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Aliases for VCY1B Gene

Aliases for VCY1B Gene

  • Variable Charge, Y-Linked 1B 2 3 5
  • Variably Charged Protein Y 3 4
  • Basic Charge, Y-Linked 1 3 4
  • BPY1B 3 4
  • Testis-Specific Basic Protein On Y, 1 3
  • Testis-Specific Basic Protein Y 1 3
  • Basic Protein On Y Chromosome, 1 3
  • VCY VCY1B 4
  • VCY1A 4
  • BPY1 4

External Ids for VCY1B Gene

Previous GeneCards Identifiers for VCY1B Gene

  • GC0YP014606
  • GC0YU900269
  • GC0YM014607
  • GC0YM016097
  • GC0YP016170

Summaries for VCY1B Gene

Entrez Gene Summary for VCY1B Gene

  • The protein encoded by this gene is a member of a family of human VCX/Y genes. This gene family has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. Members of the VCX/Y family share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. VCX/Y genes encode small and highly charged proteins of unknown function. This gene encodes a small, positively charged protein. The presence of a putative bipartite nuclear localization signal suggests that this gene encodes a nuclear protein. The genome has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. [provided by RefSeq, Jul 2008]

GeneCards Summary for VCY1B Gene

VCY1B (Variable Charge, Y-Linked 1B) is a Protein Coding gene. Diseases associated with VCY1B include Chronic Laryngitis. An important paralog of this gene is VCY.

UniProtKB/Swiss-Prot for VCY1B Gene

  • May mediate a process in spermatogenesis or may play a role in sex ratio distortion.

Additional gene information for VCY1B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCY1B Gene

Genomics for VCY1B Gene

GeneHancer (GH) Regulatory Elements for VCY1B Gene

Promoters and enhancers for VCY1B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0YI014056 Promoter 0.5 EPDnew 550.8 +0.0 21 0.1 VCY1B PNPLA4P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VCY1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VCY1B gene promoter:

Genomic Locations for VCY1B Gene

Genomic Locations for VCY1B Gene
742 bases
Plus strand

Genomic View for VCY1B Gene

Genes around VCY1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VCY1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VCY1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VCY1B Gene

Proteins for VCY1B Gene

  • Protein details for VCY1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific basic protein Y 1
    Protein Accession:

    Protein attributes for VCY1B Gene

    125 amino acids
    Molecular mass:
    12917 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VCY1B Gene

Post-translational modifications for VCY1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VCY1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VCY1B Gene

Domains & Families for VCY1B Gene

Gene Families for VCY1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for VCY1B Gene


Suggested Antigen Peptide Sequences for VCY1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the VCX/VCY family.
  • Belongs to the VCX/VCY family.
genes like me logo Genes that share domains with VCY1B: view

Function for VCY1B Gene

Molecular function for VCY1B Gene

UniProtKB/Swiss-Prot Function:
May mediate a process in spermatogenesis or may play a role in sex ratio distortion.

Phenotypes for VCY1B Gene

GenomeRNAi human phenotypes for VCY1B:
genes like me logo Genes that share phenotypes with VCY1B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VCY1B Gene

Localization for VCY1B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for VCY1B Gene

Pathways & Interactions for VCY1B Gene

SuperPathways for VCY1B Gene

No Data Available

Interacting Proteins for VCY1B Gene

Selected Interacting proteins: O14598-VCY1_HUMAN for VCY1B Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for VCY1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007420 brain development IBA --
genes like me logo Genes that share ontologies with VCY1B: view

No data available for Pathways by source and SIGNOR curated interactions for VCY1B Gene

Drugs & Compounds for VCY1B Gene

No Compound Related Data Available

Transcripts for VCY1B Gene

mRNA/cDNA for VCY1B Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for VCY1B Gene

No ASD Table

Relevant External Links for VCY1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VCY1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VCY1B Gene

Protein differential expression in normal tissues from HIPED for VCY1B Gene

This gene is overexpressed in Ovary (38.6) and Testis (30.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VCY1B Gene

Protein tissue co-expression partners for VCY1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VCY1B Gene:


mRNA Expression by UniProt/SwissProt for VCY1B Gene:

Tissue specificity: Expressed exclusively in testis.
genes like me logo Genes that share expression patterns with VCY1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for VCY1B Gene

Orthologs for VCY1B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for VCY1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC742075 33
  • 95.69 (n)
Species where no ortholog for VCY1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VCY1B Gene

Gene Tree for VCY1B (if available)
Gene Tree for VCY1B (if available)

Paralogs for VCY1B Gene

Paralogs for VCY1B Gene

(5) SIMAP similar genes for VCY1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VCY1B: view

Variants for VCY1B Gene

Sequence variations from dbSNP and Humsavar for VCY1B Gene

SNP ID Clin Chr 0Y pos Variation AA Info Type
rs113280232 -- 14,056,919(+) C/G 3_prime_UTR_variant
rs13304926 -- 14,056,247(+) G/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for VCY1B Gene

Variant ID Type Subtype PubMed ID
dgv2552e212 CNV gain 25503493
nsv469834 CNV gain 16826518

Additional Variant Information for VCY1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for VCY1B Gene

Disorders for VCY1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for VCY1B Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic laryngitis
- elite association - COSMIC cancer census association via MalaCards
Search VCY1B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for VCY1B

genes like me logo Genes that share disorders with VCY1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VCY1B Gene

Publications for VCY1B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H … Page DC (Nature 2003) 3 4 58
  3. Functional coherence of the human Y chromosome. (PMID: 9381176) Lahn BT … Page DC (Science (New York, N.Y.) 1997) 3 4 58
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58

Products for VCY1B Gene

Sources for VCY1B Gene

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