Aliases for VGLL4 Gene

Aliases for VGLL4 Gene

  • Vestigial Like Family Member 4 2 3 5
  • Transcription Cofactor Vestigial-Like Protein 4 3 4
  • Vestigial-Like Family Member 4 2
  • Vestigial Like 4 (Drosophila) 2
  • Vestigial-Like 4 3
  • Vestigial Like 4 3
  • KIAA0121 4
  • VGL-4 3
  • Vgl-4 4

External Ids for VGLL4 Gene

Previous GeneCards Identifiers for VGLL4 Gene

  • GC03M011573
  • GC03M011574
  • GC03M011597
  • GC03M011558
  • GC03M011559
  • GC03M011568
  • GC03M011569
  • GC03M011567
  • GC03M011560
  • GC03M011561
  • GC03M011562
  • GC03M011563
  • GC03M011564
  • GC03M011565

Summaries for VGLL4 Gene

GeneCards Summary for VGLL4 Gene

VGLL4 (Vestigial Like Family Member 4) is a Protein Coding gene. Diseases associated with VGLL4 include Meningioma, Familial.

UniProtKB/Swiss-Prot Summary for VGLL4 Gene

Additional gene information for VGLL4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VGLL4 Gene

Genomics for VGLL4 Gene

GeneHancer (GH) Regulatory Elements for VGLL4 Gene

Promoters and enhancers for VGLL4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J011716 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 510.2 +52.2 52194 5.7 ZNF217 NRF1 TCF12 POLR2G USF1 PHF8 TEAD4 ZFX ZIC2 POLR2A VGLL4 lnc-ATG7-2 lnc-TAMM41-5-001 TAMM41 TSEN2 lnc-TAMM41-5-002 lnc-TAMM41-4
GH03J011580 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 504.7 +188.5 188548 4.2 ZSCAN5C USF1 ZIC2 ZNF423 ZNF623 KLF7 MXI1 ZNF341 OSR2 HDAC2 VGLL4 ENSG00000271716 lnc-ATG7-1 piR-48209-507
GH03J011768 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas 500.7 +0.6 643 4.3 ZNF217 TEAD4 POLR2A ZBTB26 KLF4 TOE1 MYC TGIF2 CTBP1 TEAD1 VGLL4 TAMM41 HSALNG0024170
GH03J011845 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 31 -75.3 -75297 2.9 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 POLR2G SP1 GTF2E2 PHF8 TAMM41 VGLL4 TSEN2 RPL32 lnc-VGLL4-7
GH03J012362 Enhancer 0.9 Ensembl dbSUPER 55.4 -592.0 -591951 2.2 RBAK ZNF639 ZNF354C ZNF623 ZNF510 ZNF266 ZBTB11 ZNF426 ZNF213 ZNF189 TAMM41 VGLL4 ENSG00000271716 TSEN2 ENSG00000272263 RPL32 MKRN2 TIMP4 SYN2 PPARG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VGLL4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VGLL4

Top Transcription factor binding sites by QIAGEN in the VGLL4 gene promoter:
  • ARP-1
  • FOXD1
  • FOXF2
  • Ik-1
  • NF-kappaB1
  • Sox5
  • Sp1
  • SRY

Genomic Locations for VGLL4 Gene

Genomic Locations for VGLL4 Gene
chr3:11,556,067-11,771,350
(GRCh38/hg38)
Size:
215,284 bases
Orientation:
Minus strand
chr3:11,597,544-11,762,220
(GRCh37/hg19)
Size:
164,677 bases
Orientation:
Minus strand

Genomic View for VGLL4 Gene

Genes around VGLL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VGLL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VGLL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VGLL4 Gene

Proteins for VGLL4 Gene

  • Protein details for VGLL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14135-VGLL4_HUMAN
    Recommended name:
    Transcription cofactor vestigial-like protein 4
    Protein Accession:
    Q14135
    Secondary Accessions:
    • B4DTS7
    • J3KN68
    • Q7L5V0
    • Q9BQ78

    Protein attributes for VGLL4 Gene

    Size:
    290 amino acids
    Molecular mass:
    30948 Da
    Quaternary structure:
    • Interacts with TEFs (By similarity). Interacts with IRF2BP2.
    Miscellaneous:
    • [Isoform 3]: Probable target of nonsense-mediated mRNA decay.
    SequenceCaution:
    • Sequence=AAH03038.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAA09470.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for VGLL4 Gene

neXtProt entry for VGLL4 Gene

Post-translational modifications for VGLL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VGLL4 Gene

Domains & Families for VGLL4 Gene

Gene Families for VGLL4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for VGLL4 Gene

Blocks:
  • Protein of unknown function TDU
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VGLL4 Gene

GenScript: Design optimal peptide antigens:
  • Vestigial-like 4 (Q0H0I4_HUMAN)
  • Vestigial-like 4 (Q0H0I7_HUMAN)
  • Transcription cofactor vestigial-like protein 4 (VGLL4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14135

UniProtKB/Swiss-Prot:

VGLL4_HUMAN :
  • Belongs to the vestigial family.
Family:
  • Belongs to the vestigial family.
genes like me logo Genes that share domains with VGLL4: view

Function for VGLL4 Gene

Molecular function for VGLL4 Gene

UniProtKB/Swiss-Prot Function:
May act as a specific coactivator for the mammalian TEFs.

Phenotypes From GWAS Catalog for VGLL4 Gene

Gene Ontology (GO) - Molecular Function for VGLL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001223 transcription coactivator binding IBA 21873635
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with VGLL4: view
genes like me logo Genes that share phenotypes with VGLL4: view

Animal Models for VGLL4 Gene

MGI Knock Outs for VGLL4:
  • Vgll4 Vgll4<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for VGLL4 Gene

miRTarBase miRNAs that target VGLL4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VGLL4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VGLL4 Gene

Localization for VGLL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VGLL4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VGLL4 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VGLL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with VGLL4: view

Pathways & Interactions for VGLL4 Gene

PathCards logo

SuperPathways for VGLL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VGLL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IBA 21873635
genes like me logo Genes that share ontologies with VGLL4: view

No data available for Pathways by source and SIGNOR curated interactions for VGLL4 Gene

Drugs & Compounds for VGLL4 Gene

No Compound Related Data Available

Transcripts for VGLL4 Gene

mRNA/cDNA for VGLL4 Gene

6 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VGLL4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VGLL4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b · 18c ·
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - -
SP11: - - -
SP12:
SP13: - - - - - -
SP14:

ExUns: 18d ^ 19a · 19b · 19c · 19d · 19e
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14: -

Relevant External Links for VGLL4 Gene

GeneLoc Exon Structure for
VGLL4

Expression for VGLL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VGLL4 Gene

Protein differential expression in normal tissues from HIPED for VGLL4 Gene

This gene is overexpressed in Ovary (39.2), Islet of Langerhans (21.4), and Fetal ovary (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for VGLL4 Gene



Protein tissue co-expression partners for VGLL4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VGLL4

SOURCE GeneReport for Unigene cluster for VGLL4 Gene:

Hs.740389

Evidence on tissue expression from TISSUES for VGLL4 Gene

  • Nervous system(4.9)
  • Lung(4.4)
  • Bone marrow(4.2)
genes like me logo Genes that share expression patterns with VGLL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VGLL4 Gene

Orthologs for VGLL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VGLL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VGLL4 31
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VGLL4 31 30
  • 90.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia VGLL4 31 30
  • 88.3 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Vgll4 17 31 30
  • 86.96 (n)
rat
(Rattus norvegicus)
Mammalia Vgll4 30
  • 86.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia VGLL4 31
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VGLL4 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves VGLL4 31 30
  • 78.09 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VGLL4 31
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vgll4 30
  • 75 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15409 30
zebrafish
(Danio rerio)
Actinopterygii vgll4b 31 30
  • 76.54 (n)
OneToOne
Species where no ortholog for VGLL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VGLL4 Gene

ENSEMBL:
Gene Tree for VGLL4 (if available)
TreeFam:
Gene Tree for VGLL4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for VGLL4: view image

Paralogs for VGLL4 Gene

No data available for Paralogs for VGLL4 Gene

Variants for VGLL4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VGLL4 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs2276749 - p.Met32Ile

Additional dbSNP identifiers (rs#s) for VGLL4 Gene

Structural Variations from Database of Genomic Variants (DGV) for VGLL4 Gene

Variant ID Type Subtype PubMed ID
dgv4681n100 CNV gain 25217958
dgv762e201 CNV deletion 23290073
dgv791n67 CNV loss 20364138
dgv8220n54 CNV loss 21841781
dgv8221n54 CNV loss 21841781
dgv8222n54 CNV loss 21841781
dgv8223n54 CNV loss 21841781
dgv8224n54 CNV loss 21841781
dgv8225n54 CNV gain 21841781
dgv8226n54 CNV loss 21841781
dgv868e214 CNV gain 21293372
esv1423720 CNV deletion 17803354
esv2130512 CNV deletion 18987734
esv2283589 CNV deletion 18987734
esv25016 CNV loss 19812545
esv2512352 CNV insertion 19546169
esv26292 CNV loss 19812545
esv2661608 CNV deletion 23128226
esv2677845 CNV deletion 23128226
esv2724912 CNV deletion 23290073
esv2724913 CNV deletion 23290073
esv2724914 CNV deletion 23290073
esv2724915 CNV deletion 23290073
esv3448611 CNV duplication 20981092
esv3561475 CNV deletion 23714750
esv3595296 CNV loss 21293372
esv3595297 CNV loss 21293372
esv3595298 CNV loss 21293372
esv3595301 CNV loss 21293372
esv3595303 CNV loss 21293372
esv4117 OTHER complex 18987735
esv4895 CNV loss 18987735
nsv1073204 CNV deletion 25765185
nsv1121603 CNV deletion 24896259
nsv1149537 CNV deletion 26484159
nsv1150844 CNV deletion 26484159
nsv237362 CNV deletion 16902084
nsv436362 CNV deletion 17901297
nsv436869 CNV insertion 17901297
nsv474031 CNV novel sequence insertion 20440878
nsv511196 CNV loss 21212237
nsv513035 CNV loss 21212237
nsv517831 CNV loss 19592680
nsv520880 CNV loss 19592680
nsv589665 CNV loss 21841781
nsv589683 CNV gain 21841781
nsv589684 CNV gain 21841781
nsv589689 CNV gain+loss 21841781
nsv589691 CNV gain 21841781
nsv821986 CNV loss 20364138
nsv821990 CNV loss 20364138
nsv955314 CNV deletion 24416366
nsv999006 CNV gain 25217958

Variation tolerance for VGLL4 Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VGLL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VGLL4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VGLL4 Gene

Disorders for VGLL4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for VGLL4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
meningioma, familial
  • meningioma, familial, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search VGLL4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for VGLL4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with VGLL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VGLL4 Gene

Publications for VGLL4 Gene

  1. Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes. (PMID: 15140898) Chen HH … Stewart AF (The Journal of biological chemistry 2004) 2 3 23 54
  2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 2 3 4 54
  3. A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa. (PMID: 21079607) Wang K … Price Foundation Collaborative Group (Molecular psychiatry 2011) 3 41 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  5. IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression. (PMID: 20702774) Teng AC … Stewart AF (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010) 3 4 54

Products for VGLL4 Gene

Sources for VGLL4 Gene