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Aliases for UXT Gene

Aliases for UXT Gene

  • Ubiquitously Expressed Prefoldin Like Chaperone 2 3 5
  • Androgen Receptor Trapped Clone 27 Protein 3 4
  • Ubiquitously Expressed Transcript Protein 3 4
  • SKP2-Associated Alpha PFD 1 2 3
  • Protein UXT 3 4
  • ART-27 3 4
  • Ubiquitously-Expressed, Prefoldin-Like Chaperone 2
  • Androgen Receptor Trapped Clone 27 2
  • Ubiquitously-Expressed Transcript 2
  • STAP1 3

External Ids for UXT Gene

Previous GeneCards Identifiers for UXT Gene

  • GC0XM046313
  • GC0XM045771
  • GC0XM046557
  • GC0XM047267
  • GC0XM047396
  • GC0XM047511
  • GC0XM045223

Summaries for UXT Gene

Entrez Gene Summary for UXT Gene

  • The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for UXT Gene

UXT (Ubiquitously Expressed Prefoldin Like Chaperone) is a Protein Coding gene. Among its related pathways are E2F transcription factor network. Gene Ontology (GO) annotations related to this gene include chromatin binding and actin filament binding.

UniProtKB/Swiss-Prot for UXT Gene

  • Involved in gene transcription regulation (PubMed:28106301, PubMed:21730289). Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription (PubMed:11854421, PubMed:21730289). Together with URI1, associates with chromatin to the NKX3-1 promoter region (PubMed:21730289). Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm (PubMed:28106301). May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity (PubMed:17620405, PubMed:21307340). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:17554592). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584).
  • Isoform 1: Plays a role in protecting cells against TNF-alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP.

Gene Wiki entry for UXT Gene

Additional gene information for UXT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UXT Gene

Genomics for UXT Gene

GeneHancer (GH) Regulatory Elements for UXT Gene

Promoters and enhancers for UXT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ047657 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 611.2 +0.3 338 3.1 SP1 CC2D1A ELF3 ZFX MNT NKRF MLLT1 ZNF121 POLR2A GTF2F1 UXT UXT-AS1 INE1 ENSG00000204620 ZNF81 FTSJ1 UBA1 RBM3 ZNF182 RBM10
GH0XJ047559 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 10.8 +96.8 96751 5.4 ZNF652 ZFX SP1 SIX5 ZNF148 POLR2A GTF2F1 ZNF687 ZSCAN21 CTCF ARAF INE1 FTSJ1 ZNF81 NUS1P1 UBA1 UXT CFP CDK16 GC0XP047572
GH0XJ047231 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.7 +425.2 425162 4.7 ZFX ELF3 ZNF148 NKRF CEBPG POLR2A GTF2F1 ZNF687 MAFK YY1 USP11 INE1 ZNF81 SNORA11C ENSG00000232009 UXT WASF4P UBA1 LINC01560 GC0XP047244
GH0XJ047216 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 +440.6 440576 5.2 HDGF SP1 ZFX SIX5 NKRF POLR2A MLLT1 GTF2F1 ZNF687 ZSCAN21 LOC105373194 CDK16 ENSG00000224072 ZNF81 ZNF182 INE1 LINC01560 ZNF674-AS1 UBA1 RBM10
GH0XJ048573 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.3 -916.0 -915956 3.7 SP1 ZFX MNT NKRF MLLT1 CSDE1 ZSCAN21 NFRKB BACH1 MYC ENSG00000204620 RBM3 ZNF182 ZNF81 ENSG00000228343 ENSG00000270012 FTSJ1 PRICKLE3 PQBP1 HDAC6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UXT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UXT gene promoter:
  • CREB
  • deltaCREB

Genomic Locations for UXT Gene

Genomic Locations for UXT Gene
chrX:47,651,792-47,659,180
(GRCh38/hg38)
Size:
7,389 bases
Orientation:
Minus strand
chrX:47,511,195-47,518,560
(GRCh37/hg19)
Size:
7,366 bases
Orientation:
Minus strand

Genomic View for UXT Gene

Genes around UXT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UXT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UXT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UXT Gene

Proteins for UXT Gene

  • Protein details for UXT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBK9-UXT_HUMAN
    Recommended name:
    Protein UXT
    Protein Accession:
    Q9UBK9
    Secondary Accessions:
    • A0A0C4DFR8
    • B2R561
    • Q5JZG3
    • Q9Y6E5

    Protein attributes for UXT Gene

    Size:
    157 amino acids
    Molecular mass:
    18246 Da
    Quaternary structure:
    • Homohexamer (PubMed:16221885). Interacts with LRPPRC (PubMed:11827465, PubMed:17554592). Interacts with androgen receptor AR (via N-terminus) (PubMed:11854421). Interacts with estrogen receptor ESR1; the interaction relocalizes ESR1 from the nucleus to the cytoplasm (PubMed:28106301). In the nucleus, interacts specifically with RELA (via RHD domain) and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation (PubMed:17620405). Interacts with MECOM (PubMed:17635584). Interacts with URI1 (PubMed:21730289). Isoform 1 is part of complex I composed of TNF-alpha receptor TNFRSF1A, TRADD, TRAF2 and RIPK1 formed in response to TNF-alpha stimulation. Within the complex, interacts (via TPQE motif) with TRAF2; the interaction prevents the recruitment of FADD and CASP8/caspase 8 to complex I (PubMed:21307340).

    Alternative splice isoforms for UXT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UXT Gene

Post-translational modifications for UXT Gene

  • Ubiquitination at posLast=4848, posLast=1616, isoforms=126, isoforms=41, isoforms=154, and isoforms=113
  • Modification sites at PhosphoSitePlus

Other Protein References for UXT Gene

No data available for DME Specific Peptides for UXT Gene

Domains & Families for UXT Gene

Gene Families for UXT Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for UXT Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitously expressed transcript protein (UXT_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UBK9

UniProtKB/Swiss-Prot:

UXT_HUMAN :
  • Belongs to the UXT family.
Family:
  • Belongs to the UXT family.
genes like me logo Genes that share domains with UXT: view

Function for UXT Gene

Molecular function for UXT Gene

UniProtKB/Swiss-Prot Function:
Involved in gene transcription regulation (PubMed:28106301, PubMed:21730289). Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription (PubMed:11854421, PubMed:21730289). Together with URI1, associates with chromatin to the NKX3-1 promoter region (PubMed:21730289). Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm (PubMed:28106301). May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity (PubMed:17620405, PubMed:21307340). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:17554592). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584).
UniProtKB/Swiss-Prot Function:
Isoform 1: Plays a role in protecting cells against TNF-alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP.
GENATLAS Biochemistry:
transcript with no homology to any known gene,ubiquitously expressed,abundantly expressed in tumor tissue

Gene Ontology (GO) - Molecular Function for UXT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 21730289
GO:0003712 transcription coregulator activity IBA 21873635
GO:0003714 transcription corepressor activity IBA,IDA 21730289
GO:0005515 protein binding IPI 12762840
GO:0008017 microtubule binding TAS 12762840
genes like me logo Genes that share ontologies with UXT: view
genes like me logo Genes that share phenotypes with UXT: view

Animal Models for UXT Gene

MGI Knock Outs for UXT:
  • Uxt Uxt<tm1.2Sklo>

Animal Model Products

CRISPR Products

miRNA for UXT Gene

Clone Products

  • Applied Biological Materials (abm): Clones for UXT - Now 50% OFF >
  • * UXT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * UXT tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UXT Gene

Localization for UXT Gene

Subcellular locations from UniProtKB/Swiss-Prot for UXT Gene

Isoform 1: Cytoplasm.
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Predominantly localizes to the nucleus (PubMed:16221885). Localizes to spindle pole during mitosis (PubMed:16221885). {ECO:0000269 PubMed:16221885, ECO:0000269 PubMed:21307340}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UXT gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (3)
  • Nucleus (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UXT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA 21873635
GO:0000922 spindle pole IEA --
GO:0000930 colocalizes_with gamma-tubulin complex IDA,IBA 16221885
GO:0005634 nucleus IDA,IBA 12762840
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with UXT: view

Pathways & Interactions for UXT Gene

PathCards logo

SuperPathways for UXT Gene

genes like me logo Genes that share pathways with UXT: view

Pathways by source for UXT Gene

1 BioSystems pathway for UXT Gene

SIGNOR curated interactions for UXT Gene

Is activated by:

Gene Ontology (GO) - Biological Process for UXT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 21730289
GO:0000226 microtubule cytoskeleton organization IMP 16221885
GO:0006915 apoptotic process IEA --
GO:0007098 centrosome cycle IMP 16221885
GO:0047497 mitochondrion transport along microtubule TAS 12762840
genes like me logo Genes that share ontologies with UXT: view

Drugs & Compounds for UXT Gene

No Compound Related Data Available

Transcripts for UXT Gene

mRNA/cDNA for UXT Gene

Unigene Clusters for UXT Gene

Ubiquitously-expressed, prefoldin-like chaperone:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for UXT - Now 50% OFF >
  • * UXT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * UXT tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for UXT Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - -
SP6: - -
SP7: -
SP8:

Relevant External Links for UXT Gene

GeneLoc Exon Structure for
UXT
ECgene alternative splicing isoforms for
UXT

Expression for UXT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UXT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UXT Gene

This gene is overexpressed in Fetal ovary (7.6), Colon (7.2), and Breast (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UXT Gene



Protein tissue co-expression partners for UXT Gene

NURSA nuclear receptor signaling pathways regulating expression of UXT Gene:

UXT

SOURCE GeneReport for Unigene cluster for UXT Gene:

Hs.172791

mRNA Expression by UniProt/SwissProt for UXT Gene:

Q9UBK9-UXT_HUMAN
Tissue specificity: Ubiquitous (PubMed:10087202, PubMed:11854421, PubMed:17635584, PubMed:11827465). Expressed in prostate epithelial cells (PubMed:21730289). Expressed in mammary epithelial cells (PubMed:28106301). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus (PubMed:11854421, PubMed:17635584, PubMed:11827465). Overexpressed in a number of tumor tissues (PubMed:11854421, PubMed:16221885, PubMed:28106301).

Evidence on tissue expression from TISSUES for UXT Gene

  • Blood(4.2)
genes like me logo Genes that share expression patterns with UXT: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UXT Gene

Orthologs for UXT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UXT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UXT 35 34
  • 99.72 (n)
OneToOne
cow
(Bos Taurus)
Mammalia UXT 35 34
  • 94.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia UXT 35 34
  • 94.27 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Uxt 17 35 34
  • 91.93 (n)
rat
(Rattus norvegicus)
Mammalia Uxt 34
  • 90.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UXT 35
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UXT 35
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii uxt 35 34
  • 63.07 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta l(2)35Cc 35
  • 27 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G26660 34
  • 47.31 (n)
rice
(Oryza sativa)
Liliopsida Os07g0595800 34
  • 49.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7146 35
  • 43 (a)
OneToOne
Species where no ortholog for UXT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UXT Gene

ENSEMBL:
Gene Tree for UXT (if available)
TreeFam:
Gene Tree for UXT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UXT: view image

Paralogs for UXT Gene

No data available for Paralogs for UXT Gene

Variants for UXT Gene

Sequence variations from dbSNP and Humsavar for UXT Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000508259 -- 47,657,019(-) A/G intron_variant
rs1000944829 -- 47,656,362(-) T/A intron_variant
rs1001210462 -- 47,655,802(-) A/G intron_variant
rs1001545882 -- 47,658,915(-) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1001766142 -- 47,656,156(-) CCC/CC intron_variant

Variation tolerance for UXT Gene

Residual Variation Intolerance Score: 35.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UXT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UXT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UXT Gene

Disorders for UXT Gene

No disorders were found for UXT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UXT Gene

Publications for UXT Gene

  1. UXT is a novel centrosomal protein essential for cell viability. (PMID: 16221885) Zhao H … Greene MI (Molecular biology of the cell 2005) 2 3 4 58
  2. Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue. (PMID: 10087202) Schroer A … Nothwang H (Genomics 1999) 2 3 4 58
  3. UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells. (PMID: 28106301) Sánchez-Morgan N … Sonenshein GE (Journal of cellular biochemistry 2017) 3 4 58
  4. UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation. (PMID: 21307340) Huang Y … Wang C (Molecular biology of the cell 2011) 3 4 58
  5. Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP. (PMID: 21730289) Mita P … Logan SK (Molecular and cellular biology 2011) 3 4 58

Products for UXT Gene

Sources for UXT Gene

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