External Ids for VEZT Gene
Previous GeneCards Identifiers for VEZT Gene
This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
GeneCards Summary for VEZT Gene
VEZT (Vezatin, Adherens Junctions Transmembrane Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include myosin binding.
UniProtKB/Swiss-Prot for VEZT Gene
Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site.