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Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue dist... See more...
Aliases for VAMP3 Gene
Aliases for VAMP3 Gene
External Ids for VAMP3 Gene
- HGNC: 12644
- NCBI Entrez Gene: 9341
- Ensembl: ENSG00000049245
- OMIM®: 603657
- UniProtKB/Swiss-Prot: Q15836
Previous GeneCards Identifiers for VAMP3 Gene
- GC01P007413
- GC01P007640
- GC01P007540
- GC01P006979
Summaries for VAMP3 Gene
-
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]
GeneCards Summary for VAMP3 Gene
VAMP3 (Vesicle Associated Membrane Protein 3) is a Protein Coding gene. Diseases associated with VAMP3 include Tetanus. Among its related pathways are Vesicle-mediated transport and Phagosome. Gene Ontology (GO) annotations related to this gene include SNARE binding and syntaxin-1 binding. An important paralog of this gene is ENSG00000263620.
UniProtKB/Swiss-Prot Summary for VAMP3 Gene
-
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
Additional gene information for VAMP3 Gene
- HGNC (12644)
- NCBI Entrez Gene (9341)
- Ensembl (ENSG00000049245)
- OMIM® (603657)
- UniProtKB/Swiss-Prot (Q15836)
- Open Targets Platform(ENSG00000049245)
- Search for VAMP3 at DataMed
- Search for VAMP3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VAMP3 Gene
Genomics for VAMP3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for VAMP3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around VAMP3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VAMP3
- Top Transcription factor binding sites by QIAGEN in the VAMP3 gene promoter:
-
- CUTL1
- FOXL1
- NF-kappaB
- NF-kappaB1
- NF-kappaB2
- Nkx2-5
- POU2F1
- POU2F1a
- POU3F2
- POU3F2 (N-Oct-5a)
Genomic Locations for VAMP3 Gene
Latest Assembly
- chr1:7,771,275-7,781,432
- (GRCh38/hg38)
- Size:
- 10,158 bases
- Orientation:
- Plus strand
Previous Assembly
- chr1:7,831,356-7,841,492
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 10,137 bases
- Orientation:
- Plus strand
- chr1:7,831,329-7,841,492
- (GRCh37/hg19 by Ensembl)
- Size:
- 10,164 bases
- Orientation:
- Plus strand
Genomic View for VAMP3 Gene
Genes around VAMP3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.23 by HGNC
- 1p36.23 by Entrez Gene
- 1p36.23 by Ensembl
VAMP3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VAMP3 Gene
Proteins for VAMP3 Gene
-
Protein details for VAMP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15836-VAMP3_HUMAN
- Recommended name:
- Vesicle-associated membrane protein 3
- Protein Accession:
- Q15836
- Q9BRV4
Protein attributes for VAMP3 Gene
- Size:
- 100 amino acids
- Molecular mass:
- 11309 Da
- Quaternary structure:
-
- Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum (By similarity). Interacts with BAIAP3; this interaction is increased in the presence of calcium (PubMed:28626000). Interacts with PICALM.
Protein Expression for VAMP3 Gene
Post-translational modifications for VAMP3 Gene
- (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 59-Gln- -Phe-60 bond and probably inhibits neurotransmitter release (PubMed:22289120).
- (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 42-Lys- -Leu-43 bond and probably inhibits neurotransmitter release (PubMed:22289120). Note that humans are not known to be infected by C.botulinum type D.
- (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 41-Gln- -Lys-42 bond and probably inhibits neurotransmitter release (PubMed:22289120).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for VAMP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences VAMP3 / VAMP-3 Antibody (LS-B7211) and VAMP3 / VAMP-3 Antibody (LS-B7522)
-
Custom Antibody ServicesOriGene Antibodies for VAMP3
- Novus Biologicals Antibodies for VAMP3
-
Abcam antibodies for VAMP3
- Invitrogen Antibodies for VAMP3 (AFLGC-Vamp3)
-
Santa Cruz Biotechnology (SCBT) Antibodies for VAMP3
Protein products for research
-
OriGene Purified Proteins for VAMP3
- Search Origene for MassSpec and Protein Over-expression Lysates for VAMP3
- Origene Custom Protein Services for VAMP3
- Sino Biological Recombinant Proteins for VAMP3
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for VAMP3
- antibodies-online: Show 11 available VAMP3 Proteins ranked by validation data
- Compare Top VAMP3 Proteins
-
Quality Products:
-
Abcam proteins for VAMP3
Assay products for research
No data available for DME Specific Peptides for VAMP3 Gene
Domains & Families for VAMP3 Gene
Gene Families for VAMP3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted membrane proteins
- Transporters
Protein Domains for VAMP3 Gene
- InterPro:
- Blocks:
-
- Synaptobrevin
- ProtoNet:
Suggested Antigen Peptide Sequences for VAMP3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ92013, Homo sapiens vesicle-associated membrane protein 3 (cellubrevin)(VAMP3), mRNA (Q6FGG2_HUMAN)
- Vesicle-associated membrane protein 3 (Cellubrevin) (Q9BRV4_HUMAN)
- Synaptobrevin-3 (VAMP3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15836- Family:
-
- Belongs to the synaptobrevin family.
Function for VAMP3 Gene
Molecular function for VAMP3 Gene
- UniProtKB/Swiss-Prot Function:
- SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
Phenotypes From GWAS Catalog for VAMP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000149 | SNARE binding | IEA | -- |
| GO:0005484 | SNAP receptor activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 12130530 |
| GO:0017075 | syntaxin-1 binding | IEA,IBA | 21873635 |
| GO:0019905 | syntaxin binding | IBA | 21873635 |
Phenotypes for VAMP3 Gene
- MGI mutant phenotypes for VAMP3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for VAMP3:
Animal Models for VAMP3 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for VAMP3 - Starting at $85 >
- * VAMP3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for VAMP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VAMP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for VAMP3
miRNA for VAMP3 Gene
- miRTarBase miRNAs that target VAMP3
-
- hsa-miR-155-5p (MIRT001487)
- mmu-miR-124-3p (MIRT001721)
- hsa-miR-124-3p (MIRT002594)
- mmu-miR-340-5p (MIRT010347)
- mmu-miR-181a-5p (MIRT014189)
- mmu-miR-9-5p (MIRT015387)
- hsa-miR-98-5p (MIRT027733)
- hsa-miR-30a-5p (MIRT028609)
- hsa-miR-19b-3p (MIRT031281)
- hsa-let-7b-5p (MIRT032396)
- hsa-miR-605-3p (MIRT079547)
- hsa-miR-1299 (MIRT079552)
- hsa-miR-19a-3p (MIRT147970)
- hsa-miR-182-3p (MIRT147971)
- hsa-miR-5692a (MIRT198385)
- hsa-miR-3910 (MIRT198392)
- hsa-miR-3978 (MIRT198393)
- hsa-miR-203a-5p (MIRT346246)
- hsa-miR-152-5p (MIRT346248)
- hsa-miR-1273g-5p (MIRT442678)
- hsa-miR-597-3p (MIRT442679)
- hsa-miR-4766-5p (MIRT442680)
- hsa-miR-365b-3p (MIRT442681)
- hsa-miR-365a-3p (MIRT442682)
- hsa-miR-5706 (MIRT565047)
- hsa-miR-4782-5p (MIRT565048)
- hsa-miR-516b-5p (MIRT565049)
- hsa-miR-3202 (MIRT565050)
- hsa-miR-4533 (MIRT565051)
- hsa-miR-5093 (MIRT565052)
- hsa-miR-6128 (MIRT565053)
- hsa-miR-875-3p (MIRT565054)
- hsa-miR-29a-5p (MIRT565055)
- hsa-miR-3920 (MIRT565056)
- hsa-miR-382-5p (MIRT565057)
- hsa-miR-495-5p (MIRT565058)
- mmu-miR-1935 (MIRT603119)
- mmu-miR-298-5p (MIRT603120)
- mmu-miR-709 (MIRT603121)
- mmu-miR-5135 (MIRT603122)
- mmu-miR-1195 (MIRT603123)
- mmu-miR-3089-5p (MIRT603124)
- mmu-miR-804 (MIRT605369)
- mmu-miR-665-3p (MIRT605370)
- mmu-miR-10a-5p (MIRT605371)
- mmu-miR-10b-5p (MIRT605372)
- mmu-miR-339-5p (MIRT605373)
- mmu-miR-292a-5p (MIRT605374)
- mmu-miR-290a-5p (MIRT605375)
- hsa-miR-1286 (MIRT762242)
- hsa-miR-202-3p (MIRT763688)
- hsa-miR-302a-3p (MIRT764448)
- hsa-miR-302b-3p (MIRT764469)
- hsa-miR-302c-3p (MIRT764486)
- hsa-miR-302d-3p (MIRT764501)
- hsa-miR-302e (MIRT764517)
- hsa-miR-372-3p (MIRT767246)
- hsa-miR-373-3p (MIRT767289)
- hsa-miR-381-5p (MIRT767551)
- hsa-miR-4314 (MIRT768575)
- hsa-miR-4678 (MIRT770921)
- hsa-miR-4722-5p (MIRT771603)
- hsa-miR-519a-3p (MIRT773685)
- hsa-miR-519b-3p (MIRT773699)
- hsa-miR-519c-3p (MIRT773713)
- hsa-miR-520a-3p (MIRT773760)
- hsa-miR-520b (MIRT773780)
- hsa-miR-520c-3p (MIRT773793)
- hsa-miR-520d-3p (MIRT773809)
- hsa-miR-520e (MIRT773825)
- hsa-miR-569 (MIRT775200)
- hsa-miR-5700 (MIRT775204)
- hsa-miR-6776-5p (MIRT778773)
- hsa-miR-6861-5p (MIRT780593)
- hsa-miR-7977 (MIRT782287)
- hsa-miR-873-5p (MIRT782507)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VAMP3
- Browse OriGene Inhibitory RNA Products For VAMP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VAMP3
Clone products for research
- Applied Biological Materials (abm): Clones for VAMP3 - Starting at $45 >
- * VAMP3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for VAMP3
- Addgene plasmids for VAMP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VAMP3
Cell Lines for research
-
Horizon Cell Lines for VAMP3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VAMP3 Gene
Localization for VAMP3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for VAMP3 Gene
- Membrane. Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endosome | 5 |
| cytosol | 5 |
| golgi apparatus | 4 |
| extracellular | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005769 | early endosome | IEA | -- |
| GO:0005829 | cytosol | IEA,IDA | 22589474 |
| GO:0005886 | plasma membrane | IEA,TAS | -- |
| GO:0009986 | cell surface | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for VAMP3 Gene
Pathways & Interactions for VAMP3 Gene
Pathways by source for VAMP3 Gene
1 BioSystems pathway for VAMP3 Gene
11 Reactome pathways for VAMP3 Gene
1 PharmGKB pathway for VAMP3 Gene
2 KEGG pathways for VAMP3 Gene
1 Qiagen pathway for VAMP3 Gene
- Epithelial Tight Junctions
1 Cell Signaling Technology pathway for VAMP3 Gene
Interacting Proteins for VAMP3 Gene
Selected Interacting proteins:
Q15836-VAMP3_HUMAN
ENSP00000054666
for VAMP3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for VAMP3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001921 | positive regulation of receptor recycling | IEA,ISS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0002639 | NOT positive regulation of immunoglobulin production | IMP | 24055037 |
| GO:0006887 | exocytosis | TAS | 9885218 |
| GO:0006904 | vesicle docking involved in exocytosis | TAS | 9885218 |
Transcripts for VAMP3 Gene
mRNA/cDNA for VAMP3 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000054666 2178 nts (view in UCSC)
- ENST00000470357 954 nts (view in UCSC)
- ENST00000487194 274 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for VAMP3 - Starting at $85 >
- * VAMP3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for VAMP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VAMP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for VAMP3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VAMP3
- Browse OriGene Inhibitory RNA Products For VAMP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VAMP3
Clone products for research
- Applied Biological Materials (abm): Clones for VAMP3 - Starting at $45 >
- * VAMP3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for VAMP3
- Addgene plasmids for VAMP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VAMP3
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||
| SP8: | - |
Relevant External Links for VAMP3 Gene
- GeneLoc Exon Structure for
- VAMP3
Expression for VAMP3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Brain (25.6) and Nasal epithelium (10.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for VAMP3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VAMP3
SOURCE GeneReport for Unigene cluster for VAMP3 Gene:
Hs.66708Evidence on tissue expression from TISSUES for VAMP3 Gene
- Nervous system(4.9)
- Kidney(4.8)
- Liver(4.5)
- Blood(4.5)
- Lung(3.9)
- Skin(3.6)
- Intestine(3.5)
- Heart(2.8)
- Adrenal gland(2.7)
- Muscle(2.6)
- Spleen(2.4)
- Lymph node(2.3)
- Bone marrow(2.3)
- Eye(2.2)
- Stomach(2.2)
- Pancreas(2.1)
- Thyroid gland(2)
Primer products for research
-
OriGene qPCR primer pairs for VAMP3
-
OriGene qPCR primer pairs and template standards for VAMP3
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VAMP3 Gene
Orthologs for VAMP3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | VAMP3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | VAMP3 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Vamp3 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Vamp3 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | VAMP3 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | VAMP3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | VAMP3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | vamp3 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16507 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | vamp3 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Syb 31 |
|
ManyToMany | |
| n-syb 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | snb-1 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SNC1 31 |
|
ManyToMany | |
| SNC2 31 |
|
ManyToMany | |||
| NYV1 33 |
|
|
- Species where no ortholog for VAMP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for VAMP3 Gene
- ENSEMBL:
- Gene Tree for VAMP3 (if available)
- TreeFam:
- Gene Tree for VAMP3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for VAMP3: view image
Paralogs for VAMP3 Gene
Paralogs for VAMP3 Gene
(6) SIMAP similar genes for VAMP3 Gene using alignment to 3 proteins:
- VAMP3_HUMAN
- K7EKX0_HUMAN
- Q6FGG2_HUMAN
Variants for VAMP3 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.16;
3.62% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VAMP3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- VAMP3
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for VAMP3 Gene
Disorders for VAMP3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| tetanus |
|
|
Search VAMP3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for VAMP3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for VAMP3 Gene
Publications for VAMP3 Gene
- Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets. (PMID: 9885218) Bernstein AM … Whiteheart SW (Blood 1999) 2 3 4 23
- BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells. (PMID: 28626000) Zhang X … Martin TFJ (The Journal of cell biology 2017) 3 4
- The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM. (PMID: 22118466) Miller SE … Owen DJ (Cell 2011) 3 4
- Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban HJ … Park KJ (BMC genetics 2010) 3 41
- VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion. (PMID: 19910495) Kean MJ … Coppolino MG (Journal of cell science 2009) 3 23
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Products for VAMP3 Gene
- Custom Antibody ServicesOriGene Antibodies for VAMP3
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Sources for VAMP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
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- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
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- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
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- (77) ESI-BIO
- (78) RefSeq
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- (80) MaxQB
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- (83) Illumina
- (84) COMPARTMENTS
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- (86) PaxDb
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- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
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- (124) Horizon
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- (136) Human Protein Atlas
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