Aliases for VCAN Gene
Aliases for VCAN Gene
External Ids for VCAN Gene
- HGNC: 2464
- Entrez Gene: 1462
- Ensembl: ENSG00000038427
- OMIM: 118661
- UniProtKB: P13611
Previous HGNC Symbols for VCAN Gene
- CSPG2
Previous GeneCards Identifiers for VCAN Gene
- GC05P082804
- GC05P077975
Summaries for VCAN Gene
-
This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
GeneCards Summary for VCAN Gene
VCAN (Versican) is a Protein Coding gene. Diseases associated with VCAN include Wagner Vitreoretinopathy and Wagner Syndrome. Among its related pathways are Glycosaminoglycan metabolism and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and extracellular matrix structural constituent. An important paralog of this gene is ACAN.
UniProtKB/Swiss-Prot for VCAN Gene
-
May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
Additional gene information for VCAN Gene
- Monarch Initiative
- Search for VCAN at DataMed
- Search for VCAN at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCAN Gene
Genomics for VCAN Gene
GeneHancer (GH) Regulatory Elements for VCAN Gene
Promoters and enhancers for VCAN Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH05I083470 | Promoter/Enhancer | 2.5 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 559.9 | +2.3 | 2288 | 6.4 | PKNOX1 FOXA2 SIN3A FEZF1 ZNF2 ZNF213 ZNF143 ZNF263 SP3 REST | VCAN TMEM167A VCAN-AS1 | |
| GH05I083368 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 15.7 | -102.7 | -102653 | 1.6 | ZNF146 PKNOX1 CEBPB JUNB BATF ATF2 ZNF217 IKZF1 HMBOX1 RUNX3 | VCAN TMEM167A XRCC4 LOC105379053 GC05P083318 | |
| GH05I083306 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE | 13.1 | -164.5 | -164489 | 1.4 | BACH1 EBF1 BMI1 BATF IRF4 RELA POLR2A NFATC1 ATF7 ETV6 | VCAN LOC105379052 TMEM167A XRCC4 GC05P083318 GC05M083273 | |
| GH05I083376 | Enhancer | 1.1 | FANTOM5 Ensembl ENCODE dbSUPER | 11.4 | -94.0 | -94001 | 2.3 | CEBPB FOS EP300 | VCAN TMEM167A XRCC4 LOC105379053 GC05P083318 | |
| GH05I083374 | Enhancer | 0.8 | FANTOM5 Ensembl dbSUPER | 9.6 | -96.5 | -96464 | 0.8 | CEBPB | VCAN TMEM167A LOC105379053 GC05P083318 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around VCAN on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for VCAN Gene
Genomic Locations for VCAN Gene
- chr5:83,471,465-83,582,303
- (GRCh38/hg38)
- Size:
- 110,839 bases
- Orientation:
- Plus strand
- chr5:82,767,284-82,878,122
- (GRCh37/hg19)
Genomic View for VCAN Gene
Genes around VCAN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q14.2 by Ensembl
- 5q14.2-q14.3 by Entrez Gene
- 5q14.2-q14.3 by HGNC
VCAN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VCAN Gene
Proteins for VCAN Gene
-
Protein details for VCAN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13611-CSPG2_HUMAN
- Recommended name:
- Versican core protein
- Protein Accession:
- P13611
- P20754
- Q13010
- Q13189
- Q15123
- Q9UCL9
- Q9UNW5
Protein attributes for VCAN Gene
- Size:
- 3396 amino acids
- Molecular mass:
- 372820 Da
- Quaternary structure:
-
- Interacts with FBLN1.
Protein Expression for VCAN Gene
Post-translational modifications for VCAN Gene
- Phosphorylated by FAM20C in the extracellular medium.
- Glycosylation at isoforms=2, 3, 4, 557, isoforms=2, 3, 4, 5330, isoforms=3, 5518, posLast=615615, posLast=632632, isoforms=3, 5642, isoforms=3, 5687, isoforms=3, 5716, isoforms=3, 5751, isoforms=3, 5782, isoforms=3, 5799, isoforms=3, 5801, posLast=809809, posLast=869869, posLast=886886, posLast=981981, isoforms=3, 51092, isoforms=3, 51103, isoforms=3, 51110, posLast=11161116, isoforms=3, 51133, posLast=11911191, isoforms=3, 51221, posLast=13321332, posLast=13981398, isoforms=2, 51418, isoforms=2, 51419, isoforms=2, 51442, isoforms=2, 51468, posLast=15661566, posLast=15691569, posLast=16631663, isoforms=2, 51719, posLast=17311731, posLast=17341734, posLast=17421742, posLast=17431743, posLast=17441744, posLast=17631763, isoforms=2, 51769, posLast=17721772, isoforms=2, 51777, posLast=18981898, posLast=19091909, posLast=19171917, posLast=19261926, isoforms=2, 51942, posLast=20362036, isoforms=2, 52058, posLast=20592059, posLast=20632063, posLast=20852085, posLast=21522152, posLast=21532153, posLast=21792179, posLast=21942194, isoforms=2, 52203, posLast=22722272, posLast=22802280, isoforms=2, 52360, isoforms=2, 52385, isoforms=2, 52392, posLast=24162416, posLast=24482448, posLast=24552455, posLast=24562456, posLast=24572457, isoforms=2, 52458, posLast=24732473, isoforms=2, 52496, isoforms=2, 52503, isoforms=2, 52515, posLast=25162516, isoforms=2, 52530, posLast=25312531, isoforms=2, 52540, posLast=26282628, isoforms=2, 52656, posLast=26612661, isoforms=2, 52699, isoforms=2, 52701, posLast=27842784, posLast=29342934, posLast=30253025, isoforms=2, 53029, posLast=30673067, posLast=33693369, and posLast=33793379
- Modification sites at PhosphoSitePlus
Other Protein References for VCAN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for VCAN (Versican)
-
Custom Antibody ServicesOriGene Antibodies for VCAN
- Novus Biologicals Antibodies for VCAN
-
Abcam antibodies for VCAN
-
Cloud-Clone Corp. Antibodies for VCAN
- Invitrogen Antibodies for VCAN
- antibodies-online: Search results for 133 available Vcan Antibodies ranked by validation data
- Compare Top Vcan Antibodies
-
Recommended
- 1 IF Antibody (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 81 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 53 WB Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 58 WB Antibodies (anti-rat)
- Search GeneTex for Antibodies for VCAN
-
Santa Cruz Biotechnology (SCBT) Antibodies for VCAN
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for VCAN
- Origene Custom Protein Services for VCAN
-
Cloud-Clone Corp. Proteins for VCAN
- Search GeneTex for Proteins for VCAN
-
Abcam proteins for VCAN
No data available for DME Specific Peptides for VCAN Gene
Domains & Families for VCAN Gene
Gene Families for VCAN Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for VCAN Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for VCAN Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P13611- Family:
-
- Belongs to the aggrecan/versican proteoglycan family.
Function for VCAN Gene
Molecular function for VCAN Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
Phenotypes From GWAS Catalog for VCAN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005201 | extracellular matrix structural constituent | IBA | -- |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 23601700 |
| GO:0005539 | glycosaminoglycan binding | TAS | 7528742 |
| GO:0005540 | hyaluronic acid binding | TAS,IBA | -- |
Phenotypes for VCAN Gene
- MGI mutant phenotypes for VCAN:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for VCAN:
Animal Models for VCAN Gene
- MGI Knock Outs for VCAN:
-
- Vcan tm1.1Dzim
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for VCAN
-
-
ViGene Biosciences lentiviral particle packaged cDNA for VCAN gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VCAN gene
- Search ViGene Biosciences for VCAN
CRISPR Products
-
OriGene CRISPR knockouts for VCAN
- genomics-online: gRNA clones - Search results for available Vcan gene related products
- Applied Biological Materials CRISPR for VCAN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VCAN
- GenScript: Design CRISPR guide RNA sequences for VCAN
miRNA for VCAN Gene
- miRTarBase miRNAs that target VCAN
-
- hsa-mir-545-3p (MIRT097548)
- hsa-mir-5197-3p (MIRT097550)
- hsa-mir-103a-3p (MIRT314708)
- hsa-mir-107 (MIRT314709)
- hsa-mir-218-5p (MIRT439309)
- hsa-mir-578 (MIRT546096)
- hsa-mir-3185 (MIRT546097)
- hsa-mir-643 (MIRT546098)
- hsa-mir-335-3p (MIRT651758)
- hsa-mir-4436b-5p (MIRT651759)
- hsa-mir-627-3p (MIRT651760)
- hsa-mir-6777-3p (MIRT651761)
- hsa-mir-5003-3p (MIRT651762)
- hsa-mir-23b-3p (MIRT735532)
- hsa-mir-129-5p (MIRT783635)
- hsa-mir-302c-5p (MIRT784456)
- hsa-mir-361-3p (MIRT784958)
- hsa-mir-3680-3p (MIRT785226)
- hsa-mir-450b-5p (MIRT786069)
- hsa-mir-4666b (MIRT786356)
- hsa-mir-5011-3p (MIRT787007)
- hsa-mir-507 (MIRT787050)
- hsa-mir-552-5p (MIRT787632)
- hsa-mir-557 (MIRT787659)
miRNA Products
- Search ViGene Biosciences for VCAN
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for VCAN
- Browse OriGene Inhibitory RNA Products For VCAN
- genomics-online: shRNA clones - Search results for available Vcan gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for VCAN gene
Clone Products
-
OriGene ORF clones in human for VCAN
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for VCAN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VCAN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available Vcan gene related products
- orf clones - Search results for available Vcan gene related products
- Applied Biological Materials Clones for VCAN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for VCAN
-
ViGene Biosciences adenoviral particle packaged cDNA for VCAN gene
-
ViGene Biosciences lentiviral particle packaged cDNA for VCAN gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VCAN gene
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for VCAN Gene
Localization for VCAN Gene
Subcellular locations from UniProtKB/Swiss-Prot for VCAN Gene
- Secreted, extracellular space, extracellular matrix.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| lysosome | 4 |
| golgi apparatus | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS,IDA | -- |
| GO:0005578 | proteinaceous extracellular matrix | TAS,IBA | -- |
| GO:0005615 | extracellular space | IDA | 20551380 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0005796 | Golgi lumen | TAS | -- |
Pathways & Interactions for VCAN Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chondroitin sulfate/dermatan sulfate metabolism | ||
| 2 | Integrin Pathway |
.67
.67
.56
|
.56
|
| 3 | ERK Signaling |
.61
.58
|
.49
|
| 4 | Glycosaminoglycan metabolism | ||
| 5 | Phospholipase-C Pathway |
.56
|
|
Pathways by source for VCAN Gene
3 BioSystems pathways for VCAN Gene
20 Reactome pathways for VCAN Gene
1 KEGG pathway for VCAN Gene
2 GeneGo (Thomson Reuters) pathways for VCAN Gene
13 Qiagen pathways for VCAN Gene
Interacting Proteins for VCAN Gene
Selected Interacting proteins:
P13611-CSPG2_HUMAN
ENSP00000265077
for VCAN Gene via
IID
STRING
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | IBA | -- |
| GO:0001649 | osteoblast differentiation | IDA,HDA | 16210410 |
| GO:0007155 | cell adhesion | IEA,TAS | -- |
| GO:0007275 | multicellular organism development | TAS | 2583089 |
| GO:0007417 | central nervous system development | IBA | -- |
No data available for SIGNOR curated interactions for VCAN Gene
Drugs & Compounds for VCAN Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Hyaluronic acid | Approved, Vet_approved | Pharma | Target, binder | 535 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for VCAN Gene
mRNA/cDNA for VCAN Gene
- (4) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (485) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for VCAN
- genomics-online: gRNA clones - Search results for available Vcan gene related products
- Applied Biological Materials CRISPR for VCAN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VCAN
- GenScript: Design CRISPR guide RNA sequences for VCAN
miRNA Products
- Search ViGene Biosciences for VCAN
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for VCAN
- Browse OriGene Inhibitory RNA Products For VCAN
- genomics-online: shRNA clones - Search results for available Vcan gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for VCAN gene
Clone Products
-
OriGene ORF clones in human for VCAN
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for VCAN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VCAN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available Vcan gene related products
- orf clones - Search results for available Vcan gene related products
- Applied Biological Materials Clones for VCAN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 18a | · | 18b | ^ | 19a | · | 19b | · | 19c | · | 19d |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||
| SP2: | - | ||||||||||
| SP3: | - | ||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: | |||||||||||
| SP9: |
Expression for VCAN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Cartilage (Muscoskeletal System)
- Paraxial Mesoderm (Gastrulation Derivatives)
-
Heart (Cardiovascular System)
- Cardiomyocytes Outflow Tract
- Atrioventricular Valve Cells Atrioventricular Valves
- Bone (Muscoskeletal System)
- Lateral Plate Mesoderm (Gastrulation Derivatives)
- Neural Crest (Gastrulation Derivatives)
mRNA differential expression in normal tissues according to GTEx for VCAN Gene
This gene is overexpressed in Artery - Aorta (x8.3), Artery - Coronary (x7.4), and Whole Blood (x6.5).
This gene is overexpressed in Amniocyte (16.9), Spinal cord (10.1), Frontal cortex (8.4), and Brain (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VCAN Gene
NURSA nuclear receptor signaling pathways regulating expression of VCAN Gene:
VCANSOURCE GeneReport for Unigene cluster for VCAN Gene:
Hs.643801mRNA Expression by UniProt/SwissProt for VCAN Gene:
P13611-CSPG2_HUMAN
Tissue specificity:
Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas.
Evidence on tissue expression from TISSUES for VCAN Gene
- Nervous system(4.9)
- Lung(4.6)
- Muscle(4.6)
- Liver(4.2)
- Heart(3.2)
- Kidney(2.9)
- Blood(2.5)
- Intestine(2.5)
- Spleen(2.5)
- Skin(2.4)
- Lymph node(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for VCAN Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
Regions:
Head and neck:
- brain
- cranial nerve
- eye
- head
General:
- peripheral nervous system
Primer Products
-
OriGene qPCR primer pairs for VCAN
- genomics-online: primer clones - Search results for available Vcan gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners for VCAN Gene
Orthologs for VCAN Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | VCAN 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | VCAN 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | VCAN 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Vcan 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Vcan 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | VCAN 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | VCAN 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | VCAN 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | VCAN 34 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24776 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | vcanb 34 |
|
OneToOne | |
| -- 33 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | clec-149 34 |
|
OneToMany |
- Species where no ortholog for VCAN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for VCAN Gene
Paralogs for VCAN Gene
(18) SIMAP similar genes for VCAN Gene using alignment to 4 proteins:
Variants for VCAN Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs10233 | benign, Wagner syndrome, Vitreoretinopathy | 83,582,037(+) | T/C | 3_prime_UTR_variant | |
| rs1039368689 | uncertain-significance, Vitreoretinopathy, Wagner syndrome | 83,581,842(+) | G/A | 3_prime_UTR_variant | |
| rs10411 | benign, Wagner syndrome, Vitreoretinopathy | 83,582,112(+) | G/T | 3_prime_UTR_variant | |
| rs1046691278 | uncertain-significance, Vitreoretinopathy, Wagner syndrome | 83,471,955(+) | A/G | 5_prime_UTR_variant | |
| rs1050948 | benign, Wagner syndrome, Vitreoretinopathy | 83,582,035(+) | T/A | 3_prime_UTR_variant |
Residual Variation Intolerance Score:
70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
14.03;
96.05% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VCAN Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VCAN Gene
Disorders for VCAN Gene
(11) MalaCards diseases for VCAN Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| wagner vitreoretinopathy |
|
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| wagner syndrome |
|
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| vitreous syneresis |
|
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| tendinopathy |
|
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| odontogenic myxoma |
|
|
Search VCAN in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CSPG2_HUMAN- Wagner vitreoretinopathy (WGVRP) [MIM:143200]: A rare vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. {ECO:0000269 PubMed:16043844, ECO:0000269 PubMed:22739342}. Note=The disease is caused by mutations affecting the gene represented in this entry. The pathological mechanism involves a quantitave imbalance of the normally occurring splice variants (PubMed:22739342). {ECO:0000269 PubMed:22739342}.
Additional Disease Information for VCAN
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for VCAN Gene
Publications for VCAN Gene
- Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14). (PMID: 1478664) Iozzo RV … McPherson JD (Genomics 1992) 2 3 4 22 58
- Chondroitin sulfate proteoglycan 2 (CSPG2) gene polymorphisms rs173686 and rs251124 are not associated with intracranial aneurysms in Chinese Han nationality. (PMID: 18484070) Sun H … Zhao J (Upsala journal of medical sciences 2007) 3 22 44 58
- Identification of a novel splice site mutation of the CSPG2 gene in a Japanese family with Wagner syndrome. (PMID: 16043844) Miyamoto T … Itakura M (Investigative ophthalmology & visual science 2005) 3 4 22 58
- Versican/PG-M isoforms in vascular smooth muscle cells. (PMID: 10397680) Lemire JM … Wight TN (Arteriosclerosis, thrombosis, and vascular biology 1999) 3 4 22 58
- Differential expression of versican isoforms in brain tumors. (PMID: 8627343) Paulus W … Zimmermann DR (Journal of neuropathology and experimental neurology 1996) 3 4 22 58
Products for VCAN Gene
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- Mammalian expression: PiggyBac
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- antibodies-online: Search results for 133 available Vcan Antibodies ranked by validation data
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Sources for VCAN Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
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- (68) Cloud-Clone Corp.
- (69) OCA
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- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
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