This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates ad... See more...

Aliases for VIPR1 Gene

Aliases for VIPR1 Gene

  • Vasoactive Intestinal Peptide Receptor 1 2 3 5
  • VPAC1 2 3 4
  • Vasoactive Intestinal Polypeptide Receptor 1 3 4
  • VIP And PACAP Receptor 1 2 3
  • PACAP Type II Receptor 3 4
  • PACAP-R-2 3 4
  • PACAP-R2 3 4
  • VIP-R-1 3 4
  • VPAC1R 2 3
  • HVR1 2 3
  • RDC1 2 3
  • Pituitary Adenylate Cyclase Activating Polypeptide Receptor, Type II 3
  • Pituitary Adenylate Cyclase-Activating Polypeptide Type II Receptor 4
  • Type 1 Vasoactive Intestinal Peptide Receptor 3
  • VIP Receptor, Type I 3
  • VPAC1 Receptor 3
  • VPCAP1R 3
  • VAPC1 3
  • VIPR1 5
  • V1RG 3
  • VIPR 3
  • VIRG 3
  • II 3

External Ids for VIPR1 Gene

Previous GeneCards Identifiers for VIPR1 Gene

  • GC03P041848
  • GC03P041710
  • GC03P042350
  • GC03P042504
  • GC03P042505
  • GC03P042520

Summaries for VIPR1 Gene

Entrez Gene Summary for VIPR1 Gene

  • This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for VIPR1 Gene

VIPR1 (Vasoactive Intestinal Peptide Receptor 1) is a Protein Coding gene. Diseases associated with VIPR1 include Holoprosencephaly 3 and Hepatitis C. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and vasoactive intestinal polypeptide receptor activity. An important paralog of this gene is ADCYAP1R1.

UniProtKB/Swiss-Prot Summary for VIPR1 Gene

  • This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38.

Tocris Summary for VIPR1 Gene

  • Vasoactive intestinal peptide (VIP) receptors are a group of Gs -protein-coupled receptors that are currently divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous system.

Gene Wiki entry for VIPR1 Gene

Additional gene information for VIPR1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VIPR1 Gene

Genomics for VIPR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for VIPR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VIPR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VIPR1

Top Transcription factor binding sites by QIAGEN in the VIPR1 gene promoter:
  • AP-1
  • GATA-1
  • NF-1
  • NF-1/L
  • Nkx2-5
  • Pax-5
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for VIPR1 Gene

Genomic Locations for VIPR1 Gene
chr3:42,489,299-42,537,573
(GRCh38/hg38)
Size:
48,275 bases
Orientation:
Plus strand
chr3:42,530,791-42,579,065
(GRCh37/hg19)
Size:
48,275 bases
Orientation:
Plus strand

Genomic View for VIPR1 Gene

Genes around VIPR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VIPR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VIPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VIPR1 Gene

Proteins for VIPR1 Gene

  • Protein details for VIPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32241-VIPR1_HUMAN
    Recommended name:
    Vasoactive intestinal polypeptide receptor 1
    Protein Accession:
    P32241
    Secondary Accessions:
    • A5JUT9
    • B3KPV1
    • B4DEB5
    • B4DGI4
    • F5H1F5
    • G3V0I1
    • Q15871
    • Q6P2M6

    Protein attributes for VIPR1 Gene

    Size:
    457 amino acids
    Molecular mass:
    51547 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for VIPR1 Gene

    Alternative splice isoforms for VIPR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VIPR1 Gene

Post-translational modifications for VIPR1 Gene

  • Glycosylation at Asn58, Asn69, Asn100, and Asn290
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for VIPR1 Gene

Domains & Families for VIPR1 Gene

Gene Families for VIPR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for VIPR1 Gene

InterPro:
Blocks:
  • G-protein coupled receptors family 2 (secretin-like)
  • Vasoactive intestinal peptide receptor signature
  • Vasoactive intestinal peptide receptor 1 signature
ProtoNet:

Suggested Antigen Peptide Sequences for VIPR1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53716, highly similar to Vasoactive intestinal polypeptide receptor 1 (B4DEB5_HUMAN)
  • Pituitary adenylate cyclase-activating polypeptide type II receptor (VIPR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P32241

UniProtKB/Swiss-Prot:

VIPR1_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with VIPR1: view

Function for VIPR1 Gene

Molecular function for VIPR1 Gene

UniProtKB/Swiss-Prot Function:
This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38.
GENATLAS Biochemistry:
vasoactive intestinal peptide receptor 1,G protein coupled,secretin receptor superfamily

Phenotypes From GWAS Catalog for VIPR1 Gene

Gene Ontology (GO) - Molecular Function for VIPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004999 vasoactive intestinal polypeptide receptor activity TAS,IDA 8390245
GO:0005515 protein binding IPI 23597562
GO:0008528 G protein-coupled peptide receptor activity IBA 21873635
genes like me logo Genes that share ontologies with VIPR1: view
genes like me logo Genes that share phenotypes with VIPR1: view

Animal Models for VIPR1 Gene

MGI Knock Outs for VIPR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for VIPR1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VIPR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VIPR1 Gene

Localization for VIPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VIPR1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VIPR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for VIPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8179610
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with VIPR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VIPR1 Gene

Pathways & Interactions for VIPR1 Gene

genes like me logo Genes that share pathways with VIPR1: view

SIGNOR curated interactions for VIPR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for VIPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IDA 8390245
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with VIPR1: view

Drugs & Compounds for VIPR1 Gene

(32) Drugs for VIPR1 Gene - From: ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Secretin Approved Pharma Agonist, Full agonist, binder 38
Bay 55-9837 Pharma Agonist Potent and selective VPAC2 agonist 0
[<sup>125</sup>I]PACAP-27 Pharma Agonist 0
[Ala<sup>11,22,28</sup>]VIP Pharma Agonist 0
[Arg<sup>16</sup>]chicken secretin Pharma Agonist, Full agonist 0

(12) Additional Compounds for VIPR1 Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]VIP
Agonist, Full agonist
[Lys<sup>15</sup>,Arg<sup>16</sup>,Leu<sup>27</sup>]VIP-(1?àó7)/GRF-(8?àó27)-NH<sub>2</sub>
Agonist, Full agonist
[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human)
93965-89-0
[Ala11,22,28]VIP
291524-04-4
VIP (guinea pig)
96886-24-7

(5) Tocris Compounds for VIPR1 Gene

Compound Action Cas Number
[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) VIP receptor antagonist 93965-89-0
[Ala11,22,28]VIP Potent, highly selective VPAC1 agonist 291524-04-4
Bay 55-9837 Potent and selective VPAC2 agonist 463930-25-8
VIP (guinea pig) Involved in neurotransmission and smooth muscle relaxation 96886-24-7
VIP (human, rat, mouse, rabbit, canine, porcine) Involved in neurotransmission and smooth muscle relaxation 40077-57-4

(2) ApexBio Compounds for VIPR1 Gene

Compound Action Cas Number
[D-p-Cl-Phe6,Leu17]-VIP 102805-45-8
Bay 55-9837 463930-25-8
genes like me logo Genes that share compounds with VIPR1: view

Drug Products

Transcripts for VIPR1 Gene

mRNA/cDNA for VIPR1 Gene

5 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VIPR1

Alternative Splicing Database (ASD) splice patterns (SP) for VIPR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14 ^
SP1: - - - - - - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - -
SP9:
SP10: - - - - - - - - -
SP11:
SP12: -
SP13:
SP14: -
SP15: -
SP16:

ExUns: 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:

Relevant External Links for VIPR1 Gene

GeneLoc Exon Structure for
VIPR1

Expression for VIPR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VIPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VIPR1 Gene

This gene is overexpressed in Lung (x10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VIPR1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VIPR1

SOURCE GeneReport for Unigene cluster for VIPR1 Gene:

Hs.348500

mRNA Expression by UniProt/SwissProt for VIPR1 Gene:

P32241-VIPR1_HUMAN
Tissue specificity: In lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and SUP-T1, but not in the T-cell lines Peer, MOLT-4, HSB and YT.

Evidence on tissue expression from TISSUES for VIPR1 Gene

  • Nervous system(4.6)
  • Intestine(4.6)
  • Lung(4.5)
  • Liver(4.5)
  • Skin(2.6)
  • Blood(2.6)
  • Adrenal gland(2.5)
  • Muscle(2.3)
  • Lymph node(2.2)
  • Spleen(2.2)
  • Kidney(2.2)
  • Stomach(2.1)
  • Heart(2.1)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with VIPR1: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VIPR1 Gene

Orthologs for VIPR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for VIPR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia VIPR1 30
  • 95.44 (n)
Cow
(Bos Taurus)
Mammalia VIPR1 30 31
  • 89.93 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia VIPR1 30 31
  • 89.25 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Vipr1 30 17 31
  • 85.85 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Vipr1 30
  • 84.83 (n)
Oppossum
(Monodelphis domestica)
Mammalia VIPR1 31
  • 66 (a)
OneToOne
Chicken
(Gallus gallus)
Aves VIPR1 30 31
  • 67.82 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia VIPR1 31
  • 60 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100497291 30
  • 66.83 (n)
Zebrafish
(Danio rerio)
Actinopterygii vipr1b 30 31
  • 63.94 (n)
OneToMany
vipr1a 31
  • 55 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta EG:BACR25B3.3 32
  • 29 (a)
Species where no ortholog for VIPR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for VIPR1 Gene

ENSEMBL:
Gene Tree for VIPR1 (if available)
TreeFam:
Gene Tree for VIPR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for VIPR1: view image

Paralogs for VIPR1 Gene

(15) SIMAP similar genes for VIPR1 Gene using alignment to 4 proteins:

  • VIPR1_HUMAN
  • C9JDT8_HUMAN
  • C9JH33_HUMAN
  • F2Z2U6_HUMAN
genes like me logo Genes that share paralogs with VIPR1: view

Variants for VIPR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VIPR1 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
710729 Likely Benign: not provided 42,527,443(+) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
720915 Benign: not provided 42,536,101(+) G/A SYNONYMOUS_VARIANT
722358 Benign: not provided 42,535,047(+) G/A SYNONYMOUS_VARIANT
731807 Benign: not provided 42,525,971(+) A/G MISSENSE_VARIANT
733479 Benign: not provided 42,527,470(+) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for VIPR1 Gene

Structural Variations from Database of Genomic Variants (DGV) for VIPR1 Gene

Variant ID Type Subtype PubMed ID
nsv527430 CNV loss 19592680

Variation tolerance for VIPR1 Gene

Residual Variation Intolerance Score: 49.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VIPR1 Gene

Human Gene Mutation Database (HGMD)
VIPR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
VIPR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VIPR1 Gene

Disorders for VIPR1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for VIPR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
holoprosencephaly 3
  • hpe3
hepatitis c
  • chronic hepatitis c
gastric leiomyoma
  • leiomyoma of the stomach
achalasia
  • achalasia of cardia
nonparalytic poliomyelitis
  • acute nonparalytic poliomyelitis
- elite association - COSMIC cancer census association via MalaCards
Search VIPR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for VIPR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with VIPR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VIPR1 Gene

Publications for VIPR1 Gene

  1. A functional polymorphism of the vasoactive intestinal peptide receptor 1 gene correlates with the presence of HLA-B*2705 in Sardinia. (PMID: 18668120) Paladini F … Sorrentino R (Genes and immunity 2008) 3 23 41
  2. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 41
  3. Oligonucleotide DNA microarray profiling of lung adenocarcinoma revealed significant downregulation and deletions of vasoactive intestinal peptide receptor 1. (PMID: 20014941) Mlakar V … Glavac D (Cancer investigation 2010) 3 23
  4. Vasoactive intestinal peptide (VIP) receptor expression in monocyte-derived macrophages from COPD patients. (PMID: 20026142) Burian B … Petkov V (Peptides 2010) 3 23
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 41

Products for VIPR1 Gene

Sources for VIPR1 Gene