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This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
VCAM1 (Vascular Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with VCAM1 include Viral Encephalitis and Chronic Venous Insufficiency. Among its related pathways are Degradation of the extracellular matrix and Cellular roles of Anthrax toxin. Gene Ontology (GO) annotations related to this gene include integrin binding and primary amine oxidase activity. An important paralog of this gene is MXRA5.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005178 | integrin binding | IDA,IMP | 19738201 |
GO:0008131 | primary amine oxidase activity | IDA | 23474851 |
GO:0050839 | cell adhesion molecule binding | IPI | 12082081 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002102 | podosome | IDA | 15220135 |
GO:0005615 | extracellular space | IDA | 9290466 |
GO:0005769 | early endosome | IDA | 23474851 |
GO:0005783 | endoplasmic reticulum | IDA | 23474851 |
GO:0005794 | Golgi apparatus | IDA | 23474851 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling | ||
2 | Cytokine Signaling in Immune system | ||
3 | Interferon gamma signaling | ||
4 | Photodynamic therapy-induced NF-kB survival signaling |
Immune response MIF-mediated glucocorticoid regulation
.31
|
|
5 | Paxillin-dependent events mediated by a4b1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007155 | cell adhesion | IEA,IDA | 16809613 |
GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | IDA | 1715889 |
GO:0007159 | leukocyte cell-cell adhesion | IDA | 1381355 |
GO:0007160 | cell-matrix adhesion | IDA | 18308860 |
GO:0009308 | amine metabolic process | IDA | 23474851 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Ethanol | Approved | Pharma | Target | 3266 | ||
Carvedilol | Approved, Investigational | Pharma | Antagonist, Target, inhibitor | 199 | ||
Clove oil | Approved | Nutra | Target, antagonist | 0 | ||
Succinobucol | Investigational | Pharma | Target | 0 | ||
AGI-1067, SUCCINOBUCOL | Pharma | 0 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | VCAM1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | VCAM1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LOC534578 30 |
|
||
VCAM1 31 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Vcam1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Vcam1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | VCAM1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | VCAM1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | VCAM1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | VCAM1 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | vcam1 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
713843 | Likely Benign: not provided | 100,720,528(+) | T/C | SYNONYMOUS_VARIANT | |
731914 | Likely Benign: not provided | 100,724,703(+) | C/T | SYNONYMOUS_VARIANT | |
735674 | Likely Benign: not provided | 100,723,011(+) | C/T | INTRON_VARIANT | |
769518 | Benign: not provided | 100,731,456(+) | A/G | MISSENSE_VARIANT | |
rs34100871 | - | p.Val421Ile |
Disorder | Aliases | PubMed IDs |
---|---|---|
viral encephalitis |
|
|
chronic venous insufficiency |
|
|
leukostasis |
|
|
acute chest syndrome |
|
|
arteriosclerosis obliterans |
|