
VMP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VMP1 Gene
Proteins for VMP1 Gene
-
Protein details for VMP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96GC9-VMP1_HUMAN
- Recommended name:
- Vacuole membrane protein 1
- Protein Accession:
- Q96GC9
- B4DVV9
- Q9H0P4
- Q9P089
Protein attributes for VMP1 Gene
- Size:
- 406 amino acids
- Molecular mass:
- 46238 Da
- Quaternary structure:
-
- Interacts with BECN1 (By similarity). Interacts with TJP1 (PubMed:17724469). Interacts with TP53INP2 (PubMed:19056683). Interacts with TMEM41B (PubMed:30093494).
Protein Expression for VMP1 Gene
Post-translational modifications for VMP1 Gene
Other Protein References for VMP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for VMP1
- Novus Biologicals Antibodies for VMP1
-
Abcam antibodies for VMP1
- Invitrogen Antibodies for VMP1 (AFLGC-VMP1)
-
Biorbyt antibodies for VMP1
- Sino Biological Antibodies for VMP1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for VMP1
- Origene Custom Protein Services for VMP1
- antibodies-online: Show 3 available VMP1 Proteins ranked by validation data
- Compare Top VMP1 Proteins
-
Quality Products:
-
Signalway Proteins for VMP1
-
Abcam proteins for VMP1
Assay Products
- antibodies-online: Show 4 available VMP1 Elisa Kits ranked by validation data
- Compare Top VMP1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for VMP1 Gene
Domains & Families for VMP1 Gene
Gene Families for VMP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Protein Domains for VMP1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for VMP1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ52586, highly similar to Homo sapiens transmembrane protein 49 (TMEM49), mRNA (B4DED7_HUMAN)
- cDNA FLJ50508, highly similar to Homo sapiens transmembrane protein 49 (TMEM49), mRNA (B4DGZ7_HUMAN)
- cDNA FLJ50706, highly similar to Homo sapiens transmembrane protein 49 (TMEM49), mRNA (B4DVV9_HUMAN)
- Transmembrane protein 49, isoform CRA_b (D3DU01_HUMAN)
- Transmembrane protein 49 (VMP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96GC9UniProtKB/Swiss-Prot:
VMP1_HUMAN :- The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
- Belongs to the VMP1 family.
- Domain:
-
- The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
- Family:
-
- Belongs to the VMP1 family.
Function for VMP1 Gene
Molecular function for VMP1 Gene
- UniProtKB/Swiss-Prot Function:
- Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions (PubMed:17724469). Required for autophagosome formation (PubMed:30093494, PubMed:30933966).
Phenotypes From GWAS Catalog for VMP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17724469 |
Phenotypes for VMP1 Gene
- MGI mutant phenotypes for VMP1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for VMP1:
Animal Models for VMP1 Gene
- MGI Knock Outs for VMP1:
-
- Vmp1 Vmp1<tm1a(KOMP)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for VMP1 - Select products 50% OFF >
- * VMP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for VMP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VMP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for VMP1
miRNA for VMP1 Gene
- miRTarBase miRNAs that target VMP1
-
- hsa-miR-210-3p (MIRT006663)
- hsa-miR-1-3p (MIRT023611)
- hsa-miR-16-5p (MIRT031480)
- hsa-miR-296-3p (MIRT038376)
- hsa-miR-25-3p (MIRT050331)
- bta-miR-31 (MIRT053895)
- mmu-miR-717 (MIRT413982)
- hsa-miR-4776-3p (MIRT464155)
- hsa-miR-744-3p (MIRT464156)
- hsa-miR-4659b-5p (MIRT464157)
- hsa-miR-4659a-5p (MIRT464158)
- hsa-miR-5590-5p (MIRT464159)
- hsa-miR-7159-5p (MIRT464160)
- hsa-miR-4423-5p (MIRT464161)
- hsa-miR-6501-5p (MIRT464162)
- hsa-miR-4694-5p (MIRT464163)
- hsa-miR-5186 (MIRT464164)
- hsa-miR-7978 (MIRT464165)
- hsa-miR-181a-3p (MIRT464166)
- hsa-miR-5685 (MIRT464167)
- hsa-miR-4690-3p (MIRT464168)
- hsa-miR-1324 (MIRT464169)
- hsa-miR-4709-5p (MIRT464170)
- hsa-miR-4272 (MIRT464171)
- hsa-miR-6856-3p (MIRT464172)
- hsa-miR-513b-3p (MIRT464173)
- hsa-miR-505-3p (MIRT464174)
- hsa-miR-421 (MIRT464175)
- hsa-miR-3161 (MIRT464176)
- hsa-miR-622 (MIRT464177)
- hsa-miR-4761-5p (MIRT464178)
- hsa-miR-624-3p (MIRT464179)
- hsa-miR-132-3p (MIRT464180)
- hsa-miR-212-3p (MIRT464181)
- mmu-miR-421-3p (MIRT577012)
- mmu-miR-212-3p (MIRT577013)
- mmu-miR-132-3p (MIRT577014)
- mmu-miR-505-3p (MIRT577015)
- mmu-miR-452-3p (MIRT577016)
- mmu-miR-683 (MIRT592383)
- hsa-miR-4482-3p (MIRT651704)
- hsa-miR-7159-3p (MIRT651705)
- hsa-miR-138-2-3p (MIRT651706)
- hsa-miR-4282 (MIRT651707)
- hsa-miR-4698 (MIRT683173)
- hsa-miR-6809-3p (MIRT715340)
- hsa-miR-6833-3p (MIRT715341)
- hsa-miR-4768-5p (MIRT715342)
- hsa-miR-6873-3p (MIRT715343)
- hsa-miR-555 (MIRT715344)
- hsa-miR-6817-3p (MIRT715345)
- hsa-miR-7110-3p (MIRT715346)
- hsa-miR-6845-3p (MIRT715347)
- hsa-miR-3925-3p (MIRT715348)
- hsa-miR-766-3p (MIRT715349)
- hsa-miR-5680 (MIRT715350)
- hsa-miR-4506 (MIRT715351)
- hsa-miR-150-3p (MIRT737829)
- mmu-miR-3569-3p (MIRT791309)
- mmu-miR-499-3p (MIRT791775)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VMP1
- Browse OriGene Inhibitory RNA Products For VMP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VMP1
Clone Products
- Applied Biological Materials (abm): Clones for VMP1 - Select products 50% OFF >
- * VMP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for VMP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VMP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VMP1 Gene
Localization for VMP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for VMP1 Gene
- Endoplasmic reticulum-Golgi intermediate compartment membrane. Multi-pass membrane protein. Cell membrane. Multi-pass membrane protein. Vacuole membrane. Multi-pass membrane protein. Endoplasmic reticulum.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| plasma membrane | 4 |
| nucleus | 4 |
| extracellular | 2 |
| mitochondrion | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
- Endoplasmic reticulum (3)
- Nucleoli (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000407 | phagophore assembly site | IEA | -- |
| GO:0000421 | autophagosome membrane | IEA,ISS | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005773 | vacuole | IEA | -- |
| GO:0005774 | vacuolar membrane | IEA | -- |
Pathways & Interactions for VMP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Autophagy - animal | ||
| 2 | Alzheimers Disease | ||
| 3 | Nanoparticle triggered autophagic cell death | ||
Pathways by source for VMP1 Gene
2 BioSystems pathways for VMP1 Gene
1 KEGG pathway for VMP1 Gene
Interacting Proteins for VMP1 Gene
Selected Interacting proteins:
Q96GC9-VMP1_HUMAN
ENSP00000262291
for VMP1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for VMP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000045 | autophagosome assembly | IMP | 30093494 |
| GO:0006914 | autophagy | IBA | 21873635 |
| GO:0007030 | Golgi organization | IBA | 21873635 |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007566 | embryo implantation | IEA | -- |
No data available for SIGNOR curated interactions for VMP1 Gene
Transcripts for VMP1 Gene
mRNA/cDNA for VMP1 Gene
- 10 REFSEQ mRNAs :
- 20 NCBI additional mRNA sequence :
- 17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262291 3686 nts (view in UCSC)
- ENST00000585847 545 nts (view in UCSC)
- ENST00000586245 544 nts (view in UCSC)
- ENST00000587259 606 nts (view in UCSC)
- ENST00000587470 995 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for VMP1 - Select products 50% OFF >
- * VMP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for VMP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VMP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for VMP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VMP1
- Browse OriGene Inhibitory RNA Products For VMP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VMP1
Clone Products
- Applied Biological Materials (abm): Clones for VMP1 - Select products 50% OFF >
- * VMP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for VMP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VMP1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||
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| SP3: | - | ||||||||||||||||||||||||||||||||||||||
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| SP5: | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for VMP1 Gene
- GeneLoc Exon Structure for
- VMP1
Expression for VMP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Intestine (Gastrointestinal Tract)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for VMP1 Gene
This gene is overexpressed in Whole Blood (x9.7).
This gene is overexpressed in Breast (12.5), Ovary (11.2), and Testis (10.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VMP1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VMP1
SOURCE GeneReport for Unigene cluster for VMP1 Gene:
Hs.444569Evidence on tissue expression from TISSUES for VMP1 Gene
- Blood(4.8)
- Nervous system(4.8)
- Kidney(4.7)
- Spleen(4.5)
- Liver(4.2)
- Intestine(3.8)
- Lung(3)
- Pancreas(2.9)
- Stomach(2.9)
- Heart(2.6)
- Muscle(2.5)
- Lymph node(2.5)
- Skin(2.4)
- Thyroid gland(2.2)
- Gall bladder(2.1)
Primer Products
-
OriGene qPCR primer pairs for VMP1
-
OriGene qPCR primer pairs and template standards for VMP1
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VMP1 Gene
Orthologs for VMP1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | VMP1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | VMP1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | VMP1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Vmp1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Vmp1 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | VMP1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | VMP1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | vmp1 30 |
|
||
| Str.11181 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.13697 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | vmp1 30 31 |
|
OneToOne | |
| Dr.982 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010304 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Tango5 30 31 |
|
OneToMany | |
| CG32087 31 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | epg-3 30 31 |
|
OneToOne | |
| Y37D8A.22 32 |
|
|
|||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G05360 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os01g0778700 30 |
|
||
| Os.14351 30 |
|
||||
| Corn (Zea mays) |
Liliopsida | Zm.17241 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6481 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.10369 30 |
|
- Species where no ortholog for VMP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for VMP1 Gene
- ENSEMBL:
- Gene Tree for VMP1 (if available)
- TreeFam:
- Gene Tree for VMP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for VMP1: view image
Paralogs for VMP1 Gene
(1) SIMAP similar genes for VMP1 Gene using alignment to 15 proteins:
- VMP1_HUMAN
- B4DED7_HUMAN
- B4DGZ7_HUMAN
- B4DVV9_HUMAN
- F5H2J3_HUMAN
- K7EK01_HUMAN
- K7EL46_HUMAN
- K7EL74_HUMAN
- K7EL93_HUMAN
- K7ELS2_HUMAN
- K7EM96_HUMAN
- K7EMI0_HUMAN
- K7EMN6_HUMAN
- K7ENU2_HUMAN
- K7EPE7_HUMAN
Pseudogenes.org Pseudogenes for VMP1 Gene
Variants for VMP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VMP1 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs869025245 | Uncertain Significance: Monoclonal B-Cell Lymphocytosis | 59,738,862(+) | TTC/T | FRAMESHIFT_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1491n106 | CNV | deletion | 24896259 |
| dgv959e212 | CNV | loss | 25503493 |
| esv2483856 | CNV | deletion | 19546169 |
| esv2662935 | CNV | deletion | 23128226 |
| esv2716083 | CNV | deletion | 23290073 |
| esv3554612 | CNV | deletion | 23714750 |
| esv3640910 | CNV | loss | 21293372 |
| esv3640911 | CNV | loss | 21293372 |
| esv3640912 | CNV | loss | 21293372 |
| esv998658 | CNV | gain | 20482838 |
| nsv1109095 | CNV | deletion | 24896259 |
| nsv512497 | CNV | loss | 21212237 |
| nsv821151 | CNV | deletion | 20802225 |
| nsv828072 | CNV | gain+loss | 20364138 |
| nsv833501 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
20.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.74;
15.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VMP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- VMP1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VMP1 Gene
Disorders for VMP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pancreatitis |
|
|
| acute pancreatitis |
|
|
Search VMP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for VMP1
No data available for UniProtKB/Swiss-Prot and Genatlas for VMP1 Gene
Publications for VMP1 Gene
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4
- CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor. (PMID: 30933966) Shoemaker CJ … Denic V (PLoS biology 2019) 3 4
- Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation. (PMID: 30093494) Morita K … Mizushima N (The Journal of cell biology 2018) 3 4
- The TP53INP2 protein is required for autophagy in mammalian cells. (PMID: 19056683) Nowak J … Iovanna JL (Molecular biology of the cell 2009) 3 4
- Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells. (PMID: 17724469) Sauermann M … Arlt D (Oncogene 2008) 3 4
ExternalLinks
Products for VMP1 Gene
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Sources for VMP1 Gene
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