Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue dist... See more...

Aliases for VAMP3 Gene

Aliases for VAMP3 Gene

  • Vesicle Associated Membrane Protein 3 2 3 5
  • Cellubrevin 2 3 4
  • Vesicle-Associated Membrane Protein 3 3 4
  • Synaptobrevin-3 3 4
  • VAMP-3 3 4
  • CEB 3 4
  • SYB3 4

External Ids for VAMP3 Gene

Previous GeneCards Identifiers for VAMP3 Gene

  • GC01P007413
  • GC01P007640
  • GC01P007540
  • GC01P006979

Summaries for VAMP3 Gene

Entrez Gene Summary for VAMP3 Gene

  • Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for VAMP3 Gene

VAMP3 (Vesicle Associated Membrane Protein 3) is a Protein Coding gene. Diseases associated with VAMP3 include Tetanus. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include SNARE binding and syntaxin-1 binding. An important paralog of this gene is ENSG00000263620.

UniProtKB/Swiss-Prot Summary for VAMP3 Gene

  • SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

Gene Wiki entry for VAMP3 Gene

Additional gene information for VAMP3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VAMP3 Gene

Genomics for VAMP3 Gene

GeneHancer (GH) Regulatory Elements for VAMP3 Gene

Promoters and enhancers for VAMP3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VAMP3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VAMP3

Top Transcription factor binding sites by QIAGEN in the VAMP3 gene promoter:
  • CUTL1
  • FOXL1
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)

Genomic Locations for VAMP3 Gene

Genomic Locations for VAMP3 Gene
chr1:7,771,269-7,781,432
(GRCh38/hg38)
Size:
10,164 bases
Orientation:
Plus strand
chr1:7,831,329-7,841,492
(GRCh37/hg19)
Size:
10,164 bases
Orientation:
Plus strand

Genomic View for VAMP3 Gene

Genes around VAMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAMP3 Gene

Proteins for VAMP3 Gene

  • Protein details for VAMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15836-VAMP3_HUMAN
    Recommended name:
    Vesicle-associated membrane protein 3
    Protein Accession:
    Q15836
    Secondary Accessions:
    • Q9BRV4

    Protein attributes for VAMP3 Gene

    Size:
    100 amino acids
    Molecular mass:
    11309 Da
    Quaternary structure:
    • Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum (By similarity). Interacts with BAIAP3; this interaction is increased in the presence of calcium (PubMed:28626000). Interacts with PICALM.

neXtProt entry for VAMP3 Gene

Post-translational modifications for VAMP3 Gene

  • (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 59-Gln- -Phe-60 bond and probably inhibits neurotransmitter release (PubMed:22289120).
  • (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 42-Lys- -Leu-43 bond and probably inhibits neurotransmitter release (PubMed:22289120). Note that humans are not known to be infected by C.botulinum type D.
  • (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 41-Gln- -Lys-42 bond and probably inhibits neurotransmitter release (PubMed:22289120).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VAMP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VAMP3 Gene

Domains & Families for VAMP3 Gene

Gene Families for VAMP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins
  • Transporters

Protein Domains for VAMP3 Gene

Blocks:
  • Synaptobrevin
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VAMP3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92013, Homo sapiens vesicle-associated membrane protein 3 (cellubrevin)(VAMP3), mRNA (Q6FGG2_HUMAN)
  • Vesicle-associated membrane protein 3 (Cellubrevin) (Q9BRV4_HUMAN)
  • Synaptobrevin-3 (VAMP3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15836

UniProtKB/Swiss-Prot:

VAMP3_HUMAN :
  • Belongs to the synaptobrevin family.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with VAMP3: view

Function for VAMP3 Gene

Molecular function for VAMP3 Gene

UniProtKB/Swiss-Prot Function:
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

Phenotypes From GWAS Catalog for VAMP3 Gene

Gene Ontology (GO) - Molecular Function for VAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12130530
GO:0017075 syntaxin-1 binding IEA --
genes like me logo Genes that share ontologies with VAMP3: view
genes like me logo Genes that share phenotypes with VAMP3: view

Animal Models for VAMP3 Gene

MGI Knock Outs for VAMP3:
  • Vamp3 Vamp3<tm1Jepn>
  • Vamp3 Vamp3<tm2b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for VAMP3 Gene

miRTarBase miRNAs that target VAMP3

Clone Products

  • Addgene plasmids for VAMP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VAMP3 Gene

Localization for VAMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAMP3 Gene

Membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VAMP3 gene
Compartment Confidence
plasma membrane 5
endosome 5
cytosol 5
golgi apparatus 4
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for VAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA,IEA 22589474
GO:0005886 plasma membrane TAS,IEA --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA 9885218
genes like me logo Genes that share ontologies with VAMP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VAMP3 Gene

Pathways & Interactions for VAMP3 Gene

genes like me logo Genes that share pathways with VAMP3: view

Pathways by source for VAMP3 Gene

2 KEGG pathways for VAMP3 Gene
1 Qiagen pathway for VAMP3 Gene
  • Epithelial Tight Junctions
1 Cell Signaling Technology pathway for VAMP3 Gene

SIGNOR curated interactions for VAMP3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for VAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001921 positive regulation of receptor recycling ISS,IEA --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006887 exocytosis TAS 9885218
GO:0006904 vesicle docking involved in exocytosis TAS 9885218
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with VAMP3: view

Drugs & Compounds for VAMP3 Gene

(3) Drugs for VAMP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for VAMP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with VAMP3: view

Transcripts for VAMP3 Gene

mRNA/cDNA for VAMP3 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for VAMP3

Alternative Splicing Database (ASD) splice patterns (SP) for VAMP3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: - - - - - - - - -
SP6: - - - -
SP7: - - - - - -
SP8: -

Relevant External Links for VAMP3 Gene

GeneLoc Exon Structure for
VAMP3

Expression for VAMP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VAMP3 Gene

Protein differential expression in normal tissues from HIPED for VAMP3 Gene

This gene is overexpressed in Brain (25.6) and Nasal epithelium (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for VAMP3 Gene



Protein tissue co-expression partners for VAMP3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VAMP3

SOURCE GeneReport for Unigene cluster for VAMP3 Gene:

Hs.66708

Evidence on tissue expression from TISSUES for VAMP3 Gene

  • Nervous system(4.8)
  • Kidney(4.7)
  • Blood(4.4)
  • Liver(4.3)
  • Lung(3.6)
  • Skin(3)
  • Intestine(2.9)
  • Muscle(2.4)
  • Heart(2.3)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with VAMP3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VAMP3 Gene

Orthologs for VAMP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAMP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VAMP3 31 30
  • 99.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia VAMP3 31 30
  • 87.75 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vamp3 30
  • 86.99 (n)
mouse
(Mus musculus)
Mammalia Vamp3 17 31 30
  • 86.18 (n)
dog
(Canis familiaris)
Mammalia VAMP3 31 30
  • 85.71 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 83 (a)
OneToMany
-- 31
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves VAMP3 31 30
  • 82.41 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VAMP3 31
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vamp3 30
  • 74.07 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16507 30
zebrafish
(Danio rerio)
Actinopterygii vamp3 31 30
  • 76.32 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Syb 31
  • 36 (a)
ManyToMany
n-syb 31
  • 28 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea snb-1 31
  • 61 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNC1 31
  • 26 (a)
ManyToMany
SNC2 31
  • 26 (a)
ManyToMany
NYV1 33
Species where no ortholog for VAMP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAMP3 Gene

ENSEMBL:
Gene Tree for VAMP3 (if available)
TreeFam:
Gene Tree for VAMP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for VAMP3: view image

Paralogs for VAMP3 Gene

(6) SIMAP similar genes for VAMP3 Gene using alignment to 3 proteins:

  • VAMP3_HUMAN
  • K7EKX0_HUMAN
  • Q6FGG2_HUMAN
genes like me logo Genes that share paralogs with VAMP3: view

Variants for VAMP3 Gene

Additional dbSNP identifiers (rs#s) for VAMP3 Gene

Variation tolerance for VAMP3 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VAMP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VAMP3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for VAMP3 Gene

Disorders for VAMP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for VAMP3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tetanus
  • clostridial tetanus
- elite association - COSMIC cancer census association via MalaCards
Search VAMP3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for VAMP3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with VAMP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VAMP3 Gene

Publications for VAMP3 Gene

  1. Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets. (PMID: 9885218) Bernstein AM … Whiteheart SW (Blood 1999) 2 3 4 23 54
  2. BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells. (PMID: 28626000) Zhang X … Martin TFJ (The Journal of cell biology 2017) 3 4 54
  3. The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM. (PMID: 22118466) Miller SE … Owen DJ (Cell 2011) 3 4 54
  4. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban HJ … Park KJ (BMC genetics 2010) 3 41 54
  5. VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion. (PMID: 19910495) Kean MJ … Coppolino MG (Journal of cell science 2009) 3 23 54

Products for VAMP3 Gene

Sources for VAMP3 Gene