This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secr... See more...

Aliases for VGF Gene

Aliases for VGF Gene

  • VGF Nerve Growth Factor Inducible 2 3 5
  • Neuro-Endocrine Specific Protein VGF 2 3
  • Neurosecretory Protein VGF 3 4
  • SgVII 3
  • SCG7 3

External Ids for VGF Gene

Previous GeneCards Identifiers for VGF Gene

  • GC07M099289
  • GC07M100352
  • GC07M100365
  • GC07M100401
  • GC07M100592
  • GC07M100805
  • GC07M095398

Summaries for VGF Gene

Entrez Gene Summary for VGF Gene

  • This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for VGF Gene

VGF (VGF Nerve Growth Factor Inducible) is a Protein Coding gene. Diseases associated with VGF include Pulmonary Large Cell Neuroendocrine Carcinoma and Chronic Pain. Gene Ontology (GO) annotations related to this gene include growth factor activity and neuropeptide hormone activity.

UniProtKB/Swiss-Prot Summary for VGF Gene

  • Neurosecretory protein VGF: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity).
  • Neuroendocrine regulatory peptide-1: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons.
  • Neuroendocrine regulatory peptide-2: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (By similarity). Stimulates also feeding behavior in an orexin-dependent manner in the hypothalamus (By similarity). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (By similarity).
  • VGF-derived peptide TLQP-21: Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis (By similarity). Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (By similarity). Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (By similarity).
  • VGF-derived peptide TLQP-62: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (By similarity). Induces also insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (By similarity).
  • Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.

Additional gene information for VGF Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VGF Gene

Genomics for VGF Gene

GeneHancer (GH) Regulatory Elements for VGF Gene

Promoters and enhancers for VGF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J101159 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 750.4 +6.4 6400 8.4 ZNF785 SIN3A ZNF24 ZBTB40 SP1 SREBF1 ZBTB6 MLX RBPJ POLR2A VGF GIGYF1 SRRT PPP1R35 AP1S1 STAG3L5P NAT16 MEPCE PCOLCE-AS1 ZCWPW1
GH07J101169 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 750.6 -0.1 -66 0.8 ZNF785 ZBTB40 CTCF RUNX1 MYC CC2D1A L3MBTL2 MAX RAD21 MNT VGF MEPCE FBXO24 SRRT PILRB PPP1R35 TRIM56 ZCWPW1 SPDYE3 IFT22
GH07J101174 Promoter/Enhancer 1.2 Ensembl dbSUPER 750.6 +0.6 634 0.2 SMARCE1 ZNF280D ZNF148 GTF2F1 ZNF473 MLLT1 SP7 PRDM1 SMARCA4 MCM2 VGF SRRT MEPCE PPP1R35 GIGYF1 STAG3L5P PILRB FBXO24 ZCWPW1 LRCH4
GH07J101168 Promoter/Enhancer 0.8 Ensembl dbSUPER 750.6 +1.2 1234 0.2 PRDM1 PRDM10 CREM FOSL2 JUN KDM1A VGF MIR4653 RF00017-6494
GH07J101170 Enhancer 0.5 ENCODE dbSUPER 750.6 -1.0 -1020 0.1 EZH2 ZBTB12 VGF lnc-AP1S1-3 NAT16 RF00017-6494
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VGF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VGF gene promoter:
  • ATF
  • CREB
  • deltaCREB
  • HTF
  • Olf-1
  • Pax-5
  • Pax-6
  • STAT3

Genomic Locations for VGF Gene

Genomic Locations for VGF Gene
chr7:101,162,509-101,169,935
(GRCh38/hg38)
Size:
7,427 bases
Orientation:
Minus strand
chr7:100,805,790-100,808,874
(GRCh37/hg19)
Size:
3,085 bases
Orientation:
Minus strand

Genomic View for VGF Gene

Genes around VGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VGF Gene

Proteins for VGF Gene

  • Protein details for VGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15240-VGF_HUMAN
    Recommended name:
    Neurosecretory protein VGF
    Protein Accession:
    O15240
    Secondary Accessions:
    • Q9UDW8

    Protein attributes for VGF Gene

    Size:
    615 amino acids
    Molecular mass:
    67258 Da
    Quaternary structure:
    • VGF-derived peptide TLQP-21: Interacts with HSPA8 on cell membrane (PubMed:28934328). Interacts with C3AR1 (By similarity). Interacts with C1QBP (By similarity).

neXtProt entry for VGF Gene

Post-translational modifications for VGF Gene

  • Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure.
  • Glycosylation at Thr180, Thr187, Thr189, Thr191, Thr193, Ser252, Ser253, Thr256, Ser266, and Thr554
  • Modification sites at PhosphoSitePlus

Other Protein References for VGF Gene

Antibody Products

  • Abcam antibodies for VGF
  • Boster Bio Antibodies for VGF

No data available for DME Specific Peptides for VGF Gene

Domains & Families for VGF Gene

Gene Families for VGF Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for VGF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VGF Gene

GenScript: Design optimal peptide antigens:
  • VGF protein (Q05BJ3_HUMAN)
  • Neurosecretory protein VGF (VGF_HUMAN)
genes like me logo Genes that share domains with VGF: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for VGF Gene

Function for VGF Gene

Molecular function for VGF Gene

UniProtKB/Swiss-Prot Function:
Neurosecretory protein VGF: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity).
UniProtKB/Swiss-Prot Function:
Neuroendocrine regulatory peptide-1: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons.
UniProtKB/Swiss-Prot Function:
Neuroendocrine regulatory peptide-2: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (By similarity). Stimulates also feeding behavior in an orexin-dependent manner in the hypothalamus (By similarity). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (By similarity).
UniProtKB/Swiss-Prot Function:
VGF-derived peptide TLQP-21: Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis (By similarity). Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (By similarity). Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (By similarity).
UniProtKB/Swiss-Prot Function:
VGF-derived peptide TLQP-62: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (By similarity). Induces also insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (By similarity).
UniProtKB/Swiss-Prot Function:
Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.
GENATLAS Biochemistry:
neurotrophin responsive factor,70kDa,expressed in the brain,with a C terminal region encoding posttranslationaly processed peptides

Phenotypes From GWAS Catalog for VGF Gene

Gene Ontology (GO) - Molecular Function for VGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005184 neuropeptide hormone activity IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with VGF: view
genes like me logo Genes that share phenotypes with VGF: view

Animal Models for VGF Gene

MGI Knock Outs for VGF:
  • Vgf Vgf<tm1Vlcg>
  • Vgf Vgf<tm1Srjs>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VGF Gene

Localization for VGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for VGF Gene

Neurosecretory protein VGF: Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VGF gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 4
nucleus 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA,IBA 15706611
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005794 Golgi apparatus IDA --
GO:0030133 transport vesicle IEA --
genes like me logo Genes that share ontologies with VGF: view

Pathways & Interactions for VGF Gene

PathCards logo

SuperPathways for VGF Gene

No Data Available

Gene Ontology (GO) - Biological Process for VGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0002021 response to dietary excess IEA --
GO:0006091 generation of precursor metabolites and energy IEA --
GO:0007165 signal transduction IEA --
GO:0009409 response to cold IEA --
genes like me logo Genes that share ontologies with VGF: view

No data available for Pathways by source and SIGNOR curated interactions for VGF Gene

Drugs & Compounds for VGF Gene

(5) Drugs for VGF Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TLQP 21 Pharma VGF-derived peptide 0

(1) Additional Compounds for VGF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for VGF Gene

Compound Action Cas Number
TLQP 21 VGF-derived peptide 869988-94-3
genes like me logo Genes that share compounds with VGF: view

Transcripts for VGF Gene

mRNA/cDNA for VGF Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(86) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VGF Gene

No ASD Table

Relevant External Links for VGF Gene

GeneLoc Exon Structure for
VGF
ECgene alternative splicing isoforms for
VGF

Expression for VGF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VGF Gene

mRNA differential expression in normal tissues according to GTEx for VGF Gene

This gene is overexpressed in Brain - Hypothalamus (x14.2), Pituitary (x7.9), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Cortex (x4.7), and Brain - Frontal Cortex (BA9) (x4.6).

Protein differential expression in normal tissues from HIPED for VGF Gene

This gene is overexpressed in Cerebrospinal fluid (31.0) and Islet of Langerhans (21.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for VGF Gene



Protein tissue co-expression partners for VGF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VGF Gene:

VGF

SOURCE GeneReport for Unigene cluster for VGF Gene:

Hs.587325

mRNA Expression by UniProt/SwissProt for VGF Gene:

O15240-VGF_HUMAN
Tissue specificity: Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.

Evidence on tissue expression from TISSUES for VGF Gene

  • Nervous system(4.7)
  • Pancreas(3.1)
  • Adrenal gland(2.4)
genes like me logo Genes that share expression patterns with VGF: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for VGF Gene

Orthologs for VGF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VGF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VGF 33 32
  • 99.51 (n)
OneToOne
dog
(Canis familiaris)
Mammalia VGF 33 32
  • 90.41 (n)
OneToOne
cow
(Bos Taurus)
Mammalia VGF 33
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vgf 32
  • 85.21 (n)
mouse
(Mus musculus)
Mammalia Vgf 17 33 32
  • 84.67 (n)
oppossum
(Monodelphis domestica)
Mammalia VGF 33
  • 63 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os.46762 32
Species where no ortholog for VGF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VGF Gene

ENSEMBL:
Gene Tree for VGF (if available)
TreeFam:
Gene Tree for VGF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for VGF: view image

Paralogs for VGF Gene

No data available for Paralogs for VGF Gene

Variants for VGF Gene

Sequence variations from dbSNP and Humsavar for VGF Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1001211664 -- 101,166,014(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001503187 -- 101,163,518(-) C/G coding_sequence_variant, missense_variant
rs1001673007 -- 101,169,861(-) T/C genic_upstream_transcript_variant, intron_variant
rs1002013828 -- 101,171,210(-) G/T upstream_transcript_variant
rs1002182315 -- 101,164,973(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for VGF Gene

Variant ID Type Subtype PubMed ID
dgv11534n54 CNV loss 21841781
esv2422376 CNV duplication 17116639
esv2734888 CNV deletion 23290073
esv2752134 CNV gain 17911159
nsv1018841 CNV gain 25217958
nsv1030604 CNV gain 25217958
nsv607972 CNV loss 21841781
nsv607973 CNV loss 21841781
nsv607974 CNV loss 21841781
nsv824241 CNV gain 20364138
nsv831075 CNV loss 17160897

Variation tolerance for VGF Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VGF Gene

Human Gene Mutation Database (HGMD)
VGF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
VGF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VGF Gene

Disorders for VGF Gene

MalaCards: The human disease database

(3) MalaCards diseases for VGF Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pulmonary large cell neuroendocrine carcinoma
  • large cell lung neuroendocrine carcinoma
chronic pain
  • pain - chronic
pheochromocytoma
  • pcc
- elite association - COSMIC cancer census association via MalaCards
Search VGF in MalaCards View complete list of genes associated with diseases

Additional Disease Information for VGF

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with VGF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VGF Gene

Publications for VGF Gene

  1. Cloning, structural organization analysis, and chromosomal assignment of the human gene for the neurosecretory protein VGF. (PMID: 9344675) Canu N … Levi A (Genomics 1997) 2 3 4 23 56
  2. The expression of VGF is reduced in leukocytes of depressed patients and it is restored by effective antidepressant treatment. (PMID: 20164831) Cattaneo A … Gennarelli M (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010) 3 23 56
  3. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. (PMID: 19598235) Chakrabarti B … Baron-Cohen S (Autism research : official journal of the International Society for Autism Research 2009) 3 43 56
  4. Neuroendocrine regulatory peptide-1 and -2: novel bioactive peptides processed from VGF. (PMID: 19194657) Toshinai K … Nakazato M (Cellular and molecular life sciences : CMLS 2009) 4 23 56
  5. Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families. (PMID: 17684500) Wedenoja J … Peltonen L (Molecular psychiatry 2008) 3 23 56

Products for VGF Gene

Sources for VGF Gene