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This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are t... See more...
Aliases for VCAN Gene
Aliases for VCAN Gene
External Ids for VCAN Gene
- HGNC: 2464
- Entrez Gene: 1462
- Ensembl: ENSG00000038427
- OMIM: 118661
- UniProtKB: P13611
Previous HGNC Symbols for VCAN Gene
- CSPG2
Previous GeneCards Identifiers for VCAN Gene
- GC05P082804
- GC05P077975
Summaries for VCAN Gene
-
This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
GeneCards Summary for VCAN Gene
VCAN (Versican) is a Protein Coding gene. Diseases associated with VCAN include Wagner Vitreoretinopathy and Wagner Syndrome. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. Gene Ontology (GO) annotations related to this gene include calcium ion binding and extracellular matrix structural constituent. An important paralog of this gene is ACAN.
UniProtKB/Swiss-Prot Summary for VCAN Gene
-
May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
Additional gene information for VCAN Gene
- HGNC(2464)
- Entrez Gene(1462)
- Ensembl(ENSG00000038427)
- OMIM(118661)
- UniProtKB(P13611)
- Open Targets Platform(ENSG00000038427)
- Monarch Initiative
- Search for VCAN at DataMed
- Search for VCAN at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VCAN Gene
Genomics for VCAN Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for VCAN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around VCAN on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VCAN
- Top Transcription factor binding sites by QIAGEN in the VCAN gene promoter:
-
- AML1a
- E47
- Egr-3
- GATA-1
- GCNF
- GCNF-1
- GCNF-2
- HNF-3beta
- IRF-7A
- MyoD
Genomic Locations for VCAN Gene
Genomic Locations for VCAN Gene
- chr5:83,471,618-83,582,303
- (GRCh38/hg38)
- Size:
- 110,686 bases
- Orientation:
- Plus strand
- chr5:82,767,284-82,878,122
- (GRCh37/hg19)
- Size:
- 110,839 bases
- Orientation:
- Plus strand
Genomic View for VCAN Gene
Genes around VCAN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q14.2-q14.3 by HGNC
- 5q14.2-q14.3 by Entrez Gene
- 5q14.2 by Ensembl
VCAN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VCAN Gene
Proteins for VCAN Gene
-
Protein details for VCAN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13611-CSPG2_HUMAN
- Recommended name:
- Versican core protein
- Protein Accession:
- P13611
- P20754
- Q13010
- Q13189
- Q15123
- Q9UCL9
- Q9UNW5
Protein attributes for VCAN Gene
- Size:
- 3396 amino acids
- Molecular mass:
- 372820 Da
- Quaternary structure:
-
- Interacts with FBLN1.
Protein Expression for VCAN Gene
Post-translational modifications for VCAN Gene
- Phosphorylated by FAM20C in the extracellular medium.
-
Glycosylation at Asn57, Asn330, Asn1398, Thr1418, Thr1419, Asn1442, Asn1468, Ser510, Thr516, Thr518, Thr522, Thr1566, Thr1569, Asn615, Thr627, Asn3369, Thr632, Asn3379, Ser641, Thr642, Thr643, Asn1663, Thr687, Thr689, Thr716, Ser1716, Thr1719, Thr1731, Thr1734, Thr751, Thr754, Ser1742, Ser1743, Thr1744, Thr1763, Ser1765, Asn782, Thr1769, Ser1772, Ser1775, Thr1777, Thr1778, Thr792, Thr1780, Thr799, Ser801, Asn809, Thr869, Thr886, Thr887, Ser888, Thr889, Asn1898, Ser1909, Tyr1917, Ser1925, Thr1926, Ser1935, Ser1942, Thr1943, Ser1945, Ser976, Thr981, Thr2036, Ser2058, Thr2059, Thr2063, Thr2069, Thr1092, Thr1093, Thr2083, Ser2085, Thr2086, Ser1101, Ser1103, Thr2091, Thr1110, Thr1116, Thr1121, Thr1123, Ser1131, Ser1133, Thr2152, Thr2153, Thr2159, Thr2160, Thr1191, Asn2179, Thr2194, Ser1212, Thr2200, Ser2203, Thr1219, Thr1220, Ser1221, Asn2272, Asn2280, Asn1332, Asn2360, Asn2385, Asn2392, Thr2416, Ser2417, Ser2422, Thr2448, Ser2455, Ser2456, Thr2457, Thr2458, Ser2473, Asn2496, Thr2503, Thr2505, Thr2509, Ser2515, Thr2516, Ser2530, Thr2531, Thr2540, Asn2628, Thr2656, Ser2661, Ser2699, Thr2701, Ser2781, Thr2784, Thr2785, Asn2934, Ser3024, Thr3025, Ser3029, and Asn3067
- NX_P13611 (NX_P13611-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- CSPG2_HUMAN (1890)
Other Protein References for VCAN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Versican Polyclonal Antibody and Immunotag™ VCAN Antibody
- NSJ Bioreagents Versican Antibody
-
Custom Antibody ServicesOriGene Antibodies for VCAN
- Novus Biologicals Antibodies for VCAN
-
Abcam antibodies for VCAN
- Invitrogen Antibodies for VCAN (AFLGC-VCAN)
- antibodies-online: Show 81 available Vcan Antibodies ranked by validation data
- Compare Top Vcan Antibodies
-
Recommended
- 77 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 5 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 75 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 9 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 104 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 3 IF Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
-
Biorbyt antibodies for VCAN
-
Boster Bio Antibodies for VCAN
-
Santa Cruz Biotechnology (SCBT) Antibodies for VCAN
- Sino Biological Antibodies for VCAN
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for VCAN
- Origene Custom Protein Services for VCAN
-
Abcam proteins for VCAN
No data available for DME Specific Peptides for VCAN Gene
Domains & Families for VCAN Gene
Gene Families for VCAN Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for VCAN Gene
- InterPro:
- Blocks:
-
- Immunoglobulin V-set
- Immunoglobulin subtype
- Aspartic acid and asparagine hydroxylation site
- Type II EGF-like signature
- EGF-like calcium-binding
- Sushi domain/SCR domain/CCP module
- Link domain
- Type II antifreeze protein signature
- ProtoNet:
Suggested Antigen Peptide Sequences for VCAN Gene
- GenScript: Design optimal peptide antigens:
-
- PG-M (CSPG2_HUMAN)
- VCAN protein (Q86W61_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P13611- Family:
-
- Belongs to the aggrecan/versican proteoglycan family.
Function for VCAN Gene
Molecular function for VCAN Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
Phenotypes From GWAS Catalog for VCAN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 23601700 |
| GO:0005539 | glycosaminoglycan binding | TAS | 7528742 |
| GO:0005540 | hyaluronic acid binding | TAS,IEA | -- |
| GO:0030021 | extracellular matrix structural constituent conferring compression resistance | RCA | 20551380 |
Phenotypes for VCAN Gene
- MGI mutant phenotypes for VCAN:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for VCAN:
Animal Models for VCAN Gene
- MGI Knock Outs for VCAN:
-
- Vcan Vcan<tm1.1Dzim>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for VCAN - Select products 50% OFF >
- * VCAN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for VCAN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VCAN
-
Santa Cruz Biotechnology (SCBT) CRISPR for VCAN
miRNA for VCAN Gene
- miRTarBase miRNAs that target VCAN
-
- mmu-miR-143-3p (MIRT004532)
- mmu-miR-340-5p (MIRT010605)
- mmu-miR-185-5p (MIRT054603)
- mmu-miR-203-5p (MIRT054605)
- mmu-miR-434-3p (MIRT054607)
- mmu-miR-680 (MIRT054609)
- mmu-miR-690 (MIRT054611)
- hsa-miR-545-3p (MIRT097548)
- hsa-miR-5197-3p (MIRT097550)
- hsa-miR-103a-3p (MIRT314708)
- hsa-miR-107 (MIRT314709)
- hsa-miR-218-5p (MIRT439309)
- hsa-miR-578 (MIRT546096)
- hsa-miR-3185 (MIRT546097)
- hsa-miR-643 (MIRT546098)
- mmu-miR-129-5p (MIRT593606)
- mmu-miR-450b-5p (MIRT593607)
- mmu-miR-3079-5p (MIRT604556)
- hsa-miR-335-3p (MIRT651758)
- hsa-miR-4436b-5p (MIRT651759)
- hsa-miR-627-3p (MIRT651760)
- hsa-miR-6777-3p (MIRT651761)
- hsa-miR-5003-3p (MIRT651762)
- hsa-miR-23b-3p (MIRT735532)
- hsa-miR-129-5p (MIRT783635)
- hsa-miR-302c-5p (MIRT784456)
- hsa-miR-361-3p (MIRT784958)
- hsa-miR-3680-3p (MIRT785226)
- hsa-miR-450b-5p (MIRT786069)
- hsa-miR-4666b (MIRT786356)
- hsa-miR-5011-3p (MIRT787007)
- hsa-miR-507 (MIRT787050)
- hsa-miR-552-5p (MIRT787632)
- hsa-miR-557 (MIRT787659)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VCAN
- Browse OriGene Inhibitory RNA Products For VCAN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VCAN
Clone Products
- Applied Biological Materials (abm): Clones for VCAN - Select products 50% OFF >
- * VCAN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG225673
- MG225674
- MG225675
- MG225930
- MR225673
- MR225673L3
- MR225673L4
- MR225674
- MR225674L3
- MR225674L4
- MR225675
- MR225675L3
- MR225675L4
- MR225930
- MR231982
- RC222552
- RC222552L1
- RC226068
- RC226068L3
- RC226068L4
- RC228691
- RC228691L3
- RC228691L4
- RC228709
- RG222552
- RG226068
- RG228691
- RG228709
- RR217058
- RR217671
- RR217768
- RR217802
- MR225673L3V
- MR225673L4V
- MR225674L3V
- MR225674L4V
- MR225675L3V
- MR225675L4V
- RC222552L1V
- RC226068L3V
- RC226068L4V
- RC228691L3V
- RC228691L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for VCAN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VCAN
Cell Line Products
-
Horizon Cell Lines for VCAN
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for VCAN Gene
Localization for VCAN Gene
Subcellular locations from UniProtKB/Swiss-Prot for VCAN Gene
- Secreted, extracellular space, extracellular matrix. Cell projection, cilium, photoreceptor outer segment. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| lysosome | 4 |
| golgi apparatus | 4 |
| plasma membrane | 3 |
| nucleus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endosome | 1 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001750 | photoreceptor outer segment | IEA | -- |
| GO:0005576 | extracellular region | HDA,TAS | -- |
| GO:0005615 | extracellular space | HDA | 20551380 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0005796 | Golgi lumen | TAS | -- |
Pathways & Interactions for VCAN Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chondroitin sulfate/dermatan sulfate metabolism | ||
| 2 | Integrin Pathway |
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
|
UPA-UPAR Pathway
.56
Inhibition of Angiogenesis by TSP1
.50
Transendothelial Migration of Leukocytes
.38
|
| 3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 4 | Glycosaminoglycan metabolism | ||
| 5 | Phospholipase-C Pathway |
Phospholipase-C Pathway
.56
|
PTEN Pathway
.56
|
Pathways by source for VCAN Gene
3 BioSystems pathways for VCAN Gene
20 Reactome pathways for VCAN Gene
1 KEGG pathway for VCAN Gene
2 GeneGo (Thomson Reuters) pathways for VCAN Gene
- Cell adhesion_Cell-matrix glycoconjugates
- Cell adhesion_ECM remodeling
1 R&D Systems pathway for VCAN Gene
13 Qiagen pathways for VCAN Gene
- ERK Signaling
- FAK1 Signaling
- GnRH Signaling
- ILK Signaling
- Inhibition of Angiogenesis by TSP1
Interacting Proteins for VCAN Gene
Selected Interacting proteins:
P13611-CSPG2_HUMAN
ENSP00000265077
for VCAN Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for VCAN
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | IBA | 21873635 |
| GO:0001649 | osteoblast differentiation | HDA | 16210410 |
| GO:0007155 | cell adhesion | TAS,IEA | -- |
| GO:0007275 | multicellular organism development | TAS | 2583089 |
| GO:0007417 | central nervous system development | IBA | 21873635 |
Drugs & Compounds for VCAN Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Hyaluronic acid | Approved, Vet_approved | Pharma | Target, binder | 717 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for VCAN Gene
mRNA/cDNA for VCAN Gene
- 4 REFSEQ mRNAs :
- 20 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000265077 12345 nts (view in UCSC)
- ENST00000342785 7154 nts (view in UCSC)
- ENST00000343200 9455 nts (view in UCSC)
- ENST00000502527 2087 nts (view in UCSC)
- ENST00000503923 498 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for VCAN - Select products 50% OFF >
- * VCAN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for VCAN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VCAN
-
Santa Cruz Biotechnology (SCBT) CRISPR for VCAN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VCAN
- Browse OriGene Inhibitory RNA Products For VCAN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VCAN
Clone Products
- Applied Biological Materials (abm): Clones for VCAN - Select products 50% OFF >
- * VCAN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG225673
- MG225674
- MG225675
- MG225930
- MR225673
- MR225673L3
- MR225673L4
- MR225674
- MR225674L3
- MR225674L4
- MR225675
- MR225675L3
- MR225675L4
- MR225930
- MR231982
- RC222552
- RC222552L1
- RC226068
- RC226068L3
- RC226068L4
- RC228691
- RC228691L3
- RC228691L4
- RC228709
- RG222552
- RG226068
- RG228691
- RG228709
- RR217058
- RR217671
- RR217768
- RR217802
- MR225673L3V
- MR225673L4V
- MR225674L3V
- MR225674L4V
- MR225675L3V
- MR225675L4V
- RC222552L1V
- RC226068L3V
- RC226068L4V
- RC228691L3V
- RC228691L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for VCAN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VCAN
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 18a | · | 18b | ^ | 19a | · | 19b | · | 19c | · | 19d |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||
| SP2: | - | ||||||||||
| SP3: | - | ||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: | |||||||||||
| SP9: |
Relevant External Links for VCAN Gene
- GeneLoc Exon Structure for
- VCAN
Expression for VCAN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Cartilage (Muscoskeletal System)
-
Heart (Cardiovascular System)
- Atrioventricular Valve Cells Atrioventricular Valves
- Cardiomyocytes Outflow Tract
- Paraxial Mesoderm (Gastrulation Derivatives)
- Neural Crest (Gastrulation Derivatives)
- Lateral Plate Mesoderm (Gastrulation Derivatives)
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for VCAN Gene
This gene is overexpressed in Artery - Aorta (x8.3), Artery - Coronary (x7.4), and Whole Blood (x6.5).
This gene is overexpressed in Amniocyte (16.9), Spinal cord (10.1), Frontal cortex (8.4), and Brain (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for VCAN Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VCAN
SOURCE GeneReport for Unigene cluster for VCAN Gene:
Hs.643801mRNA Expression by UniProt/SwissProt for VCAN Gene:
P13611-CSPG2_HUMAN
Tissue specificity:
Expressed in the retina (at protein level) (PubMed:29777959). Cerebral white matter and plasma (PubMed:2469524). Isoform V0: Expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas (PubMed:8627343). Isoform V1: Expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas (PubMed:8627343). Isoform V2: Restricted to normal brain and gliomas (PubMed:8627343). Isoform V3: Found in all these tissues except medulloblastomas (PubMed:8627343).
Evidence on tissue expression from TISSUES for VCAN Gene
- Nervous system(5)
- Lung(4.7)
- Muscle(4.6)
- Liver(4.5)
- Heart(3.6)
- Kidney(3.4)
- Intestine(3.2)
- Blood(3.1)
- Spleen(3)
- Skin(2.8)
- Bone marrow(2.7)
- Lymph node(2.7)
- Pancreas(2.5)
- Adrenal gland(2.3)
- Bone(2.2)
- Eye(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for VCAN Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
Regions:
Head and neck:
- brain
- cranial nerve
- eye
- head
General:
- peripheral nervous system
Primer Products
-
OriGene qPCR primer pairs for VCAN
Gene Expression Assay Products
No data available for Protein tissue co-expression partners for VCAN Gene
Orthologs for VCAN Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | VCAN 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | VCAN 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | VCAN 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Vcan 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Vcan 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | VCAN 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | VCAN 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | VCAN 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | VCAN 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24776 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | vcanb 31 |
|
OneToOne | |
| -- 30 |
|
||||
| Worm (Caenorhabditis elegans) |
Secernentea | clec-149 31 |
|
OneToMany |
- Species where no ortholog for VCAN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for VCAN Gene
- ENSEMBL:
- Gene Tree for VCAN (if available)
- TreeFam:
- Gene Tree for VCAN (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for VCAN: view image
Paralogs for VCAN Gene
(18) SIMAP similar genes for VCAN Gene using alignment to 4 proteins:
- CSPG2_HUMAN
- D6RGZ6_HUMAN
- E9PF17_HUMAN
- Q86W61_HUMAN
Variants for VCAN Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VCAN Gene
| SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 713682 | Likely Benign: not provided | 83,540,815(+) | A/G | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 713909 | Benign: not provided | 83,537,765(+) | C/A | MISSENSE_VARIANT,INTRON_VARIANT | |
| 718741 | Benign: not provided | 83,540,459(+) | T/C | MISSENSE_VARIANT,INTRON_VARIANT | |
| 722705 | Benign: not provided | 83,580,059(+) | G/C | SYNONYMOUS_VARIANT | |
| 724226 | Likely Benign: not provided | 83,541,892(+) | C/G | SYNONYMOUS_VARIANT,INTRON_VARIANT |
Residual Variation Intolerance Score:
70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
14.03;
96.05% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VCAN Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VCAN Gene
Disorders for VCAN Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| wagner vitreoretinopathy |
|
|
| wagner syndrome |
|
|
| fundus dystrophy |
|
|
| inherited retinal disorder |
|
|
| vitreoretinopathy |
|
|
Search VCAN in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CSPG2_HUMAN- Wagner vitreoretinopathy (WGVRP) [MIM:143200]: A rare vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. {ECO:0000269 PubMed:16043844, ECO:0000269 PubMed:22739342}. Note=The disease is caused by mutations affecting the gene represented in this entry. The pathological mechanism involves a quantitative imbalance of the normally occurring splice variants (PubMed:22739342). {ECO:0000269 PubMed:22739342}.
Additional Disease Information for VCAN
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for VCAN Gene
Publications for VCAN Gene
- Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14). (PMID: 1478664) Iozzo RV … McPherson JD (Genomics 1992) 2 3 4 23
- Chondroitin sulfate proteoglycan 2 (CSPG2) gene polymorphisms rs173686 and rs251124 are not associated with intracranial aneurysms in Chinese Han nationality. (PMID: 18484070) Sun H … Zhao J (Upsala journal of medical sciences 2007) 3 23 41
- Identification of a novel splice site mutation of the CSPG2 gene in a Japanese family with Wagner syndrome. (PMID: 16043844) Miyamoto T … Itakura M (Investigative ophthalmology & visual science 2005) 3 4 23
- Versican/PG-M isoforms in vascular smooth muscle cells. (PMID: 10397680) Lemire JM … Wight TN (Arteriosclerosis, thrombosis, and vascular biology 1999) 3 4 23
- Differential expression of versican isoforms in brain tumors. (PMID: 8627343) Paulus W … Zimmermann DR (Journal of neuropathology and experimental neurology 1996) 3 4 23
ExternalLinks
Products for VCAN Gene
- View all 6 R&D Systems VCAN (Versican) Products
- View all R&D Systems VCAN (Versican) Proteins and Enzymes
- View all 3 R&D Systems VCAN (Versican) Primary Antibodies
- View all 2 R&D Systems VCAN (Versican) cDNA Clones
- Learn more about R&D Systems custom VCAN antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for VCAN
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- OriGene CRISPR knockouts for VCAN
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- RC222552
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- RC228691L3V
- RC228691L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for VCAN
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for VCAN
- Novus Biologicals proteins and lysates for VCAN
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- VectorBuilder Custom and pre-made DNA vectors for VCAN (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for VCAN (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for VCAN (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for VCAN CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for VCAN
- antibodies-online: Show 81 available Vcan Antibodies ranked by validation data
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- 77 WB Antibodies (anti-rat)
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- 5 IHC (p) Antibodies (anti-mouse)
- 3 IF Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- antibodies-online: Show 46 available Vcan Elisa Kits ranked by validation data
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- antibodies-online: Show 6 available Vcan Proteins ranked by validation data
- Compare Top Vcan Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for VCAN
- Search Santa Cruz Biotechnology (SCBT) for VCAN siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for VCAN
- Horizon Cell Lines for VCAN
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VCAN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VCAN
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- Boster Bio Antibodies for VCAN
- Browse Boster Bio ELISA Kits
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Sources for VCAN Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB