Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. ZNF161 is a C2H2-type zinc finger protein (Koyano-Nakagawa et al., 1994 [PubMed 8035792]). See MIM 603971 for general information on zinc finger proteins.[supplied by OMIM, Sep 2008] See more...

Aliases for VEZF1 Gene

Aliases for VEZF1 Gene

  • Vascular Endothelial Zinc Finger 1 2 3 4 5
  • Zinc Finger Protein 161 2 3 4
  • Putative Transcription Factor DB1 3 4
  • ZNF161 3 4
  • DB1 3 4

External Ids for VEZF1 Gene

Previous HGNC Symbols for VEZF1 Gene

  • ZNF161

Previous GeneCards Identifiers for VEZF1 Gene

  • GC17M053403
  • GC17M056048
  • GC17M051410

Summaries for VEZF1 Gene

Entrez Gene Summary for VEZF1 Gene

  • Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. ZNF161 is a C2H2-type zinc finger protein (Koyano-Nakagawa et al., 1994 [PubMed 8035792]). See MIM 603971 for general information on zinc finger proteins.[supplied by OMIM, Sep 2008]

GeneCards Summary for VEZF1 Gene

VEZF1 (Vascular Endothelial Zinc Finger 1) is a Protein Coding gene. Diseases associated with VEZF1 include Acute Apical Periodontitis and Spherocytosis, Type 4. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is MAZ.

UniProtKB/Swiss-Prot Summary for VEZF1 Gene

  • Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3.

Additional gene information for VEZF1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VEZF1 Gene

Genomics for VEZF1 Gene

GeneHancer (GH) Regulatory Elements for VEZF1 Gene

Promoters and enhancers for VEZF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VEZF1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VEZF1

Top Transcription factor binding sites by QIAGEN in the VEZF1 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • AREB6
  • Evi-1
  • Ik-1
  • MRF-2
  • NRSF form 1
  • POU2F1

Genomic Locations for VEZF1 Gene

Genomic Locations for VEZF1 Gene
chr17:57,971,547-57,988,259
(GRCh38/hg38)
Size:
16,713 bases
Orientation:
Minus strand
chr17:56,048,910-56,065,620
(GRCh37/hg19)
Size:
16,711 bases
Orientation:
Minus strand

Genomic View for VEZF1 Gene

Genes around VEZF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VEZF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VEZF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VEZF1 Gene

Proteins for VEZF1 Gene

  • Protein details for VEZF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14119-VEZF1_HUMAN
    Recommended name:
    Vascular endothelial zinc finger 1
    Protein Accession:
    Q14119

    Protein attributes for VEZF1 Gene

    Size:
    521 amino acids
    Molecular mass:
    56931 Da
    Quaternary structure:
    • Interacts with ARHGAP22.

neXtProt entry for VEZF1 Gene

Post-translational modifications for VEZF1 Gene

  • Ubiquitination at Lys362
  • Modification sites at PhosphoSitePlus

Other Protein References for VEZF1 Gene

No data available for DME Specific Peptides for VEZF1 Gene

Domains & Families for VEZF1 Gene

Gene Families for VEZF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for VEZF1 Gene

Blocks:
  • C2H2-type zinc finger signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VEZF1 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 161 (VEZF1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14119

UniProtKB/Swiss-Prot:

VEZF1_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with VEZF1: view

Function for VEZF1 Gene

Molecular function for VEZF1 Gene

UniProtKB/Swiss-Prot Function:
Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3.

Phenotypes From GWAS Catalog for VEZF1 Gene

Gene Ontology (GO) - Molecular Function for VEZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 11504723
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 11504723
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with VEZF1: view
genes like me logo Genes that share phenotypes with VEZF1: view

Animal Models for VEZF1 Gene

MGI Knock Outs for VEZF1:

Animal Model Products

Clone Products

  • Addgene plasmids for VEZF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VEZF1 Gene

Localization for VEZF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VEZF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VEZF1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for VEZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with VEZF1: view

Pathways & Interactions for VEZF1 Gene

PathCards logo

SuperPathways for VEZF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VEZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001885 endothelial cell development IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 8035792
GO:0006366 transcription by RNA polymerase II TAS 8035792
GO:0006968 cellular defense response TAS 8035792
genes like me logo Genes that share ontologies with VEZF1: view

No data available for Pathways by source and SIGNOR curated interactions for VEZF1 Gene

Drugs & Compounds for VEZF1 Gene

No Compound Related Data Available

Transcripts for VEZF1 Gene

mRNA/cDNA for VEZF1 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for VEZF1

Alternative Splicing Database (ASD) splice patterns (SP) for VEZF1 Gene

No ASD Table

Relevant External Links for VEZF1 Gene

GeneLoc Exon Structure for
VEZF1

Expression for VEZF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VEZF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VEZF1 Gene

This gene is overexpressed in Ovary (13.6), Peripheral blood mononuclear cells (13.6), Rectum (7.3), and Retina (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for VEZF1 Gene



Protein tissue co-expression partners for VEZF1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VEZF1

SOURCE GeneReport for Unigene cluster for VEZF1 Gene:

Hs.463569

mRNA Expression by UniProt/SwissProt for VEZF1 Gene:

Q14119-VEZF1_HUMAN
Tissue specificity: Ubiquitously expressed. Highest levels in skeletal muscle and kidney.

Evidence on tissue expression from TISSUES for VEZF1 Gene

  • Heart(2.7)
  • Nervous system(2.7)
  • Muscle(2.1)
  • Intestine(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with VEZF1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for VEZF1 Gene

Orthologs for VEZF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VEZF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VEZF1 31 30
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia VEZF1 31 30
  • 95.71 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Vezf1 17 31 30
  • 94.59 (n)
rat
(Rattus norvegicus)
Mammalia Vezf1 30
  • 93.52 (n)
oppossum
(Monodelphis domestica)
Mammalia VEZF1 31
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VEZF1 31 30
  • 92.91 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VEZF1 31
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves VEZF1 31 30
  • 86.56 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VEZF1 31
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vezf1 30
  • 73.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29971 30
zebrafish
(Danio rerio)
Actinopterygii vezf1b 31 30
  • 67.81 (n)
OneToMany
vezf1a 31
  • 59 (a)
OneToMany
VEZF1 (3 of 3) 31
  • 34 (a)
OneToMany
Species where no ortholog for VEZF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VEZF1 Gene

ENSEMBL:
Gene Tree for VEZF1 (if available)
TreeFam:
Gene Tree for VEZF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for VEZF1: view image

Paralogs for VEZF1 Gene

Pseudogenes.org Pseudogenes for VEZF1 Gene

genes like me logo Genes that share paralogs with VEZF1: view

Variants for VEZF1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VEZF1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
728195 Likely Benign: not provided 57,979,243(-) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for VEZF1 Gene

Structural Variations from Database of Genomic Variants (DGV) for VEZF1 Gene

Variant ID Type Subtype PubMed ID
nsv833497 CNV loss 17160897
nsv960125 CNV duplication 23825009
nsv978441 CNV duplication 23825009

Variation tolerance for VEZF1 Gene

Residual Variation Intolerance Score: 8.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VEZF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VEZF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VEZF1 Gene

Disorders for VEZF1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for VEZF1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acute apical periodontitis
  • acute apical periodontitis of pulpal origin
spherocytosis, type 4
  • sph4
hereditary spherocytosis
  • spherocytosis, type 1
- elite association - COSMIC cancer census association via MalaCards
Search VEZF1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for VEZF1

genes like me logo Genes that share disorders with VEZF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VEZF1 Gene

Publications for VEZF1 Gene

  1. Molecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoter. (PMID: 8035792) Koyano-Nakagawa N … Yokota T (Molecular and cellular biology 1994) 2 3 4 23 54
  2. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54
  3. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3 54
  4. Inhibition of microRNA-495 Enhances Therapeutic Angiogenesis of Human Induced Pluripotent Stem Cells. (PMID: 27538588) Liang J … Wang Y (Stem cells (Dayton, Ohio) 2017) 3 54
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 54

Products for VEZF1 Gene

Sources for VEZF1 Gene