Aliases for VIPR2 Gene
External Ids for VIPR2 Gene
Previous GeneCards Identifiers for VIPR2 Gene
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]
GeneCards Summary for VIPR2 Gene
VIPR2 (Vasoactive Intestinal Peptide Receptor 2) is a Protein Coding gene. Diseases associated with VIPR2 include Schizophrenia 16 and Holoprosencephaly 3. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and vasoactive intestinal polypeptide receptor activity. An important paralog of this gene is ADCYAP1R1.
UniProtKB/Swiss-Prot Summary for VIPR2 Gene
This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.
Vasoactive intestinal peptide (VIP) receptors are a group of Gs -protein-coupled receptors that are currently divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous system.