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Aliases for VGLL3 Gene

Aliases for VGLL3 Gene

  • Vestigial Like Family Member 3 2 3 5
  • VGL-3 3 4
  • Transcription Cofactor Vestigial-Like Protein 3 3
  • Colon Carcinoma Related Protein 3
  • Vestigial-Like Family Member 3 2
  • Vestigial Like 3 (Drosophila) 2
  • VGL3 3

External Ids for VGLL3 Gene

Previous GeneCards Identifiers for VGLL3 Gene

  • GC03M087071
  • GC03M086937

Summaries for VGLL3 Gene

GeneCards Summary for VGLL3 Gene

VGLL3 (Vestigial Like Family Member 3) is a Protein Coding gene. An important paralog of this gene is VGLL2.

UniProtKB/Swiss-Prot for VGLL3 Gene

  • May act as a specific coactivator for the mammalian TEFs.

Additional gene information for VGLL3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VGLL3 Gene

Genomics for VGLL3 Gene

GeneHancer (GH) Regulatory Elements for VGLL3 Gene

Promoters and enhancers for VGLL3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I086981 Promoter/Enhancer 2.9 UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 555.3 +2.8 2782 13.6 FOXA2 ARNT SIN3A ZNF335 GLIS2 SCRT2 FOS CEBPB ELF1 ZNF398 VGLL3 LOC105377196
GH03I087791 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.7 -802.1 -802076 2.9 GLIS2 ZNF213 ZNF202 ZC3H11A REST ZNF518A GMEB1 SMARCA4 GLIS1 AEBP2 HTR1F LOC105377198 CGGBP1 ZNF654 VGLL3
GH03I086966 Enhancer 0.7 ENCODE dbSUPER 11.9 +23.2 23230 2.2 MZF1 CREB1 FEZF1 EZH2 VGLL3 LOC105377196
GH03I086936 Enhancer 0.7 Ensembl ENCODE dbSUPER 11.7 +53.0 52985 3.5 ATF2 LOC105377196 VGLL3
GH03I087069 Enhancer 0.6 ENCODE 11.4 -79.0 -79035 2.1 STAT1 INSM2 CEBPB FEZF1 EP300 ZNF843 RFX5 GATA3 ZNF629 ZSCAN5C VGLL3 CHMP2B PPATP1 LINC00506
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VGLL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VGLL3 gene promoter:

Genomic Locations for VGLL3 Gene

Genomic Locations for VGLL3 Gene
114,900 bases
Minus strand

Genomic View for VGLL3 Gene

Genes around VGLL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VGLL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VGLL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VGLL3 Gene

Proteins for VGLL3 Gene

  • Protein details for VGLL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription cofactor vestigial-like protein 3
    Protein Accession:
    Secondary Accessions:
    • D3DU37
    • Q504T7

    Protein attributes for VGLL3 Gene

    326 amino acids
    Molecular mass:
    36009 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VGLL3 Gene


neXtProt entry for VGLL3 Gene

Post-translational modifications for VGLL3 Gene

No Post-translational modifications

Other Protein References for VGLL3 Gene

No data available for DME Specific Peptides for VGLL3 Gene

Domains & Families for VGLL3 Gene

Gene Families for VGLL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for VGLL3 Gene


Suggested Antigen Peptide Sequences for VGLL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the vestigial family.
  • Belongs to the vestigial family.
genes like me logo Genes that share domains with VGLL3: view

Function for VGLL3 Gene

Molecular function for VGLL3 Gene

UniProtKB/Swiss-Prot Function:
May act as a specific coactivator for the mammalian TEFs.

Phenotypes From GWAS Catalog for VGLL3 Gene

Gene Ontology (GO) - Molecular Function for VGLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003705 contributes_to transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IBA --
genes like me logo Genes that share ontologies with VGLL3: view
genes like me logo Genes that share phenotypes with VGLL3: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VGLL3 Gene

Localization for VGLL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VGLL3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VGLL3 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VGLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with VGLL3: view

Pathways & Interactions for VGLL3 Gene

SuperPathways for VGLL3 Gene

No Data Available

Interacting Proteins for VGLL3 Gene

Gene Ontology (GO) - Biological Process for VGLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with VGLL3: view

No data available for Pathways by source and SIGNOR curated interactions for VGLL3 Gene

Drugs & Compounds for VGLL3 Gene

No Compound Related Data Available

Transcripts for VGLL3 Gene

Unigene Clusters for VGLL3 Gene

Vestigial like 3 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VGLL3 Gene

No ASD Table

Relevant External Links for VGLL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VGLL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VGLL3 Gene

Protein differential expression in normal tissues from HIPED for VGLL3 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VGLL3 Gene

Protein tissue co-expression partners for VGLL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VGLL3 Gene:


SOURCE GeneReport for Unigene cluster for VGLL3 Gene:


mRNA Expression by UniProt/SwissProt for VGLL3 Gene:

Tissue specificity: Enriched in placenta.
genes like me logo Genes that share expression patterns with VGLL3: view

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for VGLL3 Gene

Orthologs for VGLL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for VGLL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VGLL3 33 34
  • 99.39 (n)
(Canis familiaris)
Mammalia VGLL3 33 34
  • 92.4 (n)
(Rattus norvegicus)
Mammalia Vgll3 33
  • 90.53 (n)
(Bos Taurus)
Mammalia VGLL3 33 34
  • 89.54 (n)
(Mus musculus)
Mammalia Vgll3 33 16 34
  • 89.44 (n)
(Monodelphis domestica)
Mammalia VGLL3 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia VGLL3 34
  • 81 (a)
(Gallus gallus)
Aves VGLL3 33 34
  • 76.87 (n)
(Anolis carolinensis)
Reptilia VGLL3 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vgll3 33
  • 67.53 (n)
(Danio rerio)
Actinopterygii LOC100331764 33
  • 50.76 (n)
VGLL3 34
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta vg 34
  • 14 (a)
Species where no ortholog for VGLL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VGLL3 Gene

Gene Tree for VGLL3 (if available)
Gene Tree for VGLL3 (if available)

Paralogs for VGLL3 Gene

Paralogs for VGLL3 Gene

genes like me logo Genes that share paralogs with VGLL3: view

Variants for VGLL3 Gene

Sequence variations from dbSNP and Humsavar for VGLL3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000008977 -- 86,973,642(-) G/A/C intron_variant
rs1000042388 -- 86,954,586(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000061522 -- 86,973,903(-) C/T intron_variant
rs1000098494 -- 86,957,969(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000119196 -- 86,986,526(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for VGLL3 Gene

Variant ID Type Subtype PubMed ID
nsv527279 CNV gain 19592680
nsv519148 CNV gain 19592680
esv3596879 CNV loss 21293372

Variation tolerance for VGLL3 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VGLL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VGLL3 Gene

Disorders for VGLL3 Gene

Additional Disease Information for VGLL3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for VGLL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VGLL3 Gene

Publications for VGLL3 Gene

  1. Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation. (PMID: 12376544) Maeda T … Stewart AF (The Journal of biological chemistry 2002) 2 3 4 22 58
  2. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks CE … Murray A (Nature genetics 2010) 3 44 58
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  4. A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases. (PMID: 27992404) Liang Y … Gudjonsson JE (Nature immunology 2017) 3 58
  5. Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. (PMID: 23449627) Cousminer DL … Early Growth Genetics (EGG) Consortium (Human molecular genetics 2013) 3 58

Products for VGLL3 Gene

Sources for VGLL3 Gene

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