External Ids for VIP Gene
Previous GeneCards Identifiers for VIP Gene
The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2014]
GeneCards Summary for VIP Gene
VIP (Vasoactive Intestinal Peptide) is a Protein Coding gene. Diseases associated with VIP include Vipoma and Vasomotor Rhinitis. Among its related pathways are Signaling by GPCR and Gastric acid production. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and neuropeptide hormone activity. An important paralog of this gene is ADCYAP1.
UniProtKB/Swiss-Prot Summary for VIP Gene
VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.
Vasoactive intestinal peptide (VIP) receptors are a group of Gs -protein-coupled receptors that are currently divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous system.