Aliases for VASH2 Gene

Aliases for VASH2 Gene

  • Vasohibin 2 2 3 5
  • Tubulinyl-Tyr Carboxypeptidase 2 3 4
  • Vasohibin-Like Protein 3 4
  • Testicular Tissue Protein Li 222 3
  • EC 3.4.17.17 4
  • Vasohibin-2 4
  • FLJ12505 2
  • VASH2 5
  • VASHL 4

External Ids for VASH2 Gene

Previous GeneCards Identifiers for VASH2 Gene

  • GC01P211190
  • GC01P213123
  • GC01P183798
  • GC01P212950

Summaries for VASH2 Gene

GeneCards Summary for VASH2 Gene

VASH2 (Vasohibin 2) is a Protein Coding gene. Diseases associated with VASH2 include Aarskog-Scott Syndrome. An important paralog of this gene is VASH1.

UniProtKB/Swiss-Prot Summary for VASH2 Gene

  • Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325). Plays a role in axon formation (PubMed:31235911).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VASH2 Gene

Genomics for VASH2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for VASH2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VASH2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VASH2

Top Transcription factor binding sites by QIAGEN in the VASH2 gene promoter:
  • AREB6

Genomic Locations for VASH2 Gene

Genomic Locations for VASH2 Gene
chr1:212,950,520-212,992,037
(GRCh38/hg38)
Size:
41,518 bases
Orientation:
Plus strand
chr1:213,123,862-213,165,379
(GRCh37/hg19)
Size:
41,518 bases
Orientation:
Plus strand

Genomic View for VASH2 Gene

Genes around VASH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VASH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VASH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VASH2 Gene

Proteins for VASH2 Gene

  • Protein details for VASH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V25-VASH2_HUMAN
    Recommended name:
    Tubulinyl-Tyr carboxypeptidase 2
    Protein Accession:
    Q86V25
    Secondary Accessions:
    • B4DYZ5
    • Q2VT46
    • Q5VTE7
    • Q5VTE9
    • Q7Z6E3
    • Q8IZ24
    • Q9H9W5

    Protein attributes for VASH2 Gene

    Size:
    355 amino acids
    Molecular mass:
    40450 Da
    Quaternary structure:
    • Interacts with SVBP; interaction enhances VASH2 tyrosine carboxypeptidase activity.

    Three dimensional structures from OCA and Proteopedia for VASH2 Gene

    Alternative splice isoforms for VASH2 Gene

neXtProt entry for VASH2 Gene

Post-translational modifications for VASH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VASH2 Gene

Domains & Families for VASH2 Gene

Gene Families for VASH2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for VASH2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VASH2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54807, highly similar to Vasohibin-like protein (B4DYZ5_HUMAN)
  • Vasohibin-like protein (VASH2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86V25

UniProtKB/Swiss-Prot:

VASH2_HUMAN :
  • Belongs to the transglutaminase-like superfamily. Vasohibin family.
Family:
  • Belongs to the transglutaminase-like superfamily. Vasohibin family.
genes like me logo Genes that share domains with VASH2: view

Function for VASH2 Gene

Molecular function for VASH2 Gene

UniProtKB/Swiss-Prot Function:
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325). Plays a role in axon formation (PubMed:31235911).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=C-terminal L-tyrosyl-L-glutamyl-L-glutamyl-[alpha-tubulin] + H2O = C-terminal detyrosinated L-glutamyl-L-glutamyl-[alpha-tubulin] + L-tyrosine; Xref=Rhea:RHEA:57444, Rhea:RHEA-COMP:14902, Rhea:RHEA-COMP:14903, ChEBI:CHEBI:15377, ChEBI:CHEBI:58315, ChEBI:CHEBI:141768, ChEBI:CHEBI:141769; EC=3.4.17.17; Evidence={ECO:0000269|PubMed:29146869, ECO:0000269|PubMed:31235911};.
UniProtKB/Swiss-Prot Induction:
By VEGF.

Enzyme Numbers (IUBMB) for VASH2 Gene

Phenotypes From GWAS Catalog for VASH2 Gene

Gene Ontology (GO) - Molecular Function for VASH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 29146869
GO:0004180 carboxypeptidase activity IEA --
GO:0004181 metallocarboxypeptidase activity IMP 31171830
GO:0005515 protein binding IPI 29146869
GO:0008017 microtubule binding IDA 31324789
genes like me logo Genes that share ontologies with VASH2: view
genes like me logo Genes that share phenotypes with VASH2: view

Animal Models for VASH2 Gene

MGI Knock Outs for VASH2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VASH2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VASH2 Gene

Localization for VASH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VASH2 Gene

Cytoplasm. Secreted. Cytoplasm, cytoskeleton. Note=Mainly localizes in the cytoplasm (PubMed:19204325). Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion (PubMed:20736312). Associates with microtubules (PubMed:31235911). {ECO:0000269 PubMed:19204325, ECO:0000269 PubMed:20736312, ECO:0000269 PubMed:31235911}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VASH2 gene
Compartment Confidence
extracellular 4
cytoskeleton 4
nucleus 3
cytosol 3
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for VASH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA 19204325
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with VASH2: view

Pathways & Interactions for VASH2 Gene

PathCards logo

SuperPathways for VASH2 Gene

No Data Available

Interacting Proteins for VASH2 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000428324 Q86V25-VASH2_HUMAN for VASH2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for VASH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000768 syncytium formation by plasma membrane fusion IEA --
GO:0001938 positive regulation of endothelial cell proliferation IDA 19204325
GO:0006508 proteolysis IEA,IDA 29146869
GO:0045765 regulation of angiogenesis IBA 21873635
GO:0045766 positive regulation of angiogenesis IDA 19204325
genes like me logo Genes that share ontologies with VASH2: view

No data available for Pathways by source and SIGNOR curated interactions for VASH2 Gene

Drugs & Compounds for VASH2 Gene

No Compound Related Data Available

Transcripts for VASH2 Gene

mRNA/cDNA for VASH2 Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VASH2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VASH2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for VASH2 Gene

GeneLoc Exon Structure for
VASH2

Expression for VASH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VASH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VASH2 Gene

This gene is overexpressed in Testis (x5.3).

Protein differential expression in normal tissues from HIPED for VASH2 Gene

This gene is overexpressed in Heart (55.9) and Adipocyte (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VASH2 Gene



Protein tissue co-expression partners for VASH2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VASH2

SOURCE GeneReport for Unigene cluster for VASH2 Gene:

Hs.96885

Evidence on tissue expression from TISSUES for VASH2 Gene

  • Nervous system(4.3)
  • Heart(2)
genes like me logo Genes that share expression patterns with VASH2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VASH2 Gene

Orthologs for VASH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VASH2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia VASH2 30 31
  • 99.36 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia VASH2 30 31
  • 93.68 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Vash2 30 17 31
  • 90.14 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Vash2 30
  • 88.13 (n)
Cow
(Bos Taurus)
Mammalia VASH2 31
  • 86 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia VASH2 31
  • 76 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia VASH2 31
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves VASH2 30 31
  • 77.67 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia VASH2 31
  • 68 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia vash2 30
  • 71.2 (n)
Zebrafish
(Danio rerio)
Actinopterygii vash2 30 31
  • 65.53 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 28 (a)
OneToMany
Species where no ortholog for VASH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for VASH2 Gene

ENSEMBL:
Gene Tree for VASH2 (if available)
TreeFam:
Gene Tree for VASH2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for VASH2: view image

Paralogs for VASH2 Gene

Paralogs for VASH2 Gene

(1) SIMAP similar genes for VASH2 Gene using alignment to 3 proteins:

  • VASH2_HUMAN
  • B4DYZ5_HUMAN
  • C9JY36_HUMAN
genes like me logo Genes that share paralogs with VASH2: view

Variants for VASH2 Gene

Additional dbSNP identifiers (rs#s) for VASH2 Gene

Structural Variations from Database of Genomic Variants (DGV) for VASH2 Gene

Variant ID Type Subtype PubMed ID
esv29349 CNV gain 19812545
esv3307325 CNV mobile element insertion 20981092

Variation tolerance for VASH2 Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VASH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VASH2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VASH2 Gene

Disorders for VASH2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for VASH2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
aarskog-scott syndrome
  • aas
- elite association - COSMIC cancer census association via MalaCards
Search VASH2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with VASH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VASH2 Gene

Publications for VASH2 Gene

  1. Isolation and characterization of vasohibin-2 as a homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin. (PMID: 16528006) Shibuya T … Sato Y (Arteriosclerosis, thrombosis, and vascular biology 2006) 2 3 4
  2. Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer. (PMID: 31324789) Zhou C … Liu Z (Nature communications 2019) 3 4
  3. Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex. (PMID: 31235911) Wang N … Huang H (Nature structural & molecular biology 2019) 3 4
  4. Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. (PMID: 31171830) Liao S … Xu C (Cell research 2019) 3 4
  5. Vasohibins encode tubulin detyrosinating activity. (PMID: 29146869) Nieuwenhuis J … Brummelkamp TR (Science (New York, N.Y.) 2017) 3 4

Products for VASH2 Gene

Sources for VASH2 Gene