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The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]
VEGFD (Vascular Endothelial Growth Factor D) is a Protein Coding gene. Diseases associated with VEGFD include Anal Canal Squamous Cell Carcinoma and Kidney Angiomyolipoma. Among its related pathways are HIF1Alpha Pathway and Signaling by GPCR. An important paralog of this gene is VEGFC.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005161 | platelet-derived growth factor receptor binding | TAS | 9479493 |
GO:0005172 | vascular endothelial growth factor receptor binding | IPI | 9435229 |
GO:0005515 | protein binding | IPI | 27107012 |
GO:0008083 | growth factor activity | IBA | 21873635 |
GO:0042056 | chemoattractant activity | IDA | 19275959 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IEA,IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0031093 | platelet alpha granule lumen | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
3 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
4 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
5 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.62
Nanog in Mammalian ESC Pluripotency
.62
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001525 | angiogenesis | IBA | 21873635 |
GO:0001666 | response to hypoxia | IBA | 21873635 |
GO:0001934 | positive regulation of protein phosphorylation | IBA | 21873635 |
GO:0001938 | positive regulation of endothelial cell proliferation | IBA | 21873635 |
GO:0002040 | sprouting angiogenesis | IBA | 21873635 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FIGF 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FIGF 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FIGF 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Figf 30 31 |
|
OneToOne | |
Vegfd 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Figf 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | FIGF 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FIGF 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FIGF 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FIGF 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | figf 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | figf 30 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
anal canal squamous cell carcinoma |
|
|
kidney angiomyolipoma |
|
|
primary lymphedema |
|
|
breast ductal carcinoma |
|
|
lymphangioleiomyomatosis |
|
|