Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VHLL Gene

Aliases for VHLL Gene

  • VHL Like 2 3 5
  • Von Hippel-Lindau Tumor Suppressor Like 2 3
  • VHL-Like Protein 3 4
  • VHL Pseudogene 2 3
  • VLP 3 4
  • Von Hippel-Lindau-Like Protein 3
  • VHLP 3

External Ids for VHLL Gene

Previous HGNC Symbols for VHLL Gene

  • VHLP

Previous GeneCards Identifiers for VHLL Gene

  • GC01M153081
  • GC01M154535
  • GC01M156268
  • GC01M127628

Summaries for VHLL Gene

Entrez Gene Summary for VHLL Gene

  • Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. [provided by RefSeq, Jan 2010]

GeneCards Summary for VHLL Gene

VHLL (VHL Like) is a Protein Coding gene. Diseases associated with VHLL include Pancreatic Serous Cystadenoma and Kidney Cancer. An important paralog of this gene is VHL.

UniProtKB/Swiss-Prot for VHLL Gene

  • Functions as a dominant-negative VHL to serve as a protector of HIFalpha.

Additional gene information for VHLL Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VHLL Gene

Genomics for VHLL Gene

GeneHancer (GH) Regulatory Elements for VHLL Gene

Promoters and enhancers for VHLL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I156295 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 0.8 +3.9 3947 1.2 ARID4B SIN3A YY1 KLF7 RUNX3 DEK SP3 NCOA1 MXD4 REST GLMP KHDC4 GON4L ENSG00000271267 MSTO1 RRNAD1 MSTO2P LMNA RUSC1-AS1 DAP3
GH01I156319 Enhancer 0.4 ENCODE 0.3 -20.1 -20148 0.2 CTCF ZNF654 RAD21 GLMP CCT3 PAQR6 SEMA4A C1orf61 BGLAP LMNA MEX3A LAMTOR2 UBQLN4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VHLL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VHLL gene promoter:

Genomic Locations for VHLL Gene

Genomic Locations for VHLL Gene
1,014 bases
Minus strand

Genomic View for VHLL Gene

Genes around VHLL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VHLL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VHLL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VHLL Gene

Proteins for VHLL Gene

  • Protein details for VHLL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    von Hippel-Lindau-like protein
    Protein Accession:
    Secondary Accessions:
    • A1L4M4

    Protein attributes for VHLL Gene

    139 amino acids
    Molecular mass:
    15781 Da
    Quaternary structure:
    • Interacts via the beta domain with the ODD domain of HIF1A. This interaction is independent of prolyl hydroxylation of HIF1A.
    • Has little or no E3 ubiquitin ligase activity as it lacks the alpha domain required for nucleating the multiprotein E3 ubiquitin ligase complex.

neXtProt entry for VHLL Gene

Post-translational modifications for VHLL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VHLL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VHLL Gene

Domains & Families for VHLL Gene

Gene Families for VHLL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for VHLL Gene

Suggested Antigen Peptide Sequences for VHLL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the VHL family.
  • Belongs to the VHL family.
genes like me logo Genes that share domains with VHLL: view

Function for VHLL Gene

Molecular function for VHLL Gene

UniProtKB/Swiss-Prot Function:
Functions as a dominant-negative VHL to serve as a protector of HIFalpha.

Gene Ontology (GO) - Molecular Function for VHLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with VHLL: view
genes like me logo Genes that share phenotypes with VHLL: view

Animal Model Products

miRNA for VHLL Gene

miRTarBase miRNAs that target VHLL

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VHLL Gene

Localization for VHLL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VHLL gene
Compartment Confidence
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for VHLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0030891 VCB complex IBA --
genes like me logo Genes that share ontologies with VHLL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for VHLL Gene

Pathways & Interactions for VHLL Gene

No Data Available

Gene Ontology (GO) - Biological Process for VHLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IBA --
genes like me logo Genes that share ontologies with VHLL: view

No data available for Pathways by source and SIGNOR curated interactions for VHLL Gene

Drugs & Compounds for VHLL Gene

No Compound Related Data Available

Transcripts for VHLL Gene

mRNA/cDNA for VHLL Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VHLL Gene

Von Hippel-Lindau tumor suppressor-like:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for VHLL Gene

No ASD Table

Relevant External Links for VHLL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VHLL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VHLL Gene

mRNA differential expression in normal tissues according to GTEx for VHLL Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.8) and Brain - Cerebellum (x8.0).

NURSA nuclear receptor signaling pathways regulating expression of VHLL Gene:


SOURCE GeneReport for Unigene cluster for VHLL Gene:


mRNA Expression by UniProt/SwissProt for VHLL Gene:

Tissue specificity: Abundantly expressed in the placenta.

Evidence on tissue expression from TISSUES for VHLL Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with VHLL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VHLL Gene

Orthologs for VHLL Gene

This gene was present in the common ancestor of chordates.

Orthologs for VHLL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VHLL 33
  • 97.52 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 58 (a)
-- 34
  • 55 (a)
(Mus musculus)
Mammalia Vhl 34
  • 41 (a)
(Gallus gallus)
Aves -- 34
  • 25 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
(Danio rerio)
Actinopterygii vhl 34
  • 26 (a)
Species where no ortholog for VHLL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VHLL Gene

Gene Tree for VHLL (if available)
Gene Tree for VHLL (if available)

Paralogs for VHLL Gene

Paralogs for VHLL Gene

(1) SIMAP similar genes for VHLL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VHLL: view

Variants for VHLL Gene

Sequence variations from dbSNP and Humsavar for VHLL Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000290695 -- 156,298,677(-) C/T 3_prime_UTR_variant
rs1000588829 -- 156,298,418(-) C/T downstream_transcript_variant
rs1000595212 -- 156,298,424(-) C/T downstream_transcript_variant
rs1000768571 -- 156,298,691(-) T/C 3_prime_UTR_variant
rs1001594585 -- 156,299,051(-) A/G coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for VHLL Gene

Variant ID Type Subtype PubMed ID
nsv509524 CNV insertion 20534489

Variation tolerance for VHLL Gene

Gene Damage Index Score: 1.34; 26.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VHLL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VHLL Gene

Disorders for VHLL Gene

MalaCards: The human disease database

(2) MalaCards diseases for VHLL Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pancreatic serous cystadenoma
kidney cancer
  • malignant neoplasm of kidney except pelvis
- elite association - COSMIC cancer census association via MalaCards
Search VHLL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for VHLL

genes like me logo Genes that share disorders with VHLL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VHLL Gene

Publications for VHLL Gene

  1. Molecular cloning and characterization of the von Hippel-Lindau-like protein. (PMID: 14757845) Qi H … Ohh M (Molecular cancer research : MCR 2004) 2 3 4 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y … Kamatani N (Nature genetics 2010) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for VHLL Gene

Sources for VHLL Gene

Loading form....