Aliases for UTS2 Gene
External Ids for UTS2 Gene
Previous GeneCards Identifiers for UTS2 Gene
This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for UTS2 Gene
UTS2 (Urotensin 2) is a Protein Coding gene. Diseases associated with UTS2 include Portal Hypertension and Congestive Heart Failure. Among its related pathways are Signaling by GPCR and ERK Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and hormone activity.
UniProtKB/Swiss-Prot Summary for UTS2 Gene
Highly potent vasoconstrictor.
The urotensin-II (UT) receptor is a Gq/11-protein-coupled receptor that mediates complex hemodynamic effects and influences neuromuscular physiology. The UT receptor displays greatest expression levels in the peripheral vasculature, heart and kidney.