Aliases for VAPA Gene
External Ids for VAPA Gene
Previous GeneCards Identifiers for VAPA Gene
The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for VAPA Gene
VAPA (VAMP Associated Protein A) is a Protein Coding gene. Diseases associated with VAPA include Amyotrophic Lateral Sclerosis 8 and Amyotrophic Lateral Sclerosis Type 14. Among its related pathways are Sphingolipid metabolism and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and structural molecule activity. An important paralog of this gene is VAPB.
UniProtKB/Swiss-Prot for VAPA Gene
Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470).