Aliases for USP37 Gene
External Ids for USP37 Gene
Previous GeneCards Identifiers for USP37 Gene
GeneCards Summary for USP37 Gene
USP37 (Ubiquitin Specific Peptidase 37) is a Protein Coding gene. Diseases associated with USP37 include External Ear Disease. Among its related pathways are Metabolism of proteins and Deubiquitination. Gene Ontology (GO) annotations related to this gene include protein kinase binding and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP29.
UniProtKB/Swiss-Prot Summary for USP37 Gene
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872).