Aliases for VMO1 Gene

Aliases for VMO1 Gene

  • Vitelline Membrane Outer Layer 1 Homolog 2 3 5
  • Vitelline Membrane Outer Layer Protein 1 Homolog 3 4
  • Vitelline Membrane Outer Layer 1 Homolog (Chicken) 2
  • ERGA6350 3
  • PRO21055 3
  • VMO1 5

External Ids for VMO1 Gene

Previous GeneCards Identifiers for VMO1 Gene

  • GC17M004636
  • GC17M004688
  • GC17M004576

Summaries for VMO1 Gene

GeneCards Summary for VMO1 Gene

VMO1 (Vitelline Membrane Outer Layer 1 Homolog) is a Protein Coding gene.

Additional gene information for VMO1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VMO1 Gene

Genomics for VMO1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for VMO1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J004786 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 614.2 -1.9 -1860 6.2 HNRNPL CREB1 GATAD2A CTCF PRDM10 REST ZNF629 TFE3 SOX13 IKZF1 VMO1 ENSG00000280254 GLTPD2 ZNF594 ENSG00000261879 DERL2 MIS12 ZZEF1 ENSG00000262227 NUP88
GH17J004769 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 8.5 +15.1 15136 3.1 HNRNPL GATAD2A RCOR2 ZIC2 RBFOX2 RXRB IRF2 SP1 FOXK2 MNT TM4SF5 CXCL16 ZMYND15 VMO1 ENSG00000262165 ARRB2 SPAG7 MINK1 SCIMP piR-50444-164
GH17J004847 Enhancer 1 FANTOM5 ENCODE dbSUPER 11.7 -63.2 -63199 4.4 ZNF24 SP1 NR3C1 RCOR1 KLF4 PKNOX1 MAX CUX1 RFX5 DPF2 lnc-CHRNE-4 CHRNE ENO3 PFN1 ZMYND15 ARRB2 C17orf107 PLD2 CXCL16 RPS12P29
GH17J004843 Promoter/Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -58.4 -58396 2.2 NFE2 ARRB2 ZMYND15 CXCL16 C17orf107 PLD2 PSMB6 GLTPD2 VMO1 RPS12P29 LOC101559451
GH17J004837 Enhancer 1 ENCODE dbSUPER 11.4 -52.7 -52676 3.9 IKZF1 ZIC2 ZSCAN4 PKNOX1 NR2C1 BRD9 DPF2 HDAC1 ZNF341 TCF12 CHRNE ENO3 SPAG7 PLD2 GLTPD2 VMO1 ZMYND15 CXCL16 ENSG00000234203 PFN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VMO1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VMO1

Top Transcription factor binding sites by QIAGEN in the VMO1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • FOXD1
  • Lmo2
  • LyF-1
  • Olf-1
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for VMO1 Gene

Genomic Locations for VMO1 Gene
1,149 bases
Minus strand
1,150 bases
Minus strand

Genomic View for VMO1 Gene

Genes around VMO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VMO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VMO1 Gene

Proteins for VMO1 Gene

  • Protein details for VMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vitelline membrane outer layer protein 1 homolog
    Protein Accession:
    Secondary Accessions:
    • C9JQ15
    • E9PAU9
    • E9PGP4
    • Q3SXP1
    • Q8IUY1

    Protein attributes for VMO1 Gene

    202 amino acids
    Molecular mass:
    21534 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VMO1 Gene


neXtProt entry for VMO1 Gene

Post-translational modifications for VMO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VMO1 Gene

No data available for DME Specific Peptides for VMO1 Gene

Domains & Families for VMO1 Gene

Gene Families for VMO1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for VMO1 Gene


Suggested Antigen Peptide Sequences for VMO1 Gene

GenScript: Design optimal peptide antigens:
  • VMO1 protein (Q3SXP2_HUMAN)
  • VMO1 protein (Q8IUY1_HUMAN)
  • Vitelline membrane outer layer protein 1 homolog (VMO1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the VMO1 family.
  • Belongs to the VMO1 family.
genes like me logo Genes that share domains with VMO1: view

Function for VMO1 Gene

Phenotypes From GWAS Catalog for VMO1 Gene

Gene Ontology (GO) - Molecular Function for VMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with VMO1: view
genes like me logo Genes that share phenotypes with VMO1: view

Animal Model Products

CRISPR Products

miRNA for VMO1 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VMO1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VMO1 Gene

Localization for VMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VMO1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VMO1 gene
Compartment Confidence
extracellular 5
mitochondrion 1
nucleus 1
lysosome 1
peroxisome 0
endoplasmic reticulum 0
cytosol 0

Gene Ontology (GO) - Cellular Components for VMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with VMO1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VMO1 Gene

Pathways & Interactions for VMO1 Gene

PathCards logo

SuperPathways for VMO1 Gene

No Data Available

Interacting Proteins for VMO1 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000328397 Q7Z5L0-VMO1_HUMAN for VMO1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for VMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with VMO1: view

No data available for Pathways by source and SIGNOR curated interactions for VMO1 Gene

Drugs & Compounds for VMO1 Gene

No Compound Related Data Available

Transcripts for VMO1 Gene

mRNA/cDNA for VMO1 Gene

8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VMO1

Alternative Splicing Database (ASD) splice patterns (SP) for VMO1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP1: -
SP3: - -

Relevant External Links for VMO1 Gene

GeneLoc Exon Structure for

Expression for VMO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VMO1 Gene

mRNA differential expression in normal tissues according to GTEx for VMO1 Gene

This gene is overexpressed in Spleen (x7.3) and Pituitary (x7.1).

Protein differential expression in normal tissues from HIPED for VMO1 Gene

This gene is overexpressed in Urine (60.1) and Nasal epithelium (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VMO1 Gene

Protein tissue co-expression partners for VMO1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VMO1

SOURCE GeneReport for Unigene cluster for VMO1 Gene:


Evidence on tissue expression from TISSUES for VMO1 Gene

  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with VMO1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VMO1 Gene

Orthologs for VMO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for VMO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VMO1 30 31
  • 99.17 (n)
(Bos Taurus)
Mammalia VMO1 30 31
  • 82.08 (n)
(Rattus norvegicus)
Mammalia Vmo1 30
  • 78.56 (n)
(Canis familiaris)
Mammalia VMO1 30 31
  • 78.11 (n)
(Mus musculus)
Mammalia Vmo1 30 17 31
  • 73.3 (n)
(Monodelphis domestica)
Mammalia VMO1 31
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia VMO1 31
  • 44 (a)
(Gallus gallus)
Aves VMO1 30 31
  • 58.28 (n)
(Anolis carolinensis)
Reptilia VMO1 31
  • 39 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101731130 30
  • 57.37 (n)
(Danio rerio)
Actinopterygii LOC793369 30
  • 54.27 (n)
VMO1 (1 of 2) 31
  • 47 (a)
VMO1 (2 of 2) 31
  • 43 (a)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.804 30
(Caenorhabditis elegans)
Secernentea Y38H6C.19 31
  • 36 (a)
F46F5.13 31
  • 30 (a)
Y54E2A.9 31
  • 29 (a)
T02H6.9 31
  • 29 (a)
F28A10.8 31
  • 29 (a)
K07E8.1 31
  • 28 (a)
C47A10.12 31
  • 21 (a)
Y9C9A.1 31
  • 19 (a)
Y40B10B.1 31
  • 19 (a)
Y39F10C.1 31
  • 18 (a)
C08G5.3 31
  • 12 (a)
Y57G11A.2 31
  • 8 (a)
Species where no ortholog for VMO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for VMO1 Gene

Gene Tree for VMO1 (if available)
Gene Tree for VMO1 (if available)
Evolutionary constrained regions (ECRs) for VMO1: view image

Paralogs for VMO1 Gene

No data available for Paralogs for VMO1 Gene

Variants for VMO1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VMO1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs2279961 - p.Thr77Ser
rs4790706 - p.Thr26Ala

Additional dbSNP identifiers (rs#s) for VMO1 Gene

Structural Variations from Database of Genomic Variants (DGV) for VMO1 Gene

Variant ID Type Subtype PubMed ID
nsv574273 CNV gain 21841781
nsv833346 CNV loss 17160897
nsv833347 CNV loss 17160897

Variation tolerance for VMO1 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VMO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VMO1 Gene

Disorders for VMO1 Gene

No disorders were found for VMO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VMO1 Gene

Publications for VMO1 Gene

  1. Analysis and comparison of proteomic profiles of tear fluid from human, cow, sheep, and camel eyes. (PMID: 22025569) Shamsi FA … Wu K (Investigative ophthalmology & visual science 2011) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3

Products for VMO1 Gene

Sources for VMO1 Gene