This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprot... See more...

Aliases for UTS2 Gene

Aliases for UTS2 Gene

  • Urotensin 2 2 3 5
  • Urotensin II 3 4
  • Urotensin-2 3 4
  • Prepro U-II 2 3
  • U-II 3 4
  • UII 3 4
  • PRO1068 3
  • UCN2 3

External Ids for UTS2 Gene

Previous GeneCards Identifiers for UTS2 Gene

  • GC01M007485
  • GC01M007716
  • GC01M007617
  • GC01M007841
  • GC01M007055

Summaries for UTS2 Gene

Entrez Gene Summary for UTS2 Gene

  • This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UTS2 Gene

UTS2 (Urotensin 2) is a Protein Coding gene. Diseases associated with UTS2 include Portal Hypertension and Congestive Heart Failure. Among its related pathways are p70S6K Signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and hormone activity.

UniProtKB/Swiss-Prot Summary for UTS2 Gene

Tocris Summary for UTS2 Gene

  • The urotensin-II (UT) receptor is a Gq/11-protein-coupled receptor that mediates complex hemodynamic effects and influences neuromuscular physiology. The UT receptor displays greatest expression levels in the peripheral vasculature, heart and kidney.

Gene Wiki entry for UTS2 Gene

Additional gene information for UTS2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UTS2 Gene

Genomics for UTS2 Gene

GeneHancer (GH) Regulatory Elements for UTS2 Gene

Promoters and enhancers for UTS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J007912 Promoter/Enhancer 0.8 EPDnew ENCODE 784.2 +0.4 446 1 POLR2A ZNF512 HDAC1 KDM1A ZEB2 CBFA2T3 UTS2 FJ601684-003 TNFRSF9 VAMP3 PER3 SLC45A1 ENSG00000238290
GH01J007853 Promoter/Enhancer 0.8 EPDnew Ensembl 750.2 +60.4 60409 0.4 CBFA2T2 IKZF1 PKNOX1 TCF7L2 OSR2 KDM1A CBFA2T3 UTS2 PARK7 ENSG00000270171 FJ601661 piR-32214-004
GH01J007914 Enhancer 0.2 Ensembl 750.6 -1.4 -1391 0.4 UTS2 TNFRSF9 VAMP3 PER3 SLC45A1 FJ601684-004
GH01J007826 Promoter/Enhancer 1.2 Ensembl ENCODE 18 +86.1 86110 2.2 ZBTB40 MYC CC2D1A ELF1 L3MBTL2 MAX GTF2F1 CSDE1 ZFX POLR2A ENSG00000236266 VAMP3 UTS2 ENSG00000270171 ENSG00000269978 PER3 SLC45A1 TNFRSF9 ENSG00000270035 ENSG00000269925
GH01J007921 Enhancer 0.7 Ensembl ENCODE 23.5 -7.9 -7918 2.7 IKZF1 RNF2 FOS FOSL1 JUN JUND SMARCA4 UTS2 PER3 PARK7 ENSG00000238290 FJ601684-004 TNFRSF9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UTS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UTS2 gene promoter:
  • ATF-2
  • CUTL1
  • E47
  • FOXD1
  • Hand1
  • Roaz

Genomic Locations for UTS2 Gene

Genomic Locations for UTS2 Gene
chr1:7,843,083-7,913,610
(GRCh38/hg38)
Size:
70,528 bases
Orientation:
Minus strand
chr1:7,903,143-7,913,572
(GRCh37/hg19)
Size:
10,430 bases
Orientation:
Minus strand

Genomic View for UTS2 Gene

Genes around UTS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTS2 Gene

Proteins for UTS2 Gene

  • Protein details for UTS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95399-UTS2_HUMAN
    Recommended name:
    Urotensin-2
    Protein Accession:
    O95399
    Secondary Accessions:
    • Q5H8X7
    • Q6UXF6
    • Q9UKP7

    Protein attributes for UTS2 Gene

    Size:
    124 amino acids
    Molecular mass:
    14296 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UTS2 Gene

    Alternative splice isoforms for UTS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UTS2 Gene

Post-translational modifications for UTS2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for UTS2 Gene

Domains & Families for UTS2 Gene

Gene Families for UTS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for UTS2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UTS2 Gene

GenScript: Design optimal peptide antigens:
  • UTS2 protein (A0AVP6_HUMAN)
  • Urotensin 2 (Q5H8X8_HUMAN)
  • Urotensin II (UTS2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95399

UniProtKB/Swiss-Prot:

UTS2_HUMAN :
  • Belongs to the urotensin-2 family.
Family:
  • Belongs to the urotensin-2 family.
genes like me logo Genes that share domains with UTS2: view

Function for UTS2 Gene

Molecular function for UTS2 Gene

UniProtKB/Swiss-Prot Function:
Highly potent vasoconstrictor.

Phenotypes From GWAS Catalog for UTS2 Gene

Gene Ontology (GO) - Molecular Function for UTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 10499587
GO:0005179 hormone activity IEA,TAS --
genes like me logo Genes that share ontologies with UTS2: view
genes like me logo Genes that share phenotypes with UTS2: view

Animal Models for UTS2 Gene

MGI Knock Outs for UTS2:
  • Uts2 Uts2<tm1b(KOMP)Wtsi>
  • Uts2 Uts2<tm1Ags>

Animal Model Products

  • Taconic Biosciences Mouse Models for UTS2

CRISPR Products

miRNA for UTS2 Gene

miRTarBase miRNAs that target UTS2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UTS2 Gene

Localization for UTS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTS2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTS2 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for UTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA,TAS 21873635
genes like me logo Genes that share ontologies with UTS2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UTS2 Gene

Pathways & Interactions for UTS2 Gene

PathCards logo

SuperPathways for UTS2 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
2 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
3 ERK Signaling
.61
.61
.58
.51
.49
4 Peptide ligand-binding receptors
5 Nanog in Mammalian ESC Pluripotency
.61
.61
.59
.48
genes like me logo Genes that share pathways with UTS2: view

Pathways by source for UTS2 Gene

1 KEGG pathway for UTS2 Gene
55 Qiagen pathways for UTS2 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

Gene Ontology (GO) - Biological Process for UTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 10499587
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007268 chemical synaptic transmission TAS 10499587
GO:0008217 regulation of blood pressure TAS,IEA --
GO:0097746 regulation of blood vessel diameter IEA --
genes like me logo Genes that share ontologies with UTS2: view

No data available for SIGNOR curated interactions for UTS2 Gene

Drugs & Compounds for UTS2 Gene

(24) Drugs for UTS2 Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[Orn5]-URP Pharma Urotensin-II (UT) receptor antagonist 0
SB 657510 Pharma Selective urotensin-II (UT) receptor antagonist 0
UFP 803 Pharma Urotensin-II (UT) antagonist 0
Urotensin II (human) Pharma Endogenous vasoactive agonist for the UT receptor 0

(14) Additional Compounds for UTS2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-AC 7954 hydrochloride
477313-09-0

(5) Tocris Compounds for UTS2 Gene

Compound Action Cas Number
(+-)-AC 7954 hydrochloride Non-peptide UT receptor agonist 477313-09-0
[Orn5]-URP Urotensin-II (UT) receptor antagonist 782485-03-4
SB 657510 Selective urotensin-II (UT) receptor antagonist 474960-44-6
UFP 803 Urotensin-II (UT) antagonist 879497-82-2
Urotensin II (human) Endogenous vasoactive agonist for the UT receptor 251293-28-4
genes like me logo Genes that share compounds with UTS2: view

Transcripts for UTS2 Gene

mRNA/cDNA for UTS2 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTS2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2: -

Relevant External Links for UTS2 Gene

GeneLoc Exon Structure for
UTS2
ECgene alternative splicing isoforms for
UTS2

Expression for UTS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UTS2 Gene

mRNA differential expression in normal tissues according to GTEx for UTS2 Gene

This gene is overexpressed in Whole Blood (x11.3), Brain - Spinal cord (cervical c-1) (x9.2), Adrenal Gland (x6.1), and Brain - Hypothalamus (x5.6).

Protein differential expression in normal tissues from HIPED for UTS2 Gene

This gene is overexpressed in Stomach (10.0) and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UTS2 Gene



Protein tissue co-expression partners for UTS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of UTS2 Gene:

UTS2

SOURCE GeneReport for Unigene cluster for UTS2 Gene:

Hs.715862

mRNA Expression by UniProt/SwissProt for UTS2 Gene:

O95399-UTS2_HUMAN
Tissue specificity: Brain specific.

Evidence on tissue expression from TISSUES for UTS2 Gene

  • Nervous system(4.6)
  • Heart(2.4)
  • Muscle(2.3)
  • Blood(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with UTS2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for UTS2 Gene

Orthologs for UTS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UTS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UTS2 32
  • 81.57 (n)
dog
(Canis familiaris)
Mammalia UTS2 32
  • 76.15 (n)
chimpanzee
(Pan troglodytes)
Mammalia UTS2 33
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uts2 32
  • 67.76 (n)
mouse
(Mus musculus)
Mammalia Uts2 17 33 32
  • 65.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UTS2 33
  • 43 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UTS2 33
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves UTS2 33
  • 40 (a)
OneToOne
Species where no ortholog for UTS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UTS2 Gene

ENSEMBL:
Gene Tree for UTS2 (if available)
TreeFam:
Gene Tree for UTS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UTS2: view image

Paralogs for UTS2 Gene

No data available for Paralogs for UTS2 Gene

Variants for UTS2 Gene

Sequence variations from dbSNP and Humsavar for UTS2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000009758 -- 7,889,996(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000107481 -- 7,906,582(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000108269 -- 7,865,948(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000108716 -- 7,895,944(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000200069 -- 7,890,971(-) C/G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UTS2 Gene

Variant ID Type Subtype PubMed ID
esv2660700 CNV deletion 23128226
esv3585131 CNV loss 21293372

Variation tolerance for UTS2 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.90; 91.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UTS2 Gene

Human Gene Mutation Database (HGMD)
UTS2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTS2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTS2 Gene

Disorders for UTS2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for UTS2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
portal hypertension
  • hypertension, portal
congestive heart failure
  • cardiac failure congestive
liver cirrhosis
  • cirrhosis
pulmonary hypertension
  • primary pulmonary hypertension
kidney disease
  • nephropathy
- elite association - COSMIC cancer census association via MalaCards
Search UTS2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UTS2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with UTS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UTS2 Gene

Publications for UTS2 Gene

  1. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. (PMID: 10499587) Ames RS … Douglas SA (Nature 1999) 2 3 4 23 56
  2. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. (PMID: 9861051) Coulouarn Y … Vaudry H (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 23 56
  3. Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese. (PMID: 15476949) Suzuki S … Oka Y (Peptides 2004) 3 23 43 56
  4. Role of urotensin II gene in genetic susceptibility to Type 2 diabetes mellitus in Japanese subjects. (PMID: 12830381) Wenyi Z … Oka Y (Diabetologia 2003) 3 23 43 56
  5. Increased plasma levels of endothelin-1 and urotensin-II in patients with coronary heart disease. (PMID: 20339975) Chai SB … Tang CS (Heart and vessels 2010) 3 23 56

Products for UTS2 Gene

Sources for UTS2 Gene