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Aliases for UVRAG Gene

Aliases for UVRAG Gene

  • UV Radiation Resistance Associated 2 3 5
  • Beclin 1 Binding Protein 2 3
  • P63 3 4
  • UV Radiation Resistance-Associated Gene Protein 3
  • UV Radiation Resistance Associated Gene 2
  • Disrupted In Heterotaxy 3
  • VPS38 3
  • DHTX 3

External Ids for UVRAG Gene

Previous GeneCards Identifiers for UVRAG Gene

  • GC11P077853
  • GC11P077065
  • GC11P075748
  • GC11P075252
  • GC11P075203
  • GC11P075526
  • GC11P071822

Summaries for UVRAG Gene

Entrez Gene Summary for UVRAG Gene

  • This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for UVRAG Gene

UVRAG (UV Radiation Resistance Associated) is a Protein Coding gene. Diseases associated with UVRAG include Ascending Colon Cancer and Cholecystolithiasis. Among its related pathways are DNA Damage and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and SNARE binding.

UniProtKB/Swiss-Prot for UVRAG Gene

  • Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300).

  • Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840).

Gene Wiki entry for UVRAG Gene

Additional gene information for UVRAG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UVRAG Gene

Genomics for UVRAG Gene

GeneHancer (GH) Regulatory Elements for UVRAG Gene

Promoters and enhancers for UVRAG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I075812 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.0 33 6.2 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YBX1 LOC100506113 UVRAG XRRA1 THAP12 NEU3 EMSY DGAT2 LOC105369391
GH11I076780 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12 +968.1 968062 5 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B CBX5 LOC101928837 TSKU EMSY UVRAG ENSG00000254632 GC11P076787
GH11I075398 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12 -413.9 -413875 4.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 RPS3 GC11P075411 GC11P075412 GC11P075414 GC11P075418 SNORD15A PIR55667 POLD3 RNF169 KLHL35
GH11I076768 Enhancer 1.4 Ensembl ENCODE dbSUPER 12 +955.3 955310 6.2 FOXA2 NEUROD1 SIN3A DMAP1 ZNF48 YY1 ZNF207 ZNF548 FOS DEK EMSY LOC101928837 UVRAG ENSG00000254632 TSKU
GH11I075327 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.3 -474.7 -474681 26.4 CLOCK MLX DMAP1 IRF4 YY1 ZNF143 SP3 NFYC GLIS1 RCOR2 ARRB1 POLD3 GDPD5 SNORD15B KLHL35 XRRA1 RNF169 NEU3 RPS3 ENSG00000254974
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UVRAG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UVRAG gene promoter:

Genomic Locations for UVRAG Gene

Genomic Locations for UVRAG Gene
chr11:75,815,167-76,144,238
(GRCh38/hg38)
Size:
329,072 bases
Orientation:
Plus strand
chr11:75,526,212-75,855,282
(GRCh37/hg19)

Genomic View for UVRAG Gene

Genes around UVRAG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UVRAG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UVRAG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UVRAG Gene

Proteins for UVRAG Gene

  • Protein details for UVRAG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2Y5-UVRAG_HUMAN
    Recommended name:
    UV radiation resistance-associated gene protein
    Protein Accession:
    Q9P2Y5
    Secondary Accessions:
    • B3KTC1
    • O00392

    Protein attributes for UVRAG Gene

    Size:
    699 amino acids
    Molecular mass:
    78151 Da
    Quaternary structure:
    • Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex II (PI3KC3-C2) in which the core composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 is associated with UVRAG; in the complex interacts directly with BECN1. PI3KC3-C2 can associate with further regulatory subunits such as RUBCN and probably SH3GLB1/Bif-1 (PubMed:16799551, PubMed:18843052, PubMed:19050071, PubMed:19270696, PubMed:20643123, PubMed:23878393, PubMed:24056303). Interacts with SH3GLB1; UVRAG bridges the interaction to BECN1 indicative for an association with the PI3K complex PI3KC3-C2 (PubMed:17891140). Interacts with RINT1. Associates with the NRZ complex under basal conditions and dissociates from it under autophagy conditions to associate with the PI3K complex; these complex associations seem to be mutually exclusive (PubMed:24056303). Interacts with VPS16; VPS11; VPS18; VPS33 (VPS33A or VPS33B) and VPS39; indicative for an association with a class C Vps tethering complex (possibly the HOPS complex) (PubMed:18552835, PubMed:25533187). Interacts with RAB7A; RAB7A competes with UVRAG for RUBCN binding (PubMed:25533187, PubMed:20974968). Interacts with STX7, VTI1B, STX8 (PubMed:24550300). Interacts with PRKDC, XRCC6 and XRCC5; indicative for an association with the DNA-dependent protein kinase complex DNA-PK. Interacts with CEP63 (PubMed:22542840). Directly interacts with FEZ1 and SCOC; the interaction with SCOC is reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1 (PubMed:22354037). Interacts with BECN1P1/BECN2 (PubMed:23954414). Interracts with SLAMF1( PubMed:22493499).
    SequenceCaution:
    • Sequence=CAA67507.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for UVRAG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UVRAG Gene

Post-translational modifications for UVRAG Gene

  • Phosphorylated at Ser-498 by MTOR under basal conditions; increases the interaction with RUBCN implicated in inhibitory effect of RUBCN on PI3KC3 and decreases interaction with RAB7,A and VPS16 and VPS39 (indicative for a class C Vps complex, possibly the HOPS complex) (PubMed:25533187).

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UVRAG (UVRAG)
  • Abcam antibodies for UVRAG
  • Santa Cruz Biotechnology (SCBT) Antibodies for UVRAG

No data available for DME Specific Peptides for UVRAG Gene

Domains & Families for UVRAG Gene

Gene Families for UVRAG Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for UVRAG Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UVRAG: view

No data available for UniProtKB/Swiss-Prot for UVRAG Gene

Function for UVRAG Gene

Molecular function for UVRAG Gene

GENATLAS Biochemistry:
UV radiation resistance-associated gene
UniProtKB/Swiss-Prot Function:
Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300).
UniProtKB/Swiss-Prot Function:
Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840).

Phenotypes From GWAS Catalog for UVRAG Gene

Gene Ontology (GO) - Molecular Function for UVRAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005515 protein binding IPI 17891140
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with UVRAG: view
genes like me logo Genes that share phenotypes with UVRAG: view

Clone Products

  • Addgene plasmids for UVRAG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UVRAG Gene

Localization for UVRAG Gene

Subcellular locations from UniProtKB/Swiss-Prot for UVRAG Gene

Late endosome. Lysosome. Early endosome. Endoplasmic reticulum. Midbody. Chromosome, centromere. Note=Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UVRAG gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
lysosome 5
endosome 5
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UVRAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm TAS 9169138
GO:0005764 lysosome IEA,IDA 19270696
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with UVRAG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UVRAG Gene

Pathways & Interactions for UVRAG Gene

genes like me logo Genes that share pathways with UVRAG: view

Pathways by source for UVRAG Gene

1 GeneTex pathway for UVRAG Gene
1 Cell Signaling Technology pathway for UVRAG Gene
2 Reactome pathways for UVRAG Gene
1 KEGG pathway for UVRAG Gene

SIGNOR curated interactions for UVRAG Gene

Activates:

Gene Ontology (GO) - Biological Process for UVRAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS,IMP 22542840
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IMP 24056303
GO:0006914 autophagy IMP 24056303
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007051 spindle organization IEA --
genes like me logo Genes that share ontologies with UVRAG: view

Drugs & Compounds for UVRAG Gene

No Compound Related Data Available

Transcripts for UVRAG Gene

Unigene Clusters for UVRAG Gene

UV radiation resistance associated:
Representative Sequences:

Clone Products

  • Addgene plasmids for UVRAG

Alternative Splicing Database (ASD) splice patterns (SP) for UVRAG Gene

No ASD Table

Relevant External Links for UVRAG Gene

GeneLoc Exon Structure for
UVRAG
ECgene alternative splicing isoforms for
UVRAG

Expression for UVRAG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UVRAG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UVRAG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.4), Lymph node (11.1), Gallbladder (6.2), and Blymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UVRAG Gene



Protein tissue co-expression partners for UVRAG Gene

NURSA nuclear receptor signaling pathways regulating expression of UVRAG Gene:

UVRAG

SOURCE GeneReport for Unigene cluster for UVRAG Gene:

Hs.202470

mRNA Expression by UniProt/SwissProt for UVRAG Gene:

Q9P2Y5-UVRAG_HUMAN
Tissue specificity: Highly expressed in brain, lung, kidney and liver.

Evidence on tissue expression from TISSUES for UVRAG Gene

  • Heart(4.3)
  • Liver(4.2)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with UVRAG: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UVRAG Gene

Orthologs for UVRAG Gene

This gene was present in the common ancestor of animals.

Orthologs for UVRAG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UVRAG 33 34
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia UVRAG 33 34
  • 91.6 (n)
cow
(Bos Taurus)
Mammalia UVRAG 33 34
  • 91.46 (n)
rat
(Rattus norvegicus)
Mammalia Uvrag 33
  • 88.91 (n)
oppossum
(Monodelphis domestica)
Mammalia UVRAG 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uvrag 33 16 34
  • 85.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UVRAG 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves UVRAG 33 34
  • 77.12 (n)
lizard
(Anolis carolinensis)
Reptilia UVRAG 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uvrag 33
  • 69.74 (n)
Str.13743 33
zebrafish
(Danio rerio)
Actinopterygii uvrag 33 34
  • 62.58 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta Uvrag 34
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
OneToOne
Species where no ortholog for UVRAG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UVRAG Gene

ENSEMBL:
Gene Tree for UVRAG (if available)
TreeFam:
Gene Tree for UVRAG (if available)

Paralogs for UVRAG Gene

No data available for Paralogs for UVRAG Gene

Variants for UVRAG Gene

Sequence variations from dbSNP and Humsavar for UVRAG Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs864622029 uncertain-significance, Malignant tumor of prostate 75,888,896(+) A/G 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000006987 -- 76,113,410(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000007562 -- 75,843,915(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000009478 -- 75,964,793(+) G/A/C intron_variant
rs1000011579 -- 75,897,079(+) G/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UVRAG Gene

Variant ID Type Subtype PubMed ID
nsv975380 CNV duplication 23825009
nsv951043 CNV duplication 24416366
nsv832212 CNV gain 17160897
nsv515973 CNV gain 19592680
nsv515484 CNV loss 19592680
nsv478610 CNV novel sequence insertion 20440878
nsv476970 CNV novel sequence insertion 20440878
nsv475840 CNV novel sequence insertion 20440878
nsv394 CNV deletion 18451855
nsv1122645 CNV deletion 24896259
nsv1070053 CNV deletion 25765185
esv3626863 CNV loss 21293372
esv3626862 CNV loss 21293372
esv3626861 CNV loss 21293372
esv3579747 CNV loss 25503493
esv3424930 CNV insertion 20981092
esv27673 CNV loss 19812545
dgv392e212 CNV loss 25503493

Variation tolerance for UVRAG Gene

Residual Variation Intolerance Score: 21.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.92; 79.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UVRAG Gene

Human Gene Mutation Database (HGMD)
UVRAG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UVRAG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UVRAG Gene

Disorders for UVRAG Gene

MalaCards: The human disease database

(2) MalaCards diseases for UVRAG Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ascending colon cancer
  • ca ascending colon
cholecystolithiasis
- elite association - COSMIC cancer census association via MalaCards
Search UVRAG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

UVRAG_HUMAN
  • Note=A chromosomal aberration involving UVRAG has been observed in a patient with heterotaxy (left-right axis malformation). Inversion Inv(11)(q13.5;q25). {ECO:0000269 PubMed:10798355}.

Additional Disease Information for UVRAG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with UVRAG: view

No data available for Genatlas for UVRAG Gene

Publications for UVRAG Gene

  1. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. (PMID: 18843052) Itakura E … Mizushima N (Molecular biology of the cell 2008) 2 3 4 58
  2. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. (PMID: 16799551) Liang C … Jung JU (Nature cell biology 2006) 2 3 4 58
  3. Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation. (PMID: 10798355) Iida A … Nakamura Y (Human genetics 2000) 3 4 22 58
  4. Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus. (PMID: 9169138) Perelman B … Canaani D (Genomics 1997) 2 3 4 58
  5. mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation. (PMID: 25533187) Kim YM … Kim DH (Molecular cell 2015) 3 4 58

Products for UVRAG Gene

  • Addgene plasmids for UVRAG

Sources for UVRAG Gene

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