Aliases for VAPB Gene
External Ids for VAPB Gene
Previous GeneCards Identifiers for VAPB Gene
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]
GeneCards Summary for VAPB Gene
VAPB (VAMP Associated Protein B And C) is a Protein Coding gene. Diseases associated with VAPB include Spinal Muscular Atrophy, Late-Onset, Finkel Type and Amyotrophic Lateral Sclerosis 8. Among its related pathways are Pathways of neurodegeneration - multiple diseases and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is VAPA.
UniProtKB/Swiss-Prot Summary for VAPB Gene
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.