The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this... See more...

Aliases for VIP Gene

Aliases for VIP Gene

  • Vasoactive Intestinal Peptide 2 3 5
  • VIP Peptides 3 4
  • Prepro-VIP 2 3
  • PHM27 3

External Ids for VIP Gene

Previous GeneCards Identifiers for VIP Gene

  • GC06P152633
  • GC06P152967
  • GC06P153103
  • GC06P153102
  • GC06P153164
  • GC06P150635

Summaries for VIP Gene

Entrez Gene Summary for VIP Gene

  • The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2014]

GeneCards Summary for VIP Gene

VIP (Vasoactive Intestinal Peptide) is a Protein Coding gene. Diseases associated with VIP include Vipoma and Vasomotor Rhinitis. Among its related pathways are Signaling by GPCR and Gastric acid production. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and neuropeptide hormone activity. An important paralog of this gene is ADCYAP1.

UniProtKB/Swiss-Prot Summary for VIP Gene

  • VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
  • PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.

Tocris Summary for VIP Gene

  • Vasoactive intestinal peptide (VIP) receptors are a group of Gs -protein-coupled receptors that are currently divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous system.

Gene Wiki entry for VIP Gene

Additional gene information for VIP Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VIP Gene

Genomics for VIP Gene

GeneHancer (GH) Regulatory Elements for VIP Gene

Promoters and enhancers for VIP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J152746 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 500.7 -1.6 -1575 0.7 TCF12 JUND FOS REST EP300 TEAD1 FOXA2 SAP130 FOSL2 CEBPB VIP lnc-MYCT1-3 MYCT1
GH06J152750 Promoter 0.7 EPDnew 500.7 +2.9 2855 0.1 REST CREB1 YY1 MBD1 RCOR1 EHMT2 DNMT3B SIN3A RAD21 MIER2 VIP piR-39099-245
GH06J152694 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 8.1 -48.9 -48918 8.2 CTCF FOS SRF NR2F2 JUND ZNF654 RAD21 GATA2 SMARCA4 JUN MYCT1 VIP HSPD1P16
GH06J153024 Enhancer 0.9 Ensembl ENCODE 10 +276.7 276654 0.6 CTCF REST RAD21 TRIM22 TEAD1 ATF2 ZKSCAN8 SMC3 CREB1 SRF piR-54131-002 MTRF1L VIP RF00994-967 RGS17
GH06J152720 Enhancer 0.5 Ensembl 17.4 -26.8 -26822 2.2 POLR2A FOS GATA2 SMARCA4 JUN JUND EGR2 STAT3 VIP lnc-MYCT1-3 HSPD1P16 MYCT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VIP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VIP

Top Transcription factor binding sites by QIAGEN in the VIP gene promoter:
  • AP-1
  • NRSF form 1
  • NRSF form 2
  • STAT1

Genomic Locations for VIP Gene

Genomic Locations for VIP Gene
chr6:152,747,923-152,759,765
(GRCh38/hg38)
Size:
11,843 bases
Orientation:
Plus strand
chr6:153,071,933-153,080,900
(GRCh37/hg19)
Size:
8,968 bases
Orientation:
Plus strand

Genomic View for VIP Gene

Genes around VIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VIP Gene

Proteins for VIP Gene

  • Protein details for VIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01282-VIP_HUMAN
    Recommended name:
    VIP peptides
    Protein Accession:
    P01282
    Secondary Accessions:
    • Q5TCY8
    • Q5TCY9
    • Q96QK3

    Protein attributes for VIP Gene

    Size:
    170 amino acids
    Molecular mass:
    19169 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for VIP Gene

    Alternative splice isoforms for VIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VIP Gene

Post-translational modifications for VIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VIP Gene

Antibody Products

  • Boster Bio Antibodies for VIP

Protein Products

  • Abcam proteins for VIP

No data available for DME Specific Peptides for VIP Gene

Domains & Families for VIP Gene

Gene Families for VIP Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for VIP Gene

Blocks:
  • Glucagon/GIP/secretin/VIP
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VIP Gene

GenScript: Design optimal peptide antigens:
  • Vasoactive intestinal peptide (Q5TCY7_HUMAN)
  • VIP peptides (VIP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01282

UniProtKB/Swiss-Prot:

VIP_HUMAN :
  • Belongs to the glucagon family.
Family:
  • Belongs to the glucagon family.
genes like me logo Genes that share domains with VIP: view

Function for VIP Gene

Molecular function for VIP Gene

UniProtKB/Swiss-Prot Function:
VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
UniProtKB/Swiss-Prot Function:
PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.
GENATLAS Biochemistry:
precursor of vasoactive intestinal and PHM (intestinal peptide homolog of porcine PHI-27) peptide

Phenotypes From GWAS Catalog for VIP Gene

Gene Ontology (GO) - Molecular Function for VIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IDA,IEA 9603988
GO:0005184 neuropeptide hormone activity IBA,TAS 21873635
GO:0005515 protein binding IPI 21314817
GO:0051428 peptide hormone receptor binding IPI 8390245
genes like me logo Genes that share ontologies with VIP: view
genes like me logo Genes that share phenotypes with VIP: view

Animal Models for VIP Gene

MGI Knock Outs for VIP:
  • Vip Vip<tm1Clw>

Animal Model Products

CRISPR Products

miRNA for VIP Gene

miRTarBase miRNAs that target VIP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VIP

Clone Products

  • Addgene plasmids for VIP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VIP Gene

Localization for VIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for VIP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VIP gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0043005 neuron projection IBA 21873635
GO:0043204 perikaryon IBA 21873635
genes like me logo Genes that share ontologies with VIP: view

Pathways & Interactions for VIP Gene

genes like me logo Genes that share pathways with VIP: view

Pathways by source for VIP Gene

1 Cell Signaling Technology pathway for VIP Gene

SIGNOR curated interactions for VIP Gene

Activates:

Gene Ontology (GO) - Biological Process for VIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA 9603988
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with VIP: view

Drugs & Compounds for VIP Gene

(115) Drugs for VIP Gene - From: ClinicalTrials, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Histamine Approved, Investigational Pharma Full agonist, Agonist 1227
Sumatriptan Approved, Investigational Pharma Full agonist, Agonist, Antagonist, Partial agonist 5-HT1 receptor agonist 113
Almotriptan Approved, Investigational Pharma 14
Ephedrine Approved Pharma Partial agonist, Agonist 462
Pseudoephedrine Approved Pharma 464

(62) Additional Compounds for VIP Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
VIP (guinea pig)
96886-24-7
VIP (human, rat, mouse, rabbit, canine, porcine)
40077-57-4

(5) Tocris Compounds for VIP Gene

Compound Action Cas Number
[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) VIP receptor antagonist 93965-89-0
[Ala11,22,28]VIP Potent, highly selective VPAC1 agonist 291524-04-4
Bay 55-9837 Potent and selective VPAC2 agonist 463930-25-8
VIP (guinea pig) Involved in neurotransmission and smooth muscle relaxation 96886-24-7
VIP (human, rat, mouse, rabbit, canine, porcine) Involved in neurotransmission and smooth muscle relaxation 40077-57-4
genes like me logo Genes that share compounds with VIP: view

Transcripts for VIP Gene

mRNA/cDNA for VIP Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VIP

Clone Products

  • Addgene plasmids for VIP

Alternative Splicing Database (ASD) splice patterns (SP) for VIP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for VIP Gene

GeneLoc Exon Structure for
VIP

Expression for VIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VIP Gene

This gene is overexpressed in Colon - Sigmoid (x11.2) and Esophagus - Muscularis (x4.0).

Protein differential expression in normal tissues from HIPED for VIP Gene

This gene is overexpressed in Colon muscle (39.1) and Colon (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VIP Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VIP

SOURCE GeneReport for Unigene cluster for VIP Gene:

Hs.53973

Evidence on tissue expression from TISSUES for VIP Gene

  • Intestine(3.7)
  • Nervous system(3.7)
  • Pancreas(3.6)
  • Muscle(3.1)
  • Stomach(2.7)
  • Adrenal gland(2.6)
  • Gall bladder(2.6)
  • Blood(2.5)
  • Heart(2.5)
  • Liver(2.3)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with VIP: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VIP Gene

Orthologs for VIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for VIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VIP 31 30
  • 99.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia VIP 31 30
  • 88.04 (n)
OneToOne
cow
(Bos Taurus)
Mammalia VIP 31 30
  • 87.06 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vip 30
  • 82.75 (n)
mouse
(Mus musculus)
Mammalia Vip 17 31 30
  • 80.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia VIP 31
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VIP 31
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves VIP 31 30
  • 71.13 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VIP 31
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vip 30
  • 70.87 (n)
African clawed frog
(Xenopus laevis)
Amphibia vip-A 30
zebrafish
(Danio rerio)
Actinopterygii vip 31 30
  • 66.67 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14201 30
Species where no ortholog for VIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VIP Gene

ENSEMBL:
Gene Tree for VIP (if available)
TreeFam:
Gene Tree for VIP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for VIP: view image

Paralogs for VIP Gene

Paralogs for VIP Gene

(1) SIMAP similar genes for VIP Gene using alignment to 2 proteins:

  • VIP_HUMAN
  • H0Y763_HUMAN
genes like me logo Genes that share paralogs with VIP: view

Variants for VIP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VIP Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
709425 Benign: not provided 152,754,294(+) T/A INTRON_VARIANT
710847 Likely Benign: not provided 152,755,262(+) G/A INTRON_VARIANT
722061 Likely Benign: not provided 152,756,140(+) C/T SYNONYMOUS_VARIANT
774186 Benign: not provided 152,756,197(+) C/T SYNONYMOUS_VARIANT
776175 Benign: not provided 152,756,182(+) A/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for VIP Gene

Structural Variations from Database of Genomic Variants (DGV) for VIP Gene

Variant ID Type Subtype PubMed ID
esv2759478 CNV loss 17122850

Variation tolerance for VIP Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VIP Gene

Human Gene Mutation Database (HGMD)
VIP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
VIP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VIP Gene

Disorders for VIP Gene

MalaCards: The human disease database

(83) MalaCards diseases for VIP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
vipoma
  • malignant vasoactive intestinal peptide-secreting tumor
vasomotor rhinitis
  • rhinitis vasomotor
ganglioneuroma
chemical colitis
somatostatinoma
  • pancreatic endocrine carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search VIP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for VIP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with VIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VIP Gene

Publications for VIP Gene

  1. Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. (PMID: 20554694) Kovanen L … Partonen T (Alcohol and alcoholism (Oxford, Oxfordshire) 2010) 3 41 54
  2. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PMID: 20398908) Saus E … Estivill X (Journal of psychiatric research 2010) 3 41 54
  3. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 41 54
  4. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PMID: 20072116) Soria V … Urretavizcaya M (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010) 3 41 54
  5. Opposing effects of two tissue transglutaminase protein isoforms in neuroblastoma cell differentiation. (PMID: 20007697) Tee AE … Liu T (The Journal of biological chemistry 2010) 3 23 54

Products for VIP Gene

  • Addgene plasmids for VIP

Sources for VIP Gene