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Aliases for VEPH1 Gene

Aliases for VEPH1 Gene

  • Ventricular Zone Expressed PH Domain Containing 1 2 3 5
  • Protein Melted 3 4
  • VEPH 3 4
  • Ventricular Zone-Expressed PH Domain-Containing Protein Homolog 1 3
  • Ventricular Zone Expressed PH Domain Homolog 1 (Zebrafish) 2
  • Ventricular Zone Expressed PH Domain Homolog 1 3
  • KIAA1692 4
  • MELT 3

External Ids for VEPH1 Gene

Previous GeneCards Identifiers for VEPH1 Gene

  • GC03M158461
  • GC03M156977
  • GC03M154373

Summaries for VEPH1 Gene

GeneCards Summary for VEPH1 Gene

VEPH1 (Ventricular Zone Expressed PH Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.

UniProtKB/Swiss-Prot for VEPH1 Gene

  • Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling.

Additional gene information for VEPH1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VEPH1 Gene

Genomics for VEPH1 Gene

GeneHancer (GH) Regulatory Elements for VEPH1 Gene

Promoters and enhancers for VEPH1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I157498 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.3 +33.9 33892 1.5 PKNOX1 NEUROD1 SIN3A BRCA1 ZNF335 GLIS2 ZNF366 RCOR1 DEK CEBPB VEPH1 CCNL1 PTX3
GH03I157530 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 569.7 +1.3 1339 4.3 ARNT NFRKB RAD21 ZBTB40 ZNF766 ARID2 ZNF143 FOS ZNF654 ZNF280D VEPH1 PQLC2L PTX3
GH03I157534 Enhancer 1 ENCODE dbSUPER 550.8 -1.2 -1231 0.4 HDAC1 CTCF ARNT TEAD4 TAL1 JUN FOSL1 TCF12 CTBP1 ZNF766 VEPH1 PQLC2L
GH03I157502 Promoter/Enhancer 0.9 EPDnew ENCODE 567.2 +29.8 29760 1.8 JUND GATA3 PKNOX1 VEPH1 PQLC2L PTX3
GH03I157496 Promoter 0.5 EPDnew 561.3 +36.9 36921 0.1 VEPH1 PQLC2L PTX3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VEPH1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VEPH1 gene promoter:

Genomic Locations for VEPH1 Gene

Genomic Locations for VEPH1 Gene
273,878 bases
Minus strand

Genomic View for VEPH1 Gene

Genes around VEPH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VEPH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VEPH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VEPH1 Gene

Proteins for VEPH1 Gene

  • Protein details for VEPH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ventricular zone-expressed PH domain-containing protein homolog 1
    Protein Accession:
    Secondary Accessions:
    • D3DNL0
    • F5GZ91
    • Q2TAA9
    • Q3MIX2
    • Q6PEL3
    • Q86TL5
    • Q8TCR3
    • Q96SP7
    • Q9C0H1
    • Q9H9Q7

    Protein attributes for VEPH1 Gene

    833 amino acids
    Molecular mass:
    94745 Da
    Quaternary structure:
    • Interacts with TGFBR1.
    • Sequence=BAB14165.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB21783.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for VEPH1 Gene


neXtProt entry for VEPH1 Gene

Post-translational modifications for VEPH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VEPH1 Gene

Domains & Families for VEPH1 Gene

Gene Families for VEPH1 Gene

Protein Domains for VEPH1 Gene

Suggested Antigen Peptide Sequences for VEPH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The PH domain is required for membrane targeting.
  • Belongs to the MELT/VEPH family.
  • The PH domain is required for membrane targeting.
  • Belongs to the MELT/VEPH family.
genes like me logo Genes that share domains with VEPH1: view

Function for VEPH1 Gene

Molecular function for VEPH1 Gene

UniProtKB/Swiss-Prot Function:
Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling.

Phenotypes From GWAS Catalog for VEPH1 Gene

genes like me logo Genes that share phenotypes with VEPH1: view

Animal Models for VEPH1 Gene

MGI Knock Outs for VEPH1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VEPH1 Gene

Localization for VEPH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VEPH1 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VEPH1 gene
Compartment Confidence
plasma membrane 3
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VEPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with VEPH1: view

Pathways & Interactions for VEPH1 Gene

SuperPathways for VEPH1 Gene

No Data Available

Interacting Proteins for VEPH1 Gene

Selected Interacting proteins: Q14D04-MELT_HUMAN for VEPH1 Gene via IID

SIGNOR curated interactions for VEPH1 Gene


Gene Ontology (GO) - Biological Process for VEPH1 Gene


No data available for Pathways by source for VEPH1 Gene

Drugs & Compounds for VEPH1 Gene

No Compound Related Data Available

Transcripts for VEPH1 Gene

Unigene Clusters for VEPH1 Gene

Ventricular zone expressed PH domain-containing 1:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VEPH1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP7: -

Relevant External Links for VEPH1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VEPH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VEPH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VEPH1 Gene

This gene is overexpressed in Adrenal Gland (x10.5), Pituitary (x10.3), Lung (x8.0), and Kidney - Cortex (x4.5).

Protein differential expression in normal tissues from HIPED for VEPH1 Gene

This gene is overexpressed in Cervix (58.6) and Heart (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VEPH1 Gene

Protein tissue co-expression partners for VEPH1 Gene

NURSA nuclear receptor signaling pathways regulating expression of VEPH1 Gene:


SOURCE GeneReport for Unigene cluster for VEPH1 Gene:


Evidence on tissue expression from TISSUES for VEPH1 Gene

  • Kidney(4.3)
  • Skin(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with VEPH1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VEPH1 Gene

Orthologs for VEPH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for VEPH1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VEPH1 33 34
  • 99.56 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 92 (a)
-- 34
  • 86 (a)
-- 34
  • 71 (a)
-- 34
  • 66 (a)
-- 34
  • 59 (a)
(Bos Taurus)
Mammalia VEPH1 33 34
  • 90.28 (n)
(Canis familiaris)
Mammalia VEPH1 33 34
  • 87.43 (n)
(Mus musculus)
Mammalia Veph1 33 16 34
  • 85.15 (n)
(Rattus norvegicus)
Mammalia Veph1 33
  • 84.25 (n)
(Monodelphis domestica)
Mammalia VEPH1 34
  • 76 (a)
(Gallus gallus)
Aves VEPH1 33 34
  • 73.56 (n)
(Anolis carolinensis)
Reptilia VEPH1 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia veph1 33
  • 66.99 (n)
(Danio rerio)
Actinopterygii veph 33 34
  • 62.63 (n)
fruit fly
(Drosophila melanogaster)
Insecta melt 34 33
  • 48.29 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007472 33
  • 48.1 (n)
(Caenorhabditis elegans)
Secernentea K10B4.3 33 34
  • 45.33 (n)
Species where no ortholog for VEPH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VEPH1 Gene

Gene Tree for VEPH1 (if available)
Gene Tree for VEPH1 (if available)

Paralogs for VEPH1 Gene

No data available for Paralogs for VEPH1 Gene

Variants for VEPH1 Gene

Sequence variations from dbSNP and Humsavar for VEPH1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs386352354 uncertain-significance, not provided 157,437,041(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000029998 -- 157,503,339(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000031187 -- 157,391,192(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000036006 -- 157,372,253(-) C/G genic_downstream_transcript_variant, intron_variant
rs1000038135 -- 157,325,551(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for VEPH1 Gene

Variant ID Type Subtype PubMed ID
esv2582112 CNV deletion 19546169
esv275099 CNV gain+loss 21479260
esv2759193 CNV gain 17122850
esv32988 CNV loss 17666407
esv3306702 CNV mobile element insertion 20981092
esv3309768 CNV mobile element insertion 20981092
esv3324631 CNV insertion 20981092
esv3360628 CNV insertion 20981092
esv3431834 CNV insertion 20981092
nsv236425 CNV insertion 16902084
nsv829766 CNV gain 17160897

Variation tolerance for VEPH1 Gene

Residual Variation Intolerance Score: 92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.74; 93.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VEPH1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VEPH1 Gene

Disorders for VEPH1 Gene

Additional Disease Information for VEPH1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for VEPH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VEPH1 Gene

Publications for VEPH1 Gene

  1. Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates. (PMID: 15388229) Muto E … Watanabe S (Biochimie 2004) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  3. Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling. (PMID: 26039994) Shathasivam P … Brown TJ (Proceedings of the National Academy of Sciences of the United States of America 2015) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for VEPH1 Gene

Sources for VEPH1 Gene

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