Aliases for VASN Gene

Aliases for VASN Gene

  • Vasorin 2 3 4 5
  • Protein Slit-Like 2 3 4
  • SLITL2 3 4
  • Slit-Like 2 (Drosophila) 2
  • Slit-Like 2 3

External Ids for VASN Gene

Previous HGNC Symbols for VASN Gene

  • SLITL2

Previous GeneCards Identifiers for VASN Gene

  • GC16P004364

Summaries for VASN Gene

GeneCards Summary for VASN Gene

VASN (Vasorin) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transforming growth factor beta binding. An important paralog of this gene is TLR8.

UniProtKB/Swiss-Prot Summary for VASN Gene

Additional gene information for VASN Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VASN Gene

Genomics for VASN Gene

GeneHancer (GH) Regulatory Elements for VASN Gene

Promoters and enhancers for VASN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VASN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VASN gene promoter:
  • CREB
  • deltaCREB
  • E47
  • MIF-1
  • NF-1
  • NF-1/L
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1beta

Genomic Locations for VASN Gene

Genomic Locations for VASN Gene
chr16:4,371,848-4,383,538
(GRCh38/hg38)
Size:
11,691 bases
Orientation:
Plus strand
chr16:4,421,849-4,433,529
(GRCh37/hg19)
Size:
11,681 bases
Orientation:
Plus strand

Genomic View for VASN Gene

Genes around VASN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VASN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VASN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VASN Gene

Proteins for VASN Gene

  • Protein details for VASN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6EMK4-VASN_HUMAN
    Recommended name:
    Vasorin
    Protein Accession:
    Q6EMK4
    Secondary Accessions:
    • Q6UXL4
    • Q6UXL5
    • Q96CX1

    Protein attributes for VASN Gene

    Size:
    673 amino acids
    Molecular mass:
    71713 Da
    Quaternary structure:
    • Interacts with TGFB1, TGFB2 and TGFB3.

neXtProt entry for VASN Gene

Post-translational modifications for VASN Gene

  • N-glycosylated. N-glycan heterogeneity at Asn-117: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5 (minor).
  • Glycosylation at Asn101, Asn117, Asn273, Thr319, Ser487, Asn500, Ser516, Asn528, and Thr567
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • VASN_HUMAN (670)

Other Protein References for VASN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VASN Gene

Domains & Families for VASN Gene

Gene Families for VASN Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for VASN Gene

GenScript: Design optimal peptide antigens:
  • Protein slit-like 2 (VASN_HUMAN)
genes like me logo Genes that share domains with VASN: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for VASN Gene

Function for VASN Gene

Molecular function for VASN Gene

UniProtKB/Swiss-Prot Function:
May act as an inhibitor of TGF-beta signaling.

Phenotypes From GWAS Catalog for VASN Gene

Gene Ontology (GO) - Molecular Function for VASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0045296 cadherin binding HDA 25468996
GO:0050431 transforming growth factor beta binding IPI,IBA 15247411
genes like me logo Genes that share ontologies with VASN: view
genes like me logo Genes that share phenotypes with VASN: view

Animal Models for VASN Gene

MGI Knock Outs for VASN:
  • Vasn Vasn<tm1Zgl>
  • Vasn Vasn<tm1.1Hsch>

Animal Model Products

  • Taconic Biosciences Mouse Models for VASN

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VASN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VASN Gene

Localization for VASN Gene

Subcellular locations from UniProtKB/Swiss-Prot for VASN Gene

Membrane; Single-pass type I membrane protein. Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VASN gene
Compartment Confidence
extracellular 5
plasma membrane 4
mitochondrion 2
golgi apparatus 1
peroxisome 0
cytosol 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA,IDA 15247411
GO:0005739 mitochondrion IEA --
GO:0005765 lysosomal membrane HDA 17897319
GO:0005886 plasma membrane IBA,IEA 21873635
genes like me logo Genes that share ontologies with VASN: view

Pathways & Interactions for VASN Gene

PathCards logo

SuperPathways for VASN Gene

No Data Available

Gene Ontology (GO) - Biological Process for VASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010719 negative regulation of epithelial to mesenchymal transition IMP 21170088
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IMP,IBA 21170088
GO:0071456 cellular response to hypoxia IEA --
GO:0071461 cellular response to redox state IEA --
genes like me logo Genes that share ontologies with VASN: view

No data available for Pathways by source and SIGNOR curated interactions for VASN Gene

Drugs & Compounds for VASN Gene

No Compound Related Data Available

Transcripts for VASN Gene

mRNA/cDNA for VASN Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(178) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VASN

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VASN Gene

No ASD Table

Relevant External Links for VASN Gene

GeneLoc Exon Structure for
VASN
ECgene alternative splicing isoforms for
VASN

Expression for VASN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VASN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VASN Gene

This gene is overexpressed in Urine (56.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for VASN Gene



Protein tissue co-expression partners for VASN Gene

NURSA nuclear receptor signaling pathways regulating expression of VASN Gene:

VASN

SOURCE GeneReport for Unigene cluster for VASN Gene:

Hs.372579

mRNA Expression by UniProt/SwissProt for VASN Gene:

Q6EMK4-VASN_HUMAN
Tissue specificity: Expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. Within the aorta, the strongest expression is found in the tunica media of the proximal ascending aorta, the descending thoracic aorta, the abdominal aorta and the coronary arteries. Within the kidney, expression is found in the interstitial cells.

Evidence on tissue expression from TISSUES for VASN Gene

  • Liver(4.2)
  • Lung(4.2)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with VASN: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for VASN Gene

Orthologs for VASN Gene

This gene was present in the common ancestor of animals.

Orthologs for VASN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VASN 33 32
  • 99.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia VASN 33 32
  • 86.21 (n)
OneToOne
dog
(Canis familiaris)
Mammalia VASN 33 32
  • 86.16 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vasn 32
  • 82.06 (n)
mouse
(Mus musculus)
Mammalia Vasn 17 33 32
  • 80.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia VASN 33
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves VASN 33 32
  • 63.22 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vasn 32
  • 53.77 (n)
zebrafish
(Danio rerio)
Actinopterygii vasna 33 32
  • 50.99 (n)
OneToMany
vasnb 33
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-14 33
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 31 (a)
OneToMany
-- 33
  • 30 (a)
OneToMany
-- 33
  • 24 (a)
OneToMany
Species where no ortholog for VASN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VASN Gene

ENSEMBL:
Gene Tree for VASN (if available)
TreeFam:
Gene Tree for VASN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for VASN: view image

Paralogs for VASN Gene

(1) SIMAP similar genes for VASN Gene using alignment to 1 proteins:

  • VASN_HUMAN
genes like me logo Genes that share paralogs with VASN: view

Variants for VASN Gene

Sequence variations from dbSNP and Humsavar for VASN Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000120584 -- 4,380,768(+) T/C intron_variant
rs1000293207 -- 4,383,129(+) G/A/T 3_prime_UTR_variant
rs1000535008 -- 4,372,891(+) G/C intron_variant
rs1000604888 -- 4,371,838(+) C/A upstream_transcript_variant
rs1000948203 -- 4,372,681(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for VASN Gene

Variant ID Type Subtype PubMed ID
esv23732 CNV gain 19812545
esv3584924 CNV gain 24956385
nsv1046986 CNV gain 25217958
nsv1160332 CNV duplication 26073780
nsv471075 CNV loss 18288195
nsv520212 CNV loss 19592680
nsv527866 CNV loss 19592680
nsv571274 CNV gain 21841781
nsv833132 CNV loss 17160897

Variation tolerance for VASN Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VASN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VASN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VASN Gene

Disorders for VASN Gene

Additional Disease Information for VASN

No disorders were found for VASN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VASN Gene

Publications for VASN Gene

  1. Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. (PMID: 15247411) Ikeda Y … Kitamura T (Proceedings of the National Academy of Sciences of the United States of America 2004) 2 3 4 23 56
  2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 56
  5. Sialylation of vasorin by ST3Gal1 facilitates TGF-β1-mediated tumor angiogenesis and progression. (PMID: 30252131) Yeo HL … Yu AL (International journal of cancer 2019) 3 56

Products for VASN Gene

Sources for VASN Gene