Aliases for VCL Gene
External Ids for VCL Gene
Previous GeneCards Identifiers for VCL Gene
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for VCL Gene
VCL (Vinculin) is a Protein Coding gene. Diseases associated with VCL include Cardiomyopathy, Dilated, 1W and Cardiomyopathy, Familial Hypertrophic, 15. Among its related pathways are RET signaling and Paradoxical activation of RAF signaling by kinase inactive BRAF. Gene Ontology (GO) annotations related to this gene include actin binding and ubiquitin protein ligase binding. An important paralog of this gene is CTNNA1.
UniProtKB/Swiss-Prot Summary for VCL Gene
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.