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This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different iso... See more...
Aliases for VCAM1 Gene
Aliases for VCAM1 Gene
External Ids for VCAM1 Gene
- HGNC: 12663
- Entrez Gene: 7412
- Ensembl: ENSG00000162692
- OMIM: 192225
- UniProtKB: P19320
Previous GeneCards Identifiers for VCAM1 Gene
- GC01P101976
- GC01P100366
- GC01P100476
- GC01P100648
- GC01P100897
- GC01P101185
- GC01P099309
Summaries for VCAM1 Gene
-
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for VCAM1 Gene
VCAM1 (Vascular Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with VCAM1 include Viral Encephalitis and Chronic Venous Insufficiency. Among its related pathways are Degradation of the extracellular matrix and Cellular roles of Anthrax toxin. Gene Ontology (GO) annotations related to this gene include integrin binding and primary amine oxidase activity. An important paralog of this gene is MXRA5.
UniProtKB/Swiss-Prot Summary for VCAM1 Gene
-
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Additional gene information for VCAM1 Gene
- HGNC(12663)
- Entrez Gene(7412)
- Ensembl(ENSG00000162692)
- OMIM(192225)
- UniProtKB(P19320)
- Open Targets Platform(ENSG00000162692)
- Monarch Initiative
- Search for VCAM1 at DataMed
- Search for VCAM1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VCAM1 Gene
Genomics for VCAM1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for VCAM1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around VCAM1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VCAM1
- Top Transcription factor binding sites by QIAGEN in the VCAM1 gene promoter:
-
- CREB
- deltaCREB
- IRF-1
- PPAR-gamma2
- STAT1
Genomic Locations for VCAM1 Gene
Genomic Locations for VCAM1 Gene
- chr1:100,719,640-100,739,045
- (GRCh38/hg38)
- Size:
- 19,406 bases
- Orientation:
- Plus strand
- chr1:101,185,196-101,204,601
- (GRCh37/hg19)
- Size:
- 19,406 bases
- Orientation:
- Plus strand
Genomic View for VCAM1 Gene
Genes around VCAM1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p21.2 by HGNC
- 1p21.2 by Entrez Gene
- 1p21.2 by Ensembl
VCAM1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VCAM1 Gene
Proteins for VCAM1 Gene
-
Protein details for VCAM1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P19320-VCAM1_HUMAN
- Recommended name:
- Vascular cell adhesion protein 1
- Protein Accession:
- P19320
- A8K6R7
- B4DKS4
- E9PDD1
- Q6NUP8
Protein attributes for VCAM1 Gene
- Size:
- 739 amino acids
- Molecular mass:
- 81276 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- [Isoform 1]: Major isoform.
Protein Expression for VCAM1 Gene
Post-translational modifications for VCAM1 Gene
Other Protein References for VCAM1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences VCAM1 / CD106 Monoclonal Antibody and VCAM1 / CD106 Antibody
- G Biosciences Immunotag™ VCAM-1 Monoclonal Antibody and Immunotag™ VCAM1 Antibody
- NSJ Bioreagents VCAM1 Antibody (Mouse Monoclonal)
- Creative Diagnostics Anti-VCAM1 monoclonal antibody, clone 5F9
-
Creative Biolabs
- Recombinant Anti-Human VCAM1 Antibody
- Recombinant Anti-Human VCAM1 VHH Single Domain Antibody
- Mouse Anti-VCAM1 Recombinant Antibody (4B9)
- Mouse Anti-VCAM1 Recombinant Antibody (CBYY-1365)
- Recombinant Mouse Anti-VCAM1 Antibody (M/K-2)
- Mouse Anti-VCAM1 Recombinant Antibody (CBYY-1332)
- Mouse Anti-VCAM1 Recombinant Antibody (CBYY-1349)
- Rabbit Anti-VCAM1 Recombinant Antibody (CBYY-1356)
- Sheep Anti-VCAM1 (AA 25-698) Recombinant Antibody (CBFYC-3222)
- Mouse Anti-VCAM1 Recombinant Antibody (CBYY-1340)
- Anti-Human VCAM1 Therapeutic Antibody (1-1)
- Mouse Anti-VCAM1 Recombinant Antibody (3H1814)
- Mouse Anti-VCAM1 Recombinant Antibody (B-N8)
- Mouse Anti-VCAM1 Recombinant Antibody (10B534)
- Recombinant Human Anti-VCAM1 Antibody scFv Fragment (7H)
- Recombinant Human Anti-VCAM1 Antibody Fab Fragment (AP003)
- Recombinant Mouse Anti-VCAM1 Antibody Fab Fragment (4B)
- Recombinant Mouse Anti-VCAM1 Antibody (4B)
- Recombinant Human Anti-VCAM1 Antibody (AP001)
- Recombinant Human Anti-VCAM1 Antibody scFv Fragment (7C)
- Recombinant Human Anti-VCAM1 Antibody (7H)
- Recombinant Rabbit Anti-VCAM1 Monoclonal Antibody (CBACN-576)
-
Custom Antibody ServicesOriGene Antibodies for VCAM1
- AM05549PU-N
- AM05549RP-N
- AM05557PU-L
- AM05557PU-N
- AM05557RP-N
- AM06443SU-N
- AM26158BT-N
- AM26158PU-N
- AM26309PU-N
- AM26718PU-N
- AM31190AF-N
- AM33018PU-N
- AP22317BT-N
- AP22317BT-S
- AP22317PU-N
- AP22317PU-S
- AP32710PU-N
- AP50835PU-N
- CF502360
- CF502361
- CF502390
- CF502391
- CF502392
- CF502411
- CF502426
- SM051B
- SM051BX
- SM1178F
- SM1178FT
- SM1178P
- SM178PT
- TA320510
- TA320511
- TA326818
- TA328468
- TA328469
- TA336775
- TA350599
- TA502360
- TA502360S
- TA502361
- TA502361S
- TA502390
- TA502390S
- TA502391
- TA502391S
- TA502392
- TA502392S
- TA502411
- TA502411S
- TA502426
- TA502426S
- TA590413
- TA590414
- TA590416
- TA600239
- TA600240
- TA700239
- Novus Biologicals Antibodies for VCAM1
-
Abcam antibodies for VCAM1
- Invitrogen Antibodies for VCAM1 (AFLGC-VCAM1)
- antibodies-online: Show 202 available VCAM1 Antibodies ranked by validation data
- Compare Top VCAM1 Antibodies
-
Recommended
- 205 WB Antibodies (anti-human)
- 77 FACS Antibodies (anti-human)
- 42 IHC (f) Antibodies (anti-human)
- 38 IHC (p) Antibodies (anti-human)
- 33 IF Antibodies (anti-human)
- 30 IP Antibodies (anti-human)
- 24 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC (fro) Antibodies (anti-human)
- 3 IF/ICC Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 LMNX Antibody (anti-human)
- 1 Purif Antibody (anti-human)
- 71 FACS Antibodies (anti-mouse)
- 51 WB Antibodies (anti-mouse)
- 47 IHC Antibodies (anti-mouse)
- 23 IHC (fro) Antibodies (anti-mouse)
- 22 IF (p) Antibodies (anti-mouse)
- 9 IP Antibodies (anti-mouse)
- 3 IF Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 1 Neut Antibody (anti-mouse)
- 47 WB Antibodies (anti-rat)
- 22 IF (p) Antibodies (anti-rat)
- 16 FACS Antibodies (anti-rat)
- 8 IHC Antibodies (anti-rat)
- 6 IHC (fro) Antibodies (anti-rat)
- 2 IF Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for VCAM1
- Sino Biological Antibodies for VCAM1
Protein Products
- G Biosciences Human CD106/VCAM-1/L1CAM, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for VCAM1
- Origene Custom Protein Services for VCAM1
- Sino Biological Cell Lysates for VCAM1
- Sino Biological Recombinant Proteins for VCAM1
- ProSpec Recombinant Proteins for VCAM1
-
Abcam proteins for VCAM1
Assay Products
- RayBiotech Human VCAM-1 ELISA
- Novus Biologicals ELISA Kits for VCAM1
- antibodies-online: Show 133 available VCAM1 Elisa Kits ranked by validation data
- Compare Top VCAM1 Elisa Kits
-
Quality Products:
- ABIN366645
- ABIN411367
- ABIN625106
- ABIN415056
- ABIN2472087
- ABIN5520087
- ABIN1888493
- ABIN2708111
- ABIN2708112
- ABIN6720121
- ABIN367720
- ABIN6730930
- ABIN411368
- ABIN625185
- ABIN2685865
- ABIN415638
- ABIN492061
- ABIN3032849
- ABIN1117771
- ABIN1888494
- ABIN416388
- ABIN1117770
- ABIN368144
- ABIN579233
- ABIN1573025
- ABIN772608
- ABIN5670384
- ABIN5591769
- ABIN5659840
- ABIN6254320
- ABIN1059756
- ABIN2540288
- ABIN6202395
- ABIN6202394
-
Abcam assays for VCAM1
- Sino Biological Assays for VCAM1
No data available for DME Specific Peptides for VCAM1 Gene
Domains & Families for VCAM1 Gene
Gene Families for VCAM1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Plasma proteins
- Predicted membrane proteins
Protein Domains for VCAM1 Gene
- InterPro:
- Blocks:
-
- Immunoglobulin C-2 type
- Immunoglobulin V-set
- Immunoglobulin I-set
- T-cell surface antigen CD2
- Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
- Vascular cell adhesion molecule-1 (VCAM-1) signature
- ProtoNet:
Suggested Antigen Peptide Sequences for VCAM1 Gene
- GenScript: Design optimal peptide antigens:
-
- Vascular cell adhesion molecule 1 (F2YYR6_HUMAN)
- Vascular cell adhesion molecule 1 (F8UU18_HUMAN)
- Vascular cell adhesion molecule 1 (F8UV74_HUMAN)
- INCAM-100 (VCAM1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P19320UniProtKB/Swiss-Prot:
VCAM1_HUMAN :- Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
- Domain:
-
- Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
Function for VCAM1 Gene
Molecular function for VCAM1 Gene
- UniProtKB/Swiss-Prot Function:
- Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
- UniProtKB/Swiss-Prot Induction:
- By cytokines (e.g. IL-1, TNF-alpha).
- GENATLAS Biochemistry:
- cell adhesion molecule,vascular 1,with alternative splicing forms,ligand for ITGA4 (VLA4A),endothelial sialoglycoprotein
Phenotypes From GWAS Catalog for VCAM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005178 | integrin binding | IDA,IMP | 19738201 |
| GO:0008131 | primary amine oxidase activity | IDA | 23474851 |
| GO:0050839 | cell adhesion molecule binding | IPI | 12082081 |
Phenotypes for VCAM1 Gene
- MGI mutant phenotypes for VCAM1:
- inferred from 8 alleles
- GenomeRNAi human phenotypes for VCAM1:
Animal Models for VCAM1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for VCAM1 - Select products 50% OFF >
- * VCAM1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for VCAM1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VCAM1
-
Santa Cruz Biotechnology (SCBT) CRISPR for VCAM1
miRNA for VCAM1 Gene
- miRTarBase miRNAs that target VCAM1
-
- dre-miR-126a-3p (MIRT002100)
- hsa-miR-200a-3p (MIRT004007)
- hsa-miR-126-3p (MIRT004081)
- mmu-miR-340-5p (MIRT010407)
- hsa-miR-155-5p (MIRT020917)
- bta-miR-145 (MIRT053908)
- bta-miR-181a (MIRT053974)
- hsa-miR-23c (MIRT504350)
- hsa-miR-23b-3p (MIRT504351)
- hsa-miR-23a-3p (MIRT504352)
- hsa-miR-130a-5p (MIRT504353)
- hsa-miR-190a-3p (MIRT504354)
- hsa-miR-6074 (MIRT504355)
- hsa-miR-5011-5p (MIRT504356)
- hsa-miR-1277-5p (MIRT504357)
- hsa-miR-6516-5p (MIRT533248)
- hsa-miR-4677-5p (MIRT533249)
- hsa-miR-3678-3p (MIRT533250)
- hsa-miR-1273h-3p (MIRT533251)
- hsa-miR-6844 (MIRT533252)
- hsa-miR-22-5p (MIRT533253)
- hsa-miR-2116-5p (MIRT533254)
- hsa-miR-2467-3p (MIRT533255)
- hsa-miR-96-3p (MIRT533256)
- hsa-miR-5694 (MIRT533257)
- hsa-miR-6856-3p (MIRT533258)
- hsa-miR-186-5p (MIRT533259)
- hsa-miR-5092 (MIRT610905)
- hsa-miR-519d-5p (MIRT619598)
- hsa-miR-3145-5p (MIRT619599)
- hsa-miR-548x-3p (MIRT635473)
- hsa-miR-548j-3p (MIRT635474)
- hsa-miR-548aq-3p (MIRT635475)
- hsa-miR-548am-3p (MIRT635476)
- hsa-miR-548aj-3p (MIRT635477)
- hsa-miR-548ah-3p (MIRT635478)
- hsa-miR-548ae-3p (MIRT635479)
- hsa-miR-7110-3p (MIRT707380)
- hsa-miR-6845-3p (MIRT707381)
- hsa-miR-136-5p (MIRT707382)
- hsa-miR-6769b-3p (MIRT707383)
- hsa-miR-4723-3p (MIRT707384)
- hsa-miR-3183 (MIRT707385)
- hsa-miR-3127-5p (MIRT715352)
- hsa-miR-3691-3p (MIRT715353)
- hsa-miR-6754-5p (MIRT715354)
- hsa-miR-4441 (MIRT715355)
- hsa-miR-4270 (MIRT715356)
- hsa-miR-211-3p (MIRT715357)
- hsa-miR-506-5p (MIRT715358)
- hsa-miR-181b-5p (MIRT715359)
- hsa-miR-4262 (MIRT715360)
- hsa-miR-181d-5p (MIRT715361)
- hsa-miR-181c-5p (MIRT715362)
- hsa-miR-181a-5p (MIRT715363)
- hsa-miR-1247-3p (MIRT761590)
- hsa-miR-1273e (MIRT761880)
- hsa-miR-15a-3p (MIRT762922)
- hsa-miR-1827 (MIRT763148)
- hsa-miR-1910-3p (MIRT763364)
- hsa-miR-219b-3p (MIRT763927)
- hsa-miR-302f (MIRT764534)
- hsa-miR-3612 (MIRT765966)
- hsa-miR-377-5p (MIRT767499)
- hsa-miR-3929 (MIRT767821)
- hsa-miR-4252 (MIRT768066)
- hsa-miR-4257 (MIRT768187)
- hsa-miR-4419b (MIRT768817)
- hsa-miR-4433a-3p (MIRT769055)
- hsa-miR-4459 (MIRT769374)
- hsa-miR-4478 (MIRT769568)
- hsa-miR-4529-5p (MIRT770060)
- hsa-miR-455-3p (MIRT770463)
- hsa-miR-4649-3p (MIRT770691)
- hsa-miR-4683 (MIRT770963)
- hsa-miR-4722-5p (MIRT771604)
- hsa-miR-4768-3p (MIRT772159)
- hsa-miR-485-5p (MIRT772661)
- hsa-miR-6086 (MIRT775629)
- hsa-miR-6499-3p (MIRT776408)
- hsa-miR-650 (MIRT776724)
- hsa-miR-6511a-5p (MIRT776863)
- hsa-miR-665 (MIRT777643)
- hsa-miR-6807-5p (MIRT779629)
- hsa-miR-6808-5p (MIRT779734)
- hsa-miR-6884-5p (MIRT781049)
- hsa-miR-6888-5p (MIRT781114)
- hsa-miR-6893-5p (MIRT781266)
- hsa-miR-7160-5p (MIRT781654)
- hsa-miR-940 (MIRT782959)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VCAM1
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Clone Products
- Applied Biological Materials (abm): Clones for VCAM1 - Select products 50% OFF >
- * VCAM1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG227630
- MR227630
- MR227630L1
- MR227630L2
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- MR227630L4
- RC209761
- RC209761L1
- RC209761L2
- RC209761L3
- RC209761L4
- RC213353
- RC213353L3
- RC213353L4
- RC234695
- RG209761
- RG213353
- RG234695
- RR207807
- RR207807L3
- RR207807L4
- MR227630L1V
- MR227630L2V
- MR227630L3V
- MR227630L4V
- RC209761L1V
- RC209761L2V
- RC209761L3V
- RC209761L4V
- RC213353L3V
- RC213353L4V
- RR207807L3V
- RR207807L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for VCAM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VCAM1
Cell Line Products
- ESI BIO PureStem Z11, Meso Progenitor and PureStem ES-209, Meso-prx/latp Progenitor for VCAM1
-
Horizon Cell Lines for VCAM1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VCAM1 Gene
Localization for VCAM1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for VCAM1 Gene
- Membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| endoplasmic reticulum | 5 |
| endosome | 5 |
| golgi apparatus | 5 |
| mitochondrion | 3 |
| peroxisome | 3 |
| nucleus | 3 |
| cytosol | 3 |
| lysosome | 2 |
- Cell Junctions (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002102 | podosome | IDA | 15220135 |
| GO:0005615 | extracellular space | IDA | 9290466 |
| GO:0005769 | early endosome | IDA | 23474851 |
| GO:0005783 | endoplasmic reticulum | IDA | 23474851 |
| GO:0005794 | Golgi apparatus | IDA | 23474851 |
Pathways & Interactions for VCAM1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling | ||
| 2 | Cytokine Signaling in Immune system | ||
| 3 | Interferon gamma signaling | ||
| 4 | Photodynamic therapy-induced NF-kB survival signaling |
Immune response MIF-mediated glucocorticoid regulation
.31
|
|
| 5 | Paxillin-dependent events mediated by a4b1 | ||
Pathways by source for VCAM1 Gene
7 BioSystems pathways for VCAM1 Gene
10 Reactome pathways for VCAM1 Gene
8 KEGG pathways for VCAM1 Gene
4 GeneGo (Thomson Reuters) pathways for VCAM1 Gene
- Apoptosis and survival Lymphotoxin-beta receptor signaling
- Development VEGF signaling and activation
- Immune response MIF-mediated glucocorticoid regulation
- Immune response_Role of integrins in NK cells cytotoxicity
5 R&D Systems pathways for VCAM1 Gene
- Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling
- Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling
- Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers
- IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types
- Mesenchymal Stem Cells and Lineage-specific Markers
3 Qiagen pathways for VCAM1 Gene
- LDL Oxidation in Atherogenesis
- Renin-Angiotensin Pathway
- Transendothelial Migration of Leukocytes
2 Cell Signaling Technology pathways for VCAM1 Gene
Interacting Proteins for VCAM1 Gene
GPS-Prot Interaction Network for VCAM1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | IEA,IDA | 16809613 |
| GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | IDA | 1715889 |
| GO:0007159 | leukocyte cell-cell adhesion | IDA | 1381355 |
| GO:0007160 | cell-matrix adhesion | IDA | 18308860 |
| GO:0009308 | amine metabolic process | IDA | 23474851 |
No data available for SIGNOR curated interactions for VCAM1 Gene
Drugs & Compounds for VCAM1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ethanol | Approved | Pharma | Target | 3266 | ||
| Carvedilol | Approved, Investigational | Pharma | Antagonist, Target, inhibitor | 199 | ||
| Clove oil | Approved | Nutra | Target, antagonist | 0 | ||
| Succinobucol | Investigational | Pharma | Target | 0 | ||
| AGI-1067, SUCCINOBUCOL | Pharma | 0 |
Transcripts for VCAM1 Gene
mRNA/cDNA for VCAM1 Gene
- 3 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000294728 3101 nts (view in UCSC)
- ENST00000347652 2812 nts (view in UCSC)
- ENST00000370115 2475 nts (view in UCSC)
- ENST00000370119 2483 nts (view in UCSC)
- ENST00000603679 3865 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for VCAM1 - Select products 50% OFF >
- * VCAM1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for VCAM1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VCAM1
-
Santa Cruz Biotechnology (SCBT) CRISPR for VCAM1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VCAM1
- Browse OriGene Inhibitory RNA Products For VCAM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VCAM1
Clone Products
- Applied Biological Materials (abm): Clones for VCAM1 - Select products 50% OFF >
- * VCAM1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG227630
- MR227630
- MR227630L1
- MR227630L2
- MR227630L3
- MR227630L4
- RC209761
- RC209761L1
- RC209761L2
- RC209761L3
- RC209761L4
- RC213353
- RC213353L3
- RC213353L4
- RC234695
- RG209761
- RG213353
- RG234695
- RR207807
- RR207807L3
- RR207807L4
- MR227630L1V
- MR227630L2V
- MR227630L3V
- MR227630L4V
- RC209761L1V
- RC209761L2V
- RC209761L3V
- RC209761L4V
- RC213353L3V
- RC213353L4V
- RR207807L3V
- RR207807L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for VCAM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VCAM1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for VCAM1 Gene
- GeneLoc Exon Structure for
- VCAM1
Expression for VCAM1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Mesenchymal Stem Cells
- Mesenchymal Stem Cells Zeugopod Periosteum
- Bone Marrow Stromal Cells Pelvic Girdle
- Adventitial Reticular Cells Bone Marrow
- Bone Marrow Stromal Cells Bone Marrow
- Bone marrow-derived mesenchymal stem cells
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
- Epicardial Progenitors Cells Epicardium
- Proepicardial Progenitor cells Proepicardium
- Cardiomyocytes Myocardium
- Left Ventricle
-
Bone (Muscoskeletal System)
- Mesenchymal Stem Cells Zeugopod Periosteum
- Adventitial Reticular Cells Bone Marrow
- Bone Marrow Stromal Cells Bone Marrow
- Bone marrow-derived mesenchymal stem cells
- Bone marrow-derived mesenchymal stem cells (family)
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Satellite Cells Sacral Muscle Satellite Pool
- Muscle Satellite Cells Thoracic Muscle Satellite Pool
- Muscle Satellite Cells Cervical Muscle Satellite Pool
- Muscle Satellite Cells Lumbar Muscle Satellite Pool
- Myoblasts Mandibular Arch Muscles
- Brain (Nervous System)
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
- Renal Vesicle
- Parietal epithelial cells (PEC)
- Epithelial Cells
- Placenta (Extraembryonic Tissues)
- Umbilical Cord (Extraembryonic Tissues)
-
Cartilage (Muscoskeletal System)
- Mesenchymal Stem Cells Zeugopod Periosteum
- Bone Marrow Stromal Cells Bone Marrow
-
Adipose (Muscoskeletal System)
- Stromal Cells Subcutaneous White Adipose
- White adipocyte-like cells(Ahfeldt T et. al. 2012)
-
Testis (Reproductive System)
- Perivascular Cells Testis Interstitium
- Sertoli cells Seminiferous Tubules
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Proepicardial Progenitor cells Proepicardium
- Pericytes Splanchnic Mesoderm
- Glial Cells
- Blood (Hematopoietic System)
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Gonad
- Perivascular Cells Testis Interstitium
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
- Hair
- Ovary (Reproductive System)
- NULL (Uncategorized)
- Spinal Cord (Nervous System)
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for VCAM1 Gene
This gene is overexpressed in Spleen (x15.9), Adrenal Gland (x4.2), and Kidney - Cortex (x4.0).
This gene is overexpressed in Serum (45.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VCAM1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VCAM1
SOURCE GeneReport for Unigene cluster for VCAM1 Gene:
Hs.109225mRNA Expression by UniProt/SwissProt for VCAM1 Gene:
P19320-VCAM1_HUMAN
Tissue specificity:
Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
Evidence on tissue expression from TISSUES for VCAM1 Gene
- Heart(4.8)
- Bone marrow(4.7)
- Eye(4.6)
- Spleen(4.1)
- Blood(3.8)
- Kidney(3.8)
- Lymph node(3.6)
- Nervous system(3.6)
- Liver(3.6)
- Muscle(3.5)
- Lung(3.4)
- Intestine(3.3)
- Skin(2.9)
- Bone(2.7)
- Adrenal gland(2.7)
- Pancreas(2.6)
- Stomach(2.5)
- Urine(2.3)
- Gall bladder(2.1)
- Thyroid gland(2.1)
Primer Products
-
OriGene qPCR primer pairs for VCAM1
-
OriGene qPCR primer pairs and template standards for VCAM1
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VCAM1 Gene
Orthologs for VCAM1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | VCAM1 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | VCAM1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LOC534578 30 |
|
||
| VCAM1 31 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Vcam1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Vcam1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | VCAM1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | VCAM1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | VCAM1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | VCAM1 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | vcam1 30 31 |
|
OneToOne |
- Species where no ortholog for VCAM1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for VCAM1 Gene
- ENSEMBL:
- Gene Tree for VCAM1 (if available)
- TreeFam:
- Gene Tree for VCAM1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for VCAM1: view image
Paralogs for VCAM1 Gene
Paralogs for VCAM1 Gene
(1) SIMAP similar genes for VCAM1 Gene using alignment to 7 proteins:
- VCAM1_HUMAN
- E9PDD2_HUMAN
- F2YYR6_HUMAN
- F8UU18_HUMAN
- F8UV74_HUMAN
- G0ZFQ0_HUMAN
- G0ZI12_HUMAN
Variants for VCAM1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VCAM1 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 713843 | Likely Benign: not provided | 100,720,528(+) | T/C | SYNONYMOUS_VARIANT | |
| 731914 | Likely Benign: not provided | 100,724,703(+) | C/T | SYNONYMOUS_VARIANT | |
| 735674 | Likely Benign: not provided | 100,723,011(+) | C/T | INTRON_VARIANT | |
| 769518 | Benign: not provided | 100,731,456(+) | A/G | MISSENSE_VARIANT | |
| rs34100871 | - | p.Val421Ile |
Residual Variation Intolerance Score:
30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.25;
62.41% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VCAM1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VCAM1 Gene
Disorders for VCAM1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| viral encephalitis |
|
|
| chronic venous insufficiency |
|
|
| leukostasis |
|
|
| acute chest syndrome |
|
|
| arteriosclerosis obliterans |
|
Search VCAM1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for VCAM1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for VCAM1 Gene
Publications for VCAM1 Gene
- Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. (PMID: 12871600) Adams GT … Kutlar A (BMC medical genetics 2003) 3 23 41
- Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution. (PMID: 7531291) Jones EY … Stuart DI (Nature 1995) 3 4 23
- Alternative splicing of human VCAM-1 in activated vascular endothelium. (PMID: 1707234) Cybulsky MI … Collins T (The American journal of pathology 1991) 3 4 23
- Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 41
- Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-kappaB p65. (PMID: 20164172) Shimada H … Rajagopalan LE (The Journal of biological chemistry 2010) 3 23
ExternalLinks
Products for VCAM1 Gene
- View all 37 R&D Systems VCAM1 (VCAM-1/CD106) Products
- View all 4 R&D Systems VCAM1 (VCAM-1/CD106) Proteins and Enzymes
- View all 23 R&D Systems VCAM1 (VCAM-1/CD106) Primary Antibodies
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- View all R&D Systems VCAM1 (VCAM-1/CD106) cDNA Clones
- Learn more about R&D Systems custom VCAM1 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for VCAM1
- AM05549PU-N
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- AM31190AF-N
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- AP22317BT-N
- AP22317BT-S
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- CF502360
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- SM051B
- SM051BX
- SM1178F
- SM1178FT
- SM1178P
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- TA320510
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- TA326818
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- OriGene qPCR primer pairs for VCAM1
- OriGene qPCR primer pairs and template standards for VCAM1
- OriGene CRISPR knockouts for VCAM1
- MG227630
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- MR227630L1
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for VCAM1
- Sino Biological Cell Lysates for VCAM1
- Sino Biological Recombinant Proteins for VCAM1
- Sino Biological Antibodies for VCAM1
- Sino Biological Assays for VCAM1
- Browse Antibodies
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for VCAM1
- Novus Biologicals proteins and lysates for VCAM1
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- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
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- Abcam antibodies for VCAM1
- Abcam proteins for VCAM1
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- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
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- ProSpec Recombinant Proteins for VCAM1
- ESI BIO PureStem Z11, Meso Progenitor and PureStem ES-209, Meso-prx/latp Progenitor for VCAM1
- Invitrogen Antibodies for VCAM1 (AFLGC-VCAM1)
- VectorBuilder Custom and pre-made DNA vectors for VCAM1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for VCAM1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for VCAM1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for VCAM1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for VCAM1
- antibodies-online: Show 202 available VCAM1 Antibodies ranked by validation data
- Compare Top VCAM1 Antibodies
- Recommended
- 205 WB Antibodies (anti-human)
- 77 FACS Antibodies (anti-human)
- 42 IHC (f) Antibodies (anti-human)
- 38 IHC (p) Antibodies (anti-human)
- 33 IF Antibodies (anti-human)
- 30 IP Antibodies (anti-human)
- 24 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC (fro) Antibodies (anti-human)
- 3 IF/ICC Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 LMNX Antibody (anti-human)
- 1 Purif Antibody (anti-human)
- 71 FACS Antibodies (anti-mouse)
- 51 WB Antibodies (anti-mouse)
- 47 IHC Antibodies (anti-mouse)
- 23 IHC (fro) Antibodies (anti-mouse)
- 22 IF (p) Antibodies (anti-mouse)
- 9 IP Antibodies (anti-mouse)
- 3 IF Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 1 Neut Antibody (anti-mouse)
- 47 WB Antibodies (anti-rat)
- 22 IF (p) Antibodies (anti-rat)
- 16 FACS Antibodies (anti-rat)
- 8 IHC Antibodies (anti-rat)
- 6 IHC (fro) Antibodies (anti-rat)
- 2 IF Antibodies (anti-rat)
- antibodies-online: Show 133 available VCAM1 Elisa Kits ranked by validation data
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- ABIN366645
- ABIN411367
- ABIN625106
- ABIN415056
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- ABIN5520087
- ABIN1888493
- ABIN2708111
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- ABIN6720121
- ABIN367720
- ABIN6730930
- ABIN411368
- ABIN625185
- ABIN2685865
- ABIN415638
- ABIN492061
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- ABIN1117771
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- ABIN368144
- ABIN579233
- ABIN1573025
- ABIN772608
- ABIN5670384
- ABIN5591769
- ABIN5659840
- ABIN6254320
- ABIN1059756
- ABIN2540288
- ABIN6202395
- ABIN6202394
- antibodies-online: Show 60 available VCAM1 Proteins ranked by validation data
- Compare Top VCAM1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for VCAM1
- Search Santa Cruz Biotechnology (SCBT) for VCAM1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for VCAM1
- Horizon Cell Lines for VCAM1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VCAM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VCAM1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for VCAM1
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Sources for VCAM1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48)