Aliases for VAMP2 Gene
External Ids for VAMP2 Gene
Previous HGNC Symbols for VAMP2 Gene
Previous GeneCards Identifiers for VAMP2 Gene
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]
GeneCards Summary for VAMP2 Gene
VAMP2 (Vesicle Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with VAMP2 include Neurodevelopmental Disorder With Hypotonia And Autistic Features With Or Without Hyperkinetic Movements and Tetanus. Among its related pathways are Uptake and actions of bacterial toxins and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include calmodulin binding and syntaxin binding. An important paralog of this gene is ENSG00000263620.
UniProtKB/Swiss-Prot Summary for VAMP2 Gene
Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.