Aliases for VEGFB Gene
External Ids for VEGFB Gene
Previous HGNC Symbols for VEGFB Gene
Previous GeneCards Identifiers for VEGFB Gene
This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]
GeneCards Summary for VEGFB Gene
VEGFB (Vascular Endothelial Growth Factor B) is a Protein Coding gene. Diseases associated with VEGFB include Macular Degeneration, Age-Related, 1 and Macular Retinal Edema. Among its related pathways are HIF1Alpha Pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is VEGFA.
UniProtKB/Swiss-Prot Summary for VEGFB Gene
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.