Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VIPR2 Gene

Aliases for VIPR2 Gene

  • Vasoactive Intestinal Peptide Receptor 2 2 3 5
  • Pituitary Adenylate Cyclase-Activating Polypeptide Type III Receptor 3 4
  • Helodermin-Preferring VIP Receptor 3 4
  • VIP And PACAP Receptor 2 2 3
  • PACAP Type III Receptor 3 4
  • PACAP-R-3 3 4
  • PACAP-R3 3 4
  • VIP-R-2 3 4
  • VPAC2 3 4
  • Vasoactive Intestinal Polypeptide Receptor 2 3
  • C16DUPq36.3 3
  • DUP7q36.3 3
  • VPCAP2R 3
  • VPAC2R 3
  • VIP2R 4

External Ids for VIPR2 Gene

Previous GeneCards Identifiers for VIPR2 Gene

  • GC07M157122
  • GC07M158123
  • GC07M158237
  • GC07M158320
  • GC07M158513
  • GC07M158820
  • GC07M152560

Summaries for VIPR2 Gene

Entrez Gene Summary for VIPR2 Gene

  • This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]

GeneCards Summary for VIPR2 Gene

VIPR2 (Vasoactive Intestinal Peptide Receptor 2) is a Protein Coding gene. Diseases associated with VIPR2 include Schizophrenia 16 and Holoprosencephaly 3. Among its related pathways are cAMP signaling pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and vasoactive intestinal polypeptide receptor activity. An important paralog of this gene is ADCYAP1R1.

UniProtKB/Swiss-Prot for VIPR2 Gene

  • This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.

Tocris Summary for VIPR2 Gene

  • Vasoactive intestinal peptide (VIP) receptors are a group of Gs -protein-coupled receptors that are currently divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous system.

Gene Wiki entry for VIPR2 Gene

Additional gene information for VIPR2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VIPR2 Gene

Genomics for VIPR2 Gene

GeneHancer (GH) Regulatory Elements for VIPR2 Gene

Promoters and enhancers for VIPR2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I159144 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 560.9 0.0 -23 1.4 ZNF777 ZNF324 ZNF335 ZFHX2 POLR2A ZNF366 PATZ1 ZBTB20 EGR2 EZH2 VIPR2 PIP5K1P2
GH07I159095 Enhancer 1.3 VISTA Ensembl ENCODE dbSUPER 20.4 +47.4 47359 4.8 SCRT1 PKNOX1 PBX2 SCRT2 NFE2 ZIC2 PIR57199 VIPR2 WDR60 PIR52507
GH07I159194 Enhancer 1.4 FANTOM5 Ensembl ENCODE 18.7 -52.8 -52810 5.9 HDGF PKNOX1 SMAD1 ATF1 ARNT NCOA2 TCF12 ZNF121 POLR2B ZNF766 VIPR2 ESYT2 PIP5K1P2
GH07I159010 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.6 +131.1 131137 6.1 PKNOX1 CLOCK ARNT NEUROD1 SIN3A FEZF1 ZBTB7B ZNF207 FOS REST ESYT2 VIPR2 LINC00689 WDR60 PIR52507
GH07I159067 Enhancer 1 Ensembl ENCODE dbSUPER 22.9 +75.8 75762 3.6 MAFF ZNF316 ATF1 MAFG MAFK EMSY CREM NR2F2 VIPR2 PIR57199 PIR52507
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VIPR2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VIPR2 gene promoter:

Genomic Locations for VIPR2 Gene

Genomic Locations for VIPR2 Gene
116,783 bases
Minus strand

Genomic View for VIPR2 Gene

Genes around VIPR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VIPR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VIPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VIPR2 Gene

Proteins for VIPR2 Gene

  • Protein details for VIPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vasoactive intestinal polypeptide receptor 2
    Protein Accession:
    Secondary Accessions:
    • Q13053
    • Q15870
    • Q53Y09
    • Q6ZN22
    • Q9UCW0

    Protein attributes for VIPR2 Gene

    438 amino acids
    Molecular mass:
    49479 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for VIPR2 Gene

    Alternative splice isoforms for VIPR2 Gene


neXtProt entry for VIPR2 Gene

Post-translational modifications for VIPR2 Gene

  • Glycosylation at isoforms=58, isoforms=88, and posLast=9292
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for VIPR2 Gene

Domains & Families for VIPR2 Gene

Gene Families for VIPR2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family.
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with VIPR2: view

Function for VIPR2 Gene

Molecular function for VIPR2 Gene

GENATLAS Biochemistry:
vasoactive intestinal peptide,also responding to the pituitary adenylate cyclase activating polypeptide in stimulating cAMP production,receptor 2,G protein coupled,secretin receptor superfamily
UniProtKB/Swiss-Prot Function:
This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.

Phenotypes From GWAS Catalog for VIPR2 Gene

Gene Ontology (GO) - Molecular Function for VIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA,TAS 7811244
GO:0004999 vasoactive intestinal polypeptide receptor activity IEA --
genes like me logo Genes that share ontologies with VIPR2: view
genes like me logo Genes that share phenotypes with VIPR2: view

Animal Models for VIPR2 Gene

MGI Knock Outs for VIPR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for VIPR2

Clone Products

  • Addgene plasmids for VIPR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for VIPR2 Gene

Localization for VIPR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VIPR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VIPR2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for VIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 7811244
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VIPR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VIPR2 Gene

Pathways & Interactions for VIPR2 Gene

genes like me logo Genes that share pathways with VIPR2: view

Gene Ontology (GO) - Biological Process for VIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS,IEA 7811244
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
GO:0007190 activation of adenylate cyclase activity IEA --
GO:0007267 cell-cell signaling TAS 8757618
genes like me logo Genes that share ontologies with VIPR2: view

No data available for SIGNOR curated interactions for VIPR2 Gene

Drugs & Compounds for VIPR2 Gene

(28) Drugs for VIPR2 Gene - From: ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Secretin Approved, Investigational Pharma Full agonist, Agonist, binder 34
Bay 55-9837 Pharma Agonist Potent and selective VPAC2 agonist 0
[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) Pharma VIP receptor antagonist 0
[<sup>125</sup>I]BAY 55-9837 Pharma Agonist 0
[<sup>125</sup>I]PACAP-27 Pharma Agonist 0

(4) Additional Compounds for VIPR2 Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist
Full agonist, Agonist
VIP (human, rat, mouse, rabbit, canine, porcine)

(5) Tocris Compounds for VIPR2 Gene

Compound Action Cas Number
[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) VIP receptor antagonist 93965-89-0
[Ala11,22,28]VIP Potent, highly selective VPAC1 agonist 291524-04-4
Bay 55-9837 Potent and selective VPAC2 agonist 463930-25-8
VIP (guinea pig) Involved in neurotransmission and smooth muscle relaxation 96886-24-7
VIP (human, rat, mouse, rabbit, canine, porcine) Involved in neurotransmission and smooth muscle relaxation 40077-57-4

(6) ApexBio Compounds for VIPR2 Gene

genes like me logo Genes that share compounds with VIPR2: view

Drug Products

Transcripts for VIPR2 Gene

Unigene Clusters for VIPR2 Gene

Vasoactive intestinal peptide receptor 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for VIPR2

Alternative Splicing Database (ASD) splice patterns (SP) for VIPR2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c
SP1: - - - -
SP2: -
SP3: -
SP5: -

Relevant External Links for VIPR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VIPR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VIPR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VIPR2 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x4.4).

Protein differential expression in normal tissues from HIPED for VIPR2 Gene

This gene is overexpressed in Plasma (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VIPR2 Gene

Protein tissue co-expression partners for VIPR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of VIPR2 Gene:


SOURCE GeneReport for Unigene cluster for VIPR2 Gene:


mRNA Expression by UniProt/SwissProt for VIPR2 Gene:

Tissue specificity: Expressed in CD4+ T-cells, but not in CD8+ T-cells. Expressed in the T-cell lines Jurkat, Peer, MOLT-4, HSB, YT and SUP-T1, but not in the T-cell lines HARRIS and HuT 78.

Evidence on tissue expression from TISSUES for VIPR2 Gene

  • Nervous system(4.6)
  • Blood(4.3)
  • Heart(4.3)
genes like me logo Genes that share expression patterns with VIPR2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for VIPR2 Gene

Orthologs for VIPR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VIPR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VIPR2 33 34
  • 99.39 (n)
(Bos Taurus)
Mammalia VIPR2 33 34
  • 86.31 (n)
(Canis familiaris)
Mammalia VIPR2 33 34
  • 83.72 (n)
(Mus musculus)
Mammalia Vipr2 33 16 34
  • 82.9 (n)
(Rattus norvegicus)
Mammalia Vipr2 33
  • 82.36 (n)
(Monodelphis domestica)
Mammalia VIPR2 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia VIPR2 34
  • 78 (a)
(Gallus gallus)
Aves VPAC2 34
  • 73 (a)
VIPR2 33
  • 70.79 (n)
(Anolis carolinensis)
Reptilia VIPR2 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vipr2 33
  • 65.35 (n)
(Danio rerio)
Actinopterygii vipr2 33 34
  • 62.07 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4810 33
Species where no ortholog for VIPR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VIPR2 Gene

Gene Tree for VIPR2 (if available)
Gene Tree for VIPR2 (if available)

Paralogs for VIPR2 Gene

Paralogs for VIPR2 Gene

(15) SIMAP similar genes for VIPR2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with VIPR2: view

Variants for VIPR2 Gene

Sequence variations from dbSNP and Humsavar for VIPR2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000030277 -- 159,037,319(-) A/G intron_variant
rs1000040364 -- 159,037,632(-) A/G intron_variant
rs1000056135 -- 159,073,754(-) C/T intron_variant
rs1000062169 -- 159,075,767(-) C/T intron_variant
rs1000086988 -- 159,073,576(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for VIPR2 Gene

Variant ID Type Subtype PubMed ID
dgv11804n54 CNV gain 21841781
dgv6772n100 CNV gain 25217958
esv1258689 CNV insertion 17803354
esv1585946 CNV insertion 17803354
esv1955405 CNV deletion 18987734
esv2080886 CNV deletion 18987734
esv23771 CNV loss 19812545
esv2621732 CNV deletion 19546169
esv2667886 CNV deletion 23128226
esv2762713 CNV loss 21179565
esv28310 CNV loss 19812545
esv3323566 CNV duplication 20981092
esv3414637 CNV duplication 20981092
esv3542830 CNV deletion 23714750
esv3576497 CNV gain 25503493
esv3615741 CNV gain 21293372
esv3615756 CNV gain 21293372
esv3615757 CNV gain 21293372
esv8515 OTHER inversion 19470904
esv998866 CNV deletion 20482838
nsv1018315 CNV gain 25217958
nsv1018458 CNV gain 25217958
nsv1020010 CNV loss 25217958
nsv1027282 CNV gain 25217958
nsv1027593 CNV loss 25217958
nsv1032688 CNV loss 25217958
nsv1032814 CNV gain 25217958
nsv1075498 CNV deletion 25765185
nsv1078848 CNV insertion 25765185
nsv1117475 CNV tandem duplication 24896259
nsv1129291 CNV insertion 24896259
nsv1132968 CNV insertion 24896259
nsv1137328 CNV deletion 24896259
nsv1140880 CNV deletion 24896259
nsv1143355 CNV deletion 24896259
nsv1146594 OTHER inversion 26484159
nsv1146819 CNV deletion 26484159
nsv1147200 CNV insertion 26484159
nsv1148146 CNV deletion 26484159
nsv435963 OTHER inversion 17901297
nsv465262 CNV gain 19166990
nsv519749 CNV loss 19592680
nsv526756 CNV gain 19592680
nsv609363 CNV loss 21841781
nsv609419 CNV gain 21841781
nsv609425 CNV loss 21841781
nsv820022 CNV loss 19587683
nsv831202 CNV gain 17160897
nsv951684 CNV deletion 24416366

Variation tolerance for VIPR2 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VIPR2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VIPR2 Gene

Disorders for VIPR2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for VIPR2 Gene - From: HGMD, OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia 16
  • sczd16
holoprosencephaly 3
  • hpe3
- elite association - COSMIC cancer census association via MalaCards
Search VIPR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for VIPR2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with VIPR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VIPR2 Gene

Publications for VIPR2 Gene

  1. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PMID: 20072116) Soria V … Urretavizcaya M (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010) 3 22 44 58
  2. Structure of the human VIPR2 gene for vasoactive intestinal peptide receptor type 2. (PMID: 10481065) Lutz EM … Harmar AJ (FEBS letters 1999) 3 4 22 58
  3. Chromosomal localization in mouse and human of the vasoactive intestinal peptide receptor type 2 gene: a possible contributor to the holoprosencephaly 3 phenotype. (PMID: 8938447) Mackay M … Harmar AJ (Genomics 1996) 3 4 22 58
  4. Molecular cloning and functional characterization of a human VIP receptor from SUP-T1 lymphoblasts. (PMID: 7811244) Svoboda M … Robberecht P (Biochemical and biophysical research communications 1994) 2 3 4 58
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 44 58

Products for VIPR2 Gene

  • Addgene plasmids for VIPR2

Sources for VIPR2 Gene

Loading form....