External Ids for VIM Gene
Previous GeneCards Identifiers for VIM Gene
This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in neuritogenesis and cholesterol transport and functions as an organizer of a number of other critical proteins involved in cell attachment, migration, and signaling. Bacterial and viral pathogens have been shown to attach to this protein on the host cell surface. Mutations in this gene are associated with congenital cataracts in human patients. [provided by RefSeq, Aug 2017]
GeneCards Summary for VIM Gene
VIM (Vimentin) is a Protein Coding gene. Diseases associated with VIM include Cataract 30, Multiple Types and Cataract 30. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Cell adhesion_Endothelial cell contacts by junctional mechanisms. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein C-terminus binding. An important paralog of this gene is DES.
UniProtKB/Swiss-Prot Summary for VIM Gene
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.