The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neu... See more...

Aliases for VAMP2 Gene

Aliases for VAMP2 Gene

  • Vesicle Associated Membrane Protein 2 2 3 5
  • VAMP-2 2 3 4
  • Vesicle-Associated Membrane Protein 2 3 4
  • Synaptobrevin 2 2 3
  • SYB2 3 4
  • Synaptobrevin-2 4
  • NEDHAHM 3
  • VAMP2 5

External Ids for VAMP2 Gene

Previous HGNC Symbols for VAMP2 Gene

  • SYB2

Previous GeneCards Identifiers for VAMP2 Gene

  • GC17U990100
  • GC17M009150
  • GC17M008005
  • GC17M008263
  • GC17M007987
  • GC17M008054
  • GC17M007957
  • GC17M008062
  • GC17M008165
  • GC17M008219
  • GC17M008585
  • GC17M008622
  • GC17M008669
  • GC17M008762
  • GC17M008270
  • GC17M008335
  • GC17M008366
  • GC17M008405
  • GC17M008437
  • GC17M008476
  • GC17M008514
  • GC17M008544

Summaries for VAMP2 Gene

Entrez Gene Summary for VAMP2 Gene

  • The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]

GeneCards Summary for VAMP2 Gene

VAMP2 (Vesicle Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with VAMP2 include Neurodevelopmental Disorder With Hypotonia And Autistic Features With Or Without Hyperkinetic Movements and Tetanus. Among its related pathways are Neuroscience and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include calmodulin binding and syntaxin binding. An important paralog of this gene is ENSG00000263620.

UniProtKB/Swiss-Prot Summary for VAMP2 Gene

  • Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.

Gene Wiki entry for VAMP2 Gene

Additional gene information for VAMP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VAMP2 Gene

Genomics for VAMP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for VAMP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VAMP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VAMP2

Top Transcription factor binding sites by QIAGEN in the VAMP2 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • p53

Genomic Locations for VAMP2 Gene

Genomic Locations for VAMP2 Gene
chr17:8,159,147-8,163,546
(GRCh38/hg38)
Size:
4,400 bases
Orientation:
Minus strand
chr17:8,062,465-8,066,864
(GRCh37/hg19)
Size:
4,400 bases
Orientation:
Minus strand

Genomic View for VAMP2 Gene

Genes around VAMP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAMP2 Gene

Proteins for VAMP2 Gene

  • Protein details for VAMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63027-VAMP2_HUMAN
    Recommended name:
    Vesicle-associated membrane protein 2
    Protein Accession:
    P63027
    Secondary Accessions:
    • P19065
    • Q9BUC2

    Protein attributes for VAMP2 Gene

    Size:
    116 amino acids
    Molecular mass:
    12663 Da
    Quaternary structure:
    • Interacts (via N-terminus) with KCNB1 (via N-terminus and C-terminus); stimulates the channel inactivation rate of KCNB1 (By similarity). Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Interacts with BVES and STX4 (By similarity). Interacts with VAPA and VAPB. Interacts with WDFY2, PRKCZ and PRKCI (PubMed:17313651). Forms a complex with WDFY2 and PRKCZ (PubMed:17313651). Interacts with SEPT8; the interaction inhibits interaction of VAMP2 with SYP. Interacts with SYP; the interaction is inhibited by interaction with SEPT8 (By similarity). Interacts with PICALM (PubMed:22118466). Interacts with alpha-synuclein/SNCA (PubMed:20798282). Interacts with STX3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for VAMP2 Gene

neXtProt entry for VAMP2 Gene

Post-translational modifications for VAMP2 Gene

  • Phosphorylated by PRKCZ in vitro and this phosphorylation is increased in the presence of WDFY2.
  • (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 76-Gln- -Phe-77 bond and probably inhibits neurotransmitter release (PubMed:7803399).
  • (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which probably hydrolyzes the 59-Lys- -Leu-60 bond and inhibits neurotransmitter release (PubMed:22289120). Note that humans are not known to be infected by C.botulinum type D.
  • (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 58-Gln- -Lys-59 bond and probably inhibits neurotransmitter release (PubMed:19543288).
  • (Microbial infection) Targeted and hydrolyzed by C.tetani tetanus toxin (tetX) which hydrolyzes the 76-Gln- -Phe-77 bond and probably inhibits neurotransmitter release (PubMed:7803399).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VAMP2 Gene

No data available for DME Specific Peptides for VAMP2 Gene

Domains & Families for VAMP2 Gene

Gene Families for VAMP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for VAMP2 Gene

InterPro:
Blocks:
  • Synaptobrevin
ProtoNet:

Suggested Antigen Peptide Sequences for VAMP2 Gene

GenScript: Design optimal peptide antigens:
  • Synaptobrevin-2 (VAMP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P63027

UniProtKB/Swiss-Prot:

VAMP2_HUMAN :
  • Belongs to the synaptobrevin family.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with VAMP2: view

Function for VAMP2 Gene

Molecular function for VAMP2 Gene

UniProtKB/Swiss-Prot Function:
Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.
GENATLAS Biochemistry:
vesicule associated membrane protein 2,synaptobrevin 2,expressed in neurons forming a synaptic core complex with syntaxin and synaptosome associated proteins,playing a central role in neural exocytosis,soluble N ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein

Phenotypes From GWAS Catalog for VAMP2 Gene

Gene Ontology (GO) - Molecular Function for VAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding ISS --
GO:0005484 SNAP receptor activity IBA 21873635
GO:0005515 protein binding IPI 9920726
GO:0005516 calmodulin binding ISS --
GO:0005543 phospholipid binding ISS --
genes like me logo Genes that share ontologies with VAMP2: view
genes like me logo Genes that share phenotypes with VAMP2: view

Animal Models for VAMP2 Gene

MGI Knock Outs for VAMP2:

Animal Model Products

CRISPR Products

miRNA for VAMP2 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VAMP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VAMP2 Gene

Localization for VAMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAMP2 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Cell membrane. Note=Neuronal synaptic vesicles. Colocalizes with PRKCZ and WDFY2 in intracellular vesicles (PubMed:17313651). {ECO:0000269 PubMed:17313651}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VAMP2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
golgi apparatus 4
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for VAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 trans-Golgi network ISS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane ISS,TAS --
GO:0005887 integral component of plasma membrane TAS 1976629
GO:0008021 synaptic vesicle TAS 10099709
genes like me logo Genes that share ontologies with VAMP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VAMP2 Gene

Pathways & Interactions for VAMP2 Gene

genes like me logo Genes that share pathways with VAMP2: view

Pathways by source for VAMP2 Gene

4 GeneGo (Thomson Reuters) pathways for VAMP2 Gene
  • Delta508-CFTR traffic / Sorting endosome formation in CF
  • Normal wtCFTR traffic / Sorting endosome formation
  • Transport Clathrin-coated vesicle cycle
  • wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
1 R&D Systems pathway for VAMP2 Gene
1 Qiagen pathway for VAMP2 Gene
  • Epithelial Tight Junctions
1 Cell Signaling Technology pathway for VAMP2 Gene

Gene Ontology (GO) - Biological Process for VAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis TAS 10099709
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0006906 vesicle fusion IBA,IMP 30929742
GO:0007269 neurotransmitter secretion TAS --
GO:0009749 response to glucose ISS --
genes like me logo Genes that share ontologies with VAMP2: view

No data available for SIGNOR curated interactions for VAMP2 Gene

Drugs & Compounds for VAMP2 Gene

(11) Drugs for VAMP2 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Botulinum Toxin Type B Approved, Investigational Pharma Target, binder 0

(6) Additional Compounds for VAMP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with VAMP2: view

Transcripts for VAMP2 Gene

mRNA/cDNA for VAMP2 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VAMP2

Alternative Splicing Database (ASD) splice patterns (SP) for VAMP2 Gene

No ASD Table

Relevant External Links for VAMP2 Gene

GeneLoc Exon Structure for
VAMP2

Expression for VAMP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VAMP2 Gene

Protein differential expression in normal tissues from HIPED for VAMP2 Gene

This gene is overexpressed in Brain (45.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for VAMP2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VAMP2

SOURCE GeneReport for Unigene cluster for VAMP2 Gene:

Hs.25348

mRNA Expression by UniProt/SwissProt for VAMP2 Gene:

P63027-VAMP2_HUMAN
Tissue specificity: Nervous system and skeletal muscle.

Evidence on tissue expression from TISSUES for VAMP2 Gene

  • Nervous system(5)
  • Blood(4.5)
  • Eye(3.7)
  • Adrenal gland(3.4)
  • Muscle(3.4)
  • Pancreas(3.3)
  • Kidney(3.2)
  • Skin(3.1)
  • Heart(2.9)
  • Lung(2.8)
  • Intestine(2.7)
  • Liver(2.4)
  • Bone marrow(2.4)
  • Spleen(2.4)
  • Thyroid gland(2.3)
  • Stomach(2.3)
  • Lymph node(2.3)
genes like me logo Genes that share expression patterns with VAMP2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VAMP2 Gene

Orthologs for VAMP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAMP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia VAMP2 30 31
  • 99.71 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia VAMP2 30
  • 96.26 (n)
Mouse
(Mus musculus)
Mammalia Vamp2 30 17 31
  • 94.25 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia VAMP2 30 31
  • 94.25 (n)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 94 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Vamp2 30
  • 93.68 (n)
Chicken
(Gallus gallus)
Aves -- 31
  • 79 (a)
ManyToMany
VAMP2 30
  • 78.99 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 97 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia vamp2 30
  • 83.33 (n)
MGC75977 30
African clawed frog
(Xenopus laevis)
Amphibia vamp2-B-prov 30
Zebrafish
(Danio rerio)
Actinopterygii vamp2 30 31
  • 79.35 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta n-syb 30 31
  • 76.32 (n)
ManyToMany
Syb 31
  • 44 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005507 30
  • 72.81 (n)
Worm
(Caenorhabditis elegans)
Secernentea snb-1 31
  • 69 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNC1 31 33
  • 32 (a)
ManyToMany
SNC2 31
  • 30 (a)
ManyToMany
Species where no ortholog for VAMP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for VAMP2 Gene

ENSEMBL:
Gene Tree for VAMP2 (if available)
TreeFam:
Gene Tree for VAMP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for VAMP2: view image

Paralogs for VAMP2 Gene

(6) SIMAP similar genes for VAMP2 Gene using alignment to 4 proteins:

  • VAMP2_HUMAN
  • F8WCA0_HUMAN
  • J3QRU4_HUMAN
  • K7ENK9_HUMAN
genes like me logo Genes that share paralogs with VAMP2: view

Variants for VAMP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VAMP2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
666257 Pathogenic: Severe neurodevelopmental delay 8,161,759(-) TCCA/T
810675 Pathogenic: NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA AND AUTISTIC FEATURES WITH OR WITHOUT HYPERKINETIC MOVEMENTS 8,161,667(-) A/G MISSENSE_VARIANT
810676 Pathogenic: NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA AND AUTISTIC FEATURES WITH OR WITHOUT HYPERKINETIC MOVEMENTS 8,161,657(-) T/G MISSENSE_VARIANT
810677 Pathogenic: NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA AND AUTISTIC FEATURES WITH OR WITHOUT HYPERKINETIC MOVEMENTS 8,161,660(-) A/G MISSENSE_VARIANT
810679 Pathogenic: NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA AND AUTISTIC FEATURES WITH OR WITHOUT HYPERKINETIC MOVEMENTS 8,161,752(-) CATG/C INFRAME_DELETION

Additional dbSNP identifiers (rs#s) for VAMP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for VAMP2 Gene

Variant ID Type Subtype PubMed ID
nsv1964 CNV insertion 18451855
nsv527475 CNV loss 19592680
nsv574336 CNV loss 21841781
nsv833352 CNV loss 17160897
nsv833353 CNV loss 17160897
nsv953826 CNV deletion 24416366

Variation tolerance for VAMP2 Gene

Residual Variation Intolerance Score: 65.5% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VAMP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VAMP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VAMP2 Gene

Disorders for VAMP2 Gene