Aliases for VKORC1L1 Gene
External Ids for VKORC1L1 Gene
Previous GeneCards Identifiers for VKORC1L1 Gene
This gene encodes an enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress may upregulate expression of this gene and the encoded protein may protect cells and membrane proteins form oxidative damage. This gene and a related gene (Gene ID: 79001) may have arisen by gene duplication of an ancestral gene. [provided by RefSeq, Oct 2016]
GeneCards Summary for VKORC1L1 Gene
VKORC1L1 (Vitamin K Epoxide Reductase Complex Subunit 1 Like 1) is a Protein Coding gene. Diseases associated with VKORC1L1 include Coumarin Resistance and Vitamin K Deficiency Bleeding. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Biosynthesis of cofactors. Gene Ontology (GO) annotations related to this gene include quinone binding and vitamin-K-epoxide reductase (warfarin-sensitive) activity. An important paralog of this gene is VKORC1.
UniProtKB/Swiss-Prot Summary for VKORC1L1 Gene
Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.