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Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue dist... See more...
Aliases for VAMP3 Gene
Aliases for VAMP3 Gene
External Ids for VAMP3 Gene
- HGNC: 12644
- Entrez Gene: 9341
- Ensembl: ENSG00000049245
- OMIM: 603657
- UniProtKB: Q15836
Previous GeneCards Identifiers for VAMP3 Gene
- GC01P007413
- GC01P007640
- GC01P007540
- GC01P006979
Summaries for VAMP3 Gene
-
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]
GeneCards Summary for VAMP3 Gene
VAMP3 (Vesicle Associated Membrane Protein 3) is a Protein Coding gene. Diseases associated with VAMP3 include Tetanus. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include SNARE binding and syntaxin-1 binding. An important paralog of this gene is ENSG00000263620.
UniProtKB/Swiss-Prot Summary for VAMP3 Gene
-
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VAMP3 Gene
Genomics for VAMP3 Gene
GeneHancer (GH) Regulatory Elements for VAMP3 Gene
Promoters and enhancers for VAMP3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around VAMP3 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VAMP3
- Top Transcription factor binding sites by QIAGEN in the VAMP3 gene promoter:
-
- CUTL1
- FOXL1
- NF-kappaB
- NF-kappaB1
- NF-kappaB2
- Nkx2-5
- POU2F1
- POU2F1a
- POU3F2
- POU3F2 (N-Oct-5a)
Genomic Locations for VAMP3 Gene
Genomic Locations for VAMP3 Gene
- chr1:7,771,269-7,781,432
- (GRCh38/hg38)
- Size:
- 10,164 bases
- Orientation:
- Plus strand
- chr1:7,831,329-7,841,492
- (GRCh37/hg19)
- Size:
- 10,164 bases
- Orientation:
- Plus strand
Genomic View for VAMP3 Gene
Genes around VAMP3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.23 by HGNC
- 1p36.23 by Entrez Gene
- 1p36.23 by Ensembl
VAMP3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VAMP3 Gene
Proteins for VAMP3 Gene
-
Protein details for VAMP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15836-VAMP3_HUMAN
- Recommended name:
- Vesicle-associated membrane protein 3
- Protein Accession:
- Q15836
- Q9BRV4
Protein attributes for VAMP3 Gene
- Size:
- 100 amino acids
- Molecular mass:
- 11309 Da
- Quaternary structure:
-
- Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum (By similarity). Interacts with BAIAP3; this interaction is increased in the presence of calcium (PubMed:28626000). Interacts with PICALM.
Protein Expression for VAMP3 Gene
Post-translational modifications for VAMP3 Gene
- (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 59-Gln- -Phe-60 bond and probably inhibits neurotransmitter release (PubMed:22289120).
- (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 42-Lys- -Leu-43 bond and probably inhibits neurotransmitter release (PubMed:22289120). Note that humans are not known to be infected by C.botulinum type D.
- (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 41-Gln- -Lys-42 bond and probably inhibits neurotransmitter release (PubMed:22289120).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for VAMP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-VAMP3 (N-terminal) polyclonal antibody
- Creative Biolabs Recombinant Anti-Human VAMP3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for VAMP3
- Novus Biologicals Antibodies for VAMP3
-
Abcam antibodies for VAMP3
- Invitrogen Antibodies for VAMP3 (AFLGC-VAMP3)
-
Santa Cruz Biotechnology (SCBT) Antibodies for VAMP3
Protein Products
- Creative Biomart Recombinant Human VAMP3
-
OriGene Purified Proteins for VAMP3
- Search Origene for MassSpec and Protein Over-expression Lysates for VAMP3
- Origene Custom Protein Services for VAMP3
- Sino Biological Recombinant Proteins for VAMP3
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for VAMP3
- antibodies-online: Show 11 available VAMP3 Proteins ranked by validation data
- Compare Top VAMP3 Proteins
-
Quality Products:
-
Abcam proteins for VAMP3
No data available for DME Specific Peptides for VAMP3 Gene
Domains & Families for VAMP3 Gene
Gene Families for VAMP3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted membrane proteins
- Transporters
Protein Domains for VAMP3 Gene
- Blocks:
-
- Synaptobrevin
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for VAMP3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ92013, Homo sapiens vesicle-associated membrane protein 3 (cellubrevin)(VAMP3), mRNA (Q6FGG2_HUMAN)
- Vesicle-associated membrane protein 3 (Cellubrevin) (Q9BRV4_HUMAN)
- Synaptobrevin-3 (VAMP3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15836- Family:
-
- Belongs to the synaptobrevin family.
Function for VAMP3 Gene
Molecular function for VAMP3 Gene
- UniProtKB/Swiss-Prot Function:
- SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
Phenotypes From GWAS Catalog for VAMP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 12130530 |
| GO:0017075 | syntaxin-1 binding | IEA | -- |
Phenotypes for VAMP3 Gene
- MGI mutant phenotypes for VAMP3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for VAMP3:
Animal Models for VAMP3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for VAMP3 - Select products 50% OFF >
- * VAMP3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * VAMP3 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for VAMP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VAMP3
- genomics-online: gRNA clones - Search for available VAMP3 gRNA products
- Overview of 143 available VAMP3 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for VAMP3
miRNA for VAMP3 Gene
- miRTarBase miRNAs that target VAMP3
-
- hsa-mir-155-5p (MIRT001487)
- hsa-mir-124-3p (MIRT002594)
- hsa-mir-98-5p (MIRT027733)
- hsa-mir-30a-5p (MIRT028609)
- hsa-mir-19b-3p (MIRT031281)
- hsa-let-7b-5p (MIRT032396)
- hsa-mir-605-3p (MIRT079547)
- hsa-mir-1299 (MIRT079552)
- hsa-mir-19a-3p (MIRT147970)
- hsa-mir-182-3p (MIRT147971)
- hsa-mir-5692a (MIRT198385)
- hsa-mir-3910 (MIRT198392)
- hsa-mir-3978 (MIRT198393)
- hsa-mir-203a-5p (MIRT346246)
- hsa-mir-152-5p (MIRT346248)
- hsa-mir-1273g-5p (MIRT442678)
- hsa-mir-597-3p (MIRT442679)
- hsa-mir-4766-5p (MIRT442680)
- hsa-mir-365b-3p (MIRT442681)
- hsa-mir-365a-3p (MIRT442682)
- hsa-mir-5706 (MIRT565047)
- hsa-mir-4782-5p (MIRT565048)
- hsa-mir-516b-5p (MIRT565049)
- hsa-mir-3202 (MIRT565050)
- hsa-mir-4533 (MIRT565051)
- hsa-mir-5093 (MIRT565052)
- hsa-mir-6128 (MIRT565053)
- hsa-mir-875-3p (MIRT565054)
- hsa-mir-29a-5p (MIRT565055)
- hsa-mir-3920 (MIRT565056)
- hsa-mir-382-5p (MIRT565057)
- hsa-mir-495-5p (MIRT565058)
- hsa-mir-1286 (MIRT762242)
- hsa-mir-202-3p (MIRT763688)
- hsa-mir-302a-3p (MIRT764448)
- hsa-mir-302b-3p (MIRT764469)
- hsa-mir-302c-3p (MIRT764486)
- hsa-mir-302d-3p (MIRT764501)
- hsa-mir-302e (MIRT764517)
- hsa-mir-372-3p (MIRT767246)
- hsa-mir-373-3p (MIRT767289)
- hsa-mir-381-5p (MIRT767551)
- hsa-mir-4314 (MIRT768575)
- hsa-mir-4678 (MIRT770921)
- hsa-mir-4722-5p (MIRT771603)
- hsa-mir-519a-3p (MIRT773685)
- hsa-mir-519b-3p (MIRT773699)
- hsa-mir-519c-3p (MIRT773713)
- hsa-mir-520a-3p (MIRT773760)
- hsa-mir-520b (MIRT773780)
- hsa-mir-520c-3p (MIRT773793)
- hsa-mir-520d-3p (MIRT773809)
- hsa-mir-520e (MIRT773825)
- hsa-mir-569 (MIRT775200)
- hsa-mir-5700 (MIRT775204)
- hsa-mir-6776-5p (MIRT778773)
- hsa-mir-6861-5p (MIRT780593)
- hsa-mir-7977 (MIRT782287)
- hsa-mir-873-5p (MIRT782507)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VAMP3
- Browse OriGene Inhibitory RNA Products For VAMP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VAMP3
- genomics-online: shRNA clones - Search for available VAMP3 shRNA products
- Overview of 143 available VAMP3 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for VAMP3 - Select products 50% OFF >
- * VAMP3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * VAMP3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for VAMP3
- Addgene plasmids for VAMP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VAMP3
- genomics-online: cdna clones - Search for available VAMP3 CDNA products
- Overview of 143 available VAMP3 gene related products
- orf clones - Search for available VAMP3 ORF products
- Overview of 143 available VAMP3 gene related products
Cell Line Products
-
Horizon Cell Lines for VAMP3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VAMP3 Gene
Localization for VAMP3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for VAMP3 Gene
- Membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endosome | 5 |
| cytosol | 5 |
| golgi apparatus | 4 |
| extracellular | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | IDA,IEA | 22589474 |
| GO:0005886 | plasma membrane | TAS,IEA | -- |
| GO:0009986 | cell surface | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | TAS,IEA | 9885218 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for VAMP3 Gene
Pathways & Interactions for VAMP3 Gene
Pathways by source for VAMP3 Gene
1 BioSystems pathway for VAMP3 Gene
11 Reactome pathways for VAMP3 Gene
1 PharmGKB pathway for VAMP3 Gene
2 KEGG pathways for VAMP3 Gene
1 Qiagen pathway for VAMP3 Gene
- Epithelial Tight Junctions
1 Cell Signaling Technology pathway for VAMP3 Gene
Interacting Proteins for VAMP3 Gene
Selected Interacting proteins:
Q15836-VAMP3_HUMAN
ENSP00000054666
for VAMP3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for VAMP3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001921 | positive regulation of receptor recycling | ISS,IEA | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006887 | exocytosis | TAS | 9885218 |
| GO:0006904 | vesicle docking involved in exocytosis | TAS | 9885218 |
| GO:0015031 | protein transport | IEA | -- |
Drugs & Compounds for VAMP3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- Creative Biomart Recombinant Human VAMP3
Transcripts for VAMP3 Gene
mRNA/cDNA for VAMP3 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000054666 2178 bps (ENST00000054666.11)
- ENST00000470357 954 bps (ENST00000470357.1)
- ENST00000487194 274 bps (ENST00000487194.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for VAMP3 - Select products 50% OFF >
- * VAMP3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * VAMP3 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for VAMP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VAMP3
- genomics-online: gRNA clones - Search for available VAMP3 gRNA products
- Overview of 143 available VAMP3 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for VAMP3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VAMP3
- Browse OriGene Inhibitory RNA Products For VAMP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VAMP3
- genomics-online: shRNA clones - Search for available VAMP3 shRNA products
- Overview of 143 available VAMP3 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for VAMP3 - Select products 50% OFF >
- * VAMP3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * VAMP3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for VAMP3
- Addgene plasmids for VAMP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VAMP3
- genomics-online: cdna clones - Search for available VAMP3 CDNA products
- Overview of 143 available VAMP3 gene related products
- orf clones - Search for available VAMP3 ORF products
- Overview of 143 available VAMP3 gene related products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||
| SP8: | - |
Relevant External Links for VAMP3 Gene
- GeneLoc Exon Structure for
- VAMP3
Expression for VAMP3 Gene
This gene is overexpressed in Brain (25.6) and Nasal epithelium (10.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for VAMP3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VAMP3
SOURCE GeneReport for Unigene cluster for VAMP3 Gene:
Hs.66708Evidence on tissue expression from TISSUES for VAMP3 Gene
- Nervous system(4.8)
- Kidney(4.7)
- Blood(4.4)
- Liver(4.3)
- Lung(3.6)
- Skin(3)
- Intestine(2.9)
- Muscle(2.4)
- Heart(2.3)
- Adrenal gland(2.2)
Primer Products
-
OriGene qPCR primer pairs for VAMP3
-
OriGene qPCR primer pairs and template standards for VAMP3
- genomics-online: primer clones - Search for available VAMP3 Primer products
- Overview of 143 available VAMP3 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VAMP3 Gene
Orthologs for VAMP3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | VAMP3 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | VAMP3 31 30 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Vamp3 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Vamp3 17 31 30 |
|
||
| dog (Canis familiaris) |
Mammalia | VAMP3 31 30 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | VAMP3 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | VAMP3 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | vamp3 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16507 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | vamp3 31 30 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Syb 31 |
|
ManyToMany | |
| n-syb 31 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | snb-1 31 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SNC1 31 |
|
ManyToMany | |
| SNC2 31 |
|
ManyToMany | |||
| NYV1 33 |
|
|
- Species where no ortholog for VAMP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for VAMP3 Gene
- ENSEMBL:
- Gene Tree for VAMP3 (if available)
- TreeFam:
- Gene Tree for VAMP3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for VAMP3: view image
Paralogs for VAMP3 Gene
Paralogs for VAMP3 Gene
(6) SIMAP similar genes for VAMP3 Gene using alignment to 3 proteins:
- VAMP3_HUMAN
- K7EKX0_HUMAN
- Q6FGG2_HUMAN
Variants for VAMP3 Gene
Residual Variation Intolerance Score:
39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.16;
3.62% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VAMP3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- VAMP3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for VAMP3 Gene
Disorders for VAMP3 Gene
Search VAMP3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for VAMP3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for VAMP3 Gene
Publications for VAMP3 Gene
- Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets. (PMID: 9885218) Bernstein AM … Whiteheart SW (Blood 1999) 2 3 4 23 54
- BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells. (PMID: 28626000) Zhang X … Martin TFJ (The Journal of cell biology 2017) 3 4 54
- The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM. (PMID: 22118466) Miller SE … Owen DJ (Cell 2011) 3 4 54
- Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban HJ … Park KJ (BMC genetics 2010) 3 41 54
- VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion. (PMID: 19910495) Kean MJ … Coppolino MG (Journal of cell science 2009) 3 23 54
ExternalLinks
Products for VAMP3 Gene
- Custom Antibody ServicesOriGene Antibodies for VAMP3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for VAMP3
- Search Origene for MassSpec and Protein Over-expression Lysates for VAMP3
- Origene Custom Protein Services for VAMP3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VAMP3
- Browse OriGene Inhibitory RNA Products For VAMP3
- OriGene qPCR primer pairs for VAMP3
- OriGene qPCR primer pairs and template standards for VAMP3
- OriGene CRISPR knockouts for VAMP3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For VAMP3
- Sino Biological Human cDNA Clone for VAMP3
- Sino Biological Recombinant Proteins for VAMP3
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for VAMP3
- Novus Biologicals proteins and lysates for VAMP3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for VAMP3
- Abcam proteins for VAMP3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Addgene plasmids for VAMP3
- antibodies-online: Show 29 available VAMP3 Antibodies ranked by validation data
- Compare Top VAMP3 Antibodies
- Quality Products:
- antibodies-online: Search results for available VAMP3 related products ranked by validation data
- antibodies-online: Show 11 available VAMP3 Proteins ranked by validation data
- Compare Top VAMP3 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for VAMP3
- Search Santa Cruz Biotechnology (SCBT) for VAMP3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for VAMP3
- Horizon Cell Lines for VAMP3
- genomics-online: cdna clones - Search for available VAMP3 CDNA products
- Overview of 143 available VAMP3 gene related products
- orf clones - Search for available VAMP3 ORF products
- Overview of 143 available VAMP3 gene related products
- genomics-online: gRNA clones - Search for available VAMP3 gRNA products
- Overview of 143 available VAMP3 gene related products
- genomics-online: primer clones - Search for available VAMP3 Primer products
- Overview of 143 available VAMP3 gene related products
- genomics-online: shRNA clones - Search for available VAMP3 shRNA products
- Overview of 143 available VAMP3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VAMP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VAMP3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for VAMP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VAMP3
Sources for VAMP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource