Aliases for VEGFA Gene
Aliases for VEGFA Gene
External Ids for VEGFA Gene
- HGNC: 12680
- Entrez Gene: 7422
- Ensembl: ENSG00000112715
- OMIM: 192240
- UniProtKB: P15692
Previous HGNC Symbols for VEGFA Gene
- VEGF
Previous GeneCards Identifiers for VEGFA Gene
- GC06P043846
- GC06P043458
Summaries for VEGFA Gene
-
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
GeneCards Summary for VEGFA Gene
VEGFA (Vascular Endothelial Growth Factor A) is a Protein Coding gene. Diseases associated with VEGFA include Microvascular Complications Of Diabetes 1 and Poems Syndrome. Among its related pathways are ERK Signaling and Gene Expression. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is PGF.
UniProtKB/Swiss-Prot for VEGFA Gene
-
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
Additional gene information for VEGFA Gene
- Monarch Initiative
- Search for VEGFA at DataMed
- Search for VEGFA at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VEGFA Gene
Genomics for VEGFA Gene
GeneHancer (GH) Regulatory Elements for VEGFA Gene
Promoters and enhancers for VEGFA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around VEGFA on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the VEGFA gene promoter:
-
- PPAR-alpha
- PPAR-gamma1
Regulatory Element Products
Genomic Locations for VEGFA Gene
Genomic Locations for VEGFA Gene
- chr6:43,770,184-43,786,487
- (GRCh38/hg38)
- Size:
- 16,304 bases
- Orientation:
- Plus strand
- chr6:43,737,921-43,754,224
- (GRCh37/hg19)
- Size:
- 16,304 bases
- Orientation:
- Plus strand
Genomic View for VEGFA Gene
Genes around VEGFA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.1 by Entrez Gene
- 6p21.1 by HGNC
- 6p21.1 by Ensembl
VEGFA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VEGFA Gene
Proteins for VEGFA Gene
-
Protein details for VEGFA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15692-VEGFA_HUMAN
- Recommended name:
- Vascular endothelial growth factor A
- Protein Accession:
- P15692
- B5BU86
- H0Y2S8
- H0Y407
- H0Y414
- H0Y462
- H0Y8N2
- H3BLW7
- O60720
- O75875
- Q074Z4
- Q16889
- Q5UB46
- Q6P0P5
- Q96KJ0
- Q96L82
- Q96NW5
- Q9H1W8
- Q9H1W9
- Q9UH58
- Q9UL23
Protein attributes for VEGFA Gene
- Size:
- 232 amino acids
- Molecular mass:
- 27042 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity). Interacts with NRP1 (PubMed:26503042).
- SequenceCaution:
-
- Sequence=AAC63102.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC63143.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAC19512.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAC19516.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for VEGFA Gene
Protein Expression for VEGFA Gene
Post-translational modifications for VEGFA Gene
Other Protein References for VEGFA Gene
- ENSEMBL proteins:
-
- ENSP00000389864
- ENSP00000361125
- ENSP00000492413
- ENSP00000429008
- ENSP00000430594
- ENSP00000492800
- ENSP00000409911
- ENSP00000388663
- ENSP00000388465
- ENSP00000429643
- ENSP00000361148
- ENSP00000483241
- ENSP00000430829
- ENSP00000430479
- ENSP00000492199
- ENSP00000478034
- ENSP00000230480
- ENSP00000421561
- ENSP00000428321
- ENSP00000478570
- ENSP00000429592
- ENSP00000361134
- ENSP00000361137
- ENSP00000430002
- ENSP00000317598
- ENSP00000484284
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for VEGFA (VEGF)
-
Custom Antibody ServicesOriGene Antibodies for VEGFA
- TA803421
- TA500042S
- TA500042
- TA500288
- TA500289
- AM01371PU-N
- AM20384PU-N
- AM33406BT-N
- AM33406PU-N
- AP02022SU-N
- AP02022SU-S
- AP23353PU-N
- AP54507PU-N
- DM308
- DM308-05
- DM3519P
- DM3520P
- DM3521P
- DM3615P
- DP3504
- DP3504S
- DP3505
- DP3505S
- DP3520
- DP3520B
- DP3520P
- DP3520S
- PP1073B1
- PP1073B2
- PP1073P1
- PP1073P2
- PP1113B1
- PP1113B2
- PP1113P1
- PP1113P2
- TA301750
- TA302292
- TA303731
- TA311162
- TA324012
- TA324020
- TA324021
- TA328470
- TA328471
- TA328560
- TA328561
- TA328598
- TA328599
- TA332855
- TA336482
- TA336487
- TA347879
- TA354144
- TA354145
- CF500042
- CF500288
- CF500289
- TA802346
- CF802346
- TA802347
- CF802347
- TA803263
- CF803263
- Novus Biologicals Antibodies for VEGFA
- Invitrogen Antibodies for VEGFA
- antibodies-online: Search results for 391 available VEGF Antibodies ranked by validation data
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- 7 IHC (p) Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 68 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 73 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 1 CC Antibody (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- GeneTex VEGFA Antibody for VEGFA
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Santa Cruz Biotechnology (SCBT) Antibodies for VEGFA
- Sino Biological Antibodies for VEGFA
Protein Products
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-
ProSci Proteins for VEGFA
- vascular endothelial growth factor A [96-767]
- vascular endothelial growth factor A [96-768]
- vascular endothelial growth factor A [96-771]
- vascular endothelial growth factor A [96-772]
- vascular endothelial growth factor A [96-773]
- vascular endothelial growth factor A [96-775]
- vascular endothelial growth factor A isoform l precursor [96-788]
- Vascular endothelial growth factor A [96-962]
- vascular endothelial growth factor A [91-069]
- vascular endothelial growth factor A [91-584]
- vascular endothelial growth factor A [91-589]
- vascular endothelial growth factor A [91-944]
- vascular endothelial growth factor A [92-494]
- vascular endothelial growth factor A [40-162]
- vascular endothelial growth factor A [40-163]
- vascular endothelial growth factor A [40-482]
- vascular endothelial growth factor A [40-491]
- vascular endothelial growth factor A [40-612]
- vascular endothelial growth factor A [40-613]
Assay Products
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for VEGFA (VEGF)
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- antibodies-online: Search results for 118 available VEGF Elisa Kits ranked by validation data
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Recommended
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- 2 Monkey ELISA Kits
- 21 Mouse (Murine) ELISA Kits
- 12 Pig (Porcine) ELISA Kits
- 7 Rabbit ELISA Kits
- 20 Rat (Rattus) ELISA Kits
- 3 Sheep (Ovine) ELISA Kits
- 2 Wild boar (Sus scrofa) ELISA Kits
- Sino Biological Assays for VEGFA
No data available for DME Specific Peptides for VEGFA Gene
Domains & Families for VEGFA Gene
Gene Families for VEGFA Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Disease related genes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for VEGFA Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for VEGFA Gene
Graphical View of Domain Structure for InterPro Entry
P15692- Family:
-
- Belongs to the PDGF/VEGF growth factor family.
Function for VEGFA Gene
Molecular function for VEGFA Gene
- UniProtKB/Swiss-Prot Function:
- Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By hypoxia. Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoglycemia and oncogenic mutations.
LifeMap Function Summary for VEGFA Gene
During embryonic development, VEGFA as signaling molecule is secreted from the following cells
- Head Mesenchyme
-
Bone
- Hypertrophic Chondrocytes (Zeugopod Growth Plate)
- Hypertrophic Chondrocytes (Rib)
- Hypertrophic Chondrocytes (Autopod Growth Plate)
- Hypertrophic Chondrocytes (Stylopod Growth Plate)
- Hypertrophic Chondrocytes (Vertebrae)
- Prehypertrophic Chondrocytes (Stylopod Growth Plate)
- Prehypertrophic Chondrocytes (Vertebrae)
- Prehypertrophic Chondrocytes (Rib)
- Prehypertrophic Chondrocytes (Zeugopod Growth Plate)
- Terminal Chondrocytes (Endochondral Facial Bones)
- Terminal Chondrocytes (Caudal Facial Endochondral Bones)
- Gut Tube
- Neural Tube
It affects the following cells:
- Neural Tube
- Lateral Plate Mesoderm
- Head Mesenchyme
-
Bone
- Endochondral Preosteoblasts (Vertebrae)
- Endochondral Preosteoblasts (Autopod Perichondrium)
- Endochondral Preosteoblasts (Stylopod Perichondrium)
- Endochondral Preosteoblasts (Rib)
- Endochondral Preosteoblasts (Zeugopod Perichondrium)
- Hypertrophic Chondrocytes (Rib)
- Hypertrophic Chondrocytes (Vertebrae)
- Hypertrophic Chondrocytes (Zeugopod Growth Plate)
- Hypertrophic Chondrocytes (Stylopod Growth Plate)
- Hypertrophic Chondrocytes (Autopod Growth Plate)
- Terminal Chondrocytes (Autopod Growth Plate)
- Terminal Chondrocytes (Vertebrae)
- Terminal Chondrocytes (Rib)
- Terminal Chondrocytes (Zeugopod Growth Plate)
- Terminal Chondrocytes (Stylopod Growth Plate)
- Endothelium
- Pancreas
Phenotypes From GWAS Catalog for VEGFA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001968 | fibronectin binding | IDA | 14570917 |
| GO:0005125 | cytokine activity | ISS | -- |
| GO:0005161 | platelet-derived growth factor receptor binding | IPI | 17470632 |
| GO:0005172 | vascular endothelial growth factor receptor binding | IPI | 10471394 |
| GO:0005515 | protein binding | IPI | 9393862 |
Phenotypes for VEGFA Gene
- MGI mutant phenotypes for VEGFA:
-
inferred from 12 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- limbs/digits/tail phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- normal phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for VEGFA:
Animal Models for VEGFA Gene
Animal Model Products
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-
CRISPR Products
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OriGene CRISPR knockouts for VEGFA
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- Overview of 387 available VEGF gene related products
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Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for VEGFA Gene
- miRTarBase miRNAs that target VEGFA
-
- hsa-mir-373-3p (MIRT000721)
- hsa-mir-302d-3p (MIRT000722)
- hsa-mir-126-3p (MIRT003428)
- hsa-mir-147a (MIRT003810)
- hsa-mir-134-5p (MIRT003811)
- hsa-mir-140-5p (MIRT003812)
- hsa-mir-29b-3p (MIRT003813)
- hsa-mir-107 (MIRT003814)
- hsa-mir-16-5p (MIRT003890)
- hsa-mir-93-5p (MIRT004055)
- hsa-mir-17-5p (MIRT004271)
- hsa-mir-150-5p (MIRT004272)
- hsa-mir-195-5p (MIRT004273)
- hsa-mir-15b-5p (MIRT004274)
- hsa-mir-15a-5p (MIRT004275)
- hsa-mir-520g-3p (MIRT004276)
- hsa-mir-378a-3p (MIRT004277)
- hsa-mir-330-3p (MIRT004278)
- hsa-mir-383-5p (MIRT004443)
- hsa-mir-125a-5p (MIRT004445)
- hsa-mir-361-5p (MIRT004447)
- hsa-mir-20a-5p (MIRT004450)
- hsa-mir-20b-5p (MIRT004451)
- hsa-mir-504-5p (MIRT004457)
- hsa-mir-520h (MIRT004458)
- hsa-mir-372-3p (MIRT004461)
- hsa-mir-106a-5p (MIRT004465)
- hsa-mir-106b-5p (MIRT004466)
- hsa-mir-34a-5p (MIRT004513)
- hsa-mir-205-5p (MIRT004518)
- hsa-mir-34b-3p (MIRT004519)
- hsa-mir-145-5p (MIRT006215)
- hsa-mir-200b-3p (MIRT006440)
- hsa-mir-200c-3p (MIRT006771)
- hsa-mir-503-5p (MIRT007224)
- hsa-mir-335-5p (MIRT016911)
- hsa-mir-29c-3p (MIRT020389)
- hsa-mir-9-5p (MIRT021401)
- hsa-mir-133a-3p (MIRT021711)
- hsa-mir-101-3p (MIRT027248)
- hsa-mir-21-5p (MIRT030717)
- hsa-mir-203a-3p (MIRT053074)
- hsa-mir-29a-3p (MIRT053585)
- hsa-mir-424-5p (MIRT100741)
- hsa-mir-497-5p (MIRT100742)
- hsa-mir-598-5p (MIRT100743)
- hsa-mir-374b-3p (MIRT100744)
- hsa-mir-3163 (MIRT100745)
- hsa-mir-4524a-5p (MIRT100746)
- hsa-mir-451b (MIRT100747)
- hsa-mir-4524b-5p (MIRT100748)
- hsa-mir-6838-5p (MIRT100749)
- hsa-mir-568 (MIRT100755)
- hsa-mir-1277-5p (MIRT100756)
- hsa-mir-423-3p (MIRT122988)
- hsa-mir-141-5p (MIRT169147)
- hsa-mir-299-3p (MIRT169150)
- hsa-mir-297 (MIRT169172)
- hsa-mir-718 (MIRT169184)
- hsa-mir-3924 (MIRT169196)
- hsa-mir-6748-5p (MIRT169215)
- hsa-mir-6756-5p (MIRT169216)
- hsa-mir-6759-5p (MIRT169217)
- hsa-mir-6766-5p (MIRT169218)
- hsa-mir-6769a-5p (MIRT169219)
- hsa-mir-6769b-5p (MIRT169225)
- hsa-mir-95-5p (MIRT317921)
- hsa-mir-1252-3p (MIRT317922)
- hsa-mir-3646 (MIRT317923)
- hsa-mir-5682 (MIRT317924)
- hsa-mir-185-5p (MIRT360955)
- hsa-mir-199a-5p (MIRT438498)
- hsa-mir-6871-3p (MIRT464228)
- hsa-mir-7-2-3p (MIRT464229)
- hsa-mir-7-1-3p (MIRT464230)
- hsa-mir-5688 (MIRT464231)
- hsa-mir-495-3p (MIRT464232)
- hsa-mir-5692a (MIRT464233)
- hsa-mir-646 (MIRT464234)
- hsa-mir-3662 (MIRT464235)
- hsa-mir-374b-5p (MIRT520223)
- hsa-mir-374a-5p (MIRT520224)
- hsa-mir-6793-5p (MIRT520225)
- hsa-mir-567 (MIRT520226)
- hsa-mir-4483 (MIRT520227)
- hsa-mir-1293 (MIRT520228)
- hsa-mir-6745 (MIRT520229)
- hsa-mir-363-5p (MIRT520230)
- hsa-mir-410-3p (MIRT520231)
- hsa-mir-5692c (MIRT520232)
- hsa-mir-5692b (MIRT520233)
- hsa-mir-369-3p (MIRT520234)
- hsa-mir-4789-5p (MIRT552961)
- hsa-mir-3941 (MIRT552962)
- hsa-mir-4719 (MIRT552963)
- hsa-mir-603 (MIRT552964)
- hsa-mir-362-3p (MIRT552965)
- hsa-mir-329-3p (MIRT552966)
- hsa-mir-8485 (MIRT552967)
- hsa-mir-576-5p (MIRT552968)
- hsa-mir-4263 (MIRT552969)
- hsa-mir-4735-5p (MIRT552970)
- hsa-mir-670-5p (MIRT651752)
- hsa-mir-6870-3p (MIRT651753)
- hsa-mir-660-3p (MIRT651754)
- hsa-mir-5193 (MIRT651755)
- hsa-mir-5694 (MIRT651756)
- hsa-mir-4497 (MIRT707039)
- hsa-mir-1-3p (MIRT731842)
- hsa-mir-125a-3p (MIRT732343)
- hsa-mir-320a (MIRT732583)
- hsa-mir-126-5p (MIRT732702)
- rno-mir-29a-3p (MIRT732732)
- hsa-mir-186-5p (MIRT732809)
- bta-mir-199a-5p (MIRT733511)
- bta-mir-150 (MIRT733512)
- bta-mir-378 (MIRT733515)
- hsa-mir-205-3p (MIRT733585)
- hsa-mir-1-5p (MIRT733700)
- hsa-mir-101-5p (MIRT733964)
- hsa-mir-181a-5p (MIRT734100)
- hsa-mir-942-3p (MIRT734268)
- hsa-mir-206 (MIRT734599)
- hsa-mir-296-5p (MIRT734906)
- hsa-mir-199a-3p (MIRT735197)
- hsa-mir-16-1-3p (MIRT735400)
- hsa-mir-429 (MIRT735515)
- hsa-mir-3126-5p (MIRT740050)
- hsa-mir-6873-5p (MIRT758089)
- hsa-mir-6875-5p (MIRT758125)
miRNA Products
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- NM_001025368.2
- NM_001025369.2
- NM_001025367.2
- NM_001025366.2
- NM_001171625.1
- NM_001171625.1
- NM_001171625.1
- NM_001171623.1
- NM_001171628.1
- NM_001171623.1
- NM_001171628.1
- NM_001171626.1
- NM_001287044.1
- NM_001287044.1
- NM_001204385.1
- NM_001204384.1
- NM_001317010.1
- NM_001171624.1
- NM_001171622.1
- NM_001171630.1
- NM_001171627.1
- NM_001171627.1
- Sino Biological Human cDNA Clone for VEGFA
- VectorBuilder custom plasmid, inducible vectors for VEGFA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VEGFA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for VEGFA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VEGFA
- genomics-online: cdna clones - Search results for 387 available VEGF gene related products
- Overview of 387 available VEGF gene related products
-
Recommended
- orf clones - Search results for 387 available VEGF gene related products
- Overview of 387 available VEGF gene related products
-
Recommended
- Applied Biological Materials Clones for VEGFA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for VEGFA
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VEGFA Gene
Localization for VEGFA Gene
Subcellular locations from UniProtKB/Swiss-Prot for VEGFA Gene
- Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 4 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| cytosol | 3 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | ISS | -- |
| GO:0005737 | cytoplasm | IDA | 17082651 |
| GO:0009986 | cell surface | IDA | 17470632 |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for VEGFA Gene
Pathways & Interactions for VEGFA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 2 | Development VEGF signaling via VEGFR2 - generic cascades | ||
| 3 | VEGF Pathway (Qiagen) |
.66
|
|
| 4 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 5 | RET signaling | ||
Pathways by source for VEGFA Gene
1 Sino Biological pathway for VEGFA Gene
2 GeneTex pathways for VEGFA Gene
27 BioSystems pathways for VEGFA Gene
26 Reactome pathways for VEGFA Gene
3 PharmGKB pathways for VEGFA Gene
20 KEGG pathways for VEGFA Gene
10 GeneGo (Thomson Reuters) pathways for VEGFA Gene
4 R&D Systems pathways for VEGFA Gene
15 Qiagen pathways for VEGFA Gene
Interacting Proteins for VEGFA Gene
Selected Interacting proteins:
P15692-VEGFA_HUMAN
ENSP00000361125
for VEGFA Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for VEGFA
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 18093989 |
| GO:0001525 | angiogenesis | IDA,IEA | 11427521 |
| GO:0001541 | ovarian follicle development | ISS | -- |
| GO:0001569 | branching involved in blood vessel morphogenesis | ISS | -- |
| GO:0001570 | vasculogenesis | TAS | 15015550 |
Drugs & Compounds for VEGFA Gene
(117) Drugs for VEGFA Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ranibizumab | Approved | Pharma | inhibitor, Target | 502 | ||
| Bevacizumab | Approved, Investigational | Pharma | antagonist, antibody, inhibitor, Target | VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 2087 | |
| pegaptanib | Approved, Investigational | Pharma | 0 | |||
| Vandetanib | Approved April 2011 | Pharma | Target, inhibitor | VEGFR, EGFR, and RET inhibitor, EGFR Inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
| Minocycline | Approved, Investigational | Pharma | Target, inhibitor | 242 |
Drug Products
Transcripts for VEGFA Gene
mRNA/cDNA for VEGFA Gene
- (20) REFSEQ mRNAs :
- (26) Additional mRNA sequences :
- (416) Selected AceView cDNA sequences:
- (32) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000476772 1683 bps (uc021yzv.2)
- ENST00000372067 3535 bps (uc063oug.1)
- ENST00000324450 954 bps (uc063oui.1)
- ENST00000417285 1081 bps (uc063ouj.1)
- ENST00000413642 1197 bps (uc063ouk.1)
Unigene Clusters for VEGFA Gene
- Vascular endothelial growth factor A:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for VEGFA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VEGFA
- genomics-online: gRNA clones - Search results for 387 available VEGF gene related products
- Overview of 387 available VEGF gene related products
-
Recommended
- Applied Biological Materials CRISPR for VEGFA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VEGFA
- GenScript: Design CRISPR guide RNA sequences for VEGFA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VEGFA
- Browse OriGene Inhibitory RNA Products For VEGFA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VEGFA
- genomics-online: shRNA clones - Search results for 387 available VEGF gene related products
- Overview of 387 available VEGF gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for VEGFA
- RC223789L1V
- RC223789L2V
- RC222078L1V
- RC222078L2V
- RC223884L1V
- RC223884L2V
- RC224389L1V
- RC224389L2V
- RC222129L1V
- RC222129L2V
- RC217312L1V
- RC217312L2V
- RC229874L1V
- RC229874L2V
- RC229732L1V
- RC229732L2V
- RC229706L1V
- RC229706L2V
- RC229686L1V
- RC229686L2V
- RC229662L1V
- RC229662L2V
- RC229636L1V
- RC229636L2V
- RC229592L1V
- RC229592L2V
- RC229663L1V
- RC229663L2V
- RC229571L1V
- RC229571L2V
- RC224244L1V
- RC224244L2V
- RC223789
- RC223789L1
- RC223789L2
- RG223789
- RC222078
- RC222078L1
- RC222078L2
- RG222078
- RC223884
- RC223884L1
- RC223884L2
- RG223884
- RC224389
- RC224389L1
- RC224389L2
- RG224389
- RC222129
- RC222129L1
- RC222129L2
- RG222129
- RC217312
- RC217312L1
- RC217312L2
- RG217312
- RC229874
- RC229874L1
- RC229874L2
- RG229874
- RC229732
- RC229732L1
- RC229732L2
- RG229732
- RC229706
- RC229706L1
- RC229706L2
- RG229706
- RC229686
- RC229686L1
- RC229686L2
- RG229686
- RC229662
- RC229662L1
- RC229662L2
- RG229662
- RC229636
- RC229636L1
- RC229636L2
- RG229636
- RC229592
- RC229592L1
- RC229592L2
- RG229592
- RC229663
- RC229663L1
- RC229663L2
- RG229663
- RC229571
- RC229571L1
- RC229571L2
- RG229571
- RC231952
- RG231952
- RC233844
- RG233844
- RC236189
- RC224244
- RC224244L1
- RC224244L2
- RG224244
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping of latest version cDNA ORF clones for VEGFA in any vector
- NM_003376.5
- NM_001033756.2
- NM_001025370.2
- NM_001025368.2
- NM_001025369.2
- NM_001025367.2
- NM_001025366.2
- NM_001171625.1
- NM_001171625.1
- NM_001171625.1
- NM_001171623.1
- NM_001171628.1
- NM_001171623.1
- NM_001171628.1
- NM_001171626.1
- NM_001287044.1
- NM_001287044.1
- NM_001204385.1
- NM_001204384.1
- NM_001317010.1
- NM_001171624.1
- NM_001171622.1
- NM_001171630.1
- NM_001171627.1
- NM_001171627.1
- Sino Biological Human cDNA Clone for VEGFA
- VectorBuilder custom plasmid, inducible vectors for VEGFA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VEGFA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for VEGFA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VEGFA
- genomics-online: cdna clones - Search results for 387 available VEGF gene related products
- Overview of 387 available VEGF gene related products
-
Recommended
- orf clones - Search results for 387 available VEGF gene related products
- Overview of 387 available VEGF gene related products
-
Recommended
- Applied Biological Materials Clones for VEGFA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||
| SP7: |
