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This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010] See more...
Aliases for VAMP8 Gene
Aliases for VAMP8 Gene
External Ids for VAMP8 Gene
- HGNC: 12647
- Entrez Gene: 8673
- Ensembl: ENSG00000118640
- OMIM: 603177
- UniProtKB: Q9BV40
Previous GeneCards Identifiers for VAMP8 Gene
- GC02P085700
- GC02P086098
- GC02P085779
- GC02P085716
- GC02P085658
- GC02P085788
- GC02P085701
Summaries for VAMP8 Gene
-
This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]
GeneCards Summary for VAMP8 Gene
VAMP8 (Vesicle Associated Membrane Protein 8) is a Protein Coding gene. Diseases associated with VAMP8 include Hemophagocytic Lymphohistiocytosis, Familial, 5 and Hemophagocytic Lymphohistiocytosis, Familial, 4. Among its related pathways are Antigen processing-Cross presentation and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include syntaxin binding and SNAP receptor activity. An important paralog of this gene is ENSG00000263620.
UniProtKB/Swiss-Prot Summary for VAMP8 Gene
-
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity).
Additional gene information for VAMP8 Gene
- HGNC(12647)
- Entrez Gene(8673)
- Ensembl(ENSG00000118640)
- OMIM(603177)
- UniProtKB(Q9BV40)
- Open Targets Platform(ENSG00000118640)
- Monarch Initiative
- Search for VAMP8 at DataMed
- Search for VAMP8 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VAMP8 Gene
Genomics for VAMP8 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for VAMP8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around VAMP8 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VAMP8
- Top Transcription factor binding sites by QIAGEN in the VAMP8 gene promoter:
-
- AP-1
- c-Fos
- c-Jun
- E2F
- E2F-1
- FosB
- JunB
- JunD
- Msx-1
- Olf-1
Genomic Locations for VAMP8 Gene
Genomic Locations for VAMP8 Gene
- chr2:85,561,562-85,582,031
- (GRCh38/hg38)
- Size:
- 20,470 bases
- Orientation:
- Plus strand
- chr2:85,788,685-85,809,156
- (GRCh37/hg19)
- Size:
- 20,472 bases
- Orientation:
- Plus strand
Genomic View for VAMP8 Gene
Genes around VAMP8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p11.2 by HGNC
- 2p11.2 by Entrez Gene
- 2p11.2 by Ensembl
VAMP8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VAMP8 Gene
Proteins for VAMP8 Gene
-
Protein details for VAMP8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BV40-VAMP8_HUMAN
- Recommended name:
- Vesicle-associated membrane protein 8
- Protein Accession:
- Q9BV40
- O60625
- Q53SP9
- Q6IB09
Protein attributes for VAMP8 Gene
- Size:
- 100 amino acids
- Molecular mass:
- 11438 Da
- Quaternary structure:
-
- Forms a SNARE complex composed of VAMP8, SNAP29 and STX17 involved in fusion of autophagosome with lysosome (PubMed:25686604). Found in a number of SNARE complexes with NAPA, SNAP23, SNAP25, STX1A, STX4, STX7, STX8 and VTI1B (PubMed:12130530). Interacts with PICALM (By similarity). SNARE complex formation and binding by PICALM are mutually exclusive processes for VAMP8 (By similarity). Interacts with SBF2/MTMR13 (PubMed:25648148). Interacts with RAB21 (in GTP-bound form) in response to starvation; the interaction probably regulates VAMP8 endolysosomal trafficking (PubMed:25648148). Interacts with STX17; this interaction is increased in the absence of TMEM39A (PubMed:31806350).
Protein Expression for VAMP8 Gene
Post-translational modifications for VAMP8 Gene
Other Protein References for VAMP8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ VAMP8 Antibody
-
Custom Antibody ServicesOriGene Antibodies for VAMP8
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- Invitrogen Antibodies for VAMP8 (AFLGC-VAMP8)
-
Santa Cruz Biotechnology (SCBT) Antibodies for VAMP8
- Sino Biological Antibodies for VAMP8
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for VAMP8
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- ProSpec Recombinant Proteins for VAMP8
- antibodies-online: Show 8 available VAMP8 Proteins ranked by validation data
- Compare Top VAMP8 Proteins
-
Quality Products:
-
Abcam proteins for VAMP8
No data available for DME Specific Peptides for VAMP8 Gene
Domains & Families for VAMP8 Gene
Gene Families for VAMP8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Protein Domains for VAMP8 Gene
- InterPro:
- Blocks:
-
- Synaptobrevin
- ProtoNet:
Suggested Antigen Peptide Sequences for VAMP8 Gene
- GenScript: Design optimal peptide antigens:
-
- Endobrevin (VAMP8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9BV40- Family:
-
- Belongs to the synaptobrevin family.
Function for VAMP8 Gene
Molecular function for VAMP8 Gene
- UniProtKB/Swiss-Prot Function:
- SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity).
- GENATLAS Biochemistry:
- vesicle associated membrane protein 8,endobrevin,member of the VAMP synaptobrevin protein family (soluble N ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein),associated with the early endosome,involved in regulating membrane traffic
Phenotypes From GWAS Catalog for VAMP8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005484 | SNAP receptor activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 22118466 |
| GO:0019869 | chloride channel inhibitor activity | IDA | 18570918 |
| GO:0019905 | syntaxin binding | IBA | 21873635 |
Phenotypes for VAMP8 Gene
- MGI mutant phenotypes for VAMP8:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for VAMP8:
Animal Models for VAMP8 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for VAMP8 - Select products 50% OFF >
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for VAMP8
miRNA for VAMP8 Gene
- miRTarBase miRNAs that target VAMP8
-
- hsa-miR-193b-3p (MIRT016522)
- hsa-miR-124-3p (MIRT022696)
- hsa-miR-7-5p (MIRT025757)
- hsa-miR-16-5p (MIRT031767)
- hsa-miR-877-5p (MIRT303874)
- hsa-miR-3125 (MIRT303875)
- hsa-miR-3916 (MIRT303876)
- hsa-miR-4428 (MIRT303877)
- hsa-miR-4524b-3p (MIRT303878)
- hsa-miR-6859-5p (MIRT303879)
- hsa-miR-4732-5p (MIRT561097)
- hsa-miR-6832-5p (MIRT561098)
- hsa-miR-20b-3p (MIRT561099)
- hsa-miR-3137 (MIRT561100)
- hsa-miR-6809-3p (MIRT649534)
- hsa-miR-6833-3p (MIRT649536)
- hsa-miR-4768-5p (MIRT649537)
- hsa-miR-7156-3p (MIRT649538)
- hsa-miR-4753-3p (MIRT649539)
- hsa-miR-6873-3p (MIRT649540)
- hsa-miR-130b-5p (MIRT649541)
- hsa-miR-6817-3p (MIRT649542)
- hsa-miR-7110-3p (MIRT649543)
- hsa-miR-455-3p (MIRT649544)
- hsa-miR-4691-3p (MIRT649545)
- hsa-miR-449b-3p (MIRT649546)
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for VAMP8 - Select products 50% OFF >
- * VAMP8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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- Sino Biological Human cDNA Clone for VAMP8
- Addgene plasmids for VAMP8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VAMP8
Cell Line Products
-
Horizon Cell Lines for VAMP8
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VAMP8 Gene
Localization for VAMP8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for VAMP8 Gene
- Lysosome membrane. Single-pass type IV membrane protein. Early endosome membrane. Single-pass type IV membrane protein. Late endosome membrane. Single-pass type IV membrane protein. Cell membrane. Single-pass type IV membrane protein. Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi (By similarity). Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell (By similarity). Cycles through the apical but not through the basolateral plasma membrane (By similarity). Apical region of acinar cells; in zymogen granule membranes (By similarity). {ECO:0000250 UniProtKB:Q9WUF4}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endosome | 5 |
| cytosol | 5 |
| lysosome | 5 |
| extracellular | 4 |
| mitochondrion | 3 |
| cytoskeleton | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Golgi apparatus (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 18253931 |
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | IEA,IDA | 23217709 |
| GO:0005768 | endosome | IEA | -- |
| GO:0005769 | early endosome | TAS | 9614193 |
Pathways & Interactions for VAMP8 Gene
Pathways by source for VAMP8 Gene
15 Reactome pathways for VAMP8 Gene
1 PharmGKB pathway for VAMP8 Gene
3 KEGG pathways for VAMP8 Gene
3 GeneGo (Thomson Reuters) pathways for VAMP8 Gene
- Transport Clathrin-coated vesicle cycle
- wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
- wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)
Interacting Proteins for VAMP8 Gene
Selected Interacting proteins:
Q9BV40-VAMP8_HUMAN
ENSP00000263864
for VAMP8 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for VAMP8
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006892 | post-Golgi vesicle-mediated transport | TAS | -- |
| GO:0006906 | vesicle fusion | IBA | 21873635 |
| GO:0006914 | autophagy | IEA | -- |
| GO:0015031 | protein transport | IEA | -- |
No data available for SIGNOR curated interactions for VAMP8 Gene
Transcripts for VAMP8 Gene
mRNA/cDNA for VAMP8 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000263864 679 nts (view in UCSC)
- ENST00000409760 805 nts (view in UCSC)
- ENST00000432071 664 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for VAMP8 - Select products 50% OFF >
- * VAMP8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for VAMP8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VAMP8
-
Santa Cruz Biotechnology (SCBT) CRISPR for VAMP8
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VAMP8
- Browse OriGene Inhibitory RNA Products For VAMP8
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Clone Products
- Applied Biological Materials (abm): Clones for VAMP8 - Select products 50% OFF >
- * VAMP8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for VAMP8
- Addgene plasmids for VAMP8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VAMP8
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||
| SP2: | - | ||||||||||||||||||
| SP3: | - | - | |||||||||||||||||
| SP4: |
Relevant External Links for VAMP8 Gene
- GeneLoc Exon Structure for
- VAMP8
Expression for VAMP8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
-
Kidney (Urinary System)
- Presumptive Podocytes Podocyte Layer
-
Epithelial Cells
- Presumptive Podocytes Podocyte Layer
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
This gene is overexpressed in Nasal epithelium (17.5), Monocytes (8.0), Peripheral blood mononuclear cells (7.9), and NK cells (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for VAMP8 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VAMP8
SOURCE GeneReport for Unigene cluster for VAMP8 Gene:
Hs.714302mRNA Expression by UniProt/SwissProt for VAMP8 Gene:
Q9BV40-VAMP8_HUMAN
Tissue specificity:
Platelets.
Evidence on tissue expression from TISSUES for VAMP8 Gene
- Lung(4.7)
- Nervous system(3.6)
- Kidney(3.2)
- Blood(3.2)
- Eye(3.1)
- Skin(3)
- Pancreas(3)
- Spleen(3)
- Lymph node(2.9)
- Liver(2.8)
- Bone marrow(2.8)
- Intestine(2.8)
- Heart(2.5)
- Stomach(2.4)
- Adrenal gland(2.3)
- Muscle(2.2)
- Thyroid gland(2.2)
Primer Products
-
OriGene qPCR primer pairs for VAMP8
-
OriGene qPCR primer pairs and template standards for VAMP8
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for VAMP8 Gene
Orthologs for VAMP8 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | VAMP8 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | VAMP8 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | VAMP8 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | VAMP8 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Vamp8 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Vamp8 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | VAMP8 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | vamp8 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | vamp8 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | vamp-8 31 |
|
OneToMany | |
| vamp-7 31 |
|
OneToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SNC1 31 |
|
ManyToMany | |
| SNC2 31 |
|
ManyToMany |
- Species where no ortholog for VAMP8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for VAMP8 Gene
- ENSEMBL:
- Gene Tree for VAMP8 (if available)
- TreeFam:
- Gene Tree for VAMP8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for VAMP8: view image
Paralogs for VAMP8 Gene
Paralogs for VAMP8 Gene
(6) SIMAP similar genes for VAMP8 Gene using alignment to 3 proteins:
- VAMP8_HUMAN
- B8ZZT4_HUMAN
- C9JXZ5_HUMAN
Variants for VAMP8 Gene
Residual Variation Intolerance Score:
65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.16;
3.55% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VAMP8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- VAMP8
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for VAMP8 Gene
Disorders for VAMP8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hemophagocytic lymphohistiocytosis, familial, 5 |
|
|
| hemophagocytic lymphohistiocytosis, familial, 4 |
|
|
| leukodystrophy, hypomyelinating, 6 |
|
|
Search VAMP8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for VAMP8
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for VAMP8 Gene
Publications for VAMP8 Gene
- Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome. (PMID: 9614193) Wong SH … Hong W (Molecular biology of the cell 1998) 2 3 4 23
- Endobrevin maps to chromosome 2 in human and chromosome 6 in mouse. (PMID: 9878266) Bui TD … Hong W (Genomics 1998) 2 3 23
- The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1. (PMID: 31806350) Miao G … Zhang H (Molecular cell 2020) 3 4
- ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes. (PMID: 25686604) Diao J … Zhong Q (Nature 2015) 3 4
- Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion. (PMID: 25648148) Jean S … Kiger AA (EMBO reports 2015) 3 4
ExternalLinks
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- VectorBuilder Viral vectors for VAMP8 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for VAMP8 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for VAMP8 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for VAMP8
- Addgene plasmids for VAMP8
- antibodies-online: Show 12 available VAMP8 Antibodies ranked by validation data
- Compare Top VAMP8 Antibodies
- antibodies-online: Search results for available VAMP8 related products ranked by validation data
- antibodies-online: Show 8 available VAMP8 Proteins ranked by validation data
- Compare Top VAMP8 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for VAMP8
- Search Santa Cruz Biotechnology (SCBT) for VAMP8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for VAMP8
- Horizon Cell Lines for VAMP8
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VAMP8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VAMP8
- Search GeneCopoeia for miRNA 3'UTR Target clone products for VAMP8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VAMP8
Sources for VAMP8 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB