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Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. ZNF161 is a C2H2-type zinc finger protein (Koyano-Nakagawa et al., 1994 [PubMed 8035792]). See MIM 603971 for general information on zinc finger proteins.[supplied by OMIM, Sep 2008]
VEZF1 (Vascular Endothelial Zinc Finger 1) is a Protein Coding gene. Diseases associated with VEZF1 include Acute Apical Periodontitis and Arthrogryposis, Distal, Type 4. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is MAZ.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 11504723 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 11504723 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001525 | angiogenesis | IEA | -- |
GO:0001885 | endothelial cell development | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | TAS,IBA | 21873635 |
GO:0006366 | transcription by RNA polymerase II | TAS | 8035792 |
GO:0006968 | cellular defense response | TAS | 8035792 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | VEZF1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | VEZF1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Vezf1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Vezf1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | VEZF1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | VEZF1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | VEZF1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | VEZF1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | VEZF1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | vezf1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.29971 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | vezf1b 30 31 |
|
OneToMany | |
vezf1a 31 |
|
OneToMany | |||
VEZF1 (3 of 3) 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
728195 | Likely Benign: not provided | 57,979,243(-) | T/C | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
acute apical periodontitis |
|
|
arthrogryposis, distal, type 4 |
|
|
spherocytosis, type 4 |
|
|
hypertensive retinopathy |
|
|
arthrogryposis, distal, type 3 |
|
|