Aliases for VDAC2 Gene
External Ids for VDAC2 Gene
Previous GeneCards Identifiers for VDAC2 Gene
This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
GeneCards Summary for VDAC2 Gene
VDAC2 (Voltage Dependent Anion Channel 2) is a Protein Coding gene. Diseases associated with VDAC2 include Alzheimer Disease and Acute Closed-Angle Glaucoma. Among its related pathways are Statin Pathway and Pathways of neurodegeneration - multiple diseases. Gene Ontology (GO) annotations related to this gene include nucleotide binding and voltage-gated anion channel activity. An important paralog of this gene is VDAC1.
UniProtKB/Swiss-Prot Summary for VDAC2 Gene
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity). The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (PubMed:31015432). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432).