Aliases for VARS2 Gene
Aliases for VARS2 Gene
External Ids for VARS2 Gene
- HGNC: 21642
- Entrez Gene: 57176
- Ensembl: ENSG00000137411
- OMIM: 612802
- UniProtKB: Q5ST30
Previous HGNC Symbols for VARS2 Gene
- VARS2L
- VARSL
Previous GeneCards Identifiers for VARS2 Gene
- GC06M031816
- GC06M031516
- GC06M031851
- GC06M031852
- GC06M031853
- GC06Pc31014
- GC06P030992
- GC06P030876
- GC06P030682
- GC06P030910
- GC06P030912
- GC06P031041
- GC06P031079
Summaries for VARS2 Gene
-
This gene encodes a mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of valine to tRNA(Val) for mitochondrial translation. Mutations in this gene cause combined oxidative phosphorylation deficiency-20, and are also associated with early-onset mitochondrial encephalopathies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2014]
GeneCards Summary for VARS2 Gene
VARS2 (Valyl-TRNA Synthetase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with VARS2 include Combined Oxidative Phosphorylation Deficiency 20. Among its related pathways are Gene Expression and tRNA Aminoacylation. Gene Ontology (GO) annotations related to this gene include nucleotide binding and aminoacyl-tRNA editing activity. An important paralog of this gene is VARS.
Additional gene information for VARS2 Gene
- Monarch Initiative
- Search for VARS2 at DataMed
- Search for VARS2 at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VARS2 Gene
Genomics for VARS2 Gene
GeneHancer (GH) Regulatory Elements for VARS2 Gene
Promoters and enhancers for VARS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around VARS2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for VARS2 Gene
Genomic Locations for VARS2 Gene
- chr6:30,908,242-30,926,459
- (GRCh38/hg38)
- Size:
- 18,218 bases
- Orientation:
- Plus strand
- chr6:30,876,019-30,894,236
- (GRCh37/hg19)
Genomic View for VARS2 Gene
Genes around VARS2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.33 by Ensembl
- 6p21.33 by Entrez Gene
- 6p21.33 by HGNC
VARS2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VARS2 Gene
Proteins for VARS2 Gene
-
Protein details for VARS2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5ST30-SYVM_HUMAN
- Recommended name:
- Valine--tRNA ligase, mitochondrial
- Protein Accession:
- Q5ST30
- A2ABL7
- B4DET4
- B4E3P5
- F5GXJ0
- F5H323
- Q2M2A0
- Q59FI1
- Q5SQ96
- Q5SS98
- Q6DKJ5
- Q6ZV24
- Q96GN2
- Q96H77
- Q96Q02
- Q9H6R2
- Q9UFH7
Protein attributes for VARS2 Gene
- Size:
- 1063 amino acids
- Molecular mass:
- 118490 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB15191.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB67778.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD92716.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence={ECO:0000305}; Sequence=CAM24842.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM25404.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAQ06763.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAQ09774.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAQ10925.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for VARS2 Gene
Selected DME Specific Peptides for VARS2 Gene
- Q5ST30:
-
- GTGAVKVTPAH
- DWCVSRQ
- AVAVHPDD
- PPPNVTG
- DALRFTL
- LPGCPTPVSFGLL
- GRKMSKS
- LPFSKVLLH
- RYTHLHG
- SRQLWWGHQIPA
- VIAEDGTMTSLCGDWLQGLHRFVAREKI
- YVEAAWYPWW
- DHAGIATQ
- LDTWFSS
- YMELQGLVDPQ
- MVRDRQGRKMSKSLGNVLDPR
- QWFVRCQEMG
- GFFKPEY
- GPPQVLFSCAD
- LHIGHALT
- SVAFPVDGEPD
- MSKSLGN
- LHIGHAL
- GTDALRF
- DVLDTWFS
- GEKKDVS
- SAISDIEV
- AVTEAFVR
Post-translational modifications for VARS2 Gene
Other Protein References for VARS2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for VARS2
- Novus Biologicals Antibodies for VARS2
- Invitrogen Antibodies for VARS2
- Search GeneTex for Antibodies for VARS2
Protein Products
-
OriGene Purified Proteins for VARS2
- Search Origene for MassSpec and Protein Over-expression Lysates for VARS2
- Origene Custom Protein Services for VARS2
- antibodies-online: Search results for 3 available VARS2 Proteins ranked by validation data
- Compare Top VARS2 Proteins
-
Quality Products:
- Search GeneTex for Proteins for VARS2
Assay Products
Domains & Families for VARS2 Gene
Gene Families for VARS2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for VARS2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for VARS2 Gene
Graphical View of Domain Structure for InterPro Entry
Q5ST30- Family:
-
- Belongs to the class-I aminoacyl-tRNA synthetase family.
Function for VARS2 Gene
Molecular function for VARS2 Gene
- GENATLAS Biochemistry:
- valyl-tRNA synthetase 2,same as G7a,see HTFAG@
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).
Enzyme Numbers (IUBMB) for VARS2 Gene
Phenotypes From GWAS Catalog for VARS2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002161 | aminoacyl-tRNA editing activity | IEA | -- |
| GO:0004812 | aminoacyl-tRNA ligase activity | IEA | -- |
| GO:0004832 | valine-tRNA ligase activity | IBA,IEA | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016874 | ligase activity | IEA | -- |
Phenotypes for VARS2 Gene
- GenomeRNAi human phenotypes for VARS2:
Animal Model Products
-
Taconic Biosciences Mouse Models for VARS2
- Cyagen custom Knockout/knockin (KOKI) mouse models for VARS2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for VARS2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VARS2 gene
- Search ViGene Biosciences for VARS2
CRISPR Products
-
OriGene CRISPR knockouts for VARS2
- genomics-online: gRNA clones - Search results for available VARS2 gene related products
- Applied Biological Materials CRISPR for VARS2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VARS2
- GenScript: Design CRISPR guide RNA sequences for VARS2
miRNA Products
- Search ViGene Biosciences for VARS2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for VARS2
- Browse OriGene Inhibitory RNA Products For VARS2
- genomics-online: shRNA clones - Search results for available VARS2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for VARS2 gene
Clone Products
-
OriGene ORF clones in human for VARS2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for VARS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VARS2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available VARS2 gene related products
- orf clones - Search results for available VARS2 gene related products
- Applied Biological Materials Clones for VARS2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for VARS2
-
ViGene Biosciences adenoviral particle packaged cDNA for VARS2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for VARS2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VARS2 gene
No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VARS2 Gene
Localization for VARS2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for VARS2 Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 1 |
| cytosol | 1 |
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005829 | NOT cytosol | IBA | -- |
Pathways & Interactions for VARS2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | tRNA Aminoacylation | ||
| 2 | Gene Expression |
.48
|
|
Pathways by source for VARS2 Gene
3 Reactome pathways for VARS2 Gene
1 KEGG pathway for VARS2 Gene
Interacting Proteins for VARS2 Gene
Selected Interacting proteins:
Q5ST30-SYVM_HUMAN
ENSP00000441000
for VARS2 Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006412 | translation | IEA | -- |
| GO:0006418 | tRNA aminoacylation for protein translation | IEA | -- |
| GO:0006438 | valyl-tRNA aminoacylation | IEA,IBA | -- |
| GO:0006450 | regulation of translational fidelity | IEA | -- |
| GO:0106074 | aminoacyl-tRNA metabolism involved in translational fidelity | IEA | -- |
No data available for SIGNOR curated interactions for VARS2 Gene
Drugs & Compounds for VARS2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Transcripts for VARS2 Gene
mRNA/cDNA for VARS2 Gene
- (3) REFSEQ mRNAs :
- (20) Additional mRNA sequences :
- (149) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for VARS2 Gene
- Valyl-tRNA synthetase 2, mitochondrial:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for VARS2
- genomics-online: gRNA clones - Search results for available VARS2 gene related products
- Applied Biological Materials CRISPR for VARS2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VARS2
- GenScript: Design CRISPR guide RNA sequences for VARS2
miRNA Products
- Search ViGene Biosciences for VARS2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for VARS2
- Browse OriGene Inhibitory RNA Products For VARS2
- genomics-online: shRNA clones - Search results for available VARS2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for VARS2 gene
Clone Products
-
OriGene ORF clones in human for VARS2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for VARS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VARS2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available VARS2 gene related products
- orf clones - Search results for available VARS2 gene related products
- Applied Biological Materials Clones for VARS2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 14b | · | 14c |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: |
Expression for VARS2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Kidney (17.1) and Lymph node (11.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VARS2 Gene
NURSA nuclear receptor signaling pathways regulating expression of VARS2 Gene:
VARS2SOURCE GeneReport for Unigene cluster for VARS2 Gene:
Hs.597526Evidence on tissue expression from TISSUES for VARS2 Gene
- Nervous system(4.8)
- Eye(4.1)
- Skin(4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for VARS2 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- head
- skull
Primer Products
-
OriGene qPCR primer pairs for VARS2
-
OriGene qPCR primer pairs and template standards for VARS2
- genomics-online: primer clones - Search results for available VARS2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VARS2 Gene
Orthologs for VARS2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | VARS2 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | VARS2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | VARS2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Vars2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Vars2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | VARS2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | VARS2 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | VARS2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100493727 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | vars2 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Aats-val 35 |
|
|
|
| CG5660 35 34 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | vrs-2 35 |
|
|
|
| vrs-1 35 |
|
|
|||
| vars-1 34 |
|
OneToOne | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VAS1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for VARS2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for VARS2 Gene
(1) SIMAP similar genes for VARS2 Gene using alignment to 4 proteins:
Variants for VARS2 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs138855624 | uncertain-significance, not provided, not specified | 30,924,438(+) | C/T | coding_sequence_variant, missense_variant | |
| rs142520878 | likely-benign, not provided, not specified | 30,924,387(+) | C/G/T | coding_sequence_variant, missense_variant | |
| rs55865499 | likely-benign, not provided, not specified | 30,923,211(+) | G/A | coding_sequence_variant, missense_variant | |
| rs587777583 | pathogenic, Combined oxidative phosphorylation deficiency 20, Combined oxidative phosphorylation deficiency 20 (COXPD20) [MIM:615917] | 30,918,886(+) | G/A | coding_sequence_variant, missense_variant | |
| rs587777584 | pathogenic, Combined oxidative phosphorylation deficiency 20, Combined oxidative phosphorylation deficiency 20 (COXPD20) [MIM:615917] | 30,921,976(+) | C/A | coding_sequence_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2088436 | CNV | deletion | 18987734 |
| esv2670269 | CNV | deletion | 23128226 |
| esv2677874 | CNV | deletion | 23128226 |
| esv2731791 | CNV | deletion | 23290073 |
| esv3411275 | CNV | duplication | 20981092 |
| esv3567511 | CNV | deletion | 23714750 |
| esv3608518 | CNV | gain | 21293372 |
| nsv1031677 | CNV | gain | 25217958 |
| nsv1074389 | CNV | deletion | 25765185 |
| nsv1122126 | CNV | deletion | 24896259 |
| nsv1144137 | CNV | deletion | 24896259 |
| nsv523346 | CNV | loss | 19592680 |
| nsv525438 | CNV | gain | 19592680 |
| nsv601264 | CNV | loss | 21841781 |
| nsv601481 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
17.90;
98.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VARS2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VARS2 Gene
Disorders for VARS2 Gene
(1) MalaCards diseases for VARS2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| combined oxidative phosphorylation deficiency 20 |
|
Search VARS2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SYVM_HUMAN- Combined oxidative phosphorylation deficiency 20 (COXPD20) [MIM:615917]: A disorder due to mitochondrial respiratory chain complex defects. Clinical features are variable and include muscle weakness with hypotonia, central neurological disease with progressive external ophthalmoplegia, ptosis and ataxia, delayed psychomotor development, cardiomyopathy, abnormal liver function, facial dysmorphism, microcephaly and epilepsy. {ECO:0000269 PubMed:24827421, ECO:0000269 PubMed:25058219}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for VARS2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for VARS2 Gene
Publications for VARS2 Gene
- Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
- VARS2 and TARS2 mutations in patients with mitochondrial encephalomyopathies. (PMID: 24827421) Diodato D … Ghezzi D (Human mutation 2014) 3 4 58
- Use of whole-exome sequencing to determine the genetic basis of multiple mitochondrial respiratory chain complex deficiencies. (PMID: 25058219) Taylor RW … Chinnery PF (JAMA 2014) 3 4 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
- High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
Products for VARS2 Gene
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- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for VARS2
- Novus Biologicals lysates and proteins for VARS2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for VARS2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for VARS2
- Cyagen custom Knockout/knockin (KOKI) mouse models for VARS2
- VectorBuilder custom plasmid, inducible vectors for VARS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VARS2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 23 available VARS2 Antibodies ranked by validation data
- Compare Top VARS2 Antibodies
- antibodies-online: Search results for available VARS2 related products ranked by validation data
- antibodies-online: Search results for 3 available VARS2 Proteins ranked by validation data
- Compare Top VARS2 Proteins
- Quality Products:
- Search GeneTex for Antibodies for VARS2
- Search GeneTex for Proteins for VARS2
- ViGene Biosciences adenoviral particle packaged cDNA for VARS2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for VARS2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for VARS2 gene
- Search ViGene Biosciences for VARS2
- Horizon Cell Lines for VARS2
- genomics-online: cdna clones - Search results for available VARS2 gene related products
- orf clones - Search results for available VARS2 gene related products
- genomics-online: gRNA clones - Search results for available VARS2 gene related products
- genomics-online: primer clones - Search results for available VARS2 gene related products
- genomics-online: shRNA clones - Search results for available VARS2 gene related products
Sources for VARS2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
