Aliases for UTS2R Gene

Aliases for UTS2R Gene

  • Urotensin 2 Receptor 2 3 5
  • G-Protein Coupled Receptor 14 3 4
  • Urotensin II Receptor 3 4
  • Urotensin-2 Receptor 3 4
  • UR-II-R 3 4
  • UR-2-R 3 4
  • GPR14 3 4
  • G Protein-Coupled Receptor 14 2
  • UTS2R 5
  • UTR2 3
  • UTR 3

External Ids for UTS2R Gene

Previous HGNC Symbols for UTS2R Gene

  • GPR14

Previous GeneCards Identifiers for UTS2R Gene

  • GC17P077925
  • GC17P080332
  • GC17P075730

Summaries for UTS2R Gene

GeneCards Summary for UTS2R Gene

UTS2R (Urotensin 2 Receptor) is a Protein Coding gene. Diseases associated with UTS2R include Pheochromocytoma and Rhabdomyosarcoma. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and urotensin II receptor activity. An important paralog of this gene is SSTR5.

UniProtKB/Swiss-Prot Summary for UTS2R Gene

  • High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for UTS2R Gene

  • The urotensin-II (UT) receptor is a Gq/11-protein-coupled receptor that mediates complex hemodynamic effects and influences neuromuscular physiology. The UT receptor displays greatest expression levels in the peripheral vasculature, heart and kidney.

Gene Wiki entry for UTS2R Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UTS2R Gene

Genomics for UTS2R Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UTS2R Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UTS2R on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UTS2R

Top Transcription factor binding sites by QIAGEN in the UTS2R gene promoter:
  • Arnt
  • Bach2
  • E47
  • FOXJ2
  • FOXJ2 (long isoform)
  • MyoD
  • PPAR-alpha
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for UTS2R Gene

Latest Assembly
chr17:82,371,400-82,377,458
(GRCh38/hg38)
Size:
6,059 bases
Orientation:
Plus strand

Previous Assembly
chr17:80,329,641-80,335,334
(GRCh37/hg19 by Entrez Gene)
Size:
5,694 bases
Orientation:
Plus strand

chr17:80,332,153-80,333,462
(GRCh37/hg19 by Ensembl)
Size:
1,310 bases
Orientation:
Plus strand

Genomic View for UTS2R Gene

Genes around UTS2R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTS2R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTS2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTS2R Gene

Proteins for UTS2R Gene

  • Protein details for UTS2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKP6-UR2R_HUMAN
    Recommended name:
    Urotensin-2 receptor
    Protein Accession:
    Q9UKP6
    Secondary Accessions:
    • B2RMV8

    Protein attributes for UTS2R Gene

    Size:
    389 amino acids
    Molecular mass:
    42130 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UTS2R Gene

neXtProt entry for UTS2R Gene

Post-translational modifications for UTS2R Gene

  • Glycosylation at Asn29 and Asn33
  • Modification sites at PhosphoSitePlus

Other Protein References for UTS2R Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UTS2R Gene

Domains & Families for UTS2R Gene

Gene Families for UTS2R Gene

IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for UTS2R Gene

InterPro:
Blocks:
  • SENR orphan receptor signature

Suggested Antigen Peptide Sequences for UTS2R Gene

GenScript: Design optimal peptide antigens:
  • Urotensin II receptor (UR2R_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UKP6

UniProtKB/Swiss-Prot:

UR2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with UTS2R: view

Function for UTS2R Gene

Molecular function for UTS2R Gene

UniProtKB/Swiss-Prot Function:
High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.

Phenotypes From GWAS Catalog for UTS2R Gene

Gene Ontology (GO) - Molecular Function for UTS2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001604 urotensin II receptor activity IBA 21873635
GO:0004930 G protein-coupled receptor activity TAS 10499587
GO:0008528 G protein-coupled peptide receptor activity IBA 21873635
genes like me logo Genes that share ontologies with UTS2R: view
genes like me logo Genes that share phenotypes with UTS2R: view

Animal Models for UTS2R Gene

MGI Knock Outs for UTS2R:

Animal Models for research

  • Taconic Biosciences Mouse Models for UTS2R

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UTS2R

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for UTS2R Gene

Localization for UTS2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTS2R Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTS2R gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for UTS2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane TAS 8666380
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UTS2R: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UTS2R Gene

Pathways & Interactions for UTS2R Gene

genes like me logo Genes that share pathways with UTS2R: view

SIGNOR curated interactions for UTS2R Gene

Gene Ontology (GO) - Biological Process for UTS2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10499587
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007218 neuropeptide signaling pathway IBA 21873635
GO:0008015 blood circulation TAS 10499587
GO:0008217 regulation of blood pressure IEA --
genes like me logo Genes that share ontologies with UTS2R: view

Drugs & Compounds for UTS2R Gene

(25) Drugs for UTS2R Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palosuran Pharma Antagonist Urotensin-II receptor antagonist 0
[Orn5]-URP Pharma Urotensin-II (UT) receptor antagonist 0
SB 657510 Pharma Selective urotensin-II (UT) receptor antagonist 0
UFP 803 Pharma Urotensin-II (UT) antagonist 0
Urotensin II (human) Pharma Endogenous vasoactive agonist for the UT receptor 0

(2) Additional Compounds for UTS2R Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-AC 7954 hydrochloride
477313-09-0

(5) Tocris Compounds for UTS2R Gene

Compound Action Cas Number
(+-)-AC 7954 hydrochloride Non-peptide UT receptor agonist 477313-09-0
[Orn5]-URP Urotensin-II (UT) receptor antagonist 782485-03-4
SB 657510 Selective urotensin-II (UT) receptor antagonist 474960-44-6
UFP 803 Urotensin-II (UT) antagonist 879497-82-2
Urotensin II (human) Endogenous vasoactive agonist for the UT receptor 251293-28-4

(9) ApexBio Compounds for UTS2R Gene

Compound Action Cas Number
(±)-AC 7954 hydrochloride 477313-09-0
[Orn5]-URP 782485-03-4
GSK 1562590 hydrochloride 1003878-07-6
Palosuran Urotensin-II receptor antagonist 540769-28-6
SB 611812 345892-71-9
SB 657510 474960-44-6
SB 706375 733734-61-7
UFP 803 879497-82-2
Urotensin II (human) 251293-28-4
genes like me logo Genes that share compounds with UTS2R: view

Drug products for research

Transcripts for UTS2R Gene

mRNA/cDNA for UTS2R Gene

2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UTS2R

Alternative Splicing Database (ASD) splice patterns (SP) for UTS2R Gene

No ASD Table

Relevant External Links for UTS2R Gene

GeneLoc Exon Structure for
UTS2R

Expression for UTS2R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UTS2R Gene

mRNA differential expression in normal tissues according to GTEx for UTS2R Gene

This gene is overexpressed in Testis (x14.5), Thyroid (x4.5), and Heart - Atrial Appendage (x4.1).

Protein differential expression in normal tissues from HIPED for UTS2R Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UTS2R Gene



Protein tissue co-expression partners for UTS2R Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UTS2R

SOURCE GeneReport for Unigene cluster for UTS2R Gene:

Hs.192720

mRNA Expression by UniProt/SwissProt for UTS2R Gene:

Q9UKP6-UR2R_HUMAN
Tissue specificity: Most abundant expression in the heart and pancreas.

Evidence on tissue expression from TISSUES for UTS2R Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with UTS2R: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for UTS2R Gene

Orthologs for UTS2R Gene

This gene was present in the common ancestor of animals.

Orthologs for UTS2R Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia UTS2R 29 30
  • 99.14 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia UTS2R 29 30
  • 82.26 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia UTS2R 29 30
  • 80.6 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Uts2r 29 16 30
  • 78.71 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Uts2r 29
  • 78.23 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia UTS2R 30
  • 63 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia UTS2R 30
  • 46 (a)
OneToOne
Chicken
(Gallus gallus)
Aves UTS2R 29 30
  • 65.12 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia UTS2R 30
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100485936 29
  • 67.55 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC559133 29
  • 59.96 (n)
UTS2R 30
  • 50 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea npr-16 30
  • 18 (a)
OneToOne
Species where no ortholog for UTS2R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for UTS2R Gene

ENSEMBL:
Gene Tree for UTS2R (if available)
TreeFam:
Gene Tree for UTS2R (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UTS2R: view image
Alliance of Genome Resources:
Additional Orthologs for UTS2R

Paralogs for UTS2R Gene

(6) SIMAP similar genes for UTS2R Gene using alignment to 1 proteins:

  • UR2R_HUMAN
genes like me logo Genes that share paralogs with UTS2R: view

Variants for UTS2R Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UTS2R Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs34582297 Benign: not provided 82,374,867(+) G/A
NM_018949.2(UTS2R):c.543G>A (p.Thr181=)
SYNONYMOUS
rs34668956 Benign: not provided 82,374,420(+) C/T
NM_018949.2(UTS2R):c.96C>T (p.Leu32=)
SYNONYMOUS
rs41367349 Benign: not provided 82,374,685(+) G/T
NM_018949.2(UTS2R):c.361G>T (p.Val121Leu)
MISSENSE
rs770047242 A breast cancer sample p.Ser146Arg
rs34442190 -- p.Ala70Pro

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UTS2R Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UTS2R Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv2760445 CNV gain 21179565
esv2762577 CNV gain+loss 21179565
esv3641423 CNV gain 21293372
nsv1059334 CNV gain 25217958
nsv1067194 CNV gain 25217958
nsv428351 CNV gain 18775914
nsv469561 CNV loss 16826518
nsv833572 CNV loss 17160897
nsv833573 CNV loss 17160897
nsv952394 CNV deletion 24416366

Variation tolerance for UTS2R Gene

Gene Damage Index Score: 2.20; 39.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UTS2R Gene

Human Gene Mutation Database (HGMD)
UTS2R
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTS2R
Leiden Open Variation Database (LOVD)
UTS2R

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTS2R Gene

Disorders for UTS2R Gene

MalaCards: The human disease database

(3) MalaCards diseases for UTS2R Gene - From: COP and GCD

Disorder Aliases PubMed IDs
pheochromocytoma
  • pheochromocytoma, susceptibility to
rhabdomyosarcoma
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards
Search UTS2R in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UTS2R

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with UTS2R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UTS2R Gene

Publications for UTS2R Gene

  1. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. (PMID: 10499587) Ames RS … Douglas SA (Nature 1999) 2 3 4 22
  2. Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance. (PMID: 16597476) Ong KL … Cheung BM (Peptides 2006) 3 22 40
  3. Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain. (PMID: 14550283) Sugo T … Fujino M (Biochemical and biophysical research communications 2003) 3 4 22
  4. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. (PMID: 8666380) Marchese A … Gregor P (Genomics 1995) 2 3 22
  5. Increased expression of urotensin II and GPR14 in patients with cirrhosis and portal hypertension. (PMID: 20428787) Liu D … Wang Y (International journal of molecular medicine 2010) 3 22

Products for UTS2R Gene

Sources for UTS2R Gene