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This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]
VAMP8 (Vesicle Associated Membrane Protein 8) is a Protein Coding gene. Diseases associated with VAMP8 include Hemophagocytic Lymphohistiocytosis, Familial, 5 and Hemophagocytic Lymphohistiocytosis, Familial, 4. Among its related pathways are Antigen processing-Cross presentation and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include syntaxin binding and SNAP receptor activity. An important paralog of this gene is ENSG00000263620.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005484 | SNAP receptor activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 22118466 |
GO:0019869 | chloride channel inhibitor activity | IDA | 18570918 |
GO:0019905 | syntaxin binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IDA | 18253931 |
GO:0005764 | lysosome | IEA | -- |
GO:0005765 | lysosomal membrane | IEA,IDA | 23217709 |
GO:0005768 | endosome | IEA | -- |
GO:0005769 | early endosome | TAS | 9614193 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
GO:0006892 | post-Golgi vesicle-mediated transport | TAS | -- |
GO:0006906 | vesicle fusion | IBA | 21873635 |
GO:0006914 | autophagy | IEA | -- |
GO:0015031 | protein transport | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||
SP2: | - | ||||||||||||||||||
SP3: | - | - | |||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | VAMP8 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | VAMP8 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | VAMP8 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | VAMP8 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Vamp8 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Vamp8 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | VAMP8 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | vamp8 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | vamp8 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | vamp-8 31 |
|
OneToMany | |
vamp-7 31 |
|
OneToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SNC1 31 |
|
ManyToMany | |
SNC2 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
hemophagocytic lymphohistiocytosis, familial, 5 |
|
|
hemophagocytic lymphohistiocytosis, familial, 4 |
|
|
leukodystrophy, hypomyelinating, 6 |
|
|