Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This pr... See more...
Aliases for VEGFD Gene
Aliases for VEGFD Gene
External Ids for VEGFD Gene
- HGNC: 3708
- NCBI Entrez Gene: 2277
- Ensembl: ENSG00000165197
- OMIM®: 300091
- UniProtKB/Swiss-Prot: O43915
Previous HGNC Symbols for VEGFD Gene
- FIGF
Summaries for VEGFD Gene
-
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]
GeneCards Summary for VEGFD Gene
VEGFD (Vascular Endothelial Growth Factor D) is a Protein Coding gene. Diseases associated with VEGFD include Anal Canal Squamous Cell Carcinoma and Kidney Angiomyolipoma. Among its related pathways are HIF1Alpha Pathway and Nanog in Mammalian ESC Pluripotency. An important paralog of this gene is VEGFC.
UniProtKB/Swiss-Prot Summary for VEGFD Gene
-
Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Additional gene information for VEGFD Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VEGFD Gene
Genomics for VEGFD Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for VEGFD Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around VEGFD on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VEGFD
Genomic Locations for VEGFD Gene
Latest Assembly
- chrX:15,345,596-15,384,413
- (GRCh38/hg38)
- Size:
- 38,818 bases
- Orientation:
- Minus strand
Previous Assembly
- chrX:15,363,718-15,402,535
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 38,818 bases
- Orientation:
- Minus strand
Genomic View for VEGFD Gene
Genes around VEGFD on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.2 by HGNC
- Xp22.2 by Entrez Gene
- Xp22.2 by Ensembl
VEGFD Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VEGFD Gene
Proteins for VEGFD Gene
-
Protein details for VEGFD Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43915-VEGFD_HUMAN
- Recommended name:
- Vascular endothelial growth factor D
- Protein Accession:
- O43915
- B2R7Z3
Protein attributes for VEGFD Gene
- Size:
- 354 amino acids
- Molecular mass:
- 40444 Da
- Quaternary structure:
-
- Homodimer; non-covalent and antiparallel.
Post-translational modifications for VEGFD Gene
- Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
-
Glycosylation at Asn155, Asn185, and Asn287
- NX_O43915 (NX_O43915-1)
- Modification sites at PhosphoSitePlus
Other Protein References for VEGFD Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences VEGFD Antibody
- G Biosciences Immunotag™ VEGFD Antibody and Immunotag™ FIGF Antibody
- GeneTex Anti-VEGFD antibody [N3C3] and Anti-VEGFD antibody
- NSJ Bioreagents VEGFD Antibody
- Novus Biologicals Antibodies for VEGFD
-
Abcam antibodies for VEGFD
- Invitrogen Antibodies for VEGFD (AFLGC-VEGFD)
-
Custom Antibody ServicesProSci Antibodies for VEGFD
- Sino Biological Antibodies for VEGFD
Protein products for research
-
OriGene Purified Proteins for VEGFD
- Search Origene for MassSpec and Protein Over-expression Lysates for VEGFD
- Origene Custom Protein Services for VEGFD
- Sino Biological Cell Lysates for VEGFD
- Sino Biological Recombinant Proteins for VEGFD
- ProSpec Recombinant Proteins for VEGFD
-
Abcam proteins for VEGFD
Assay products for research
- RayBiotech Human VEGF-D ELISA
- Novus Biologicals ELISA Kits for VEGFD
- antibodies-online: Show 68 available FIGF Elisa Kits ranked by validation data
- Compare Top FIGF Elisa Kits
-
Quality Products:
- ABIN1117761
- ABIN365313
- ABIN414936
- ABIN5676240
- ABIN1030137
- ABIN625370
- ABIN1380058
- ABIN3198494
- ABIN5523677
- ABIN2684279
- ABIN1117758
- ABIN365460
- ABIN1030138
- ABIN5523678
- ABIN5670119
- ABIN415599
- ABIN773947
- ABIN5659878
- ABIN4973738
- ABIN2540314
- ABIN1117757
- ABIN365595
- ABIN1573054
- ABIN5523679
- ABIN5670795
- ABIN5593992
- ABIN772614
- ABIN6254623
- ABIN4973737
- ABIN2952368
- ABIN2851619
- ABIN996755
- ABIN4973739
No data available for DME Specific Peptides for VEGFD Gene
Domains & Families for VEGFD Gene
Gene Families for VEGFD Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for VEGFD Gene
- InterPro:
- Blocks:
-
- Platelet-derived growth factor (PDGF)
- CXCXC repeat
Suggested Antigen Peptide Sequences for VEGFD Gene
- GenScript: Design optimal peptide antigens:
-
- c-Fos-induced growth factor (VEGFD_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O43915- Family:
-
- Belongs to the PDGF/VEGF growth factor family.
Function for VEGFD Gene
Molecular function for VEGFD Gene
- UniProtKB/Swiss-Prot Function:
- Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Phenotypes From GWAS Catalog for VEGFD Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005161 | platelet-derived growth factor receptor binding | TAS | 9479493 |
| GO:0005172 | vascular endothelial growth factor receptor binding | IPI | 9435229 |
| GO:0005515 | protein binding | IPI | 27107012 |
| GO:0008083 | growth factor activity | IBA | 21873635 |
| GO:0042056 | chemoattractant activity | IDA | 19275959 |
Phenotypes for VEGFD Gene
- MGI mutant phenotypes for VEGFD:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for VEGFD:
-
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, decreased FA abundance, increased cell elongation
Animal Models for research
-
Taconic Biosciences Mouse Models for VEGFD
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for VEGFD - Starting at $85 >
- * VEGFD CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for VEGFD
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VEGFD
miRNA for VEGFD Gene
- miRTarBase miRNAs that target VEGFD
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VEGFD
- Browse OriGene Inhibitory RNA Products For VEGFD
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VEGFD
Clone products for research
- Applied Biological Materials (abm): Clones for VEGFD - Starting at $45 >
- * VEGFD as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for VEGFD
- Addgene plasmids for VEGFD
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VEGFD
Cell Lines for research
-
Horizon Cell Lines for VEGFD
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VEGFD Gene
Localization for VEGFD Gene
Subcellular locations from UniProtKB/Swiss-Prot for VEGFD Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA,IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0031093 | platelet alpha granule lumen | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for VEGFD Gene
Pathways & Interactions for VEGFD Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
| 3 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.40
|
| 4 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 5 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.61
Nanog in Mammalian ESC Pluripotency
.61
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
Pathways by source for VEGFD Gene
2 BioSystems pathways for VEGFD Gene
8 Reactome pathways for VEGFD Gene
10 KEGG pathways for VEGFD Gene
1 GeneGo (Thomson Reuters) pathway for VEGFD Gene
- Development VEGF-family signaling
62 Qiagen pathways for VEGFD Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
Interacting Proteins for VEGFD Gene
Selected Interacting proteins:
O43915-VEGFD_HUMAN
ENSP00000297904
for VEGFD Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for VEGFD
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001666 | response to hypoxia | IBA | 21873635 |
| GO:0001934 | positive regulation of protein phosphorylation | IBA | 21873635 |
| GO:0001938 | positive regulation of endothelial cell proliferation | IBA | 21873635 |
| GO:0002040 | sprouting angiogenesis | IBA | 21873635 |
Transcripts for VEGFD Gene
mRNA/cDNA for VEGFD Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000297904 2069 nts (view in UCSC)
- ENST00000488351 600 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for VEGFD - Starting at $85 >
- * VEGFD CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for VEGFD
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VEGFD
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VEGFD
- Browse OriGene Inhibitory RNA Products For VEGFD
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VEGFD
Clone products for research
- Applied Biological Materials (abm): Clones for VEGFD - Starting at $45 >
- * VEGFD as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for VEGFD
- Addgene plasmids for VEGFD
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VEGFD
Relevant External Links for VEGFD Gene
- GeneLoc Exon Structure for
- VEGFD
Expression for VEGFD Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
- Limb Bud Mesenchyme Cells Limb Bud
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
-
Testis (Reproductive System)
- Testicular Interstitial Cells Testis Interstitium
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VEGFD
mRNA Expression by UniProt/SwissProt for VEGFD Gene:
O43915-VEGFD_HUMAN
Tissue specificity:
Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.
Evidence on tissue expression from TISSUES for VEGFD Gene
- Lung(4.5)
- Heart(3.1)
- Nervous system(2.8)
- Muscle(2.7)
- Lymph node(2.4)
- Blood(2.3)
- Intestine(2.2)
- Bone marrow(2.2)
- Kidney(2.1)
- Stomach(2.1)
- Eye(2)
Primer products for research
-
OriGene qPCR primer pairs for VEGFD
-
OriGene qPCR primer pairs and template standards for VEGFD
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VEGFD Gene
Orthologs for VEGFD Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FIGF 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FIGF 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FIGF 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Figf 29 30 |
|
OneToOne | |
| Vegfd 16 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | Figf 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FIGF 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FIGF 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FIGF 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FIGF 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | figf 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | figf 29 30 |
|
OneToOne |
- Species where no ortholog for VEGFD was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for VEGFD Gene
- ENSEMBL:
- Gene Tree for VEGFD (if available)
- TreeFam:
- Gene Tree for VEGFD (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for VEGFD: view image
- Alliance of Genome Resources:
- Additional Orthologs for VEGFD
Paralogs for VEGFD Gene
Variants for VEGFD Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VEGFD Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs149425095 | Benign: not provided | 15,355,260(-) |
T/C NM_004469.5(VEGFD):c.531A>G (p.Glu177=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
| rs745810706 | Likely Benign: not provided | 15,358,015(-) |
G/A NM_004469.5(VEGFD):c.480C>T (p.Tyr160=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.35;
41.83% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VEGFD Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VEGFD Gene
Disorders for VEGFD Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| anal canal squamous cell carcinoma |
|
|
| kidney angiomyolipoma |
|
|
| primary lymphedema |
|
|
| breast ductal carcinoma |
|
|
| lymphangioleiomyomatosis |
|
|
Search VEGFD in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for VEGFD
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for VEGFD Gene
Publications for VEGFD Gene
- Human FIGF: cloning, gene structure, and mapping to chromosome Xp22.1 between the PIGA and the GRPR genes. (PMID: 9479493) Rocchigiani M … Oliviero S (Genomics 1998) 2 3 4 22
- Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers. (PMID: 10542248) Stacker SA … Achen MG (The Journal of biological chemistry 1999) 3 4 22
- Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). (PMID: 9435229) Achen MG … Stacker SA (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 22
- Molecular cloning of a novel vascular endothelial growth factor, VEGF-D. (PMID: 9205122) Yamada Y … Hirata Y (Genomics 1997) 3 4 22
- [Expressions of VEGF-C and VEGF-D and their correlation with lymphangiogenesis and angiogenesis in gallbladder carcinoma]. (PMID: 20450586) Jiang L … Wang XX (Zhonghua zhong liu za zhi [Chinese journal of oncology] 2010) 3 22
ExternalLinks
Products for VEGFD Gene
- View all 13 R&D Systems VEGFD (VEGF-D) Products
- View all R&D Systems VEGFD (VEGF-D) Proteins and Enzymes
- View all 9 R&D Systems VEGFD (VEGF-D) Primary Antibodies
- View all 2 R&D Systems VEGFD (VEGF-D) ELISAs
- View all R&D Systems VEGFD (VEGF-D) Luminex Assays
- Learn more about R&D Systems custom VEGFD antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for VEGFD
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for VEGFD
- Search Origene for MassSpec and Protein Over-expression Lysates for VEGFD
- Origene Custom Protein Services for VEGFD
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VEGFD
- Browse OriGene Inhibitory RNA Products For VEGFD
- OriGene qPCR primer pairs for VEGFD
- OriGene qPCR primer pairs and template standards for VEGFD
- OriGene CRISPR knockouts for VEGFD
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For VEGFD
- Sino Biological Human cDNA Clone for VEGFD
- Sino Biological Cell Lysates for VEGFD
- Sino Biological Recombinant Proteins for VEGFD
- Sino Biological Antibodies for VEGFD
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for VEGFD
- Novus Biologicals proteins and lysates for VEGFD
- Novus Biologicals ELISA Kits for VEGFD
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for VEGFD
- Abcam proteins for VEGFD
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for VEGFD
- Taconic Biosciences Mouse Models for VEGFD
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for VEGFD (AFLGC-VEGFD)
- VectorBuilder Custom and pre-made DNA vectors for VEGFD (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for VEGFD (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for VEGFD (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for VEGFD CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for VEGFD
- Addgene plasmids for VEGFD
- antibodies-online: Show 57 available FIGF Antibodies ranked by validation data
- Compare Top FIGF Antibodies
- antibodies-online: Show 68 available FIGF Elisa Kits ranked by validation data
- Compare Top FIGF Elisa Kits
- Quality Products:
- ABIN1117761
- ABIN365313
- ABIN414936
- ABIN5676240
- ABIN1030137
- ABIN625370
- ABIN1380058
- ABIN3198494
- ABIN5523677
- ABIN2684279
- ABIN1117758
- ABIN365460
- ABIN1030138
- ABIN5523678
- ABIN5670119
- ABIN415599
- ABIN773947
- ABIN5659878
- ABIN4973738
- ABIN2540314
- ABIN1117757
- ABIN365595
- ABIN1573054
- ABIN5523679
- ABIN5670795
- ABIN5593992
- ABIN772614
- ABIN6254623
- ABIN4973737
- ABIN2952368
- ABIN2851619
- ABIN996755
- ABIN4973739
- antibodies-online: Show 33 available FIGF Proteins ranked by validation data
- Compare Top FIGF Proteins
- Custom Antibody ServicesProSci Antibodies for VEGFD
- Horizon Cell Lines for VEGFD
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VEGFD
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VEGFD
- Search GeneCopoeia for miRNA 3'UTR Target clone products for VEGFD
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VEGFD
Sources for VEGFD Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources