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Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]
VAMP3 (Vesicle Associated Membrane Protein 3) is a Protein Coding gene. Diseases associated with VAMP3 include Tetanus. Among its related pathways are Neuroscience and Antigen processing-Cross presentation. Gene Ontology (GO) annotations related to this gene include SNARE binding and syntaxin-1 binding. An important paralog of this gene is VAMP2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000149 | SNARE binding | IEA | -- |
GO:0005484 | SNAP receptor activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 12130530 |
GO:0017075 | syntaxin-1 binding | IEA,IBA | 21873635 |
GO:0019905 | syntaxin binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | IEA,IDA | 22589474 |
GO:0005886 | plasma membrane | IEA,TAS | -- |
GO:0009986 | cell surface | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA,TAS | 9885218 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001921 | positive regulation of receptor recycling | IEA,ISS | -- |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
GO:0006887 | exocytosis | TAS | 9885218 |
GO:0006904 | vesicle docking involved in exocytosis | TAS | 9885218 |
GO:0006906 | vesicle fusion | IBA | 21873635 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||||||||
SP7: | - | - | - | - | - | - | |||||||||||||||||||||
SP8: | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | VAMP3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | VAMP3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Vamp3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Vamp3 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | VAMP3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | VAMP3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | VAMP3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | vamp3 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.16507 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | vamp3 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Syb 31 |
|
ManyToMany | |
n-syb 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | snb-1 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SNC1 31 |
|
ManyToMany | |
SNC2 31 |
|
ManyToMany | |||
NYV1 33 |
|
|