Aliases for VMAC Gene

Aliases for VMAC Gene

  • Vimentin Type Intermediate Filament Associated Coiled-Coil Protein 2 3 5
  • Vimentin-Type Intermediate Filament-Associated Coiled-Coil Protein 3 4
  • Vimentin-Type IF-Associated Coiled-Coil Protein 3

External Ids for VMAC Gene

Previous GeneCards Identifiers for VMAC Gene

  • GC19P005855
  • GC19P005664

Summaries for VMAC Gene

GeneCards Summary for VMAC Gene

VMAC (Vimentin Type Intermediate Filament Associated Coiled-Coil Protein) is a Protein Coding gene.

Additional gene information for VMAC Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VMAC Gene

Genomics for VMAC Gene

GeneHancer (GH) Regulatory Elements for VMAC Gene

Promoters and enhancers for VMAC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VMAC on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VMAC

Top Transcription factor binding sites by QIAGEN in the VMAC gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPalpha
  • E47
  • MIF-1
  • Pax-4a

Genomic Locations for VMAC Gene

Genomic Locations for VMAC Gene
6,013 bases
Plus strand
6,013 bases
Plus strand

Genomic View for VMAC Gene

Genes around VMAC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VMAC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VMAC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VMAC Gene

Proteins for VMAC Gene

  • Protein details for VMAC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vimentin-type intermediate filament-associated coiled-coil protein
    Protein Accession:
    Secondary Accessions:
    • B3KW55

    Protein attributes for VMAC Gene

    169 amino acids
    Molecular mass:
    18348 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VMAC Gene

Post-translational modifications for VMAC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VMAC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VMAC Gene

Domains & Families for VMAC Gene

Gene Families for VMAC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for VMAC Gene


Suggested Antigen Peptide Sequences for VMAC Gene

GenScript: Design optimal peptide antigens:
  • Vimentin-type IF-associated coiled-coil protein, isoform CRA_a (D6W640_HUMAN)
  • Vimentin-type intermediate filament-associated coiled-coil protein (VMAC_HUMAN)
genes like me logo Genes that share domains with VMAC: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for VMAC Gene

Function for VMAC Gene

Phenotypes From GWAS Catalog for VMAC Gene

Gene Ontology (GO) - Molecular Function for VMAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 28514442
genes like me logo Genes that share ontologies with VMAC: view
genes like me logo Genes that share phenotypes with VMAC: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VMAC Gene

Localization for VMAC Gene

Subcellular locations from UniProtKB/Swiss-Prot for VMAC Gene

Cytoplasm. Note=Colocalizes with vimentin-type intermediate filaments. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VMAC gene
Compartment Confidence
cytoskeleton 3
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for VMAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0045098 type III intermediate filament IBA,IEA 21873635
genes like me logo Genes that share ontologies with VMAC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VMAC Gene

Pathways & Interactions for VMAC Gene

PathCards logo

SuperPathways for VMAC Gene

No Data Available

Gene Ontology (GO) - Biological Process for VMAC Gene


No data available for Pathways by source and SIGNOR curated interactions for VMAC Gene

Drugs & Compounds for VMAC Gene

No Compound Related Data Available

Transcripts for VMAC Gene

mRNA/cDNA for VMAC Gene

3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VMAC Gene

No ASD Table

Relevant External Links for VMAC Gene

GeneLoc Exon Structure for

Expression for VMAC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VMAC Gene

Protein differential expression in normal tissues from HIPED for VMAC Gene

This gene is overexpressed in Skin (37.6) and Salivary gland (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VMAC Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VMAC

SOURCE GeneReport for Unigene cluster for VMAC Gene:

genes like me logo Genes that share expression patterns with VMAC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for VMAC Gene

Orthologs for VMAC Gene

This gene was present in the common ancestor of chordates.

Orthologs for VMAC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VMAC 31 30
  • 99.61 (n)
(Canis familiaris)
Mammalia VMAC 30
  • 89.74 (n)
-- 31
  • 89 (a)
(Bos Taurus)
Mammalia VMAC 31 30
  • 86.35 (n)
(Rattus norvegicus)
Mammalia Vmac 30
  • 79.49 (n)
(Mus musculus)
Mammalia Vmac 17 31 30
  • 78.9 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 54 (a)
(Danio rerio)
Actinopterygii LOC570934 30
  • 57.79 (n)
  • 46 (a)
Species where no ortholog for VMAC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VMAC Gene

Gene Tree for VMAC (if available)
Gene Tree for VMAC (if available)
Evolutionary constrained regions (ECRs) for VMAC: view image

Paralogs for VMAC Gene

No data available for Paralogs for VMAC Gene

Variants for VMAC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VMAC Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
786664 Benign: not provided 5,908,839(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for VMAC Gene

Structural Variations from Database of Genomic Variants (DGV) for VMAC Gene

Variant ID Type Subtype PubMed ID
esv27099 CNV loss 19812545

Variation tolerance for VMAC Gene

Gene Damage Index Score: 3.62; 56.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VMAC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VMAC Gene

Disorders for VMAC Gene

Additional Disease Information for VMAC

No disorders were found for VMAC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VMAC Gene

Publications for VMAC Gene

  1. Vmac: a novel protein associated with vimentin-type intermediate filament in podocytes of rat kidney. (PMID: 14985129) Yamamoto Y … Takai Y (Biochemical and biophysical research communications 2004) 2 3 54
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54

Products for VMAC Gene

Sources for VMAC Gene