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This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free ... See more...
Aliases for VAV3 Gene
Aliases for VAV3 Gene
External Ids for VAV3 Gene
- HGNC: 12659
- NCBI Entrez Gene: 10451
- Ensembl: ENSG00000134215
- OMIM®: 605541
- UniProtKB/Swiss-Prot: Q9UKW4
Previous GeneCards Identifiers for VAV3 Gene
- GC01M108614
- GC01M107096
- GC01M107270
- GC01M107468
- GC01M107825
- GC01M107915
- GC01M108113
- GC01M106059
Summaries for VAV3 Gene
-
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for VAV3 Gene
VAV3 (Vav Guanine Nucleotide Exchange Factor 3) is a Protein Coding gene. Diseases associated with VAV3 include Anterior Foramen Magnum Meningioma and Glaucoma, Normal Tension. Among its related pathways are Integrin Pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is VAV1.
UniProtKB/Swiss-Prot Summary for VAV3 Gene
-
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).
Additional gene information for VAV3 Gene
- HGNC (12659)
- NCBI Entrez Gene (10451)
- Ensembl (ENSG00000134215)
- OMIM® (605541)
- UniProtKB/Swiss-Prot (Q9UKW4)
- Open Targets Platform(ENSG00000134215)
- Monarch Initiative
- Search for VAV3 at DataMed
- Search for VAV3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VAV3 Gene
Genomics for VAV3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for VAV3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around VAV3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VAV3
- Top Transcription factor binding sites by QIAGEN in the VAV3 gene promoter:
-
- AML1a
- FOXL1
- NF-1
- STAT3
Genomic Locations for VAV3 Gene
Latest Assembly
- chr1:107,571,161-107,965,180
- (GRCh38/hg38)
- Size:
- 394,020 bases
- Orientation:
- Minus strand
Previous Assembly
- chr1:108,113,783-108,507,802
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 394,020 bases
- Orientation:
- Minus strand
- chr1:108,113,782-108,507,766
- (GRCh37/hg19 by Ensembl)
- Size:
- 393,985 bases
- Orientation:
- Minus strand
Genomic View for VAV3 Gene
Genes around VAV3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.3 by HGNC
- 1p13.3 by Entrez Gene
- 1p13.3 by Ensembl
VAV3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VAV3 Gene
Proteins for VAV3 Gene
-
Protein details for VAV3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UKW4-VAV3_HUMAN
- Recommended name:
- Guanine nucleotide exchange factor VAV3
- Protein Accession:
- Q9UKW4
- B1AMM0
- B1APV5
- B4E232
- B7ZLR1
- E9PQ97
- O60498
- O95230
- Q9Y5X8
Protein attributes for VAV3 Gene
- Size:
- 847 amino acids
- Molecular mass:
- 97776 Da
- Quaternary structure:
-
- Interacts with the PH domain of APS. Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation.
- SequenceCaution:
-
- Sequence=AAD03799.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 3]: May be produced by alternative promoter usage.
Protein Expression for VAV3 Gene
Post-translational modifications for VAV3 Gene
- Phosphorylated. Phosphorylation can be mediated by ROS1. In osteoclasts, undergoes tyrosine phosphorylation in response to CSF1 (By similarity).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for VAV3 Gene
Antibodies for research
- LifeSpan BioSciences VAV3 Antibody (LS-B3237) and VAV3 Antibody (LS-B15490)
- G Biosciences Immunotag™ Phospho-VAV3(Tyr173) Antibody
-
Custom Antibody ServicesOriGene Antibodies for VAV3
- Novus Biologicals Antibodies for VAV3
-
Abcam antibodies for VAV3
- Invitrogen Antibodies for VAV3 (AFLGC-VAV3)
-
Biorbyt antibodies for VAV3
-
Boster Bio Antibodies for VAV3
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for VAV3
- Origene Custom Protein Services for VAV3
- Novus Biologicals lysates for VAV3
-
Abcam proteins for VAV3
Assay products for research
-
Boster Bio ELISA Kits for VAV3
No data available for DME Specific Peptides for VAV3 Gene
Domains & Families for VAV3 Gene
Gene Families for VAV3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for VAV3 Gene
- InterPro:
- Blocks:
-
- SH2 domain signature
- SH3 domain signature
- Pleckstrin-like
- Variant SH3
- DH domain
- Calponin-like actin-binding
- ProtoNet:
Suggested Antigen Peptide Sequences for VAV3 Gene
- GenScript: Design optimal peptide antigens:
-
- VAV3 protein (B7ZLR1_HUMAN)
- Guanine nucleotide exchange factor VAV3 (VAV3_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for VAV3 Gene
Function for VAV3 Gene
Molecular function for VAV3 Gene
- UniProtKB/Swiss-Prot Function:
- Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).
- UniProtKB/Swiss-Prot Induction:
- Down-regulated by EGF and TGF-beta.
Phenotypes From GWAS Catalog for VAV3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA,TAS | -- |
| GO:0005096 | GTPase activator activity | TAS | 10523675 |
| GO:0005154 | epidermal growth factor receptor binding | IEA | -- |
| GO:0005515 | protein binding | IEA,IPI | 12577067 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for VAV3 Gene
- MGI mutant phenotypes for VAV3:
-
inferred from 2 alleles
- normal phenotype
- nervous system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- immune system phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- GenomeRNAi human phenotypes for VAV3:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for VAV3 - Starting at $85 >
- * VAV3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for VAV3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VAV3
-
Santa Cruz Biotechnology (SCBT) CRISPR for VAV3
miRNA for VAV3 Gene
- miRTarBase miRNAs that target VAV3
-
- mmu-let-7b-5p (MIRT012277)
- hsa-miR-193b-3p (MIRT016326)
- hsa-miR-186-5p (MIRT021094)
- hsa-miR-98-5p (MIRT027493)
- hsa-miR-149-5p (MIRT045501)
- hsa-miR-27a-5p (MIRT456102)
- hsa-miR-4290 (MIRT456103)
- hsa-miR-378g (MIRT456104)
- hsa-miR-939-3p (MIRT456105)
- hsa-miR-6791-5p (MIRT456106)
- hsa-miR-4292 (MIRT456107)
- hsa-miR-4667-3p (MIRT456108)
- hsa-miR-6779-3p (MIRT456109)
- hsa-miR-28-3p (MIRT456110)
- hsa-miR-4432 (MIRT456111)
- hsa-miR-185-3p (MIRT456112)
- hsa-miR-762 (MIRT456113)
- hsa-miR-5001-5p (MIRT456114)
- hsa-miR-4498 (MIRT456115)
- hsa-miR-6787-5p (MIRT456116)
- hsa-miR-4492 (MIRT456117)
- hsa-miR-663a (MIRT456118)
- hsa-miR-1908-5p (MIRT456119)
- hsa-miR-4508 (MIRT456120)
- hsa-miR-5089-3p (MIRT488376)
- hsa-miR-500a-3p (MIRT488377)
- hsa-miR-760 (MIRT488378)
- hsa-miR-8072 (MIRT488379)
- hsa-miR-3194-3p (MIRT488380)
- hsa-miR-6804-3p (MIRT488381)
- hsa-miR-3960 (MIRT488382)
- hsa-miR-18a-3p (MIRT488383)
- hsa-miR-324-3p (MIRT488384)
- hsa-miR-1913 (MIRT488385)
- hsa-miR-4793-3p (MIRT488386)
- hsa-miR-3130-3p (MIRT488387)
- hsa-miR-6741-3p (MIRT488388)
- hsa-miR-455-5p (MIRT488389)
- hsa-miR-6079 (MIRT499219)
- hsa-miR-6763-3p (MIRT499220)
- hsa-miR-513b-5p (MIRT499221)
- hsa-miR-6789-3p (MIRT499222)
- hsa-miR-671-5p (MIRT499223)
- hsa-miR-6828-5p (MIRT499224)
- hsa-miR-2115-5p (MIRT499225)
- hsa-miR-6886-3p (MIRT499226)
- hsa-miR-938 (MIRT499227)
- hsa-miR-6799-3p (MIRT499228)
- hsa-miR-3173-5p (MIRT499229)
- hsa-miR-6846-3p (MIRT499230)
- hsa-miR-7706 (MIRT499231)
- hsa-miR-4680-5p (MIRT499232)
- hsa-miR-7110-3p (MIRT499233)
- hsa-miR-6845-3p (MIRT499234)
- hsa-miR-3925-3p (MIRT499235)
- hsa-miR-766-3p (MIRT499236)
- hsa-miR-4315 (MIRT499237)
- hsa-miR-6769b-3p (MIRT499238)
- hsa-miR-4723-3p (MIRT499239)
- hsa-miR-3183 (MIRT499240)
- hsa-miR-6784-5p (MIRT499241)
- hsa-miR-6752-3p (MIRT499242)
- hsa-miR-4532 (MIRT499243)
- hsa-miR-5587-3p (MIRT499244)
- hsa-miR-4707-5p (MIRT499245)
- hsa-miR-6837-5p (MIRT499246)
- hsa-miR-4685-5p (MIRT499247)
- hsa-miR-7113-5p (MIRT499248)
- hsa-miR-4673 (MIRT499249)
- hsa-miR-4645-5p (MIRT499250)
- hsa-miR-125b-2-3p (MIRT499251)
- hsa-miR-4457 (MIRT499252)
- hsa-miR-525-3p (MIRT499253)
- hsa-miR-524-3p (MIRT499254)
- hsa-miR-4428 (MIRT499255)
- hsa-miR-4511 (MIRT499256)
- hsa-miR-3133 (MIRT499257)
- hsa-miR-573 (MIRT504200)
- hsa-miR-3616-5p (MIRT504201)
- hsa-miR-519e-5p (MIRT504202)
- hsa-miR-515-5p (MIRT504203)
- hsa-miR-4665-3p (MIRT504204)
- hsa-miR-4436b-5p (MIRT504205)
- hsa-miR-23c (MIRT504206)
- hsa-miR-23b-3p (MIRT504207)
- hsa-miR-23a-3p (MIRT504208)
- hsa-miR-130a-5p (MIRT504209)
- hsa-miR-7114-3p (MIRT504210)
- hsa-miR-1180-5p (MIRT504211)
- hsa-miR-3664-3p (MIRT504212)
- hsa-miR-7107-5p (MIRT504213)
- hsa-miR-1234-3p (MIRT504214)
- hsa-miR-5088-3p (MIRT504215)
- hsa-miR-5000-3p (MIRT504216)
- hsa-miR-4436a (MIRT504217)
- hsa-miR-4717-3p (MIRT504218)
- hsa-miR-4802-3p (MIRT504219)
- hsa-miR-4435 (MIRT533260)
- hsa-miR-525-5p (MIRT533261)
- hsa-miR-520a-5p (MIRT533262)
- hsa-miR-6743-3p (MIRT533263)
- hsa-miR-3670 (MIRT533264)
- hsa-miR-6511b-3p (MIRT533265)
- hsa-miR-6511a-3p (MIRT533266)
- hsa-miR-4733-3p (MIRT533267)
- hsa-miR-1226-3p (MIRT533268)
- hsa-miR-4482-3p (MIRT544245)
- hsa-miR-4670-3p (MIRT544246)
- hsa-miR-4518 (MIRT544247)
- hsa-miR-1266-5p (MIRT544248)
- hsa-miR-138-2-3p (MIRT544249)
- hsa-miR-6809-3p (MIRT550780)
- hsa-miR-4753-3p (MIRT550781)
- hsa-miR-2117 (MIRT550782)
- hsa-miR-130b-5p (MIRT550783)
- hsa-miR-148a-5p (MIRT550784)
- hsa-miR-3912-5p (MIRT570329)
- hsa-miR-6842-3p (MIRT570330)
- hsa-miR-647 (MIRT570331)
- hsa-miR-1226-5p (MIRT570332)
- hsa-miR-6771-5p (MIRT570333)
- hsa-miR-425-3p (MIRT570334)
- hsa-miR-6084 (MIRT570335)
- hsa-miR-211-5p (MIRT570336)
- hsa-miR-204-5p (MIRT570337)
- hsa-miR-4529-5p (MIRT570338)
- hsa-miR-196a-3p (MIRT570339)
- hsa-miR-7160-5p (MIRT570340)
- hsa-miR-214-5p (MIRT570341)
- hsa-miR-4721 (MIRT570342)
- hsa-miR-3616-3p (MIRT570343)
- hsa-miR-4539 (MIRT570344)
- hsa-miR-4685-3p (MIRT570345)
- hsa-miR-4287 (MIRT570346)
- hsa-miR-6078 (MIRT570347)
- hsa-miR-6748-3p (MIRT570348)
- hsa-miR-6832-3p (MIRT570349)
- hsa-miR-6785-3p (MIRT570350)
- hsa-miR-6733-3p (MIRT570351)
- hsa-miR-892c-5p (MIRT570352)
- hsa-miR-15a-3p (MIRT570353)
- hsa-miR-30e-3p (MIRT572735)
- hsa-miR-30d-3p (MIRT572736)
- hsa-miR-30a-3p (MIRT572737)
- hsa-miR-3127-5p (MIRT572738)
- hsa-miR-199b-5p (MIRT572739)
- hsa-miR-199a-5p (MIRT572740)
- hsa-miR-1825 (MIRT572741)
- hsa-miR-6798-5p (MIRT572742)
- hsa-miR-1250-3p (MIRT572743)
- hsa-miR-6783-5p (MIRT572744)
- hsa-miR-3178 (MIRT608681)
- hsa-miR-4634 (MIRT608682)
- hsa-miR-6499-5p (MIRT608683)
- hsa-miR-6892-3p (MIRT608684)
- hsa-miR-6840-5p (MIRT608685)
- hsa-miR-6865-3p (MIRT608686)
- hsa-miR-6856-3p (MIRT608687)
- hsa-miR-449b-5p (MIRT608688)
- hsa-miR-449a (MIRT608689)
- hsa-miR-34c-5p (MIRT608690)
- hsa-miR-34a-5p (MIRT608691)
- hsa-miR-6499-3p (MIRT608692)
- hsa-miR-498 (MIRT686341)
- hsa-miR-561-5p (MIRT686342)
- hsa-miR-499a-5p (MIRT732990)
- mmu-miR-31-5p (MIRT733477)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VAV3
- Browse OriGene Inhibitory RNA Products For VAV3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VAV3
Clone products for research
- Applied Biological Materials (abm): Clones for VAV3 - Starting at $45 >
- * VAV3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG210938
- MG226734
- MR210938
- MR210938L3
- MR210938L4
- MR226734
- MR226734L3
- MR226734L4
- RC218352
- RC218352L1
- RC218352L2
- RC218352L3
- RC218352L4
- RC220550
- RC220550L3
- RC220550L4
- RG218352
- RG220550
- RR217259
- MR210938L3V
- MR210938L4V
- MR226734L3V
- MR226734L4V
- RC218352L1V
- RC218352L2V
- RC218352L3V
- RC218352L4V
- RC220550L3V
- RC220550L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for VAV3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VAV3
Cell Lines for research
-
Horizon Cell Lines for VAV3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VAV3 Gene
Localization for VAV3 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| extracellular | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001772 | immunological synapse | IDA | 15708849 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for VAV3 Gene
Pathways & Interactions for VAV3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | p75 NTR receptor-mediated signalling |
.36
|
|
| 3 | TCR Signaling (Qiagen) |
PKC-Theta Pathway
.68
TCR Signaling
.68
|
ITK and TCR Signaling
.54
Fc-EpsilonRI Pathway
.49
|
| 4 | Signaling by GPCR | ||
| 5 | Focal Adhesion |
.61
|
|
Pathways by source for VAV3 Gene
3 Sino Biological pathways for VAV3 Gene
15 BioSystems pathways for VAV3 Gene
29 Reactome pathways for VAV3 Gene
1 GeneGo (Thomson Reuters) pathway for VAV3 Gene
- Immune response Role of DAP12 receptors in NK cells
16 Qiagen pathways for VAV3 Gene
- EGF Pathway
- EphB-EphrinB Signaling
- Fc-EpsilonRI Pathway
- Fc-GammaR Pathway
- Fc-GammaR-Mediated Phagocytosis in Macrophages
1 Cell Signaling Technology pathway for VAV3 Gene
Interacting Proteins for VAV3 Gene
Selected Interacting proteins:
Q9UKW4-VAV3_HUMAN
ENSP00000359073
for VAV3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for VAV3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0006906 | vesicle fusion | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IMP | 17875758 |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
| GO:0007229 | integrin-mediated signaling pathway | IEA | -- |
Drugs & Compounds for VAV3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| DG(16:0/24:0/0:0) |
|
|
||||
| Diglycerides Group A |
|
|
||||
| Diglycerides Group B |
|
257891-89-7 |
|
|||
| Diglycerides Group C |
|
91125-76-7, 29541-66-0, 51621-26-2 |
|
|||
| Diglycerides Group D |
|
|
Transcripts for VAV3 Gene
mRNA/cDNA for VAV3 Gene
- 2 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000343258 2552 nts (view in UCSC)
- ENST00000370056 5025 nts (view in UCSC)
- ENST00000415432 1293 nts (view in UCSC)
- ENST00000469325 2487 nts (view in UCSC)
- ENST00000479977 549 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for VAV3 - Starting at $85 >
- * VAV3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for VAV3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VAV3
-
Santa Cruz Biotechnology (SCBT) CRISPR for VAV3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VAV3
- Browse OriGene Inhibitory RNA Products For VAV3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VAV3
Clone products for research
- Applied Biological Materials (abm): Clones for VAV3 - Starting at $45 >
- * VAV3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG210938
- MG226734
- MR210938
- MR210938L3
- MR210938L4
- MR226734
- MR226734L3
- MR226734L4
- RC218352
- RC218352L1
- RC218352L2
- RC218352L3
- RC218352L4
- RC220550
- RC220550L3
- RC220550L4
- RG218352
- RG220550
- RR217259
- MR210938L3V
- MR210938L4V
- MR226734L3V
- MR226734L4V
- RC218352L1V
- RC218352L2V
- RC218352L3V
- RC218352L4V
- RC220550L3V
- RC220550L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for VAV3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VAV3
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: |
| ExUns: | 27 | ^ | 28 | ^ | 29 | ^ | 30 |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: |
Relevant External Links for VAV3 Gene
- GeneLoc Exon Structure for
- VAV3
Expression for VAV3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Ureteric Bud Tip Cells Ureteric Bud
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
- Retina
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
- Adult Dopaminergic Neurons Substantia Nigra pars Compacta
-
Brain (Nervous System)
- Adult Dopaminergic Neurons Substantia Nigra pars Compacta
- Medulla Oblongata
- Gut Tube (Gastrointestinal Tract)
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
- Lower Urinary Tract (Urinary System)
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for VAV3 Gene
This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x6.3), Esophagus - Mucosa (x5.6), Skin - Sun Exposed (Lower leg) (x5.5), and Kidney - Cortex (x4.6).
This gene is overexpressed in Monocytes (15.4), Peripheral blood mononuclear cells (15.3), Plasma (14.8), and Lymph node (10.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VAV3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VAV3
SOURCE GeneReport for Unigene cluster for VAV3 Gene:
Hs.267659mRNA Expression by UniProt/SwissProt for VAV3 Gene:
Q9UKW4-VAV3_HUMAN
Tissue specificity:
Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable.
Evidence on tissue expression from TISSUES for VAV3 Gene
- Skin(4.5)
- Nervous system(3.3)
- Kidney(2.7)
- Blood(2.5)
- Spleen(2.2)
- Intestine(2.2)
- Lymph node(2.1)
- Bone marrow(2)
Primer products for research
-
OriGene qPCR primer pairs for VAV3
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for VAV3 Gene
Orthologs for VAV3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | VAV3 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | VAV3 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | VAV3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | VAV3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Vav3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Vav3 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | VAV3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | VAV3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | vav3 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | VAV3 (1 of 3) 31 |
|
OneToMany | |
| vav3b 30 31 |
|
OneToMany | |||
| vav3a 31 |
|
OneToMany | |||
| wufk86g11 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | vav 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | vav-1 30 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC24 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1542 31 |
|
OneToMany |
- Species where no ortholog for VAV3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for VAV3 Gene
- ENSEMBL:
- Gene Tree for VAV3 (if available)
- TreeFam:
- Gene Tree for VAV3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for VAV3: view image
Paralogs for VAV3 Gene
Paralogs for VAV3 Gene
(9) SIMAP similar genes for VAV3 Gene using alignment to 6 proteins:
- VAV3_HUMAN
- E9PMJ5_HUMAN
- F5GXH7_HUMAN
- H0YCG7_HUMAN
- H0YDG2_HUMAN
- H9KV67_HUMAN
Variants for VAV3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VAV3 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs12072686 | Benign: not provided | 107,874,927(-) |
A/G NM_006113.5(VAV3):c.295T>C (p.Leu99=) |
SYNONYMOUS | |
| rs138170759 | Likely Benign: not provided | 107,964,797(-) |
A/G NM_006113.5(VAV3):c.73T>C (p.Trp25Arg) |
MISSENSE | |
| rs138334746 | Likely Benign: not provided | 107,609,935(-) |
G/T NM_006113.5(VAV3):c.2011C>A (p.Pro671Thr) |
MISSENSE | |
| rs142245622 | Likely Benign: not provided | 107,574,093(-) |
G/A NM_006113.5(VAV3):c.2456C>T (p.Thr819Ile) |
MISSENSE | |
| rs142499589 | Likely Benign: not provided. Benign: not provided | 107,964,861(-) |
C/GC/T NM_006113.5(VAV3):c.9G>C (p.Pro3=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.00;
74.90% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VAV3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VAV3 Gene
Disorders for VAV3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| anterior foramen magnum meningioma |
|
|
| glaucoma, normal tension |
|
|
| foramen magnum meningioma |
|
|
| osteopetrosis |
|
|
| prostatitis |
|
|
Search VAV3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for VAV3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for VAV3 Gene
Publications for VAV3 Gene
- Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. (PMID: 12400014) Yabana N … Shibuya M (Oncogene 2002) 3 4 23
- Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. (PMID: 10523675) Movilla N … Bustelo XR (Molecular and cellular biology 1999) 3 4 23
- Novel associations for hypothyroidism include known autoimmune risk loci. (PMID: 22493691) Eriksson N … Do CB (PloS one 2012) 3 41
- The molecular mechanism of Vav3 oncogene on upregulation of androgen receptor activity in prostate cancer cells. (PMID: 20126983) Liu Y … Lu S (International journal of oncology 2010) 3 23
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
ExternalLinks
Products for VAV3 Gene
- Custom Antibody ServicesOriGene Antibodies for VAV3
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for VAV3
- Origene Custom Protein Services for VAV3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VAV3
- Browse OriGene Inhibitory RNA Products For VAV3
- OriGene qPCR primer pairs for VAV3
- OriGene CRISPR knockouts for VAV3
- MG210938
- MG226734
- MR210938
- MR210938L3
- MR210938L4
- MR226734
- MR226734L3
- MR226734L4
- RC218352
- RC218352L1
- RC218352L2
- RC218352L3
- RC218352L4
- RC220550
- RC220550L3
- RC220550L4
- RG218352
- RG220550
- RR217259
- MR210938L3V
- MR210938L4V
- MR226734L3V
- MR226734L4V
- RC218352L1V
- RC218352L2V
- RC218352L3V
- RC218352L4V
- RC220550L3V
- RC220550L4V
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