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Aliases for VDAC3 Gene

Aliases for VDAC3 Gene

  • Voltage Dependent Anion Channel 3 2 3 5
  • Outer Mitochondrial Membrane Protein Porin 3 3 4
  • VDAC-3 3 4
  • Voltage-Dependent Anion-Selective Channel Protein 3 3
  • HD-VDAC3 3
  • HVDAC3 4

External Ids for VDAC3 Gene

Previous GeneCards Identifiers for VDAC3 Gene

  • GC08P041661
  • GC08P042274
  • GC08P041990
  • GC08P042266
  • GC08P040772
  • GC08P042249

Summaries for VDAC3 Gene

Entrez Gene Summary for VDAC3 Gene

  • This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for VDAC3 Gene

VDAC3 (Voltage Dependent Anion Channel 3) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Necroptosis. Gene Ontology (GO) annotations related to this gene include nucleotide binding and voltage-gated anion channel activity. An important paralog of this gene is VDAC2.

UniProtKB/Swiss-Prot for VDAC3 Gene

  • Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.

Gene Wiki entry for VDAC3 Gene

Additional gene information for VDAC3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VDAC3 Gene

Genomics for VDAC3 Gene

GeneHancer (GH) Regulatory Elements for VDAC3 Gene

Promoters and enhancers for VDAC3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I042390 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.6 612 2.9 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 DKK4 VDAC3 POLB IKBKB KAT6A ENSG00000254165 PIR58107
GH08I042393 Promoter 0.5 EPDnew 550.8 +2.2 2197 0.1 VDAC3 POLB DKK4 PIR58107
GH08I042171 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.5 -219.8 -219782 1.1 ATF1 FOXA2 ARID4B SIN3A NFXL1 ZNF2 RAD21 ZNF335 ZNF121 SCRT2 PIR61234 POLB PLAT IKBKB LOC101929897 VDAC3 DKK4 AP3M2
GH08I042176 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.4 -214.0 -214022 1.3 HDGF EBF1 BATF KLF5 IRF4 RELA FOXK2 NFATC1 ATF7 ETV6 AP3M2 IKBKB LOC101929897 POLB VDAC3 DKK4 PIR61234 PLAT
GH08I042296 Enhancer 1.1 Ensembl ENCODE dbSUPER 11 -92.2 -92207 5.4 NCOA3 HDAC1 MXI1 JUN MAX FOSL1 ZNF121 GATA3 POLR2A SMC3 LOC105379395 POLB LOC101929897 IKBKB VDAC3 DKK4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VDAC3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VDAC3 gene promoter:

Genomic Locations for VDAC3 Gene

Genomic Locations for VDAC3 Gene
14,314 bases
Plus strand

Genomic View for VDAC3 Gene

Genes around VDAC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VDAC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VDAC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VDAC3 Gene

Proteins for VDAC3 Gene

  • Protein details for VDAC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Voltage-dependent anion-selective channel protein 3
    Protein Accession:
    Secondary Accessions:
    • Q9UIS0

    Protein attributes for VDAC3 Gene

    283 amino acids
    Molecular mass:
    30659 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VDAC3 Gene


neXtProt entry for VDAC3 Gene

Post-translational modifications for VDAC3 Gene

  • Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Ubiquitination at isoforms=220, isoforms=253, and posLast=110110

No data available for DME Specific Peptides for VDAC3 Gene

Domains & Families for VDAC3 Gene

Gene Families for VDAC3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for VDAC3 Gene

Suggested Antigen Peptide Sequences for VDAC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.
  • Belongs to the eukaryotic mitochondrial porin family.
  • Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.
  • Belongs to the eukaryotic mitochondrial porin family.
genes like me logo Genes that share domains with VDAC3: view

Function for VDAC3 Gene

Molecular function for VDAC3 Gene

GENATLAS Biochemistry:
voltage-dependent anion channel 3,mitochondrial outer membrane,porin 3,allowing diffusion of small hydrophilic molecules,homolog to murine Vdac3,previously mapped to chromosome 12
UniProtKB/Swiss-Prot Function:
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.

Gene Ontology (GO) - Molecular Function for VDAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0008308 voltage-gated anion channel activity IEA,TAS 9781040
GO:0015288 porin activity IEA --
genes like me logo Genes that share ontologies with VDAC3: view
genes like me logo Genes that share phenotypes with VDAC3: view

Animal Models for VDAC3 Gene

MGI Knock Outs for VDAC3:

Animal Model Products

CRISPR Products

miRNA for VDAC3 Gene

miRTarBase miRNAs that target VDAC3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VDAC3 Gene

Localization for VDAC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VDAC3 Gene

Mitochondrion outer membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VDAC3 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 3
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for VDAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,HDA 21630459
GO:0005739 mitochondrion IDA,IEA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with VDAC3: view

Pathways & Interactions for VDAC3 Gene

genes like me logo Genes that share pathways with VDAC3: view

Gene Ontology (GO) - Biological Process for VDAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007268 chemical synaptic transmission IEA --
GO:0007270 neuron-neuron synaptic transmission IEA --
genes like me logo Genes that share ontologies with VDAC3: view

No data available for SIGNOR curated interactions for VDAC3 Gene

Drugs & Compounds for VDAC3 Gene

(4) Drugs for VDAC3 Gene - From: DrugBank, ApexBio, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aluminium monostearate Experimental Pharma Target, inhibitor 0
PRLX 93936 Investigational Pharma Target 0
Erastin Pharma 0

(1) ApexBio Compounds for VDAC3 Gene

Compound Action Cas Number
Erastin 571203-78-6
genes like me logo Genes that share compounds with VDAC3: view

Drug Products

Transcripts for VDAC3 Gene

Unigene Clusters for VDAC3 Gene

Voltage-dependent anion channel 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for VDAC3 Gene

No ASD Table

Relevant External Links for VDAC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VDAC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VDAC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VDAC3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.2).

Protein differential expression in normal tissues from HIPED for VDAC3 Gene

This gene is overexpressed in Nasal epithelium (30.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VDAC3 Gene

Protein tissue co-expression partners for VDAC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VDAC3 Gene:


SOURCE GeneReport for Unigene cluster for VDAC3 Gene:


mRNA Expression by UniProt/SwissProt for VDAC3 Gene:

Tissue specificity: Widely expressed. Highest in testis.

Evidence on tissue expression from TISSUES for VDAC3 Gene

  • Nervous system(4.4)
  • Skin(4.3)
  • Blood(4.2)
  • Eye(2.8)
  • Heart(2.7)
  • Muscle(2.6)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with VDAC3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for VDAC3 Gene

Orthologs for VDAC3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VDAC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VDAC3 33 34
  • 99.76 (n)
(Bos Taurus)
Mammalia VDAC5P 34
  • 98 (a)
VDAC3 33
  • 93.64 (n)
-- 34
  • 76 (a)
(Mus musculus)
Mammalia Vdac3-ps1 34
  • 98 (a)
Vdac3 33 16 34
  • 91.76 (n)
(Canis familiaris)
Mammalia VDAC3 33 34
  • 94.58 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 92 (a)
-- 34
  • 77 (a)
(Rattus norvegicus)
Mammalia Vdac3 33
  • 90.69 (n)
(Ornithorhynchus anatinus)
Mammalia VDAC3 34
  • 86 (a)
(Gallus gallus)
Aves VDAC3 33 34
  • 77.27 (n)
(Anolis carolinensis)
Reptilia VDAC3 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vdac3 33
  • 71.61 (n)
Str.5756 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.2509 33
(Danio rerio)
Actinopterygii VDAC3 (3 of 3) 34
  • 77 (a)
VDAC3 (2 of 3) 34
  • 72 (a)
vdac3 33 34
  • 69.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta porin 35 34
  • 58 (a)
CG17137 35
  • 35 (a)
Porin2 34
  • 35 (a)
CG17139 34
  • 18 (a)
CG17140 34
  • 17 (a)
(Caenorhabditis elegans)
Secernentea R05G6.7 35
  • 39 (a)
vdac-1 34
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POR1 34 36
  • 27 (a)
POR2 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11255 34
  • 54 (a)
Species where no ortholog for VDAC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VDAC3 Gene

Gene Tree for VDAC3 (if available)
Gene Tree for VDAC3 (if available)

Paralogs for VDAC3 Gene

Paralogs for VDAC3 Gene

(2) SIMAP similar genes for VDAC3 Gene using alignment to 8 proteins: Pseudogenes for VDAC3 Gene

genes like me logo Genes that share paralogs with VDAC3: view

Variants for VDAC3 Gene

Sequence variations from dbSNP and Humsavar for VDAC3 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000306647 -- 42,393,060(+) C/G intron_variant
rs1000356617 -- 42,393,028(+) T/C intron_variant
rs1000443456 -- 42,392,749(+) C/G intron_variant
rs1000638835 -- 42,395,155(+) A/G intron_variant
rs1000720408 -- 42,391,887(+) A/G 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for VDAC3 Gene

Variant ID Type Subtype PubMed ID
esv3380474 CNV insertion 20981092
nsv831301 CNV loss 17160897

Variation tolerance for VDAC3 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VDAC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VDAC3 Gene

Disorders for VDAC3 Gene

Additional Disease Information for VDAC3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for VDAC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VDAC3 Gene

Publications for VDAC3 Gene

  1. The tissue-specific, alternatively spliced single ATG exon of the type 3 voltage-dependent anion channel gene does not create a truncated protein isoform in vivo. (PMID: 10833333) Decker WK … Craigen WJ (Molecular genetics and metabolism 2000) 3 4 22 58
  2. Isolation of a novel human voltage-dependent anion channel gene. (PMID: 9781040) Rahmani Z … Siddiqui A (European journal of human genetics : EJHG 1998) 2 3 4 58
  3. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. (PMID: 9653160) Mao M … Chen Z (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide? (PMID: 17683036) Lefièvre L … Barratt CL (Proteomics 2007) 3 22 58

Products for VDAC3 Gene

Sources for VDAC3 Gene

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