Aliases for VAMP2 Gene
External Ids for VAMP2 Gene
Previous HGNC Symbols for VAMP2 Gene
Previous GeneCards Identifiers for VAMP2 Gene
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]
GeneCards Summary for VAMP2 Gene
VAMP2 (Vesicle Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with VAMP2 include Neurodevelopmental Disorder With Hypotonia And Autistic Features With Or Without Hyperkinetic Movements and Tetanus. Among its related pathways are Neuroscience and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include calmodulin binding and syntaxin binding. An important paralog of this gene is ENSG00000263620.
UniProtKB/Swiss-Prot Summary for VAMP2 Gene
Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.