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This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel fo... See more...
Aliases for VEGFA Gene
Aliases for VEGFA Gene
External Ids for VEGFA Gene
- HGNC: 12680
- Entrez Gene: 7422
- Ensembl: ENSG00000112715
- OMIM: 192240
- UniProtKB: P15692
Previous HGNC Symbols for VEGFA Gene
- VEGF
Previous GeneCards Identifiers for VEGFA Gene
- GC06P043846
- GC06P043737
- GC06P043458
Summaries for VEGFA Gene
-
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. The VEGF levels are increased in SARS-CoV-2 infection, thus promoting inflammation by increasing the level of angiopoietin II (Ang II), one of the two products of the SARS-CoV-2-attacking target, angiotensin-converting enzyme 2 (ACE2). In turn, Ang II facilitates the elevation of VEGF, forming a vicious cycle in the release of inflammatory cytokines. [provided by RefSeq, Jun 2020]
GeneCards Summary for VEGFA Gene
VEGFA (Vascular Endothelial Growth Factor A) is a Protein Coding gene. Diseases associated with VEGFA include Microvascular Complications Of Diabetes 1 and Poems Syndrome. Among its related pathways are HIF1Alpha Pathway and Cell adhesion_Plasmin signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is PGF.
UniProtKB/Swiss-Prot Summary for VEGFA Gene
-
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
Additional gene information for VEGFA Gene
- HGNC(12680)
- Entrez Gene(7422)
- Ensembl(ENSG00000112715)
- OMIM(192240)
- UniProtKB(P15692)
- Open Targets Platform(ENSG00000112715)
- Monarch Initiative
- Search for VEGFA at DataMed
- Search for VEGFA at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VEGFA Gene
Genomics for VEGFA Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for VEGFA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around VEGFA on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VEGFA
- Top Transcription factor binding sites by QIAGEN in the VEGFA gene promoter:
-
- PPAR-alpha
- PPAR-gamma1
Genomic Locations for VEGFA Gene
Genomic Locations for VEGFA Gene
- chr6:43,770,184-43,786,487
- (GRCh38/hg38)
- Size:
- 16,304 bases
- Orientation:
- Plus strand
- chr6:43,737,921-43,754,224
- (GRCh37/hg19)
- Size:
- 16,304 bases
- Orientation:
- Plus strand
Genomic View for VEGFA Gene
Genes around VEGFA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.1 by HGNC
- 6p21.1 by Entrez Gene
- 6p21.1 by Ensembl
VEGFA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VEGFA Gene
Proteins for VEGFA Gene
-
Protein details for VEGFA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15692-VEGFA_HUMAN
- Recommended name:
- Vascular endothelial growth factor A
- Protein Accession:
- P15692
- B5BU86
- H0Y2S8
- H0Y407
- H0Y414
- H0Y462
- H0Y8N2
- H3BLW7
- O60720
- O75875
- Q074Z4
- Q16889
- Q5UB46
- Q6P0P5
- Q96KJ0
- Q96L82
- Q96NW5
- Q9H1W8
- Q9H1W9
- Q9UH58
- Q9UL23
Protein attributes for VEGFA Gene
- Size:
- 232 amino acids
- Molecular mass:
- 27042 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity). Interacts with NRP1 (PubMed:26503042).
- SequenceCaution:
-
- Sequence=AAC63102.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC63143.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform L-VEGF165]: Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon. Post-translationally processed to produce the secreted VEGF peptide and a N-terminal peptide N-VEGF. The unprocessed protein and the N-VEGF peptide may localize to the nucleus (PubMed:15896327), the endoplasmic reticulum and the Golgi (PubMed:11731620) or the extracellular matrix (PubMed:11563986).
- [Isoform L-VEGF121]: Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon. Post-translationally processed to produce the secreted VEGF peptide and a N-terminal peptide N-VEGF. The unprocessed protein and the N-VEGF peptide may localize to the nucleus (PubMed:15896327), the endoplasmic reticulum and the Golgi (PubMed:11731620) or the extracellular matrix (PubMed:11563986).
- [Isoform L-VEGF189]: Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon. Post-translationally processed to produce the secreted VEGF peptide and a N-terminal peptide N-VEGF. The unprocessed protein and the N-VEGF peptide may localize to the nucleus (PubMed:15896327), the endoplasmic reticulum and the Golgi (PubMed:11731620) or the extracellular matrix (PubMed:11563986).
- [Isoform L-VEGF206]: Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon.
- [Isoform 15]: Starts at an alternative upstream CUG codon.
- [Isoform 16]: Starts at an alternative upstream CUG codon.
- [Isoform 17]: Starts at an alternative upstream CUG codon.
- [Isoform 18]: Starts at an alternative upstream CUG codon.
Three dimensional structures from OCA and Proteopedia for VEGFA Gene
Protein Expression for VEGFA Gene
Post-translational modifications for VEGFA Gene
Other Protein References for VEGFA Gene
- ENSEMBL proteins:
-
- ENSP00000361137
- ENSP00000500082
- ENSP00000317598
- ENSP00000388663
- ENSP00000389864
- ENSP00000361125
- ENSP00000421561
- ENSP00000388465
- ENSP00000361134
- ENSP00000361148
- ENSP00000430594
- ENSP00000428321
- ENSP00000430479
- ENSP00000429643
- ENSP00000409911
- ENSP00000430829
- ENSP00000429008
- ENSP00000430002
- ENSP00000230480
- ENSP00000429592
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ VEGF Antibody and Immunotag™ VEGFA Antibody
- NSJ Bioreagents VEGFA Antibody
-
Custom Antibody ServicesOriGene Antibodies for VEGFA
- AB0063-200
- AM01371PU-N
- AM20384PU-N
- AM33406BT-N
- AM33406PU-N
- AP01112BT-N
- AP01112BT-S
- AP01112PU-N
- AP01112PU-S
- AP02022SU-N
- AP02022SU-S
- AP23353PU-N
- AP54507PU-N
- CF500042
- CF500288
- CF500289
- CF802346
- CF802347
- CF803263
- CF803421
- DM3519P
- DM3520P
- DM3521P
- DM3615P
- DP3504
- DP3504S
- DP3505
- DP3505S
- DP3520
- DP3520B
- DP3520P
- DP3520S
- PP1073B1
- PP1073B2
- PP1073P1
- PP1073P2
- PP1113B1
- PP1113B2
- PP1113P1
- PP1113P2
- TA301750
- TA302292
- TA303731
- TA311162
- TA324012
- TA324020
- TA324021
- TA328470
- TA328471
- TA328560
- TA328561
- TA328598
- TA328599
- TA332855
- TA336482
- TA336487
- TA347879
- TA354341
- TA500042
- TA500042S
- TA500288
- TA500288S
- TA500289
- TA500289S
- TA802346
- TA802346S
- TA802347
- TA802347S
- TA803263
- TA803263S
- TA803421
- TA803421S
- Novus Biologicals Antibodies for VEGFA
- Invitrogen Antibodies for VEGFA (AFLGC-VEGFA)
-
Custom Antibody ServicesProSci Antibodies for VEGFA
-
Santa Cruz Biotechnology (SCBT) Antibodies for VEGFA
- Sino Biological Antibodies for VEGFA
Protein Products
-
BioLegend
- Recombinant Human VEGF-121 (carrier-free) (583202)
- Recombinant Human VEGF-121 (carrier-free) (583208)
- Recombinant Human VEGF-165 (carrier-free) (583708)
- Recombinant Human VEGF-165 (carrier-free) (583702)
- Recombinant Human VEGF-121 (carrier-free) (583204)
- Recombinant Human VEGF-165 (carrier-free) (583706)
- Recombinant Human VEGF-121 (carrier-free) (583206)
- Recombinant Human VEGF-165 (carrier-free) (583704)
- Recombinant Human VEGF-165 (Animal-Free)
- Recombinant Human VEGF (ELISA Std.)
-
OriGene Purified Proteins for VEGFA
- NM_001033756
- NM_001025366
- NM_001025370
- NM_001025366
- NM_001033756
- NM_001033756
- NM_001025366
- NM_001025370
- NM_001025366
- NM_001033756
- NM_001025366
- NM_001025366
- NM_001025250
- NM_001025250
- NM_001025366
- NM_001025366
- NM_001025250
- NM_001025250
- NM_001025250
- NM_001025250
- NM_001025250
- NM_001025250
- NM_001025250
- NM_001025250
- NM_001025250
- NM_001110333
- NM_001110333
- NM_001110333
- NM_001110333
- NM_001110333
- NM_001110333
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001110333
- NM_001110333
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025366
- NM_001025250
- NM_001025250
- NM_001025250
- NM_001025250
- NM_001110336
- NM_001033756
- NM_001033756
- NM_009505
- NM_009505
- NM_001025370
- NM_003376
- NM_001025366
- NM_001025366
- Search Origene for MassSpec and Protein Over-expression Lysates for VEGFA
- Origene Custom Protein Services for VEGFA
- Sino Biological Cell Lysates for VEGFA
- Sino Biological Recombinant Proteins for VEGFA
- ProSpec Recombinant Proteins for VEGFA
-
ProSci Proteins for VEGFA
- vascular endothelial growth factor A [91-944]
- vascular endothelial growth factor A [40-482]
- vascular endothelial growth factor A [40-491]
- vascular endothelial growth factor A [91-069]
- vascular endothelial growth factor A [40-612]
- vascular endothelial growth factor A [40-613]
- vascular endothelial growth factor A [96-767]
- vascular endothelial growth factor A [96-768]
- vascular endothelial growth factor A [96-771]
- vascular endothelial growth factor A [96-772]
- vascular endothelial growth factor A [96-773]
- vascular endothelial growth factor A [96-775]
- vascular endothelial growth factor A isoform l precursor [96-788]
- vascular endothelial growth factor A [92-494]
- Vascular endothelial growth factor A [96-962]
- vascular endothelial growth factor A [91-584]
- vascular endothelial growth factor A [91-589]
- vascular endothelial growth factor A [40-162]
- vascular endothelial growth factor A [40-163]
Assay Products
- RayBiotech Human VEGF-A ELISA and Human VEGF-A ELISA (For Lysates)
- Novus Biologicals ELISA Kits for VEGFA
- Sino Biological Assays for VEGFA
No data available for DME Specific Peptides for VEGFA Gene
Domains & Families for VEGFA Gene
Gene Families for VEGFA Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Disease related genes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for VEGFA Gene
- InterPro:
- Blocks:
-
- Platelet-derived growth factor (PDGF)
- ProtoNet:
Suggested Antigen Peptide Sequences for VEGFA Gene
- GenScript: Design optimal peptide antigens:
-
- Vascular endothelial growth factor (A2A2V4_HUMAN)
- Vascular endothelial growth factor A splice variant VEGF 117 (Q6WZM0_HUMAN)
- VEGFA protein (Q96FD9_HUMAN)
- Vascular endothelial growth factor (Q9UNS8_HUMAN)
- Vascular permeability factor (VEGFA_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P15692- Family:
-
- Belongs to the PDGF/VEGF growth factor family.
Function for VEGFA Gene
Molecular function for VEGFA Gene
- UniProtKB/Swiss-Prot Function:
- Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By hypoxia. Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoglycemia and oncogenic mutations.
LifeMap Function Summary for VEGFA Gene
During embryonic development, VEGFA as signaling molecule is secreted from the following cells
- Head Mesenchyme
-
Bone
- Hypertrophic Chondrocytes (Zeugopod Growth Plate)
- Hypertrophic Chondrocytes (Rib)
- Hypertrophic Chondrocytes (Autopod Growth Plate)
- Hypertrophic Chondrocytes (Stylopod Growth Plate)
- Hypertrophic Chondrocytes (Vertebrae)
- Prehypertrophic Chondrocytes (Stylopod Growth Plate)
- Prehypertrophic Chondrocytes (Vertebrae)
- Prehypertrophic Chondrocytes (Rib)
- Prehypertrophic Chondrocytes (Zeugopod Growth Plate)
- Terminal Chondrocytes (Endochondral Facial Bones)
- Terminal Chondrocytes (Caudal Facial Endochondral Bones)
- Gut Tube
- Neural Tube
It affects the following cells:
- Neural Tube
- Lateral Plate Mesoderm
- Head Mesenchyme
-
Bone
- Endochondral Preosteoblasts (Vertebrae)
- Endochondral Preosteoblasts (Autopod Perichondrium)
- Endochondral Preosteoblasts (Stylopod Perichondrium)
- Endochondral Preosteoblasts (Rib)
- Endochondral Preosteoblasts (Zeugopod Perichondrium)
- Hypertrophic Chondrocytes (Rib)
- Hypertrophic Chondrocytes (Vertebrae)
- Hypertrophic Chondrocytes (Zeugopod Growth Plate)
- Hypertrophic Chondrocytes (Stylopod Growth Plate)
- Hypertrophic Chondrocytes (Autopod Growth Plate)
- Terminal Chondrocytes (Autopod Growth Plate)
- Terminal Chondrocytes (Vertebrae)
- Terminal Chondrocytes (Rib)
- Terminal Chondrocytes (Zeugopod Growth Plate)
- Terminal Chondrocytes (Stylopod Growth Plate)
- Endothelium
- Pancreas
Phenotypes From GWAS Catalog for VEGFA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001968 | fibronectin binding | IDA | 14570917 |
| GO:0005125 | cytokine activity | ISS | -- |
| GO:0005161 | platelet-derived growth factor receptor binding | IPI | 17470632 |
| GO:0005172 | vascular endothelial growth factor receptor binding | IPI | 10471394 |
| GO:0005515 | protein binding | IPI | 9393862 |
Phenotypes for VEGFA Gene
- MGI mutant phenotypes for VEGFA:
-
inferred from 12 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for VEGFA:
Animal Models for VEGFA Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for VEGFA - Select products 50% OFF >
- * VEGFA CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for VEGFA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VEGFA
-
Santa Cruz Biotechnology (SCBT) CRISPR for VEGFA
miRNA for VEGFA Gene
- miRTarBase miRNAs that target VEGFA
-
- hsa-miR-373-3p (MIRT000721)
- hsa-miR-302d-3p (MIRT000722)
- hsa-miR-126-3p (MIRT003428)
- mmu-miR-150-5p (MIRT003805)
- hsa-miR-147a (MIRT003810)
- hsa-miR-134-5p (MIRT003811)
- hsa-miR-140-5p (MIRT003812)
- hsa-miR-29b-3p (MIRT003813)
- hsa-miR-107 (MIRT003814)
- hsa-miR-16-5p (MIRT003890)
- hsa-miR-93-5p (MIRT004055)
- hsa-miR-17-5p (MIRT004271)
- hsa-miR-150-5p (MIRT004272)
- hsa-miR-195-5p (MIRT004273)
- hsa-miR-15b-5p (MIRT004274)
- hsa-miR-15a-5p (MIRT004275)
- hsa-miR-520g-3p (MIRT004276)
- hsa-miR-378a-3p (MIRT004277)
- hsa-miR-330-3p (MIRT004278)
- mmu-miR-20b-5p (MIRT004421)
- hsa-miR-383-5p (MIRT004443)
- hsa-miR-125a-5p (MIRT004445)
- hsa-miR-361-5p (MIRT004447)
- hsa-miR-20a-5p (MIRT004450)
- hsa-miR-20b-5p (MIRT004451)
- hsa-miR-504-5p (MIRT004457)
- hsa-miR-520h (MIRT004458)
- hsa-miR-372-3p (MIRT004461)
- hsa-miR-106a-5p (MIRT004465)
- hsa-miR-106b-5p (MIRT004466)
- hsa-miR-34a-5p (MIRT004513)
- hsa-miR-205-5p (MIRT004518)
- hsa-miR-34b-3p (MIRT004519)
- mmu-miR-16-5p (MIRT005923)
- hsa-miR-145-5p (MIRT006215)
- hsa-miR-200b-3p (MIRT006440)
- hsa-miR-200c-3p (MIRT006771)
- hsa-miR-503-5p (MIRT007224)
- mmu-miR-340-5p (MIRT010455)
- mmu-miR-93-5p (MIRT011075)
- hsa-miR-335-5p (MIRT016911)
- hsa-miR-29c-3p (MIRT020389)
- hsa-miR-9-5p (MIRT021401)
- hsa-miR-133a-3p (MIRT021711)
- hsa-miR-101-3p (MIRT027248)
- hsa-miR-21-5p (MIRT030717)
- hsa-miR-203a-3p (MIRT053074)
- hsa-miR-29a-3p (MIRT053585)
- mmu-miR-499-5p (MIRT054735)
- hsa-miR-424-5p (MIRT100741)
- hsa-miR-497-5p (MIRT100742)
- hsa-miR-598-5p (MIRT100743)
- hsa-miR-374b-3p (MIRT100744)
- hsa-miR-3163 (MIRT100745)
- hsa-miR-4524a-5p (MIRT100746)
- hsa-miR-451b (MIRT100747)
- hsa-miR-4524b-5p (MIRT100748)
- hsa-miR-6838-5p (MIRT100749)
- hsa-miR-568 (MIRT100755)
- hsa-miR-1277-5p (MIRT100756)
- hsa-miR-423-3p (MIRT122988)
- hsa-miR-141-5p (MIRT169147)
- hsa-miR-299-3p (MIRT169150)
- hsa-miR-297 (MIRT169172)
- hsa-miR-718 (MIRT169184)
- hsa-miR-3924 (MIRT169196)
- hsa-miR-6748-5p (MIRT169215)
- hsa-miR-6756-5p (MIRT169216)
- hsa-miR-6759-5p (MIRT169217)
- hsa-miR-6766-5p (MIRT169218)
- hsa-miR-6769a-5p (MIRT169219)
- hsa-miR-6769b-5p (MIRT169225)
- hsa-miR-95-5p (MIRT317921)
- hsa-miR-1252-3p (MIRT317922)
- hsa-miR-3646 (MIRT317923)
- hsa-miR-5682 (MIRT317924)
- hsa-miR-185-5p (MIRT360955)
- rno-miR-203a-3p (MIRT438062)
- rno-miR-29b-3p (MIRT438064)
- rno-miR-29a-3p (MIRT438065)
- hsa-miR-199a-5p (MIRT438498)
- mmu-miR-20a-5p (MIRT438659)
- mmu-miR-17-5p (MIRT438660)
- mmu-miR-15a-5p (MIRT438760)
- mmu-miR-106a-5p (MIRT438769)
- hsa-miR-6871-3p (MIRT464228)
- hsa-miR-7-2-3p (MIRT464229)
- hsa-miR-7-1-3p (MIRT464230)
- hsa-miR-5688 (MIRT464231)
- hsa-miR-495-3p (MIRT464232)
- hsa-miR-5692a (MIRT464233)
- hsa-miR-646 (MIRT464234)
- hsa-miR-3662 (MIRT464235)
- hsa-miR-374b-5p (MIRT520223)
- hsa-miR-374a-5p (MIRT520224)
- hsa-miR-6793-5p (MIRT520225)
- hsa-miR-567 (MIRT520226)
- hsa-miR-4483 (MIRT520227)
- hsa-miR-1293 (MIRT520228)
- hsa-miR-6745 (MIRT520229)
- hsa-miR-363-5p (MIRT520230)
- hsa-miR-410-3p (MIRT520231)
- hsa-miR-5692c (MIRT520232)
- hsa-miR-5692b (MIRT520233)
- hsa-miR-369-3p (MIRT520234)
- hsa-miR-4789-5p (MIRT552961)
- hsa-miR-3941 (MIRT552962)
- hsa-miR-4719 (MIRT552963)
- hsa-miR-603 (MIRT552964)
- hsa-miR-362-3p (MIRT552965)
- hsa-miR-329-3p (MIRT552966)
- hsa-miR-8485 (MIRT552967)
- hsa-miR-576-5p (MIRT552968)
- hsa-miR-4263 (MIRT552969)
- hsa-miR-4735-5p (MIRT552970)
- mmu-miR-539-3p (MIRT588500)
- mmu-miR-381-3p (MIRT588501)
- mmu-miR-466f-3p (MIRT588502)
- mmu-miR-329-3p (MIRT588503)
- mmu-miR-466i-3p (MIRT588504)
- mmu-miR-362-3p (MIRT588505)
- hsa-miR-670-5p (MIRT651752)
- hsa-miR-6870-3p (MIRT651753)
- hsa-miR-660-3p (MIRT651754)
- hsa-miR-5193 (MIRT651755)
- hsa-miR-5694 (MIRT651756)
- hsa-miR-4497 (MIRT707039)
- hsa-miR-1-3p (MIRT731842)
- hsa-miR-125a-3p (MIRT732343)
- hsa-miR-320a (MIRT732583)
- rno-miR-150-5p (MIRT732627)
- hsa-miR-126-5p (MIRT732702)
- rno-miR-29a-3p (MIRT732732)
- hsa-miR-186-5p (MIRT732809)
- hsa-miR-20a-5p (MIRT732861)
- bta-miR-199a-5p (MIRT733511)
- bta-miR-150 (MIRT733512)
- bta-miR-378 (MIRT733515)
- hsa-miR-205-3p (MIRT733585)
- hsa-miR-1-5p (MIRT733700)
- mmu-miR-146a-5p (MIRT733716)
- mmu-miR-126a-3p (MIRT733890)
- hsa-miR-101-5p (MIRT733964)
- hsa-miR-181a-5p (MIRT734100)
- hsa-miR-942-3p (MIRT734268)
- mmu-miR-29b-3p (MIRT734375)
- hsa-miR-206 (MIRT734599)
- hsa-miR-296-5p (MIRT734906)
- mmu-miR-17-3p (MIRT734990)
- hsa-miR-199a-3p (MIRT735197)
- hsa-miR-16-1-3p (MIRT735400)
- hsa-miR-429 (MIRT735515)
- hsa-miR-3126-5p (MIRT740050)
- hsa-miR-6873-5p (MIRT758089)
- hsa-miR-6875-5p (MIRT758125)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VEGFA
- Browse OriGene Inhibitory RNA Products For VEGFA
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Clone Products
- Applied Biological Materials (abm): Clones for VEGFA - Select products 50% OFF >
- * VEGFA as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
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- SC216842
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for VEGFA
- Addgene plasmids for VEGFA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VEGFA
Cell Line Products
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Horizon Cell Lines for VEGFA
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VEGFA Gene
Localization for VEGFA Gene
Subcellular locations from UniProtKB/Swiss-Prot for VEGFA Gene
- Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a significant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 4 |
| nucleus | 4 |
| cytosol | 4 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| endoplasmic reticulum | 3 |
| endosome | 3 |
| lysosome | 3 |
| peroxisome | 2 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA,ISS | -- |
| GO:0005737 | cytoplasm | IDA | 17082651 |
| GO:0005912 | adherens junction | IDA | 26598555 |
| GO:0009986 | cell surface | IDA | 17470632 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for VEGFA Gene
Pathways & Interactions for VEGFA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 2 | Development VEGF signaling via VEGFR2 - generic cascades |
Development VEGF signaling and activation
.42
Development VEGF signaling via VEGFR2 - generic cascades
.42
|
|
| 3 | VEGF Pathway (Qiagen) |
VEGF Family Ligands and Receptor Interactions
.66
VEGF Pathway
.66
|
Development VEGF-family signaling
.34
|
| 4 | Regulation of activated PAK-2p34 by proteasome mediated degradation | ||
| 5 | RET signaling | ||
Pathways by source for VEGFA Gene
1 Sino Biological pathway for VEGFA Gene
27 BioSystems pathways for VEGFA Gene
26 Reactome pathways for VEGFA Gene
3 PharmGKB pathways for VEGFA Gene
10 GeneGo (Thomson Reuters) pathways for VEGFA Gene
- Cell adhesion_Plasmin signaling
- Cytoskeleton remodeling FAK signaling
- Development VEGF signaling and activation
- Development VEGF signaling via VEGFR2 - generic cascades
- Development VEGF-family signaling
4 R&D Systems pathways for VEGFA Gene
15 Qiagen pathways for VEGFA Gene
- Colorectal Cancer Metastasis
- CRHR Pathway
- eNOS Signaling
- HIF1Alpha Pathway
- ILK Signaling
2 GeneTex pathways for VEGFA Gene
SIGNOR curated interactions for VEGFA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 18093989 |
| GO:0001525 | angiogenesis | IBA,IDA | 11427521 |
| GO:0001541 | ovarian follicle development | ISS | -- |
| GO:0001569 | branching involved in blood vessel morphogenesis | ISS | -- |
| GO:0001570 | vasculogenesis | TAS | 15015550 |
Drugs & Compounds for VEGFA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ranibizumab | Approved | Pharma | Target, inhibitor | 546 | ||
| Bevacizumab | Approved, Investigational | Pharma | Target, antagonist, antibody, inhibitor | VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 2368 | |
| pegaptanib | Approved, Investigational | Pharma | 0 | |||
| Aflibercept | Approved | Pharma | Target, binder, inhibitor | Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
| Minocycline | Approved, Investigational | Pharma | Target, inhibitor | 229 |
(2) ApexBio Compounds for VEGFA Gene
| Compound | Action | Cas Number |
|---|---|---|
| Combretastatin A4 | 117048-59-6 | |
| Nintedanib (BIBF 1120) | VEGFR/PDGFR/FGFR inhibitor | 928326-83-4 |
Drug Products
-
BioLegend
- Recombinant Human VEGF-121 (carrier-free) (583202)
- Recombinant Human VEGF-121 (carrier-free) (583208)
- Recombinant Human VEGF-165 (carrier-free) (583708)
- Recombinant Human VEGF-165 (carrier-free) (583702)
- Recombinant Human VEGF-121 (carrier-free) (583204)
- Recombinant Human VEGF-165 (carrier-free) (583706)
- Recombinant Human VEGF-121 (carrier-free) (583206)
- Recombinant Human VEGF-165 (carrier-free) (583704)
- Recombinant Human VEGF-165 (Animal-Free)
- Recombinant Human VEGF (ELISA Std.)
- ApexBio compounds for VEGFA