Aliases for UTS2B Gene

Aliases for UTS2B Gene

  • Urotensin 2B 2 3 5
  • URP 2 3 4
  • Urotensin-2 Domain-Containing Protein 3 4
  • Urotensin 2 Domain Containing 2 3
  • Urotensin II-Related Peptide 3 4
  • Urotensin IIB 3 4
  • Urotensin-2B 3 4
  • Prepro-URP 2 3
  • U-IIB 3 4
  • UTS2D 3 4
  • UIIB 3 4
  • U2B 2 3
  • UTS2B 5

External Ids for UTS2B Gene

Previous HGNC Symbols for UTS2B Gene

  • UTS2D

Previous GeneCards Identifiers for UTS2B Gene

  • GC03M190985

Summaries for UTS2B Gene

GeneCards Summary for UTS2B Gene

UTS2B (Urotensin 2B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include hormone activity and G protein-coupled receptor binding.

UniProtKB/Swiss-Prot Summary for UTS2B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UTS2B Gene

Genomics for UTS2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UTS2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J191328 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 256.1 -0.1 -143 5.2 BCLAF1 SP1 ZNF207 NCOR1 MYC IKZF1 ZNF592 ATF2 POLR2A CEBPA CCDC50 UTS2B lnc-GMNC-4 HSALNG0031595 PYDC2
GH03J191282 Promoter 0.4 EPDnew 261.3 +48.2 48193 0.1 CEBPB UTS2B CCDC50 OSTN-AS1 piR-34822-241 lnc-GMNC-4 OSTN
GH03J191350 Enhancer 1.1 Ensembl ENCODE dbSUPER 18.2 -20.5 -20465 6.8 ZNF600 YY1 FEZF1 FOXA2 RXRA SAP130 ZNF585B SMARCA5 FOSL2 JUND CCDC50 UTS2B OSTN HSALNG0031595 lnc-GMNC-4 PYDC2
GH03J191235 Enhancer 1.2 FANTOM5 Ensembl ENCODE 15.5 +92.4 92435 6.2 BCLAF1 SP1 POLR2A CEBPA BCL11A CEBPB FOXA1 ZNF592 TRIM22 HOMEZ UTS2B CCDC50 OSTN-AS1 OSTN
GH03J191375 Enhancer 1.1 Ensembl ENCODE dbSUPER 17.4 -47.4 -47365 4.2 ZNF600 FEZF1 KLF9 ZNF316 ZNF843 NFE2 KLF16 PRDM6 INSM2 MAFK CCDC50 UTS2B OSTN HSALNG0031597 lnc-PYDC2-7 PYDC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UTS2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UTS2B

Genomic Locations for UTS2B Gene

Latest Assembly
chr3:191,266,465-191,330,536
(GRCh38/hg38)
Size:
64,072 bases
Orientation:
Minus strand

Previous Assembly
chr3:190,984,957-191,048,325
(GRCh37/hg19 by Entrez Gene)
Size:
63,369 bases
Orientation:
Minus strand

chr3:190,984,957-191,048,325
(GRCh37/hg19 by Ensembl)
Size:
63,369 bases
Orientation:
Minus strand

Genomic View for UTS2B Gene

Genes around UTS2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTS2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTS2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTS2B Gene

Proteins for UTS2B Gene

  • Protein details for UTS2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q765I0-UTS2B_HUMAN
    Recommended name:
    Urotensin-2B
    Protein Accession:
    Q765I0
    Secondary Accessions:
    • B3KQY8
    • D3DNW1
    • Q2M1Z2

    Protein attributes for UTS2B Gene

    Size:
    119 amino acids
    Molecular mass:
    13749 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UTS2B Gene

Post-translational modifications for UTS2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for UTS2B Gene

Domains & Families for UTS2B Gene

Gene Families for UTS2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for UTS2B Gene

InterPro:
Blocks:
  • Urotensin II

Suggested Antigen Peptide Sequences for UTS2B Gene

GenScript: Design optimal peptide antigens:
  • Urotensin-2 domain-containing protein (UTS2B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q765I0

UniProtKB/Swiss-Prot:

UTS2B_HUMAN :
  • Belongs to the urotensin-2 family.
Family:
  • Belongs to the urotensin-2 family.
genes like me logo Genes that share domains with UTS2B: view

Function for UTS2B Gene

Molecular function for UTS2B Gene

UniProtKB/Swiss-Prot Function:
Potent vasoconstrictor.

Phenotypes From GWAS Catalog for UTS2B Gene

Gene Ontology (GO) - Molecular Function for UTS2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G protein-coupled receptor binding IBA 21873635
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with UTS2B: view
genes like me logo Genes that share phenotypes with UTS2B: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UTS2B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UTS2B Gene

Localization for UTS2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTS2B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTS2B gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for UTS2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with UTS2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UTS2B Gene

Pathways & Interactions for UTS2B Gene

genes like me logo Genes that share pathways with UTS2B: view

Gene Ontology (GO) - Biological Process for UTS2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0008217 regulation of blood pressure IBA 21873635
GO:0097746 regulation of blood vessel diameter IEA --
genes like me logo Genes that share ontologies with UTS2B: view

No data available for SIGNOR curated interactions for UTS2B Gene

Drugs & Compounds for UTS2B Gene

No Compound Related Data Available

Transcripts for UTS2B Gene

mRNA/cDNA for UTS2B Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UTS2B

Alternative Splicing Database (ASD) splice patterns (SP) for UTS2B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: -
SP2: - - -
SP3:
SP4: - -

Relevant External Links for UTS2B Gene

GeneLoc Exon Structure for
UTS2B

Expression for UTS2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UTS2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UTS2B Gene

This gene is overexpressed in Testis (x7.0) and Brain - Amygdala (x4.8).

Protein differential expression in normal tissues from HIPED for UTS2B Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UTS2B Gene



Protein tissue co-expression partners for UTS2B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UTS2B

SOURCE GeneReport for Unigene cluster for UTS2B Gene:

Hs.518492

Evidence on tissue expression from TISSUES for UTS2B Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with UTS2B: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UTS2B Gene

Orthologs for UTS2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for UTS2B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia UTS2D 29 30
  • 98.6 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia UTS2B 29 30
  • 82.35 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia UTS2B 29 30
  • 81.51 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Uts2b 29
  • 72.08 (n)
Mouse
(Mus musculus)
Mammalia Uts2b 29 16 30
  • 69.05 (n)
OneToOne
Chicken
(Gallus gallus)
Aves UTS2D 29 30
  • 58.48 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia uts2b 29
  • 59.32 (n)
Species where no ortholog for UTS2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for UTS2B Gene

ENSEMBL:
Gene Tree for UTS2B (if available)
TreeFam:
Gene Tree for UTS2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UTS2B: view image
Alliance of Genome Resources:
Additional Orthologs for UTS2B

Paralogs for UTS2B Gene

No data available for Paralogs for UTS2B Gene

Variants for UTS2B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UTS2B Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs9847278 Benign: not specified 191,329,743(-) A/G
NM_178335.3(CCDC50):c.49+20A>G
INTRON
rs6788319 -- p.Ser21Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UTS2B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UTS2B Gene

Variant ID Type Subtype PubMed ID
esv2668071 CNV deletion 23128226
esv26911 CNV loss 19812545
esv2759209 CNV gain+loss 17122850
esv2763330 CNV loss 21179565
esv3304195 CNV mobile element insertion 20981092
esv3308454 CNV mobile element insertion 20981092
esv3365700 CNV insertion 20981092
esv3404133 CNV insertion 20981092
esv3599089 CNV loss 21293372
esv3599090 CNV gain 21293372
esv3599094 CNV loss 21293372
esv3599095 CNV loss 21293372
esv3599096 CNV gain 21293372
esv3599098 CNV loss 21293372
esv3599099 CNV gain 21293372
esv3599101 CNV loss 21293372
esv3599102 CNV loss 21293372
esv3599103 CNV gain 21293372
esv7437 CNV gain 19470904
nsv1012488 CNV loss 25217958
nsv10369 CNV loss 18304495
nsv10370 CNV loss 18304495
nsv4169 CNV deletion 18451855
nsv428428 CNV gain 18775914
nsv509873 OTHER sequence alteration 20534489
nsv997716 CNV loss 25217958
nsv998208 CNV gain 25217958

Variation tolerance for UTS2B Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 50.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UTS2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTS2B
Leiden Open Variation Database (LOVD)
UTS2B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTS2B Gene

Disorders for UTS2B Gene

Additional Disease Information for UTS2B

No disorders were found for UTS2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTS2B Gene

Publications for UTS2B Gene

  1. Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain. (PMID: 14550283) Sugo T … Fujino M (Biochemical and biophysical research communications 2003) 2 3 4 22
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  4. Urotensin-II system in genetic control of blood pressure and renal function. (PMID: 24391740) Debiec R … Tomaszewski M (PloS one 2013) 3
  5. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney SJ … AddNeuroMed Consortium (Molecular psychiatry 2011) 3

Products for UTS2B Gene

Sources for UTS2B Gene