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This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
VCAN (Versican) is a Protein Coding gene. Diseases associated with VCAN include Wagner Vitreoretinopathy and Wagner Syndrome. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. Gene Ontology (GO) annotations related to this gene include calcium ion binding and extracellular matrix structural constituent. An important paralog of this gene is ACAN.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005509 | calcium ion binding | IEA | -- |
GO:0005515 | protein binding | IPI | 23601700 |
GO:0005539 | glycosaminoglycan binding | TAS | 7528742 |
GO:0005540 | hyaluronic acid binding | TAS,IEA | -- |
GO:0030021 | extracellular matrix structural constituent conferring compression resistance | RCA | 20551380 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001750 | photoreceptor outer segment | IEA | -- |
GO:0005576 | extracellular region | HDA,TAS | -- |
GO:0005615 | extracellular space | HDA | 20551380 |
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
GO:0005796 | Golgi lumen | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Chondroitin sulfate/dermatan sulfate metabolism | ||
2 | Integrin Pathway |
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
|
UPA-UPAR Pathway
.56
Inhibition of Angiogenesis by TSP1
.50
Transendothelial Migration of Leukocytes
.38
|
3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
4 | Glycosaminoglycan metabolism | ||
5 | Phospholipase-C Pathway |
Phospholipase-C Pathway
.56
|
PTEN Pathway
.56
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001501 | skeletal system development | IBA | 21873635 |
GO:0001649 | osteoblast differentiation | HDA | 16210410 |
GO:0007155 | cell adhesion | TAS,IEA | -- |
GO:0007275 | multicellular organism development | TAS | 2583089 |
GO:0007417 | central nervous system development | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Hyaluronic acid | Approved, Vet_approved | Pharma | Target, binder | 717 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
ExUns: | 18a | · | 18b | ^ | 19a | · | 19b | · | 19c | · | 19d |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||
SP2: | - | ||||||||||
SP3: | - | ||||||||||
SP4: | |||||||||||
SP5: | |||||||||||
SP6: | |||||||||||
SP7: | |||||||||||
SP8: | |||||||||||
SP9: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | VCAN 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | VCAN 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | VCAN 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Vcan 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Vcan 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | VCAN 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | VCAN 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | VCAN 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | VCAN 31 |
|
OneToOne | |
African clawed frog (Xenopus laevis) |
Amphibia | Xl.24776 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | vcanb 31 |
|
OneToOne | |
-- 30 |
|
||||
Worm (Caenorhabditis elegans) |
Secernentea | clec-149 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
713682 | Likely Benign: not provided | 83,540,815(+) | A/G | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
713909 | Benign: not provided | 83,537,765(+) | C/A | MISSENSE_VARIANT,INTRON_VARIANT | |
718741 | Benign: not provided | 83,540,459(+) | T/C | MISSENSE_VARIANT,INTRON_VARIANT | |
722705 | Benign: not provided | 83,580,059(+) | G/C | SYNONYMOUS_VARIANT | |
724226 | Likely Benign: not provided | 83,541,892(+) | C/G | SYNONYMOUS_VARIANT,INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
wagner vitreoretinopathy |
|
|
wagner syndrome |
|
|
fundus dystrophy |
|
|
inherited retinal disorder |
|
|
vitreoretinopathy |
|
|