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Aliases for VMO1 Gene

Aliases for VMO1 Gene

  • Vitelline Membrane Outer Layer 1 Homolog 2 3 5
  • Vitelline Membrane Outer Layer 1 Homolog (Chicken) 2
  • Vitelline Membrane Outer Layer Protein 1 Homolog 3
  • ERGA6350 3
  • PRO21055 3

External Ids for VMO1 Gene

Previous GeneCards Identifiers for VMO1 Gene

  • GC17M004636
  • GC17M004688
  • GC17M004576

Summaries for VMO1 Gene

GeneCards Summary for VMO1 Gene

VMO1 (Vitelline Membrane Outer Layer 1 Homolog) is a Protein Coding gene.

Additional gene information for VMO1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VMO1 Gene

Genomics for VMO1 Gene

GeneHancer (GH) Regulatory Elements for VMO1 Gene

Promoters and enhancers for VMO1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I004786 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 564.1 -2.3 -2305 5.3 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 E2F8 ZNF207 ZNF143 VMO1 ENSG00000280254 GLTPD2 ZNF594 LOC100130950 PELP1 RNF167 PSMB6 GC17M004737
GH17I004769 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 8.5 +15.1 15137 3.1 FOXA2 ARID4B DMAP1 ZNF48 YY1 SLC30A9 FOS PAF1 RXRA SP5 TM4SF5 CXCL16 ZMYND15 VMO1 ENSG00000262165 ARRB2 SPAG7 MINK1 SCIMP GC17M004737
GH17I004847 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -63.2 -63198 4.4 PKNOX1 ZBTB6 MAX ZBTB40 RFX5 SMC3 RCOR1 FOS SMARCE1 STAT1 CHRNE ENO3 PFN1 ZMYND15 ARRB2 C17orf107 PLD2 CXCL16 LOC101559451 PELP1
GH17I004842 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -58.1 -58066 3.4 CEBPB NFE2 SPI1 CHRNE ARRB2 ZMYND15 CXCL16 C17orf107 PLD2 ENO3 PSMB6 RPS12P29 VMO1
GH17I004837 Enhancer 1 ENCODE dbSUPER 11.4 -52.7 -52675 3.9 HDAC1 HDGF PKNOX1 TAF9B ARNT NFRKB ZSCAN4 ZBTB40 ZNF335 TCF12 CHRNE ENO3 SPAG7 PLD2 GLTPD2 VMO1 CXCL16 ZMYND15 ENSG00000234203 PFN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VMO1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VMO1 gene promoter:

Genomic Locations for VMO1 Gene

Genomic Locations for VMO1 Gene
1,150 bases
Minus strand

Genomic View for VMO1 Gene

Genes around VMO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VMO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VMO1 Gene

Proteins for VMO1 Gene

  • Protein details for VMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vitelline membrane outer layer protein 1 homolog
    Protein Accession:
    Secondary Accessions:
    • C9JQ15
    • E9PAU9
    • E9PGP4
    • Q3SXP1
    • Q8IUY1

    Protein attributes for VMO1 Gene

    202 amino acids
    Molecular mass:
    21534 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VMO1 Gene


neXtProt entry for VMO1 Gene

Post-translational modifications for VMO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VMO1 Gene

No data available for DME Specific Peptides for VMO1 Gene

Domains & Families for VMO1 Gene

Gene Families for VMO1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for VMO1 Gene


Suggested Antigen Peptide Sequences for VMO1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the VMO1 family.
  • Belongs to the VMO1 family.
genes like me logo Genes that share domains with VMO1: view

Function for VMO1 Gene

Phenotypes From GWAS Catalog for VMO1 Gene

Gene Ontology (GO) - Molecular Function for VMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with VMO1: view
genes like me logo Genes that share phenotypes with VMO1: view

Animal Model Products

CRISPR Products

miRNA for VMO1 Gene

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VMO1 Gene

Localization for VMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VMO1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VMO1 gene
Compartment Confidence
extracellular 5
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for VMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with VMO1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VMO1 Gene

Pathways & Interactions for VMO1 Gene

No Data Available

Interacting Proteins for VMO1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q7Z5L0-VMO1_HUMAN ENSP00000328397 for VMO1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for VMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with VMO1: view

No data available for Pathways by source and SIGNOR curated interactions for VMO1 Gene

Drugs & Compounds for VMO1 Gene

No Compound Related Data Available

Transcripts for VMO1 Gene

Unigene Clusters for VMO1 Gene

Vitelline membrane outer layer 1 homolog (chicken):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VMO1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP1: -
SP3: - -

Relevant External Links for VMO1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VMO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VMO1 Gene

mRNA differential expression in normal tissues according to GTEx for VMO1 Gene

This gene is overexpressed in Spleen (x7.3) and Pituitary (x7.1).

Protein differential expression in normal tissues from HIPED for VMO1 Gene

This gene is overexpressed in Urine (60.1) and Nasal epithelium (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VMO1 Gene

Protein tissue co-expression partners for VMO1 Gene

NURSA nuclear receptor signaling pathways regulating expression of VMO1 Gene:


SOURCE GeneReport for Unigene cluster for VMO1 Gene:


Evidence on tissue expression from TISSUES for VMO1 Gene

  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with VMO1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VMO1 Gene

Orthologs for VMO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for VMO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VMO1 33 34
  • 99.17 (n)
(Bos Taurus)
Mammalia VMO1 33 34
  • 82.08 (n)
(Rattus norvegicus)
Mammalia Vmo1 33
  • 78.56 (n)
(Canis familiaris)
Mammalia VMO1 33 34
  • 78.11 (n)
(Mus musculus)
Mammalia Vmo1 33 16 34
  • 73.3 (n)
(Monodelphis domestica)
Mammalia VMO1 34
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia VMO1 34
  • 44 (a)
(Gallus gallus)
Aves VMO1 33 34
  • 58.28 (n)
(Anolis carolinensis)
Reptilia VMO1 34
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731130 33
  • 57.37 (n)
(Danio rerio)
Actinopterygii LOC793369 33
  • 54.27 (n)
VMO1 (1 of 2) 34
  • 47 (a)
VMO1 (2 of 2) 34
  • 43 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.804 33
(Caenorhabditis elegans)
Secernentea Y38H6C.19 34
  • 36 (a)
F46F5.13 34
  • 30 (a)
F28A10.8 34
  • 29 (a)
T02H6.9 34
  • 29 (a)
Y54E2A.9 34
  • 29 (a)
K07E8.1 34
  • 28 (a)
C47A10.12 34
  • 21 (a)
Y40B10B.1 34
  • 19 (a)
Y9C9A.1 34
  • 19 (a)
Y39F10C.1 34
  • 18 (a)
C08G5.3 34
  • 12 (a)
Y57G11A.2 34
  • 8 (a)
Species where no ortholog for VMO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VMO1 Gene

Gene Tree for VMO1 (if available)
Gene Tree for VMO1 (if available)

Paralogs for VMO1 Gene

No data available for Paralogs for VMO1 Gene

Variants for VMO1 Gene

Sequence variations from dbSNP and Humsavar for VMO1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000138304 -- 4,788,385(-) A/G upstream_transcript_variant
rs1000237291 -- 4,786,975(-) C/G upstream_transcript_variant
rs1000458431 -- 4,786,668(-) G/T upstream_transcript_variant
rs1000466331 -- 4,788,081(-) C/T upstream_transcript_variant
rs1002404578 -- 4,786,645(-) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for VMO1 Gene

Variant ID Type Subtype PubMed ID
nsv574273 CNV gain 21841781
nsv833346 CNV loss 17160897
nsv833347 CNV loss 17160897

Variation tolerance for VMO1 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VMO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VMO1 Gene

Disorders for VMO1 Gene

Additional Disease Information for VMO1

No disorders were found for VMO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VMO1 Gene

Publications for VMO1 Gene

  1. Analysis and comparison of proteomic profiles of tear fluid from human, cow, sheep, and camel eyes. (PMID: 22025569) Shamsi FA … Wu K (Investigative ophthalmology & visual science 2011) 2 3 58
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 58

Products for VMO1 Gene

Sources for VMO1 Gene

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