The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008] See more...

Aliases for VAPB Gene

Aliases for VAPB Gene

  • VAMP Associated Protein B And C 2 3 5
  • VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B And C 2 3
  • Vesicle-Associated Membrane Protein-Associated Protein B/C 3 4
  • VAMP-Associated 33 KDa Protein 3
  • VAMP-Associated Protein B/C 4
  • VAMP-B/VAMP-C 4
  • VAP-B/VAP-C 4
  • VAMP-B 3
  • VAP-B 3
  • ALS8 3

External Ids for VAPB Gene

Previous GeneCards Identifiers for VAPB Gene

  • GC20P056692
  • GC20P057602
  • GC20P057649
  • GC20P056397
  • GC20P056964
  • GC20P053747

Summaries for VAPB Gene

Entrez Gene Summary for VAPB Gene

  • The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]

GeneCards Summary for VAPB Gene

VAPB (VAMP Associated Protein B And C) is a Protein Coding gene. Diseases associated with VAPB include Spinal Muscular Atrophy, Late-Onset, Finkel Type and Amyotrophic Lateral Sclerosis 8. Among its related pathways are Sphingolipid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is VAPA.

UniProtKB/Swiss-Prot Summary for VAPB Gene

  • Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.

Gene Wiki entry for VAPB Gene

Additional gene information for VAPB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VAPB Gene

Genomics for VAPB Gene

GeneHancer (GH) Regulatory Elements for VAPB Gene

Promoters and enhancers for VAPB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J058388 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 523.6 +1.1 1115 4.1 LARP7 FOXK2 HNRNPK ZNF217 SIN3A NRF1 POLR2G PHF8 PHB2 ZFX VAPB lnc-APCDD1L-5 STX16 PPP4R1L ENSG00000254419 GNAS-AS1 piR-36260-049
GH20J058420 Enhancer 1 Ensembl ENCODE 36.5 +33.4 33364 4.2 USF1 TEAD4 FOS ZNF10 WT1 ZBTB17 FOSL1 CEBPG MLLT1 RBM22 lnc-APCDD1L-2 VAPB PPP4R1L RAB22A GNAS-AS1 lnc-RAB22A-2
GH20J058436 Enhancer 0.9 Ensembl ENCODE 36.5 +49.7 49667 3.6 NCOR1 ZFX TGIF2 FOXA2 SIN3A CREB1 ZNF316 MAFF ZNF207 SAP130 VAPB PPP4R1L RAB22A lnc-RAB22A-2 lnc-APCDD1L-2
GH20J058432 Enhancer 0.8 Ensembl ENCODE 37.2 +44.0 43982 3.4 JUND FOS ZFX FOXA2 NR2F2 ZBTB33 RBM22 FOSL1 KLF9 ZNF664 VAPB NELFCD STX16 GNAS-AS1 lnc-APCDD1L-2 lnc-RAB22A-2
GH20J058407 Enhancer 0.9 ENCODE 35.9 +19.3 19280 2.5 ZBTB11 ZBTB25 TGIF2 OSR2 NCOR1 MYNN TCF12 WT1 ZNF316 ARNT VAPB NELFCD STX16 ENSG00000225806 NPEPL1 ANKRD60 piR-36260-049
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VAPB on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VAPB

Top Transcription factor binding sites by QIAGEN in the VAPB gene promoter:
  • C/EBPalpha
  • Cart-1
  • Chx10
  • FOXO3
  • FOXO3a
  • FOXO3b
  • Pbx1a
  • SRY
  • TBP
  • ZIC2

Genomic Locations for VAPB Gene

Genomic Locations for VAPB Gene
chr20:58,389,119-58,451,101
(GRCh38/hg38)
Size:
61,983 bases
Orientation:
Plus strand
chr20:56,964,175-57,026,157
(GRCh37/hg19)
Size:
61,983 bases
Orientation:
Plus strand

Genomic View for VAPB Gene

Genes around VAPB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAPB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAPB Gene

Proteins for VAPB Gene

  • Protein details for VAPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95292-VAPB_HUMAN
    Recommended name:
    Vesicle-associated membrane protein-associated protein B/C
    Protein Accession:
    O95292
    Secondary Accessions:
    • A2A2F2
    • O95293
    • Q9P0H0

    Protein attributes for VAPB Gene

    Size:
    243 amino acids
    Molecular mass:
    27228 Da
    Quaternary structure:
    • Homodimer, and heterodimer with VAPA (PubMed:20940299). Interacts with VAMP1 and VAMP2 (PubMed:9920726, PubMed:20940299). Interacts (via MSP domain) with ZFYVE27 (PubMed:21976701, PubMed:19289470). Interacts with RMDN3 (PubMed:22131369). Interacts with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701). Interacts with STARD3 (via FFAT motif) (PubMed:24105263). Interacts with STARD3NL (via FFAT motif) (PubMed:24105263). Interacts with CERT (PubMed:16895911).
    • (Microbial infection) Interacts with HCV protein NS5A and NS5B.

    Three dimensional structures from OCA and Proteopedia for VAPB Gene

    Alternative splice isoforms for VAPB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VAPB Gene

Post-translational modifications for VAPB Gene

  • Ubiquitination at Lys155
  • Modification sites at PhosphoSitePlus

Other Protein References for VAPB Gene

No data available for DME Specific Peptides for VAPB Gene

Domains & Families for VAPB Gene

Gene Families for VAPB Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for VAPB Gene

Blocks:
  • Major sperm protein (MSP) domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VAPB Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ13179 fis, clone NT2RP3003918, highly similar to Vesicle-associated membrane protein-associated protein B/C (Q53XM7_HUMAN)
  • Vesicle-associated membrane protein-associated protein B/C (VAPB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95292

UniProtKB/Swiss-Prot:

VAPB_HUMAN :
  • Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
Family:
  • Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
genes like me logo Genes that share domains with VAPB: view

Function for VAPB Gene

Molecular function for VAPB Gene

UniProtKB/Swiss-Prot Function:
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.

Gene Ontology (GO) - Molecular Function for VAPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9920726
GO:0008017 microtubule binding IDA 18713837
GO:0019899 enzyme binding IPI 17540579
GO:0033149 FFAT motif binding IPI 24105263
GO:0042803 protein homodimerization activity IPI 9920726
genes like me logo Genes that share ontologies with VAPB: view
genes like me logo Genes that share phenotypes with VAPB: view

Human Phenotype Ontology for VAPB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for VAPB Gene

MGI Knock Outs for VAPB:
  • Vapb Vapb<tm1.2Ics>

Animal Model Products

  • Taconic Biosciences Mouse Models for VAPB

CRISPR Products

Clone Products

  • Addgene plasmids for VAPB

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for VAPB Gene

Localization for VAPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAPB Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane. {ECO:0000269 PubMed:22131369}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VAPB gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 4
mitochondrion 3
cytosol 3
cytoskeleton 2
peroxisome 2
nucleus 2
endosome 2
lysosome 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VAPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005623 cell IEA --
GO:0005737 cytoplasm IDA 25468996
GO:0005783 endoplasmic reticulum IDA,IEA 15372378
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
genes like me logo Genes that share ontologies with VAPB: view

Pathways & Interactions for VAPB Gene

genes like me logo Genes that share pathways with VAPB: view

Pathways by source for VAPB Gene

Gene Ontology (GO) - Biological Process for VAPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis IEA,IMP 22131369
GO:0006888 ER to Golgi vesicle-mediated transport IMP 18713837
GO:0006986 response to unfolded protein IEA --
GO:0007029 endoplasmic reticulum organization IMP 18713837
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with VAPB: view

No data available for SIGNOR curated interactions for VAPB Gene

Drugs & Compounds for VAPB Gene

No Compound Related Data Available

Transcripts for VAPB Gene

mRNA/cDNA for VAPB Gene

2 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for VAPB

Alternative Splicing Database (ASD) splice patterns (SP) for VAPB Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - - -
SP2: - - -
SP3:
SP4: - - - -
SP5: - - - - - - -
SP6:

Relevant External Links for VAPB Gene

GeneLoc Exon Structure for
VAPB

Expression for VAPB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VAPB Gene

Protein differential expression in normal tissues from HIPED for VAPB Gene

This gene is overexpressed in Brain (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for VAPB Gene



Protein tissue co-expression partners for VAPB Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VAPB

SOURCE GeneReport for Unigene cluster for VAPB Gene:

Hs.182625

mRNA Expression by UniProt/SwissProt for VAPB Gene:

O95292-VAPB_HUMAN
Tissue specificity: Ubiquitous. Isoform 1 predominates.

Evidence on tissue expression from TISSUES for VAPB Gene

  • Nervous system(4.9)
  • Heart(4.4)
  • Liver(4.4)
  • Adrenal gland(4.3)
  • Blood(4.2)
  • Kidney(2.8)
  • Lung(2.4)
  • Muscle(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for VAPB Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • epiglottis
  • face
  • head
  • jaw
  • larynx
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • pharynx
  • skull
  • tongue
  • vocal cord
Thorax:
  • bronchus
  • clavicle
  • esophagus
  • heart
  • lung
  • scapula
  • trachea
Abdomen:
  • biliary tract
  • liver
  • stomach
Limb:
  • arm
  • digit
  • finger
  • foot
  • forearm
  • hand
  • humerus
  • lower limb
  • shin
  • shoulder
  • thigh
  • toe
  • upper limb
General:
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • spinal cord
genes like me logo Genes that share expression patterns with VAPB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for VAPB Gene

Orthologs for VAPB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAPB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VAPB 31 30
  • 99.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia VAPB 31 30
  • 92.59 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VAPB 31
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VAPB 31
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VAPB 31 30
  • 91.5 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Vapb 17 31 30
  • 87.52 (n)
rat
(Rattus norvegicus)
Mammalia Vapb 30
  • 85.46 (n)
chicken
(Gallus gallus)
Aves VAPB 31 30
  • 83.4 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VAPB 31
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76271 30 30
  • 74.34 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29271 30
zebrafish
(Danio rerio)
Actinopterygii vapb 31 30
  • 71.49 (n)
OneToOne
wufa96d05 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000626 30
  • 50.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta Vap-33-1 31 32 30
  • 47.13 (n)
ManyToMany
fan 31
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea vpr-1 31 30
  • 44.96 (n)
OneToMany
F33D11.11 32
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCS22 31
  • 26 (a)
ManyToMany
SCS2 31
  • 19 (a)
ManyToMany
Species where no ortholog for VAPB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAPB Gene

ENSEMBL:
Gene Tree for VAPB (if available)
TreeFam:
Gene Tree for VAPB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for VAPB: view image

Paralogs for VAPB Gene

Paralogs for VAPB Gene

(2) SIMAP similar genes for VAPB Gene using alignment to 3 proteins:

  • VAPB_HUMAN
  • E5RK64_HUMAN
  • Q53XM7_HUMAN

Pseudogenes.org Pseudogenes for VAPB Gene

genes like me logo Genes that share paralogs with VAPB: view

Variants for VAPB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VAPB Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
639834 Uncertain Significance: Amyotrophic lateral sclerosis type 8; Spinal muscular atrophy, late-onset, finkel type 58,444,171(+) G/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT
647542 Uncertain Significance: Amyotrophic lateral sclerosis type 8; Spinal muscular atrophy, late-onset, finkel type 58,444,177(+) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT
650970 Uncertain Significance: Amyotrophic lateral sclerosis type 8; Spinal muscular atrophy, late-onset, finkel type 58,444,191(+) T/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT
656346 Uncertain Significance: Amyotrophic lateral sclerosis type 8; Spinal muscular atrophy, late-onset, finkel type 58,418,351(+) A/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
702264 Benign: not provided 58,418,257(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for VAPB Gene

Structural Variations from Database of Genomic Variants (DGV) for VAPB Gene

Variant ID Type Subtype PubMed ID
esv2722621 CNV deletion 23290073
nsv1118919 CNV deletion 24896259
nsv1160685 CNV deletion 26073780
nsv3428 CNV deletion 18451855
nsv834019 CNV loss 17160897

Variation tolerance for VAPB Gene

Residual Variation Intolerance Score: 46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VAPB Gene

Human Gene Mutation Database (HGMD)
VAPB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
VAPB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VAPB Gene

Disorders for VAPB Gene

MalaCards: The human disease database

(28) MalaCards diseases for VAPB Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search VAPB in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

VAPB_HUMAN
  • Amyotrophic lateral sclerosis 8 (ALS8) [MIM:608627]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. {ECO:0000269 PubMed:15372378, ECO:0000269 PubMed:16891305, ECO:0000269 PubMed:20940299, ECO:0000269 PubMed:22131369}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Spinal muscular atrophy, proximal, adult, autosomal dominant (SMAPAD) [MIM:182980]: A form of spinal muscular atrophy, a neuromuscular disorder characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAPAD is characterized by proximal muscle weakness that begins in the lower limbs and then progresses to upper limbs, onset in late adulthood (after third decade) and a benign course. Most of the patients remain ambulatory 10 to 40 years after clinical onset. {ECO:0000269 PubMed:15372378}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for VAPB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with VAPB: view

No data available for Genatlas for VAPB Gene

Publications for VAPB Gene

  1. Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT. (PMID: 16895911) Kawano M … Hanada K (The Journal of biological chemistry 2006) 3 4 23 54
  2. Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8). (PMID: 16891305) Kanekura K … Matsuoka M (The Journal of biological chemistry 2006) 3 4 23 54
  3. Sporadic ALS is not associated with VAPB gene mutations in Southern Italy. (PMID: 16729899) Conforti FL … Quattrone A (Journal of negative results in biomedicine 2006) 3 23 41 54
  4. A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. (PMID: 15372378) Nishimura AL … Zatz M (American journal of human genetics 2004) 3 4 23 54
  5. Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins. (PMID: 9920726) Nishimura Y … Tanaka T (Biochemical and biophysical research communications 1999) 2 3 4 54

Products for VAPB Gene

Sources for VAPB Gene